메뉴 건너뛰기




Volumn 12, Issue 1, 2013, Pages

Tumor glycolysis as a target for cancer therapy: Progress and prospects

Author keywords

Antiglycolytic agents; Cancer metabolism; Chemotherapy; Glycolysis

Indexed keywords

CELL NUCLEUS DNA; FRUCTOSE 1,6 BISPHOSPHATE; FUMARIC ACID; GLUCOSE 6 PHOSPHATE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; GLYCOLYTIC ENZYME; ISOCITRATE DEHYDROGENASE; LACTATE DEHYDROGENASE; MAMMALIAN TARGET OF RAPAMYCIN; MITOCHONDRIAL DNA; OXIDOREDUCTASE; PHOSPHOENOLPYRUVATE; PYRUVATE KINASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; SUCCINATE DEHYDROGENASE;

EID: 84888798201     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/1476-4598-12-152     Document Type: Review
Times cited : (959)

References (121)
  • 1
    • 0035296491 scopus 로고    scopus 로고
    • Clinical role of positron emission tomography in oncology
    • 10.1016/S1470-2045(00)00257-6, 11902566
    • Bomanji JB, Costa DC, Ell PJ. Clinical role of positron emission tomography in oncology. Lancet Oncol 2001, 2(3):157-164. 10.1016/S1470-2045(00)00257-6, 11902566.
    • (2001) Lancet Oncol , vol.2 , Issue.3 , pp. 157-164
    • Bomanji, J.B.1    Costa, D.C.2    Ell, P.J.3
  • 2
    • 12444279265 scopus 로고
    • On the origin of cancer cells
    • 0036-8075 (Print), 10.1126/science.123.3191.309, 13298683
    • Warburg O. On the origin of cancer cells. Science 1956, 123(3191):309-314. 0036-8075 (Print), 10.1126/science.123.3191.309, 13298683.
    • (1956) Science , vol.123 , Issue.3191 , pp. 309-314
    • Warburg, O.1
  • 3
    • 0001221508 scopus 로고
    • On respiratory impairment in cancer cells
    • PMID- 13471593 OWN - NLM STAT- MEDLINE (0036-8075 (Print))
    • Warburg O. On respiratory impairment in cancer cells. Science 1956, 124(3215):269-270. PMID- 13471593 OWN - NLM STAT- MEDLINE (0036-8075 (Print)).
    • (1956) Science , vol.124 , Issue.3215 , pp. 269-270
    • Warburg, O.1
  • 4
    • 2942511577 scopus 로고    scopus 로고
    • Recently elucidated energy catabolism pathways provide opportunities for novel treatments in hepatocellular carcinoma
    • 10.1586/14737140.4.3.449, 15161443
    • Geschwind JF, Georgiades CS, Ko YH, Pedersen PL. Recently elucidated energy catabolism pathways provide opportunities for novel treatments in hepatocellular carcinoma. Expert Rev Anticancer Ther 2004, 4(3):449-457. 10.1586/14737140.4.3.449, 15161443.
    • (2004) Expert Rev Anticancer Ther , vol.4 , Issue.3 , pp. 449-457
    • Geschwind, J.F.1    Georgiades, C.S.2    Ko, Y.H.3    Pedersen, P.L.4
  • 5
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • 10.1016/j.cell.2011.02.013, 21376230
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011, 144(5):646-674. 10.1016/j.cell.2011.02.013, 21376230.
    • (2011) Cell , vol.144 , Issue.5 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 6
    • 12944262229 scopus 로고    scopus 로고
    • Molecular and cellular regulation of glucose transporter (GLUT) proteins in cancer
    • 10.1002/jcp.20166, 15389572
    • Macheda ML, Rogers S, Best JD. Molecular and cellular regulation of glucose transporter (GLUT) proteins in cancer. J Cell Physiol 2005, 202(3):654-662. 10.1002/jcp.20166, 15389572.
    • (2005) J Cell Physiol , vol.202 , Issue.3 , pp. 654-662
    • Macheda, M.L.1    Rogers, S.2    Best, J.D.3
  • 7
    • 33746879141 scopus 로고    scopus 로고
    • Glycolysis inhibition for anticancer treatment
    • 10.1038/sj.onc.1209597, 16892078
    • Pelicano H, Martin DS, Xu RH, Huang P. Glycolysis inhibition for anticancer treatment. Oncogene 2006, 25(34):4633-4646. 10.1038/sj.onc.1209597, 16892078.
    • (2006) Oncogene , vol.25 , Issue.34 , pp. 4633-4646
    • Pelicano, H.1    Martin, D.S.2    Xu, R.H.3    Huang, P.4
  • 8
    • 57649130593 scopus 로고    scopus 로고
    • Induction of pyruvate dehydrogenase kinase-3 by hypoxia-inducible factor-1 promotes metabolic switch and drug resistance
    • 10.1074/jbc.M803508200, 2661383, 18718909
    • Lu CW, Lin SC, Chen KF, Lai YY, Tsai SJ. Induction of pyruvate dehydrogenase kinase-3 by hypoxia-inducible factor-1 promotes metabolic switch and drug resistance. J Biol Chem 2008, 283(42):28106-28114. 10.1074/jbc.M803508200, 2661383, 18718909.
    • (2008) J Biol Chem , vol.283 , Issue.42 , pp. 28106-28114
    • Lu, C.W.1    Lin, S.C.2    Chen, K.F.3    Lai, Y.Y.4    Tsai, S.J.5
  • 9
    • 0034089167 scopus 로고    scopus 로고
    • Energy metabolism of human LoVo colon carcinoma cells: correlation to drug resistance and influence of lonidamine
    • Fanciulli M, Bruno T, Giovannelli A, Gentile FP, Di Padova M, Rubiu O, Floridi A. Energy metabolism of human LoVo colon carcinoma cells: correlation to drug resistance and influence of lonidamine. Clin Cancer Res 2000, 6(4):1590-1597.
    • (2000) Clin Cancer Res , vol.6 , Issue.4 , pp. 1590-1597
    • Fanciulli, M.1    Bruno, T.2    Giovannelli, A.3    Gentile, F.P.4    Di Padova, M.5    Rubiu, O.6    Floridi, A.7
  • 10
    • 52649107626 scopus 로고    scopus 로고
    • Cancer cell metabolism: Warburg and beyond
    • 10.1016/j.cell.2008.08.021, 18775299
    • Hsu PP, Sabatini DM. Cancer cell metabolism: Warburg and beyond. Cell 2008, 134(5):703-707. 10.1016/j.cell.2008.08.021, 18775299.
    • (2008) Cell , vol.134 , Issue.5 , pp. 703-707
    • Hsu, P.P.1    Sabatini, D.M.2
  • 11
    • 79955759406 scopus 로고    scopus 로고
    • Therapeutic targeting of cancer cell metabolism
    • 10.1007/s00109-011-0730-x, 3345191, 21301795
    • Dang CV, Hamaker M, Sun P, Le A, Gao P. Therapeutic targeting of cancer cell metabolism. J Mol Med 2011, 89(3):205-212. 10.1007/s00109-011-0730-x, 3345191, 21301795.
    • (2011) J Mol Med , vol.89 , Issue.3 , pp. 205-212
    • Dang, C.V.1    Hamaker, M.2    Sun, P.3    Le, A.4    Gao, P.5
  • 12
    • 84863695624 scopus 로고    scopus 로고
    • Untuning the tumor metabolic machine: targeting cancer metabolism: a bedside lesson
    • 10.1038/nm.2870, 22772555
    • Birsoy K, Sabatini DM, Possemato R. Untuning the tumor metabolic machine: targeting cancer metabolism: a bedside lesson. Nat Med 2012, 18(7):1022-1023. 10.1038/nm.2870, 22772555.
    • (2012) Nat Med , vol.18 , Issue.7 , pp. 1022-1023
    • Birsoy, K.1    Sabatini, D.M.2    Possemato, R.3
  • 13
    • 84860512005 scopus 로고    scopus 로고
    • Links between metabolism and cancer
    • 10.1101/gad.189365.112, 3347786, 22549953
    • Dang CV. Links between metabolism and cancer. Genes Dev 2012, 26(9):877-890. 10.1101/gad.189365.112, 3347786, 22549953.
