-
1
-
-
33750375542
-
Cisplatin preferentially binds mitochondrial DNA and voltage-dependent anion channel protein in the mitochondrial membrane of head and neck squamous cell carcinoma: Possible role in apoptosis
-
DOI 10.1158/1078-0432.CCR-06-1037
-
Yang Z, Schumaker L, Egorin M, Zuhowski E, Guo Z, Cullen KJ (2006) Cisplatin preferentially binds mitochondrial DNA and voltage-dependent anion channel protein in the mitochondrial membrane of head and neck squamous cell carcinoma: possible role in apoptosis. Clin Cancer Res 12(19):5817-5825. doi:10.1158/1078-0432 (Pubitemid 44629614)
-
(2006)
Clinical Cancer Research
, vol.12
, Issue.19
, pp. 5817-5825
-
-
Yang, Z.1
Schumaker, L.M.2
Egorin, M.J.3
Zuhowski, E.G.4
Quo, Z.5
Cullen, K.J.6
-
2
-
-
20144366731
-
18F]fluorothymidine positron emission tomography: The effect of cisplatin on a fibrosarcoma tumor model in vivo
-
DOI 10.1158/0008-5472.CAN-04-4008
-
Leyton J, Latigo JR, Perumal M, Dhaliwal H, He Q, Aboagye EO (2005) Early detection of tumor response to chemotherapy by 3′-Deoxy-3′-[18F] fluorothymidine positron emission tomography: the effect of cisplatin on a fibrosarcoma tumor model In vivo. Cancer Res 65:4202-4210. doi:10.1158/0008- 5472.CAN-04-4008 (Pubitemid 40775658)
-
(2005)
Cancer Research
, vol.65
, Issue.10
, pp. 4202-4210
-
-
Leyton, J.1
Latigo, J.R.2
Perumal, M.3
Dhaliwal, H.4
He, Q.5
Aboagye, E.O.6
-
4
-
-
79952284127
-
Hallmarks of cancer: The next generation
-
doi:10.1016/j.cell.2011.02.013
-
Hanahan D, Weinberg R (2011) Hallmarks of cancer: the next generation. Cell 144:646-674. doi:10.1016/j.cell.2011.02.013
-
(2011)
Cell
, vol.144
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.2
-
5
-
-
0037114462
-
Hypoxia increases tumor cell sensitivity to glycolytic inhibitors: A strategy for solid tumor therapy (Model C)
-
DOI 10.1016/S0006-2952(02)01456-9, PII S0006295202014569
-
Liu H, Savaraj N, Priebe W, Lampidis TJ (2002) Hypoxia increases tumor cell sensitivity to glycolytic inhibitors: a strategy for solid tumor therapy (Model C). Biochem Pharmacol 64(12):1745-1751. doi:10.1016/S0006-2952(02)01456-9 (Pubitemid 35351581)
-
(2002)
Biochemical Pharmacology
, vol.64
, Issue.12
, pp. 1745-1751
-
-
Liu, H.1
Savaraj, N.2
Priebe, W.3
Lampidis, T.J.4
-
6
-
-
48249117884
-
Targeting hypoxia, a novel treatment for advanced retinoblastoma
-
doi:10.1167/iovs.08-1751
-
Boutrid H, Jockovich ME, Murray TG, Pina Y, Feuer WJ, Lampidis TJ, Cebulla CM (2008) Targeting hypoxia, a novel treatment for advanced retinoblastoma. Invest Ophthalmol Vis Sci 49(7):2799-2805. doi:10.1167/iovs.08- 1751
-
(2008)
Invest Ophthalmol Vis Sci
, vol.49
, Issue.7
, pp. 2799-2805
-
-
Boutrid, H.1
Jockovich, M.E.2
Murray, T.G.3
Pina, Y.4
Feuer, W.J.5
Lampidis, T.J.6
Cebulla, C.M.7
-
7
-
-
1642494855
-
2-Deoxy-D-glucose Increases the Efficacy of Adriamycin and Paclitaxel in Human Osteosarcoma and Non-Small Cell Lung Cancers in Vivo
-
DOI 10.1158/0008-5472.CAN-03-3294
-
