Inhibition of VEGF induces cellular senescence in colorectal cancer cells

International Journal of Cancer

Volumn 129, Issue 9, 2011, Pages 2115-2123

  Hasan, Mohammad R ^a,b   Ho, Shirley H Y ^a,b   Owen, David A ^a   Tai, Isabella T ^a,b  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b BRITISH COLUMBIA CANCER AGENCY   (Canada)

Author keywords

cellular senescence; colorectal cancer; p16; p53; VEGF inhibition

Indexed keywords

BEVACIZUMAB; FLUOROURACIL; IRINOTECAN; PROTEIN P16; PROTEIN P53; SMALL INTERFERING RNA; VASCULOTROPIN; VASCULOTROPIN A; VASCULOTROPIN RECEPTOR 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL; CANCER INHIBITION; CELL AGING; COLORECTAL CANCER; COLORECTAL TUMOR; CONTROLLED STUDY; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE; TUMOR XENOGRAFT; UPREGULATION;

ANGIOGENESIS INHIBITORS; ANIMALS; ANTIBODIES, MONOCLONAL, HUMANIZED; CELL AGING; CELL LINE, TUMOR; CELL SURVIVAL; COLORECTAL NEOPLASMS; CYCLIN-DEPENDENT KINASE INHIBITOR P16; HUMANS; MICE; MICE, NUDE; VASCULAR ENDOTHELIAL GROWTH FACTOR A; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 80052273035     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.26179     Document Type: Article

References (23)

1. Bulusu VR,. Irinotecan and 5-fluorouracil in colorectal cancer: time for a pause? Eur J Cancer 1998; 34: 286-9. (Pubitemid 28183823)
2. Cohen MH, Gootenberg J, Keegan P, Pazdur R,. FDA drug approval summary: bevacizumab plus FOLFOX4 as second-line treatment of colorectal cancer. Oncologist 2007; 12: 356-61. (Pubitemid 46556802)
3. Hurwitz H, Fehrenbacher L, Novotny W, Cartwright T, Hainsworth J, Heim W, Berlin J, Baron A, Griffing S, Holmgren E, Ferrara N, Fyfe G, et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 2004; 350: 2335-42. (Pubitemid 38702844)
4. Presta LG, Chen H, O'Connor SJ, Chisholm V, Meng YG, Krummen L, Winkler M, Ferrara N,. Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders. Cancer Res 1997; 57: 4593-99. (Pubitemid 27441066)
5. Harper J, Moses M,. Molecular regulation of tumor angiogenesis: mechanisms and therapeutic implications. EXS 2006; 96: 223-68.
6. Dallas NA, Fan F, Gray MJ, Van Buren G, 2nd, Lim SJ, Xia L, Ellis LM,. Functional significance of vascular endothelial growth factor receptors on gastrointestinal cancer cells. Cancer Metastasis Rev 2007; 26: 433-41. (Pubitemid 350115100)
7. Barleon B, Hauser S, Schöllmann C, Weindel K, Marmé D, Yayon A, Weich HA,. Differential expression of the two VEGF receptors flt and KDR in placenta and vascular endothelial cells. J Cell Biochem 1994; 54: 56-66. (Pubitemid 24073733)
8. Rydén L, Linderholm B, Nielsen NH, Emdin S, Jönsson PE, Landberg G,. Tumor specific VEGF-A and VEGFR2/KDR protein are co-expressed in breast cancer. Breast Cancer Res Treat 2003; 82: 147-54. (Pubitemid 37521970)
9. Wu W, Shu W, Hovsepyan H, Mosteller RD, Broek D,. VEGF receptor expression and signaling in human bladder tumors. Oncogene 2003; 22: 3361-70. (Pubitemid 36713733)
10. Abdelrahim M, Baker CH, Abbruzzese JL, Sheikh-Hamad D, Liu S, Cho SD, Yoon K, Safe S,. Regulation of vascular endothelial growth factor receptor-1 expression by specificity proteins 1, 3, and 4 in pancreatic cancer cells. Cancer Res 2007; 67: 3286-94. (Pubitemid 46724867)
11. Tian X, Song S, Wu J, Meng L, Dong Z, Shou C,. Vascular endothelial growth factor: acting as an autocrine growth factor for human gastric adenocarcinoma cell MGC803. Biochem Biophys Res Commun 2001; 286: 505-12. (Pubitemid 32916148)
12. Fan F, Wey JS, McCarty MF, Belcheva A, Liu W, Bauer TW, Somcio RJ, Wu Y, Hooper A, Hicklin DJ, Ellis LM,. Expression and function of vascular endothelial growth factor receptor-1 on human colorectal cancer cells. Oncogene 2005; 24: 2647-53. (Pubitemid 40593092)
13. Okita NT, Yamada Y, Takahari D, Hirashima Y, Matsubara J, Kato K, Hamaguchi T, Shirao K, Shimada Y, Taniguchi H, Shimoda T,. Vascular endothelial growth factor receptor expression as a prognostic marker for survival in colorectal cancer. Jpn J Clin Oncol 2009; 39: 595-600.
14. Zafirellis K, Agrogiannis G, Zachaki A, Gravani K, Karameris A, Kombouras C,. Prognostic significance of VEGF expression evaluated by quantitative immunohistochemical analysis in colorectal cancer. J Surg Res 2008; 147: 99-107. (Pubitemid 351626074)
15. Mulkeen AL, Silva T, Yoo PS, Schmitz JC, Uchio E, Chu E, Cha C,. Short interfering RNA-mediated gene silencing of vascular endothelial growth factor. Arch Surg 2006; 41: 367-74.
16. Watanabe Y, Lee SW, Detmar M, Ajioka I, Dvorak HF,. Vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) delays and induces escape from senescence in human dermal microvascular endothelial cells. Oncogene 1997; 14: 2025-32. (Pubitemid 27237005)
17. Bello LJ,. Studies on gene activity in synchronized culture of mammalian cells. Biochim Biophys Acta 1969; 179: 204-13.
18. Gary RK, Kindell SM,. Quantitative assay of senescence-associated β-galactosidase activity in mammalian cell extracts. Anal Biochem 2005; 343: 329-34. (Pubitemid 41074047)
19. Beauséjour CM, Krtolica A, Galimi F, Narita M, Lowe SW, Yaswen P, Campisi J,. Reversal of human cellular senescence: roles of the p53 and p16 pathways. EMBO J 2003; 22: 4212-22. (Pubitemid 37021749)
20. Reinacher-Schick A, Pohl M, Schmiegel W,. Drug insight: antiangiogenic therapies for gastrointestinal cancers-focus on monoclonal antibodies. Nat Clin Pract Gastroenterol Hepatol 2008; 5: 250-267. (Pubitemid 351637911)
21. Campisi J, d'Adda di Fagagna F,. Cellular senescence: when bad things happen to good cells. Nat Rev Mol Cell Biol 2007; 8: 729-40. (Pubitemid 47312822)
22. Pons J, Huang Y, Arakawa-Hoyt J, Washko D, Takagawa J, Ye J, Grossman W, Su H,. VEGF improves survival of mesenchymal stem cells in infarcted hearts. Biochem Biophys Res Commun 2008; 376: 419-22.
23. Calvani M, Trisciuoglio D, Bergamaschi C, Shoemaker RH, Melillo G,. Differential involvement of vascular endothelial growth factor in the survival of hypoxic colon cancer cells. Cancer Res 2008; 68: 285-91. (Pubitemid 351380130)