    • (2012) Genes Dev , vol.26 , Issue.9 , pp. 877-890
    • Dang, C.V.1
  • 14
    • 84864402951 scopus 로고    scopus 로고
    • Anticancer agents that counteract tumor glycolysis
    • 10.1002/cmdc.201200176, 3516916, 22684868
    • Granchi C, Minutolo F. Anticancer agents that counteract tumor glycolysis. Chem Med Chem 2012, 7(8):1318-1350. 10.1002/cmdc.201200176, 3516916, 22684868.
    • (2012) Chem Med Chem , vol.7 , Issue.8 , pp. 1318-1350
    • Granchi, C.1    Minutolo, F.2
  • 15
    • 84858604270 scopus 로고    scopus 로고
    • Metabolic reprogramming: a cancer hallmark even warburg did not anticipate
    • 10.1016/j.ccr.2012.02.014, 3311998, 22439925
    • Ward PS, Thompson CB. Metabolic reprogramming: a cancer hallmark even warburg did not anticipate. Cancer Cell 2012, 21(3):297-308. 10.1016/j.ccr.2012.02.014, 3311998, 22439925.
    • (2012) Cancer Cell , vol.21 , Issue.3 , pp. 297-308
    • Ward, P.S.1    Thompson, C.B.2
  • 16
    • 84868542684 scopus 로고    scopus 로고
    • Targeting the latest hallmark of cancer: another attempt at 'magic bullet' drugs targeting cancers' metabolic phenotype
    • 10.2217/fon.12.121, 23130930
    • Cuperlovic-Culf M, Culf AS, Touaibia M, Lefort N. Targeting the latest hallmark of cancer: another attempt at 'magic bullet' drugs targeting cancers' metabolic phenotype. Future Oncol 2012, 8(10):1315-1330. 10.2217/fon.12.121, 23130930.
    • (2012) Future Oncol , vol.8 , Issue.10 , pp. 1315-1330
    • Cuperlovic-Culf, M.1    Culf, A.S.2    Touaibia, M.3    Lefort, N.4
  • 17
    • 84875890762 scopus 로고    scopus 로고
    • Targeting cellular metabolism to improve cancer therapeutics
    • 10.1038/cddis.2013.60, 3613838, 23470539
    • Zhao Y, Butler EB, Tan M. Targeting cellular metabolism to improve cancer therapeutics. Cell Death Dis 2013, 4:e532. 10.1038/cddis.2013.60, 3613838, 23470539.
    • (2013) Cell Death Dis , vol.4
    • Zhao, Y.1    Butler, E.B.2    Tan, M.3
  • 18
    • 84890159876 scopus 로고    scopus 로고
    • Cancer cell metabolism: implications for therapeutic targets
    • 10.1038/emm.2013.85, 3809361, 24091747
    • Jang M, Kim SS, Lee J. Cancer cell metabolism: implications for therapeutic targets. Exp Mol Med 2013, 45:e45. 10.1038/emm.2013.85, 3809361, 24091747.
    • (2013) Exp Mol Med , vol.45
    • Jang, M.1    Kim, S.S.2    Lee, J.3
  • 19
    • 84873462831 scopus 로고    scopus 로고
    • Altered energy metabolism in cancer: a unique opportunity for therapeutic intervention
    • 10.4161/cbt.22958, 23192270
    • Zhang Y, Yang JM. Altered energy metabolism in cancer: a unique opportunity for therapeutic intervention. Cancer Biol Ther 2013, 14(2):81-89. 10.4161/cbt.22958, 23192270.
    • (2013) Cancer Biol Ther , vol.14 , Issue.2 , pp. 81-89
    • Zhang, Y.1    Yang, J.M.2
  • 22
    • 84861534727 scopus 로고    scopus 로고
    • Novel role of NOX in supporting aerobic glycolysis in cancer cells with mitochondrial dysfunction and as a potential target for cancer therapy
    • 10.1371/journal.pbio.1001326, 3348157, 22589701
    • Lu W, Hu Y, Chen G, Chen Z, Zhang H, Wang F, Feng L, Pelicano H, Wang H, Keating MJ, Liu J, McKeehan W, Wang H, Luo Y, Huang P. Novel role of NOX in supporting aerobic glycolysis in cancer cells with mitochondrial dysfunction and as a potential target for cancer therapy. PLoS Biol 2012, 10(5):e1001326. 10.1371/journal.pbio.1001326, 3348157, 22589701.
    • (2012) PLoS Biol , vol.10 , Issue.5
    • Lu, W.1    Hu, Y.2    Chen, G.3    Chen, Z.4    Zhang, H.5    Wang, F.6    Feng, L.7    Pelicano, H.8    Wang, H.9    Keating, M.J.10    Liu, J.11    McKeehan, W.12    Wang, H.13    Luo, Y.14    Huang, P.15
  • 23
    • 84866665390 scopus 로고    scopus 로고
    • Mitochondria and cancer
    • 10.1038/nrc3365, 23001348
    • Wallace DC. Mitochondria and cancer. Nat Rev Cancer 2012, 12(10):685-698. 10.1038/nrc3365, 23001348.
    • (2012) Nat Rev Cancer , vol.12 , Issue.10 , pp. 685-698
    • Wallace, D.C.1
  • 24
    • 0030728737 scopus 로고    scopus 로고
    • Diminished tumorigenic phenotype after depletion of mitochondrial DNA
    • Cavalli LR, Varella-Garcia M, Liang BC. Diminished tumorigenic phenotype after depletion of mitochondrial DNA. Cell Growth Differ 1997, 8(11):1189-1198.
    • (1997) Cell Growth Differ , vol.8 , Issue.11 , pp. 1189-1198
    • Cavalli, L.R.1    Varella-Garcia, M.2    Liang, B.C.3
  • 25
    • 0024448458 scopus 로고
    • Human cells lacking mtDNA: repopulation with exogenous mitochondria by complementation
    • 10.1126/science.2814477, 2814477
    • King MP, Attardi G. Human cells lacking mtDNA: repopulation with exogenous mitochondria by complementation. Science 1989, 246(4929):500-503. 10.1126/science.2814477, 2814477.
    • (1989) Science , vol.246 , Issue.4929 , pp. 500-503
    • King, M.P.1    Attardi, G.2
  • 26
    • 83755207529 scopus 로고    scopus 로고
    • Defining the molecular basis of tumor metabolism: a continuing challenge since Warburg's discovery
    • 10.1159/000335792, 22178931
    • de Souza AC, Justo GZ, de Araujo DR, Cavagis AD. Defining the molecular basis of tumor metabolism: a continuing challenge since Warburg's discovery. Cell Physiol Biochem 2011, 28(5):771-792. 10.1159/000335792, 22178931.
    • (2011) Cell Physiol Biochem , vol.28 , Issue.5 , pp. 771-792
    • de Souza, A.C.1    Justo, G.Z.2    de Araujo, D.R.3    Cavagis, A.D.4
  • 27
    • 0035917865 scopus 로고    scopus 로고
    • Cooperation and competition in the evolution of ATP-producing pathways
    • 10.1126/science.1058079, 11283355
    • Pfeiffer T, Schuster S, Bonhoeffer S. Cooperation and competition in the evolution of ATP-producing pathways. Science 2001, 292(5516):504-507. 10.1126/science.1058079, 11283355.
    • (2001) Science , vol.292 , Issue.5516 , pp. 504-507
    • Pfeiffer, T.1    Schuster, S.2    Bonhoeffer, S.3
  • 29
    • 77954248039 scopus 로고    scopus 로고
    • Altered metabolism in cancer
    • 10.1186/1741-7007-8-88, 2892450, 20598111
    • Locasale JW, Cantley LC. Altered metabolism in cancer. BMC Biol 2010, 8:88. 10.1186/1741-7007-8-88, 2892450, 20598111.
    • (2010) BMC Biol , vol.8 , pp. 88
    • Locasale, J.W.1    Cantley, L.C.2
  • 30
    • 8144228566 scopus 로고    scopus 로고
    • Why do cancers have high aerobic glycolysis?
    • 10.1038/nrc1478, 15516961
    • Gatenby RA, Gillies RJ. Why do cancers have high aerobic glycolysis?. Nat Rev Cancer 2004, 4(11):891-899. 10.1038/nrc1478, 15516961.