Maschek G, Savaraj N, Priebe W, Braunschweiger P, Hamilton K, Tidmarsh GF, De Young LR, Lampidis TJ (2004) 2-deoxy-D-glucose increases the efficacy of adriamycin and paclitaxel in human osteosarcoma and non-small cell lung cancers in vivo. Cancer Res 64:31-34. doi:10.1158/0008-5472.CAN-03-3294 (Pubitemid 38114078)
-
(2004)
Cancer Research
, vol.64
, Issue.1
, pp. 31-34
-
-
Maschek, G.1
Savaraj, N.2
Priebe, W.3
Braunschweiger, P.4
Hamilton, K.5
Tidmarsh, G.F.6
De Young, L.R.7
Lampidis, T.J.8
-
8
-
-
33746927077
-
Mitochondrial hexokinases, novel mediators of the antiapoptotic effects of growth factors and Akt
-
DOI 10.1038/sj.onc.1209595, PII 1209595
-
Robey RB, Hay N (2006) Mitochondrial Hexokinases, novel mediators of the antiapoptotic effects of growth factors and Akt. Oncogene 25:4683-4696. doi:10.1038/sj.onc.1209595 (Pubitemid 44187618)
-
(2006)
Oncogene
, vol.25
, Issue.34
, pp. 4683-4696
-
-
Robey, R.B.1
Hay, N.2
-
9
-
-
33746924468
-
Hexokinase II: Cancer's double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria
-
DOI 10.1038/sj.onc.1209603, PII 1209603
-
Mathupala SP, Ko YH, Pedersen PL (2006) Hexokinase II: cancer's double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria. Oncogene 25:4777-4786. doi:10.1038/sj.onc.1209603 (Pubitemid 44187625)
-
(2006)
Oncogene
, vol.25
, Issue.34
, pp. 4777-4786
-
-
Mathupala, S.P.1
Ko, Y.H.2
Pedersen, P.L.3
-
10
-
-
0036510541
-
Mitochondrial binding of hexokinase II inhibits Bax-induced cytochrome c release and apoptosis
-
DOI 10.1074/jbc.M109950200
-
Pastorino JG, Shulga N, Hoek JB (2002) Mitochondrial binding of hexokinase II inhibits Bax-induced cytochrome c release and apoptosis. J Biol Chem 277(9):7610-7618. doi:10.1074/jbc.M109950200 (Pubitemid 34953160)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.9
, pp. 7610-7618
-
-
Pastorino, J.G.1
Shulga, N.2
Hoek, J.B.3
-
11
-
-
14744284637
-
Multifaceted roles of glycolytic enzymes
-
doi:10.1016/j.tibs.2005.01.005
-
Kim JW, Dang CV (2005) Multifaceted roles of glycolytic enzymes. Trends Biochem Sci 30:142-150. doi:10.1016/j.tibs.2005.01.005
-
(2005)
Trends Biochem Sci
, vol.30
, pp. 142-150
-
-
Kim, J.W.1
Dang, C.V.2
-
12
-
-
9744221185
-
Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak
-
DOI 10.1016/j.molcel.2004.11.014, PII S1097276504006781
-
Majewski N, Nogueira V, Bhaskar P, Coy PE, Skeen JE, Gottlob K, Chandel NS, Thompson CB, Robey RB, Hay N (2004) Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak. Mol Cell 16:819-830. doi:10.1016/j.molcel.2004.11.014 (Pubitemid 39586539)
-
(2004)
Molecular Cell
, vol.16
, Issue.5
, pp. 819-830
-
-
Majewski, N.1
Nogueira, V.2
Bhaskar, P.3
Coy, P.E.4
Skeen, J.E.5
Gottlob, K.6
Chandel, N.S.7
Thompson, C.B.8
Robey, R.B.9
Hay, N.10
-
13
-
-
0030058890
-
Functional organization of mammalian hexokinase II retention of catalytic and regulatory function in both the NH- and COOH-terminal halves
-
doi:10.1074/jbc.271.4.1849
-
