Dichloroacetate enhances apoptotic cell death via oxidative damage and attenuates lactate production in metformin-treated breast cancer cells

Breast Cancer Research and Treatment

Volumn 147, Issue 3, 2014, Pages 539-550

  Haugrud, Allison B ^a   Zhuang, Yongxian ^a   Coppock, Joseph D ^a   Miskimins, W Keith ^a  

^a SANFORD RESEARCH   (United States)

Author keywords

Apoptosis; Breast cancer; Dichloroacetate; Lactate; Metformin

Indexed keywords

DICHLOROACETIC ACID; LACTIC ACID; METFORMIN; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; REACTIVE OXYGEN METABOLITE; ANTINEOPLASTIC AGENT; LACTIC ACID DERIVATIVE; PROTEIN SERINE THREONINE KINASE; PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING) KINASE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER CELL LINE; BREAST EPITHELIUM; CELL COUNTING; CELL DEATH; CELL METABOLISM; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOTOXICITY; DRUG POTENTIATION; ENZYME INHIBITION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LACTATE PRODUCTION; MCF 7 CELL LINE; METABOLISM; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; PHASE CONTRAST MICROSCOPY; T47D CELL LINE; WESTERN BLOTTING; ANTAGONISTS AND INHIBITORS; BREAST NEOPLASMS; DRUG EFFECTS; FEMALE; GENETICS; PATHOLOGY; TUMOR CELL LINE;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; BREAST NEOPLASMS; CELL LINE, TUMOR; DICHLOROACETIC ACID; DRUG SYNERGISM; FEMALE; HUMANS; LACTATES; MCF-7 CELLS; METFORMIN; OXIDATIVE PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; REACTIVE OXYGEN SPECIES;

EID: 84918591412     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-014-3128-y     Document Type: Article

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