    • (2004) Nat Rev Cancer , vol.4 , Issue.11 , pp. 891-899
    • Gatenby, R.A.1    Gillies, R.J.2
  • 31
    • 80054046029 scopus 로고    scopus 로고
    • Aerobic glycolysis: meeting the metabolic requirements of cell proliferation
    • 10.1146/annurev-cellbio-092910-154237, 21985671
    • Lunt SY, Vander Heiden MG. Aerobic glycolysis: meeting the metabolic requirements of cell proliferation. Annu Rev Cell Dev Biol 2011, 27:441-464. 10.1146/annurev-cellbio-092910-154237, 21985671.
    • (2011) Annu Rev Cell Dev Biol , vol.27 , pp. 441-464
    • Lunt, S.Y.1    Vander Heiden, M.G.2
  • 32
    • 43749083041 scopus 로고    scopus 로고
    • Brick by brick: metabolism and tumor cell growth
    • 10.1016/j.gde.2008.02.003, 2476215, 18387799
    • Deberardinis RJ, Sayed N, Ditsworth D, Thompson CB. Brick by brick: metabolism and tumor cell growth. Curr Opin Genet Dev 2008, 18(1):54-61. 10.1016/j.gde.2008.02.003, 2476215, 18387799.
    • (2008) Curr Opin Genet Dev , vol.18 , Issue.1 , pp. 54-61
    • Deberardinis, R.J.1    Sayed, N.2    Ditsworth, D.3    Thompson, C.B.4
  • 33
    • 84858008628 scopus 로고    scopus 로고
    • The role of glutathione in brain tumor drug resistance
    • 10.1016/j.bcp.2011.11.016, 22138445
    • Backos DS, Franklin CC, Reigan P. The role of glutathione in brain tumor drug resistance. Biochem Pharmacol 2012, 83(8):1005-1012. 10.1016/j.bcp.2011.11.016, 22138445.
    • (2012) Biochem Pharmacol , vol.83 , Issue.8 , pp. 1005-1012
    • Backos, D.S.1    Franklin, C.C.2    Reigan, P.3
  • 35
    • 71049144941 scopus 로고    scopus 로고
    • STAT1-dependent expression of energy metabolic pathways links tumour growth and radioresistance to the Warburg effect
    • 10.1186/1741-7015-7-68, 2780454, 19891767
    • Pitroda SP, Wakim BT, Sood RF, Beveridge MG, Beckett MA, MacDermed DM, Weichselbaum RR, Khodarev NN. STAT1-dependent expression of energy metabolic pathways links tumour growth and radioresistance to the Warburg effect. BMC Med 2009, 7:68. 10.1186/1741-7015-7-68, 2780454, 19891767.
    • (2009) BMC Med , vol.7 , pp. 68
    • Pitroda, S.P.1    Wakim, B.T.2    Sood, R.F.3    Beveridge, M.G.4    Beckett, M.A.5    MacDermed, D.M.6    Weichselbaum, R.R.7    Khodarev, N.N.8
  • 36
    • 84863486244 scopus 로고    scopus 로고
    • The pentose phosphate pathway: an antioxidant defense and a crossroad in tumor cell fate
    • 10.1016/j.freeradbiomed.2012.05.006, 22580150
    • Riganti C, Gazzano E, Polimeni M, Aldieri E, Ghigo D. The pentose phosphate pathway: an antioxidant defense and a crossroad in tumor cell fate. Free Radic Biol Med 2012, 53(3):421-436. 10.1016/j.freeradbiomed.2012.05.006, 22580150.
    • (2012) Free Radic Biol Med , vol.53 , Issue.3 , pp. 421-436
    • Riganti, C.1    Gazzano, E.2    Polimeni, M.3    Aldieri, E.4    Ghigo, D.5
  • 37
    • 60549110886 scopus 로고    scopus 로고
    • Transketolase-like protein 1 (TKTL1) is required for rapid cell growth and full viability of human tumor cells
    • 10.1002/ijc.24078, 19065656
    • Xu X, Zur Hausen A, Coy JF, Lochelt M. Transketolase-like protein 1 (TKTL1) is required for rapid cell growth and full viability of human tumor cells. Int J Cancer 2009, 124(6):1330-1337. 10.1002/ijc.24078, 19065656.
    • (2009) Int J Cancer , vol.124 , Issue.6 , pp. 1330-1337
    • Xu, X.1    Zur Hausen, A.2    Coy, J.F.3    Lochelt, M.4
  • 38
    • 76049104247 scopus 로고    scopus 로고
    • TKTL1 is activated by promoter hypomethylation and contributes to head and neck squamous cell carcinoma carcinogenesis through increased aerobic glycolysis and HIF1alpha stabilization
    • 10.1158/1078-0432.CCR-09-2604, 2824550, 20103683
    • Sun W, Liu Y, Glazer CA, Shao C, Bhan S, Demokan S, Zhao M, Rudek MA, Ha PK, Califano JA. TKTL1 is activated by promoter hypomethylation and contributes to head and neck squamous cell carcinoma carcinogenesis through increased aerobic glycolysis and HIF1alpha stabilization. Clin Cancer Res 2010, 16(3):857-866. 10.1158/1078-0432.CCR-09-2604, 2824550, 20103683.
    • (2010) Clin Cancer Res , vol.16 , Issue.3 , pp. 857-866
    • Sun, W.1    Liu, Y.2    Glazer, C.A.3    Shao, C.4    Bhan, S.5    Demokan, S.6    Zhao, M.7    Rudek, M.A.8    Ha, P.K.9    Califano, J.A.10
  • 39
    • 84866910992 scopus 로고    scopus 로고
    • Tp53-induced glycolysis and apoptosis regulator (TIGAR) protects glioma cells from starvation-induced cell death by up-regulating respiration and improving cellular redox homeostasis
    • 10.1074/jbc.M112.384578, 3460445, 22887998
    • Wanka C, Steinbach JP, Rieger J. Tp53-induced glycolysis and apoptosis regulator (TIGAR) protects glioma cells from starvation-induced cell death by up-regulating respiration and improving cellular redox homeostasis. J Biol Chem 2012, 287(40):33436-33446. 10.1074/jbc.M112.384578, 3460445, 22887998.
    • (2012) J Biol Chem , vol.287 , Issue.40 , pp. 33436-33446
    • Wanka, C.1    Steinbach, J.P.2    Rieger, J.3
  • 41
    • 84874810369 scopus 로고    scopus 로고
    • Increased anaerobic metabolism is a distinctive signature in a colorectal cancer cellular model of resistance to antiepidermal growth factor receptor antibody
    • 10.1002/pmic.201200303, 23281225
    • Monteleone F, Rosa R, Vitale M, D'Ambrosio C, Succoio M, Formisano L, Nappi L, Romano MF, Scaloni A, Tortora G, Bianco R, Zambrano N. Increased anaerobic metabolism is a distinctive signature in a colorectal cancer cellular model of resistance to antiepidermal growth factor receptor antibody. Proteomics 2013, 13(5):866-877. 10.1002/pmic.201200303, 23281225.
    • (2013) Proteomics , vol.13 , Issue.5 , pp. 866-877
    • Monteleone, F.1    Rosa, R.2    Vitale, M.3    D'Ambrosio, C.4    Succoio, M.5    Formisano, L.6    Nappi, L.7    Romano, M.F.8    Scaloni, A.9    Tortora, G.10    Bianco, R.11    Zambrano, N.12
  • 42
    • 14744284637 scopus 로고    scopus 로고
    • Multifaceted roles of glycolytic enzymes
    • 10.1016/j.tibs.2005.01.005, 15752986
    • Kim JW, Dang CV. Multifaceted roles of glycolytic enzymes. Trends Biochem Sci 2005, 30(3):142-150. 10.1016/j.tibs.2005.01.005, 15752986.
    • (2005) Trends Biochem Sci , vol.30 , Issue.3 , pp. 142-150
    • Kim, J.W.1    Dang, C.V.2
  • 43
    • 0036510541 scopus 로고    scopus 로고
    • Mitochondrial binding of hexokinase II inhibits Bax-induced cytochrome c release and apoptosis
    • 10.1074/jbc.M109950200, 11751859
    • Pastorino JG, Shulga N, Hoek JB. Mitochondrial binding of hexokinase II inhibits Bax-induced cytochrome c release and apoptosis. J Biol Chem 2002, 277(9):7610-7618. 10.1074/jbc.M109950200, 11751859.