Ardehali H, Yano Y, Printz RL, Koch S, Whitesell RR, May JM et al (1996) Functional organization of mammalian hexokinase II retention of catalytic and regulatory function in both the NH- and COOH-terminal halves. J Biol Chem 271:1849-1852. doi:10.1074/jbc.271.4.1849
-
(1996)
J Biol Chem
, vol.271
, pp. 1849-1852
-
-
Ardehali, H.1
Yano, Y.2
Printz, R.L.3
Koch, S.4
Whitesell, R.R.5
May, J.M.6
-
14
-
-
33847353815
-
Hypoxia-inducible factor-1 confers resistance to the glycolytic inhibitor 2-deoxy-D-glucose
-
DOI 10.1158/1535-7163.MCT-06-0407
-
Maher JC, Wangpaichitr M, Savaraj N, Kurtoglu M, Lampidis TJ (2007) Hypoxia-inducible factor-1 confers resistance to the glycolytic inhibitor 2-deoxy-D-glucose. Mol Cancer Ther 6(2):732-741. doi:10.1158/1535-7163.MCT-06- 0407 (Pubitemid 46332474)
-
(2007)
Molecular Cancer Therapeutics
, vol.6
, Issue.2
, pp. 732-741
-
-
Maher, J.C.1
Wangpaichitr, M.2
Savaraj, N.3
Kurtoglu, M.4
Lampidis, T.J.5
-
15
-
-
53349091778
-
SIRT1 contributes in part to cisplatin resistance in cancer cells by altering mitochondrial metabolism
-
doi:10.1158/1541-7786.MCR-07-2130
-
Liang X, Finkel T, Shen D, Yin J, Aszalos A, Gottesman MM (2008) SIRT1 contributes in part to cisplatin resistance in cancer cells by altering mitochondrial metabolism. Mol Cancer Res 6(9):1499-1506. doi:10.1158/1541-7786. MCR-07-2130
-
(2008)
Mol Cancer Res
, vol.6
, Issue.9
, pp. 1499-1506
-
-
Liang, X.1
Finkel, T.2
Shen, D.3
Yin, J.4
Aszalos, A.5
Gottesman, M.M.6
-
16
-
-
84859400366
-
The relationship of thioredoxin-1 and cisplatin resistance: Its impact on ROS and oxidative metabolism in lung cancer cells
-
doi:10.1158/1535-7163.MCT-11-0599
-
Wangpaichitr M, Sullivan EJ, Theodoropoulos G, Wu C, You M, Feun L, Lampidis TJ, Kuo MT, Savaraj N (2012) The relationship of thioredoxin-1 and cisplatin resistance: its impact on ROS and oxidative metabolism in lung cancer cells. Mol Cancer Ther 11:604-615. doi:10.1158/1535-7163.MCT-11-0599
-
(2012)
Mol Cancer Ther
, vol.11
, pp. 604-615
-
-
Wangpaichitr, M.1
Sullivan, E.J.2
Theodoropoulos, G.3
Wu, C.4
You, M.5
Feun, L.6
Lampidis, T.J.7
Kuo, M.T.8
Savaraj, N.9
-
17
-
-
84868352739
-
Thermal stability of siRNA modulates aptamer- conjugated siRNA inhibition
-
doi:10.1038/mtna.2012.41
-
Berezhnoy A, Brenneman R, Bajgelman M, Seales D, Gilboa E (2012) Thermal stability of siRNA modulates aptamer- conjugated siRNA inhibition. Mol Ther Nucleic Acids 16(1):e51. doi:10.1038/mtna.2012.41
-
(2012)
Mol Ther Nucleic Acids
, vol.16
, Issue.1
-
-
Berezhnoy, A.1
Brenneman, R.2
Bajgelman, M.3
Seales, D.4
Gilboa, E.5
-
18
-
-
0442313668
-
Greater cell cycle inhibition and cytotoxicity induced by 2-deoxy-D-glucose in tumor cells treated under hypoxic vs aerobic conditions
-
DOI 10.1007/s00280-003-0724-7
-
Maher JC, Krishan A, Lampidis TJ (2004) Greater cell cycle inhibition and cytotoxicity induced by 2-deoxy-D-glucose in tumor cells treated under hypoxic vs aerobic conditions. Cancer Chemother Pharmacol 53(2):116-122. doi:10.1007/s00280-003-0724-7 (Pubitemid 38186989)
-
(2004)
Cancer Chemotherapy and Pharmacology
, vol.53
, Issue.2
, pp. 116-122
-
-
