Phase 1 trial of dichloroacetate (DCA) in adults with recurrent malignant brain tumors

Investigational New Drugs

Volumn 32, Issue 3, 2014, Pages 452-464

  Dunbar, E M ^a,b   Coats, B S ^a   Shroads, A L ^a   Langaee, T ^c   Lew, A ^a   Forder, J R ^a   Shuster, J J ^a   Wagner, D A ^d   Stacpoole, P W ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b PIEDMONT HOSPITAL   (United States)

^c UNIVERSITY OF FLORIDA HEALTH   (United States)

^d METABOLIC SOLUTIONS INC   (United States)

Author keywords

Dichloroacetate; Malignant (high grade) glioma; Phase 1 trial; Pyruvate dehydrogenase complex; Pyruvate dehydrogenase kinase; Warburg effect

Indexed keywords

DICHLOROACETIC ACID; GLUTATHIONE TRANSFERASE; GLUTATHIONE TRANSFERASE ZETA 1; ISOMERASE; MALEYLACETOACETATE ISOMERASE; UNCLASSIFIED DRUG; ACETONE; ALANINE AMINOTRANSFERASE; ANTINEOPLASTIC AGENT; ASPARTATE AMINOTRANSFERASE; GSTZ1 PROTEIN, HUMAN; MALEIC ACID DERIVATIVE; MALEYLACETONE; PYRUVIC ACID;

ADULT; AGED; ARTICLE; BRAIN METASTASIS; CANCER GRADING; CANCER RECURRENCE; CATALYSIS; CHRONIC DRUG ADMINISTRATION; CLINICAL ARTICLE; CONTROLLED STUDY; DISTAL PARESTHESIA; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG SAFETY; DRUG STRUCTURE; DRUG TOLERABILITY; DRUG WITHDRAWAL; EVENING DOSAGE; FATIGUE; FEMALE; GAIT DISORDER; GLIOMA; HUMAN; MALE; MIDDLE AGED; MORNING DOSAGE; MULTIPLE CYCLE TREATMENT; ONSET AGE; PERIPHERAL NEUROPATHY; PHASE 1 CLINICAL TRIAL; PRIMARY TUMOR; PRIORITY JOURNAL; SOMNOLENCE; TREATMENT DURATION; ANALOGS AND DERIVATIVES; BLOOD; BRAIN NEOPLASMS; BREATH ANALYSIS; CLINICAL TRIAL; GENETICS; HAPLOTYPE; METABOLISM; URINE;

ACETONE; ADULT; AGED; ALANINE TRANSAMINASE; ANTINEOPLASTIC AGENTS; ASPARTATE AMINOTRANSFERASES; BRAIN NEOPLASMS; BREATH TESTS; DICHLOROACETIC ACID; FEMALE; GLUTATHIONE TRANSFERASE; HAPLOTYPES; HUMANS; MALE; MALEATES; MIDDLE AGED; PYRUVIC ACID;

EID: 84904631827     PISSN: 01676997     EISSN: 15730646     Source Type: Journal    
DOI: 10.1007/s10637-013-0047-4     Document Type: Article

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