    • (2002) J Biol Chem , vol.277 , Issue.9 , pp. 7610-7618
    • Pastorino, J.G.1    Shulga, N.2    Hoek, J.B.3
  • 44
    • 9744221185 scopus 로고    scopus 로고
    • Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak
    • 10.1016/j.molcel.2004.11.014, 15574336
    • Majewski N, Nogueira V, Bhaskar P, Coy PE, Skeen JE, Gottlob K, Chandel NS, Thompson CB, Robey RB, Hay N. Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak. Mol Cell 2004, 16(5):819-830. 10.1016/j.molcel.2004.11.014, 15574336.
    • (2004) Mol Cell , vol.16 , Issue.5 , pp. 819-830
    • Majewski, N.1    Nogueira, V.2    Bhaskar, P.3    Coy, P.E.4    Skeen, J.E.5    Gottlob, K.6    Chandel, N.S.7    Thompson, C.B.8    Robey, R.B.9    Hay, N.10
  • 45
    • 84867569407 scopus 로고    scopus 로고
    • GAPDH and intermediary metabolism
    • 10.1007/978-94-007-4716-6_2, 22851446
    • Seidler NW. GAPDH and intermediary metabolism. Adv Exp Med Biol 2013, 985:37-59. 10.1007/978-94-007-4716-6_2, 22851446.
    • (2013) Adv Exp Med Biol , vol.985 , pp. 37-59
    • Seidler, N.W.1
  • 46
    • 84867514319 scopus 로고    scopus 로고
    • Basic biology of GAPDH
    • 10.1007/978-94-007-4716-6_1, 22851445
    • Seidler NW. Basic biology of GAPDH. Adv Exp Med Biol 2013, 985:1-36. 10.1007/978-94-007-4716-6_1, 22851445.
    • (2013) Adv Exp Med Biol , vol.985 , pp. 1-36
    • Seidler, N.W.1
  • 47
    • 84868610892 scopus 로고    scopus 로고
    • Glyceraldehyde-3-phosphate dehydrogenase: a promising target for molecular therapy in hepatocellular carcinoma
    • 3660062, 22964488
    • Ganapathy-Kanniappan S, Kunjithapatham R, Geschwind JF. Glyceraldehyde-3-phosphate dehydrogenase: a promising target for molecular therapy in hepatocellular carcinoma. Oncotarget 2012, 3(9):940-953. 3660062, 22964488.
    • (2012) Oncotarget , vol.3 , Issue.9 , pp. 940-953
    • Ganapathy-Kanniappan, S.1    Kunjithapatham, R.2    Geschwind, J.F.3
  • 48
    • 84871757347 scopus 로고    scopus 로고
    • Dual roles of PKM2 in cancer metabolism
    • 10.1093/abbs/gms106, 23212076
    • Wu S, Le H. Dual roles of PKM2 in cancer metabolism. Acta Biochim Biophys Sin (Shanghai) 2013, 45(1):27-35. 10.1093/abbs/gms106, 23212076.
    • (2013) Acta Biochim Biophys Sin (Shanghai) , vol.45 , Issue.1 , pp. 27-35
    • Wu, S.1    Le, H.2
  • 50
    • 84867140008 scopus 로고    scopus 로고
    • Emerging roles of PKM2 in cell metabolism and cancer progression
    • 10.1016/j.tem.2012.06.010, 3466350, 22824010
    • Luo W, Semenza GL. Emerging roles of PKM2 in cell metabolism and cancer progression. Trends Endocrinol Metab 2012, 23(11):560-566. 10.1016/j.tem.2012.06.010, 3466350, 22824010.
    • (2012) Trends Endocrinol Metab , vol.23 , Issue.11 , pp. 560-566
    • Luo, W.1    Semenza, G.L.2
  • 51
    • 80555147884 scopus 로고    scopus 로고
    • Pyruvate kinase M2 regulates glucose metabolism by functioning as a coactivator for hypoxia-inducible factor 1 in cancer cells
    • 3248177, 21709315
    • Luo W, Semenza GL. Pyruvate kinase M2 regulates glucose metabolism by functioning as a coactivator for hypoxia-inducible factor 1 in cancer cells. Oncotarget 2011, 2(7):551-556. 3248177, 21709315.
    • (2011) Oncotarget , vol.2 , Issue.7 , pp. 551-556
    • Luo, W.1    Semenza, G.L.2
  • 52
    • 84870598190 scopus 로고    scopus 로고
    • ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect
    • 10.1038/ncb2629, 3511602, 23178880
    • Yang W, Zheng Y, Xia Y, Ji H, Chen X, Guo F, Lyssiotis CA, Aldape K, Cantley LC, Lu Z. ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect. Nat Cell Biol 2012, 14(12):1295-1304. 10.1038/ncb2629, 3511602, 23178880.
    • (2012) Nat Cell Biol , vol.14 , Issue.12 , pp. 1295-1304
    • Yang, W.1    Zheng, Y.2    Xia, Y.3    Ji, H.4    Chen, X.5    Guo, F.6    Lyssiotis, C.A.7    Aldape, K.8    Cantley, L.C.9    Lu, Z.10
  • 53
    • 84890211594 scopus 로고    scopus 로고
    • Cancer metabolism meets systems biology: Pyruvate kinase isoform PKM2 is a metabolic master regulator
    • 10.4103/1477-3163.115423, 3746496, 23961261
    • Filipp FV. Cancer metabolism meets systems biology: Pyruvate kinase isoform PKM2 is a metabolic master regulator. J Carcinog 2013, 12:14. 10.4103/1477-3163.115423, 3746496, 23961261.
    • (2013) J Carcinog , vol.12 , pp. 14
    • Filipp, F.V.1
  • 54
    • 84865266173 scopus 로고    scopus 로고
    • PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis
    • 10.1016/j.cell.2012.07.018, 3431020, 22901803
    • Yang W, Xia Y, Hawke D, Li X, Liang J, Xing D, Aldape K, Hunter T, Alfred Yung WK, Lu Z. PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis. Cell 2012, 150(4):685-696. 10.1016/j.cell.2012.07.018, 3431020, 22901803.
    • (2012) Cell , vol.150 , Issue.4 , pp. 685-696
    • Yang, W.1    Xia, Y.2    Hawke, D.3    Li, X.4    Liang, J.5    Xing, D.6    Aldape, K.7    Hunter, T.8    Alfred Yung, W.K.9    Lu, Z.10
  • 55
    • 82555170271 scopus 로고    scopus 로고
    • Nuclear PKM2 regulates beta-catenin transactivation upon EGFR activation
    • 3235705, 22056988
    • Yang W, Xia Y, Ji H, Zheng Y, Liang J, Huang W, Gao X, Aldape K, Lu Z. Nuclear PKM2 regulates beta-catenin transactivation upon EGFR activation. Nature 2011, 480(7375):118-122. 3235705, 22056988.
    • (2011) Nature , vol.480 , Issue.7375 , pp. 118-122
    • Yang, W.1    Xia, Y.2    Ji, H.3    Zheng, Y.4    Liang, J.5    Huang, W.6    Gao, X.7    Aldape, K.8    Lu, Z.9
  • 56
    • 40749099894 scopus 로고    scopus 로고
    • Pyruvate kinase M2 is a phosphotyrosine-binding protein
    • 10.1038/nature06667, 18337815
    • Christofk HR, Vander Heiden MG, Wu N, Asara JM, Cantley LC. Pyruvate kinase M2 is a phosphotyrosine-binding protein. Nature 2008, 452(7184):181-186. 10.1038/nature06667, 18337815.
    • (2008) Nature , vol.452 , Issue.7184 , pp. 181-186
    • Christofk, H.R.1    Vander Heiden, M.G.2    Wu, N.3    Asara, J.M.4    Cantley, L.C.5
  • 57
    • 55249118618 scopus 로고    scopus 로고
    • Mitochondrial oxidative phosphorylation is regulated by fructose 1,6-bisphosphate. A possible role in Crabtree effect induction?
    • 10.1074/jbc.M800408200, 18682403
    • Diaz-Ruiz R, Averet N, Araiza D, Pinson B, Uribe-Carvajal S, Devin A, Rigoulet M. Mitochondrial oxidative phosphorylation is regulated by fructose 1,6-bisphosphate. A possible role in Crabtree effect induction?. J Biol Chem 2008, 283(40):26948-26955. 10.1074/jbc.M800408200, 18682403.