Maher, J.C.1
Krishan, A.2
Lampidis, T.J.3
-
19
-
-
84874116164
-
A phase I dose-escalation trial of 2-deoxy-D-glucose alone or combined with docetaxel in patients with advanced solid tumors
-
doi:10.1007/s00280-012-2045-1
-
Raez LE, Papadopoulos K, Ricart AD, Chiorean EG, Dipaola RS, Stein MN, Rocha Lima CM, Schlesselman JJ, Tolba K, Langmuir VK, Kroll S, Jung DT, Kurtoglu M, Rosenblatt J, Lampidis TJ (2013) A phase I dose-escalation trial of 2-deoxy-D-glucose alone or combined with docetaxel in patients with advanced solid tumors. Cancer Chemother Pharmacol 71(2):523-530. doi:10.1007/s00280-012- 2045-1
-
(2013)
Cancer Chemother Pharmacol
, vol.71
, Issue.2
, pp. 523-530
-
-
Raez, L.E.1
Papadopoulos, K.2
Ricart, A.D.3
Chiorean, E.G.4
Dipaola, R.S.5
Stein, M.N.6
Rocha Lima, C.M.7
Schlesselman, J.J.8
Tolba, K.9
Langmuir, V.K.10
Kroll, S.11
Jung, D.T.12
Kurtoglu, M.13
Rosenblatt, J.14
Lampidis, T.J.15
-
20
-
-
84870667447
-
Repeated cisplatin treatment can lead to a multiresistant tumor cell population with stem cell features and sensitivity to 3-bromopyruvate
-
doi:10.4161/cbt.22007
-
Wintzell M, Löfstedt L, Johansson J, Pedersen AB, Fuxe J, Shoshan M (2012) Repeated cisplatin treatment can lead to a multiresistant tumor cell population with stem cell features and sensitivity to 3-bromopyruvate. Cancer Bio Ther 13(14):1454-1462. doi:10.4161/cbt.22007
-
(2012)
Cancer Bio Ther
, vol.13
, Issue.14
, pp. 1454-1462
-
-
Wintzell, M.1
Löfstedt, L.2
Johansson, J.3
Pedersen, A.B.4
Fuxe, J.5
Shoshan, M.6
-
21
-
-
84859941115
-
Retinoblastoma treatment: Utilization of the glycolytic inhibitor, 2-deoxy-2-fluoro-D-glucose (2-FG), to target the chemoresistant hypoxic regions in LHBETATAG retinal tumors
-
doi:10.1167/iovs.11-8265
-
Piña Y, Decatur C, Murray TG, Houston SK, Lopez-Cavalcante M, Hernandez E, Celdran M M, Shah N, Feuer W, Lampidis T (2012) Retinoblastoma treatment: utilization of the glycolytic inhibitor, 2-deoxy-2-fluoro-D-glucose (2-FG), to target the chemoresistant hypoxic regions in LHBETATAG retinal tumors. Invest Ophthalmol Vis Sci 53:996-1002. doi:10.1167/iovs.11-8265
-
(2012)
Invest Ophthalmol Vis Sci
, vol.53
, pp. 996-1002
-
-
Piña, Y.1
Decatur, C.2
Murray, T.G.3
Houston, S.K.4
Lopez-Cavalcante, M.5
Hernandez, E.6
Celdran, M.M.7
Shah, N.8
Feuer, W.9
Lampidis, T.10
-
22
-
-
46749123261
-
Hierarchical involvement of Bak, VDAC1 and Bax in cisplatin-induced cell death
-
DOI 10.1038/onc.2008.63, PII ONC200863
-
Tajeddine N, Galluzzi L, Kepp O, Hangen E, Morselli E, Senovilla L, Araujo N, Pinna G, Larochette N, Zamzami N, Modjtahedi N, Harel-Bellan A, Kroemer G (2008) Hierarchical involvement of Bak, VDAC1 and Bax in cisplatin-induced cell death. Oncogene 27:4221-4232. doi:10.1038/onc.2008.63 (Pubitemid 351969915)
-
(2008)
Oncogene
, vol.27
, Issue.30
, pp. 4221-4232
-
-
Tajeddine, N.1
Galluzzi, L.2
Kepp, O.3
Hangen, E.4
Morselli, E.5
Senovilla, L.6
Araujo, N.7
Pinna, G.8
Larochette, N.9
Zamzami, N.10
Modjtahedi, N.11
Harel-Bellan, A.12
Kroemer, G.13
|