    • (2008) J Biol Chem , vol.283 , Issue.40 , pp. 26948-26955
    • Diaz-Ruiz, R.1    Averet, N.2    Araiza, D.3    Pinson, B.4    Uribe-Carvajal, S.5    Devin, A.6    Rigoulet, M.7
  • 60
    • 79954603194 scopus 로고    scopus 로고
    • Monocarboxylate transporters 1 and 4 are involved in the invasion activity of human lung cancer cells
    • 10.1111/j.1349-7006.2011.01908.x, 21306479
    • Izumi H, Takahashi M, Uramoto H, Nakayama Y, Oyama T, Wang KY, Sasaguri Y, Nishizawa S, Kohno K. Monocarboxylate transporters 1 and 4 are involved in the invasion activity of human lung cancer cells. Cancer Sci 2011, 102(5):1007-1013. 10.1111/j.1349-7006.2011.01908.x, 21306479.
    • (2011) Cancer Sci , vol.102 , Issue.5 , pp. 1007-1013
    • Izumi, H.1    Takahashi, M.2    Uramoto, H.3    Nakayama, Y.4    Oyama, T.5    Wang, K.Y.6    Sasaguri, Y.7    Nishizawa, S.8    Kohno, K.9
  • 61
    • 0025993621 scopus 로고
    • Cellular differentiation and the microcompartmentation of glycolysis
    • 10.1016/0047-6374(91)90003-I, 1779698
    • Masters C. Cellular differentiation and the microcompartmentation of glycolysis. Mech Ageing Dev 1991, 61(1):11-22. 10.1016/0047-6374(91)90003-I, 1779698.
    • (1991) Mech Ageing Dev , vol.61 , Issue.1 , pp. 11-22
    • Masters, C.1
  • 62
    • 69949122828 scopus 로고    scopus 로고
    • Nuclear targeting of 6-phosphofructo-2-kinase (PFKFB3) increases proliferation via cyclin-dependent kinases
    • 10.1074/jbc.M109.016816, 2782016, 19473963
    • Yalcin A, Clem BF, Simmons A, Lane A, Nelson K, Clem AL, Brock E, Siow D, Wattenberg B, Telang S, Chesney J. Nuclear targeting of 6-phosphofructo-2-kinase (PFKFB3) increases proliferation via cyclin-dependent kinases. J Biol Chem 2009, 284(36):24223-24232. 10.1074/jbc.M109.016816, 2782016, 19473963.
    • (2009) J Biol Chem , vol.284 , Issue.36 , pp. 24223-24232
    • Yalcin, A.1    Clem, B.F.2    Simmons, A.3    Lane, A.4    Nelson, K.5    Clem, A.L.6    Brock, E.7    Siow, D.8    Wattenberg, B.9    Telang, S.10    Chesney, J.11
  • 63
    • 70449525136 scopus 로고    scopus 로고
    • Direct binding of glyceraldehyde 3-phosphate dehydrogenase to telomeric DNA protects telomeres against chemotherapy-induced rapid degradation
    • 10.1016/j.jmb.2009.09.062, 2789664, 19800890
    • Demarse NA, Ponnusamy S, Spicer EK, Apohan E, Baatz JE, Ogretmen B, Davies C. Direct binding of glyceraldehyde 3-phosphate dehydrogenase to telomeric DNA protects telomeres against chemotherapy-induced rapid degradation. J Mol Biol 2009, 394(4):789-803. 10.1016/j.jmb.2009.09.062, 2789664, 19800890.
    • (2009) J Mol Biol , vol.394 , Issue.4 , pp. 789-803
    • Demarse, N.A.1    Ponnusamy, S.2    Spicer, E.K.3    Apohan, E.4    Baatz, J.E.5    Ogretmen, B.6    Davies, C.7
  • 64
    • 34547957476 scopus 로고    scopus 로고
    • Glyceraldehyde-3-phosphate dehydrogenase enhances transcriptional activity of androgen receptor in prostate cancer cells
    • 10.1074/jbc.M610724200, 17553795
    • Harada N, Yasunaga R, Higashimura Y, Yamaji R, Fujimoto K, Moss J, Inui H, Nakano Y. Glyceraldehyde-3-phosphate dehydrogenase enhances transcriptional activity of androgen receptor in prostate cancer cells. J Biol Chem 2007, 282(31):22651-22661. 10.1074/jbc.M610724200, 17553795.
    • (2007) J Biol Chem , vol.282 , Issue.31 , pp. 22651-22661
    • Harada, N.1    Yasunaga, R.2    Higashimura, Y.3    Yamaji, R.4    Fujimoto, K.5    Moss, J.6    Inui, H.7    Nakano, Y.8
  • 65
    • 0032053510 scopus 로고    scopus 로고
    • Modulation of DNA polymerases alpha, delta and epsilon by lactate dehydrogenase and 3-phosphoglycerate kinase
    • 10.1016/S0167-4781(97)00229-7, 9545551
    • Popanda O, Fox G, Thielmann HW. Modulation of DNA polymerases alpha, delta and epsilon by lactate dehydrogenase and 3-phosphoglycerate kinase. Biochim Biophys Acta 1998, 1397(1):102-117. 10.1016/S0167-4781(97)00229-7, 9545551.
    • (1998) Biochim Biophys Acta , vol.1397 , Issue.1 , pp. 102-117
    • Popanda, O.1    Fox, G.2    Thielmann, H.W.3
  • 66
    • 0034652620 scopus 로고    scopus 로고
    • High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in human cervical cancers
    • Walenta S, Wetterling M, Lehrke M, Schwickert G, Sundfor K, Rofstad EK, Mueller-Klieser W. High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in human cervical cancers. Cancer Res 2000, 60(4):916-921.
    • (2000) Cancer Res , vol.60 , Issue.4 , pp. 916-921
    • Walenta, S.1    Wetterling, M.2    Lehrke, M.3    Schwickert, G.4    Sundfor, K.5    Rofstad, E.K.6    Mueller-Klieser, W.7
  • 68
    • 81455128226 scopus 로고    scopus 로고
    • Lactate shuttles at a glance: from physiological paradigms to anti-cancer treatments
    • 10.1242/dmm.007724, 3209642, 22065843
    • Draoui N, Feron O. Lactate shuttles at a glance: from physiological paradigms to anti-cancer treatments. Dis Model Mech 2011, 4(6):727-732. 10.1242/dmm.007724, 3209642, 22065843.
    • (2011) Dis Model Mech , vol.4 , Issue.6 , pp. 727-732
    • Draoui, N.1    Feron, O.2
  • 69
    • 57449115616 scopus 로고    scopus 로고
    • Tumor metabolism: cancer cells give and take lactate
    • 2582934, 19033652
    • Semenza GL. Tumor metabolism: cancer cells give and take lactate. J Clin Invest 2008, 118(12):3835-3837. 2582934, 19033652.
    • (2008) J Clin Invest , vol.118 , Issue.12 , pp. 3835-3837
    • Semenza, G.L.1
  • 71
    • 69949124867 scopus 로고    scopus 로고
    • Pyruvate into lactate and back: from the Warburg effect to symbiotic energy fuel exchange in cancer cells
    • 10.1016/j.radonc.2009.06.025, 19604589
    • Feron O. Pyruvate into lactate and back: from the Warburg effect to symbiotic energy fuel exchange in cancer cells. Radiother Oncol 2009, 92(3):329-333. 10.1016/j.radonc.2009.06.025, 19604589.
    • (2009) Radiother Oncol , vol.92 , Issue.3 , pp. 329-333
    • Feron, O.1
  • 72
    • 79955725303 scopus 로고    scopus 로고
    • Mitochondrial and plasma membrane lactate transporter and lactate dehydrogenase isoform expression in breast cancer cell lines
    • 10.1152/physiolgenomics.00177.2010, 3068517, 21177384
    • Hussien R, Brooks GA. Mitochondrial and plasma membrane lactate transporter and lactate dehydrogenase isoform expression in breast cancer cell lines. Physiol Genomics 2011, 43(5):255-264. 10.1152/physiolgenomics.00177.2010, 3068517, 21177384.
    • (2011) Physiol Genomics , vol.43 , Issue.5 , pp. 255-264
    • Hussien, R.1    Brooks, G.A.2
  • 73
    • 0026019452 scopus 로고
    • Differences in glycolytic capacity and hypoxia tolerance between hepatoma cells and hepatocytes
    • 10.1002/hep.1840130215, 1847350
    • Hugo-Wissemann D, Anundi I, Lauchart W, Viebahn R, de Groot H. Differences in glycolytic capacity and hypoxia tolerance between hepatoma cells and hepatocytes. Hepatology 1991, 13(2):297-303. 10.1002/hep.1840130215, 1847350.
    • (1991) Hepatology , vol.13 , Issue.2 , pp. 297-303
    • Hugo-Wissemann, D.1    Anundi, I.2    Lauchart, W.3    Viebahn, R.4    de Groot, H.5
  • 74
    • 34247860855 scopus 로고    scopus 로고
    • Expression of glycolytic enzymes is increased in pancreatic cancerous tissues as evidenced by proteomic profiling by two-dimensional electrophoresis and liquid chromatography-mass spectrometry/mass spectrometry
    • Mikuriya K, Kuramitsu Y, Ryozawa S, Fujimoto M, Mori S, Oka M, Hamano K, Okita K, Sakaida I, Nakamura K. Expression of glycolytic enzymes is increased in pancreatic cancerous tissues as evidenced by proteomic profiling by two-dimensional electrophoresis and liquid chromatography-mass spectrometry/mass spectrometry. Int J Oncol 2007, 30(4):849-855.
    • (2007) Int J Oncol , vol.30 , Issue.4 , pp. 849-855
    • Mikuriya, K.1    Kuramitsu, Y.2    Ryozawa, S.3    Fujimoto, M.4    Mori, S.5    Oka, M.6    Hamano, K.7    Okita, K.8    Sakaida, I.9    Nakamura, K.10
  • 75
    • 38749126716 scopus 로고    scopus 로고
    • Significance of the glycolytic pathway and glycolysis related-genes in tumorigenesis of human colorectal cancers
    • Yeh CS, Wang JY, Chung FY, Lee SC, Huang MY, Kuo CW, Yang MJ, Lin SR. Significance of the glycolytic pathway and glycolysis related-genes in tumorigenesis of human colorectal cancers. Oncol Rep 2008, 19(1):81-91.
    • (2008) Oncol Rep , vol.19 , Issue.1 , pp. 81-91
    • Yeh, C.S.1    Wang, J.Y.2    Chung, F.Y.3    Lee, S.C.4    Huang, M.Y.5    Kuo, C.W.6    Yang, M.J.7    Lin, S.R.8
  • 76
    • 34247136256 scopus 로고    scopus 로고
    • Metabolic enzymes regulated by the Myc oncogene are possible targets for chemotherapy or chemoprevention
    • Rimpi S, Nilsson JA. Metabolic enzymes regulated by the Myc oncogene are possible targets for chemotherapy or chemoprevention. Biochem Soc Trans 2007, 35(Pt 2):305-310.
    • (2007) Biochem Soc Trans , vol.35 , Issue.PART 2 , pp. 305-310
    • Rimpi, S.1    Nilsson, J.A.2
  • 77
    • 18644366801 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1alpha and the glycolytic phenotype in tumors
    • 10.1593/neo.04430, 1501147, 15967109
    • Robey IF, Lien AD, Welsh SJ, Baggett BK, Gillies RJ. Hypoxia-inducible factor-1alpha and the glycolytic phenotype in tumors. Neoplasia 2005, 7(4):324-330. 10.1593/neo.04430, 1501147, 15967109.
    • (2005) Neoplasia , vol.7 , Issue.4 , pp. 324-330
    • Robey, I.F.1    Lien, A.D.2    Welsh, S.J.3    Baggett, B.K.4    Gillies, R.J.5
  • 79
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-Kinase AKT pathway in human cancer
    • 10.1038/nrc839, 12094235
    • Vivanco I, Sawyers CL. The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer 2002, 2(7):489-501. 10.1038/nrc839, 12094235.
    • (2002) Nat Rev Cancer , vol.2 , Issue.7 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.L.2
  • 81
    • 84859890862 scopus 로고    scopus 로고
    • Appetite for destruction: the inhibition of glycolysis as a therapy for tuberous sclerosis complex-related tumors
    • 10.1186/1741-7007-9-69, 3198763, 22018140
    • Csibi A, Blenis J. Appetite for destruction: the inhibition of glycolysis as a therapy for tuberous sclerosis complex-related tumors. BMC Biol 2011, 9:69. 10.1186/1741-7007-9-69, 3198763, 22018140.
    • (2011) BMC Biol , vol.9 , pp. 69
    • Csibi, A.1    Blenis, J.2
  • 82
    • 44849114657 scopus 로고    scopus 로고
    • The tuberous sclerosis complex regulates trafficking of glucose transporters and glucose uptake
    • 10.2353/ajpath.2008.070958, 2408433, 18511518
    • Jiang X, Kenerson H, Aicher L, Miyaoka R, Eary J, Bissler J, Yeung RS. The tuberous sclerosis complex regulates trafficking of glucose transporters and glucose uptake. Am J Pathol 2008, 172(6):1748-1756. 10.2353/ajpath.2008.070958, 2408433, 18511518.
    • (2008) Am J Pathol , vol.172 , Issue.6 , pp. 1748-1756
    • Jiang, X.1    Kenerson, H.2    Aicher, L.3    Miyaoka, R.4    Eary, J.5    Bissler, J.6    Yeung, R.S.7
  • 84
    • 84856364753 scopus 로고    scopus 로고
    • Is there a role for carbohydrate restriction in the treatment and prevention of cancer?
    • 10.1186/1743-7075-8-75, 3267662, 22029671
    • Klement RJ, Kammerer U. Is there a role for carbohydrate restriction in the treatment and prevention of cancer?. Nutr Metab (Lond) 2011, 8:75. 10.1186/1743-7075-8-75, 3267662, 22029671.
    • (2011) Nutr Metab (Lond) , vol.8 , pp. 75
    • Klement, R.J.1    Kammerer, U.2
  • 85
    • 84864875404 scopus 로고    scopus 로고
    • A small-molecule inhibitor of glucose transporter 1 downregulates glycolysis, induces cell-cycle arrest, and inhibits cancer cell growth in vitro and in vivo
    • 10.1158/1535-7163.MCT-12-0131, 22689530
    • Liu Y, Cao Y, Zhang W, Bergmeier S, Qian Y, Akbar H, Colvin R, Ding J, Tong L, Wu S, Hines J, Chen X. A small-molecule inhibitor of glucose transporter 1 downregulates glycolysis, induces cell-cycle arrest, and inhibits cancer cell growth in vitro and in vivo. Mol Cancer Ther 2012, 11(8):1672-1682. 10.1158/1535-7163.MCT-12-0131, 22689530.
    • (2012) Mol Cancer Ther , vol.11 , Issue.8 , pp. 1672-1682
    • Liu, Y.1    Cao, Y.2    Zhang, W.3    Bergmeier, S.4    Qian, Y.5    Akbar, H.6    Colvin, R.7    Ding, J.8    Tong, L.9    Wu, S.10    Hines, J.11    Chen, X.12
  • 86
    • 33746924468 scopus 로고    scopus 로고
    • Hexokinase II: cancer's double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria
    • 10.1038/sj.onc.1209603, 3385868, 16892090
    • Mathupala SP, Ko YH, Pedersen PL. Hexokinase II: cancer's double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria. Oncogene 2006, 25(34):4777-4786. 10.1038/sj.onc.1209603, 3385868, 16892090.
    • (2006) Oncogene , vol.25 , Issue.34 , pp. 4777-4786
    • Mathupala, S.P.1    Ko, Y.H.2    Pedersen, P.L.3
  • 87
    • 60249083822 scopus 로고    scopus 로고
    • Hexokinase-2 bound to mitochondria: cancer's stygian link to the " Warburg Effect" and a pivotal target for effective therapy
    • 10.1016/j.semcancer.2008.11.006, 2714668, 19101634
    • Mathupala SP, Ko YH, Pedersen PL. Hexokinase-2 bound to mitochondria: cancer's stygian link to the " Warburg Effect" and a pivotal target for effective therapy. Semin Cancer Biol 2009, 19(1):17-24. 10.1016/j.semcancer.2008.11.006, 2714668, 19101634.
    • (2009) Semin Cancer Biol , vol.19 , Issue.1 , pp. 17-24
    • Mathupala, S.P.1    Ko, Y.H.2    Pedersen, P.L.3
  • 88
    • 0029922497 scopus 로고    scopus 로고
    • Pharmacokinetics and toxicity of oral and intravenous lonidamine in dogs
    • 10.1007/s002800050460, 8616902
    • Price GS, Page RL, Riviere JE, Cline JM, Thrall DE. Pharmacokinetics and toxicity of oral and intravenous lonidamine in dogs. Cancer Chemother Pharmacol 1996, 38(2):129-135. 10.1007/s002800050460, 8616902.
    • (1996) Cancer Chemother Pharmacol , vol.38 , Issue.2 , pp. 129-135
    • Price, G.S.1    Page, R.L.2    Riviere, J.E.3    Cline, J.M.4    Thrall, D.E.5
  • 89
    • 0442313668 scopus 로고    scopus 로고
    • Greater cell cycle inhibition and cytotoxicity induced by 2-deoxy-D-glucose in tumor cells treated under hypoxic vs aerobic conditions
    • 10.1007/s00280-003-0724-7, 14605866
    • Maher JC, Krishan A, Lampidis TJ. Greater cell cycle inhibition and cytotoxicity induced by 2-deoxy-D-glucose in tumor cells treated under hypoxic vs aerobic conditions. Cancer Chemother Pharmacol 2004, 53(2):116-122. 10.1007/s00280-003-0724-7, 14605866.
    • (2004) Cancer Chemother Pharmacol , vol.53 , Issue.2 , pp. 116-122
    • Maher, J.C.1    Krishan, A.2    Lampidis, T.J.3
  • 90
    • 36749078674 scopus 로고    scopus 로고
    • Under normoxia, 2-deoxy-D-glucose elicits cell death in select tumor types not by inhibition of glycolysis but by interfering with N-linked glycosylation
    • 10.1158/1535-7163.MCT-07-0310, 18025288
    • Kurtoglu M, Gao N, Shang J, Maher JC, Lehrman MA, Wangpaichitr M, Savaraj N, Lane AN, Lampidis TJ. Under normoxia, 2-deoxy-D-glucose elicits cell death in select tumor types not by inhibition of glycolysis but by interfering with N-linked glycosylation. Mol Cancer Ther 2007, 6(11):3049-3058. 10.1158/1535-7163.MCT-07-0310, 18025288.
    • (2007) Mol Cancer Ther , vol.6 , Issue.11 , pp. 3049-3058
    • Kurtoglu, M.1    Gao, N.2    Shang, J.3    Maher, J.C.4    Lehrman, M.A.5    Wangpaichitr, M.6    Savaraj, N.7    Lane, A.N.8    Lampidis, T.J.9
  • 91
    • 42249111525 scopus 로고    scopus 로고
    • 2-Deoxyglucose induces Akt phosphorylation via a mechanism independent of LKB1/AMP-activated protein kinase signaling activation or glycolysis inhibition
    • 10.1158/1535-7163.MCT-07-0559, 18413794
    • Zhong D, Liu X, Schafer-Hales K, Marcus AI, Khuri FR, Sun SY, Zhou W. 2-Deoxyglucose induces Akt phosphorylation via a mechanism independent of LKB1/AMP-activated protein kinase signaling activation or glycolysis inhibition. Mol Cancer Ther 2008, 7(4):809-817. 10.1158/1535-7163.MCT-07-0559, 18413794.
    • (2008) Mol Cancer Ther , vol.7 , Issue.4 , pp. 809-817
    • Zhong, D.1    Liu, X.2    Schafer-Hales, K.3    Marcus, A.I.4    Khuri, F.R.5    Sun, S.Y.6    Zhou, W.7
  • 92
    • 69949122823 scopus 로고    scopus 로고
    • The glycolytic inhibitor 2-deoxyglucose activates multiple prosurvival pathways through IGF1R
    • 10.1074/jbc.M109.005280, 2749096, 19574224
    • Zhong D, Xiong L, Liu T, Liu X, Liu X, Chen J, Sun SY, Khuri FR, Zong Y, Zhou Q, Zhou W. The glycolytic inhibitor 2-deoxyglucose activates multiple prosurvival pathways through IGF1R. J Biol Chem 2009, 284(35):23225-23233. 10.1074/jbc.M109.005280, 2749096, 19574224.
    • (2009) J Biol Chem , vol.284 , Issue.35 , pp. 23225-23233
    • Zhong, D.1    Xiong, L.2    Liu, T.3    Liu, X.4    Liu, X.5    Chen, J.6    Sun, S.Y.7    Khuri, F.R.8    Zong, Y.9    Zhou, Q.10    Zhou, W.11
  • 93
    • 33847353815 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1 confers resistance to the glycolytic inhibitor 2-deoxy-D-glucose
    • 10.1158/1535-7163.MCT-06-0407, 17308069
    • Maher JC, Wangpaichitr M, Savaraj N, Kurtoglu M, Lampidis TJ. Hypoxia-inducible factor-1 confers resistance to the glycolytic inhibitor 2-deoxy-D-glucose. Mol Cancer Ther 2007, 6(2):732-741. 10.1158/1535-7163.MCT-06-0407, 17308069.
    • (2007) Mol Cancer Ther , vol.6 , Issue.2 , pp. 732-741
    • Maher, J.C.1    Wangpaichitr, M.2    Savaraj, N.3    Kurtoglu, M.4    Lampidis, T.J.5
  • 94
    • 1642494855 scopus 로고    scopus 로고
    • 2-deoxy-D-glucose increases the efficacy of adriamycin and paclitaxel in human osteosarcoma and non-small cell lung cancers in vivo
    • 10.1158/0008-5472.CAN-03-3294, 14729604
    • Maschek G, Savaraj N, Priebe W, Braunschweiger P, Hamilton K, Tidmarsh GF, De Young LR, Lampidis TJ. 2-deoxy-D-glucose increases the efficacy of adriamycin and paclitaxel in human osteosarcoma and non-small cell lung cancers in vivo. Cancer Res 2004, 64(1):31-34. 10.1158/0008-5472.CAN-03-3294, 14729604.
    • (2004) Cancer Res , vol.64 , Issue.1 , pp. 31-34
    • Maschek, G.1    Savaraj, N.2    Priebe, W.3    Braunschweiger, P.4    Hamilton, K.5    Tidmarsh, G.F.6    De Young, L.R.7    Lampidis, T.J.8
  • 95
    • 69849087571 scopus 로고    scopus 로고
    • Targeting glucose metabolism with 2-deoxy-D-glucose for improving cancer therapy
    • 10.2217/fon.09.44, 19519197
    • Dwarakanath B, Jain V. Targeting glucose metabolism with 2-deoxy-D-glucose for improving cancer therapy. Future Oncol 2009, 5(5):581-585. 10.2217/fon.09.44, 19519197.
    • (2009) Future Oncol , vol.5 , Issue.5 , pp. 581-585
    • Dwarakanath, B.1    Jain, V.2
  • 96
    • 33747505788 scopus 로고    scopus 로고
    • 6-Phosphofructo-2-Kinase/fructose-2,6-Bisphosphatase and Tumor Cell Glycolysis
    • 10.1097/01.mco.0000241661.15514.fb, 16912547
    • Chesney J. 6-Phosphofructo-2-Kinase/fructose-2,6-Bisphosphatase and Tumor Cell Glycolysis. Curr Opin Clin Nutr Metab Care 2006, 9(5):535-539. 10.1097/01.mco.0000241661.15514.fb, 16912547.
    • (2006) Curr Opin Clin Nutr Metab Care , vol.9 , Issue.5 , pp. 535-539
    • Chesney, J.1
  • 98
    • 79955945922 scopus 로고    scopus 로고
    • Glyoxalase in tumourigenesis and multidrug resistance
    • 10.1016/j.semcdb.2011.02.006, 21315826
    • Thornalley PJ, Rabbani N. Glyoxalase in tumourigenesis and multidrug resistance. Semin Cell Dev Biol 2011, 22(3):318-325. 10.1016/j.semcdb.2011.02.006, 21315826.
    • (2011) Semin Cell Dev Biol , vol.22 , Issue.3 , pp. 318-325
    • Thornalley, P.J.1    Rabbani, N.2
  • 100
    • 34249945104 scopus 로고    scopus 로고
    • The cancer cell's " power plants" as promising therapeutic targets: an overview
    • 10.1007/s10863-007-9070-5, 17404823
    • Pedersen PL. The cancer cell's " power plants" as promising therapeutic targets: an overview. J Bioenerg Biomembr 2007, 39(1):1-12. 10.1007/s10863-007-9070-5, 17404823.
    • (2007) J Bioenerg Biomembr , vol.39 , Issue.1 , pp. 1-12
    • Pedersen, P.L.1
  • 102
    • 84873027161 scopus 로고    scopus 로고
    • Anticancer efficacy of the metabolic blocker 3-bromopyruvate: specific molecular targeting
    • Ganapathy-Kanniappan S, Kunjithapatham R, Geschwind JF. Anticancer efficacy of the metabolic blocker 3-bromopyruvate: specific molecular targeting. Anticancer Res 2013, 33(1):13-20.
    • (2013) Anticancer Res , vol.33 , Issue.1 , pp. 13-20
    • Ganapathy-Kanniappan, S.1    Kunjithapatham, R.2    Geschwind, J.F.3
  • 105
    • 44949224444 scopus 로고    scopus 로고
    • Isotype-specific inhibitors of the glycolytic key regulator pyruvate kinase subtype M2 moderately decelerate tumor cell proliferation
    • 10.1002/ijc.23512, 18425820
    • Spoden GA, Mazurek S, Morandell D, Bacher N, Ausserlechner MJ, Jansen-Durr P, Eigenbrodt E, Zwerschke W. Isotype-specific inhibitors of the glycolytic key regulator pyruvate kinase subtype M2 moderately decelerate tumor cell proliferation. Int J Cancer 2008, 123(2):312-321. 10.1002/ijc.23512, 18425820.
    • (2008) Int J Cancer , vol.123 , Issue.2 , pp. 312-321
    • Spoden, G.A.1    Mazurek, S.2    Morandell, D.3    Bacher, N.4    Ausserlechner, M.J.5    Jansen-Durr, P.6    Eigenbrodt, E.7    Zwerschke, W.8
  • 106
    • 21844468220 scopus 로고    scopus 로고
    • Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis
    • 10.1021/bi0474923, 15996096
    • Dombrauckas JD, Santarsiero BD, Mesecar AD. Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis. Biochemistry 2005, 44(27):9417-9429. 10.1021/bi0474923, 15996096.
    • (2005) Biochemistry , vol.44 , Issue.27 , pp. 9417-9429
    • Dombrauckas, J.D.1    Santarsiero, B.D.2    Mesecar, A.D.3
  • 107
    • 80054883247 scopus 로고    scopus 로고
    • Shikonin and its analogs inhibit cancer cell glycolysis by targeting tumor pyruvate kinase-M2
    • 10.1038/onc.2011.137, 21516121
    • Chen J, Xie J, Jiang Z, Wang B, Wang Y, Hu X. Shikonin and its analogs inhibit cancer cell glycolysis by targeting tumor pyruvate kinase-M2. Oncogene 2011, 30(42):4297-4306. 10.1038/onc.2011.137, 21516121.
    • (2011) Oncogene , vol.30 , Issue.42 , pp. 4297-4306
    • Chen, J.1    Xie, J.2    Jiang, Z.3    Wang, B.4    Wang, Y.5    Hu, X.6
  • 108
    • 84856913587 scopus 로고    scopus 로고
    • Pyruvate kinase M2-specific siRNA induces apoptosis and tumor regression
    • 10.1084/jem.20111487, 3280873, 22271574
    • Goldberg MS, Sharp PA. Pyruvate kinase M2-specific siRNA induces apoptosis and tumor regression. J Exp Med 2012, 209(2):217-224. 10.1084/jem.20111487, 3280873, 22271574.
    • (2012) J Exp Med , vol.209 , Issue.2 , pp. 217-224
    • Goldberg, M.S.1    Sharp, P.A.2
  • 113
    • 77955699976 scopus 로고    scopus 로고
    • Loco-regional treatment of hepatocellular carcinoma
    • 10.1002/hep.23725, 20564355
    • Lencioni R. Loco-regional treatment of hepatocellular carcinoma. Hepatology 2010, 52(2):762-773. 10.1002/hep.23725, 20564355.
    • (2010) Hepatology , vol.52 , Issue.2 , pp. 762-773
    • Lencioni, R.1
  • 114
    • 0037099685 scopus 로고    scopus 로고
    • Novel therapy for liver cancer: direct intraarterial injection of a potent inhibitor of ATP production
    • Geschwind JF, Ko YH, Torbenson MS, Magee C, Pedersen PL. Novel therapy for liver cancer: direct intraarterial injection of a potent inhibitor of ATP production. Cancer Res 2002, 62(14):3909-3913.
    • (2002) Cancer Res , vol.62 , Issue.14 , pp. 3909-3913
    • Geschwind, J.F.1    Ko, Y.H.2    Torbenson, M.S.3    Magee, C.4    Pedersen, P.L.5
  • 115
    • 33947726287 scopus 로고    scopus 로고
    • Intraarterial therapy with a new potent inhibitor of tumor metabolism (3-bromopyruvate): identification of therapeutic dose and method of injection in an animal model of liver cancer
    • Vali M, Liapi E, Kowalski J, Hong K, Khwaja A, Torbenson MS, Georgiades C, Geschwind JF. Intraarterial therapy with a new potent inhibitor of tumor metabolism (3-bromopyruvate): identification of therapeutic dose and method of injection in an animal model of liver cancer. J Vasc Interv Radiol 2007, 18(1 Pt 1):95-101.
    • (2007) J Vasc Interv Radiol , vol.18 , Issue.1 PART 1 , pp. 95-101
    • Vali, M.1    Liapi, E.2    Kowalski, J.3    Hong, K.4    Khwaja, A.5    Torbenson, M.S.6    Georgiades, C.7    Geschwind, J.F.8
  • 118
    • 41549113465 scopus 로고    scopus 로고
    • Synergistic antipancreatic tumor effect by simultaneously targeting hypoxic cancer cells with HSP90 inhibitor and glycolysis inhibitor
    • 10.1158/1078-0432.CCR-07-1607, 18347186
    • Cao X, Bloomston M, Zhang T, Frankel WL, Jia G, Wang B, Hall NC, Koch RM, Cheng H, Knopp MV, Sun D. Synergistic antipancreatic tumor effect by simultaneously targeting hypoxic cancer cells with HSP90 inhibitor and glycolysis inhibitor. Clin Cancer Res 2008, 14(6):1831-1839. 10.1158/1078-0432.CCR-07-1607, 18347186.
    • (2008) Clin Cancer Res , vol.14 , Issue.6 , pp. 1831-1839
    • Cao, X.1    Bloomston, M.2    Zhang, T.3    Frankel, W.L.4    Jia, G.5    Wang, B.6    Hall, N.C.7    Koch, R.M.8    Cheng, H.9    Knopp, M.V.10    Sun, D.11
  • 119
    • 79960263592 scopus 로고    scopus 로고
    • Metabolic oxidative stress elicited by the copper(II) complex [Cu(isaepy)2] triggers apoptosis in SH-SY5Y cells through the induction of the AMP-activated protein kinase/p38MAPK/p53 signalling axis: evidence for a combined use with 3-bromopyruvate in neuroblastoma treatment
    • 10.1042/BJ20110510, 21548882
    • Filomeni G, Cardaci S, Da Costa Ferreira AM, Rotilio G, Ciriolo MR. Metabolic oxidative stress elicited by the copper(II) complex [Cu(isaepy)2] triggers apoptosis in SH-SY5Y cells through the induction of the AMP-activated protein kinase/p38MAPK/p53 signalling axis: evidence for a combined use with 3-bromopyruvate in neuroblastoma treatment. Biochem J 2011, 437(3):443-453. 10.1042/BJ20110510, 21548882.
    • (2011) Biochem J , vol.437 , Issue.3 , pp. 443-453
    • Filomeni, G.1    Cardaci, S.2    Da Costa Ferreira, A.M.3    Rotilio, G.4    Ciriolo, M.R.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.