메뉴 건너뛰기




Volumn 27, Issue 10, 2010, Pages 2085-2097

Silibinin exerts sustained growth suppressive effect against human colon carcinoma SW480 xenograft by targeting multiple signaling molecules

Author keywords

catenin; angiogenesis; colorectal cancer; silibinin; SW480 cells

Indexed keywords

BETA CATENIN; CYCLIN D1; GLYCOGEN SYNTHASE KINASE 3BETA; INDUCIBLE NITRIC OXIDE SYNTHASE; MYC PROTEIN; SILIBININ; SURVIVIN; VASCULOTROPIN;

EID: 77957355392     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-010-0207-6     Document Type: Article
Times cited : (43)

References (51)
  • 2
    • 0347753599 scopus 로고    scopus 로고
    • Immunoprotection by botanical drugs in cancer chemotherapy
    • DOI 10.1016/j.jep.2003.09.023
    • S Diwanay D Chitre B Patwardhan 2004 Immunoprotection by botanical drugs in cancer chemotherapy J Ethnopharmacol. 90 49 55 10.1016/j.jep.2003.09.023 14698508 (Pubitemid 38091685)
    • (2004) Journal of Ethnopharmacology , vol.90 , Issue.1 , pp. 49-55
    • Diwanay, S.1    Chitre, D.2    Patwardhan, B.3
  • 3
    • 34548266731 scopus 로고    scopus 로고
    • Current and future clinical strategies in colon cancer prevention and the emerging role of chemoprevention
    • DOI 10.2174/138161207781368783
    • B Boursi N Arber 2007 Current and future clinical strategies in colon cancer prevention and the emerging role of chemoprevention Curr Pharm Des. 13 2274 2282 10.2174/138161207781368783 17692000 1:CAS:528:DC%2BD2sXptl2jt7Y%3D (Pubitemid 47317035)
    • (2007) Current Pharmaceutical Design , vol.13 , Issue.22 , pp. 2274-2282
    • Boursi, B.1    Arber, N.2
  • 4
    • 0037294160 scopus 로고    scopus 로고
    • Beneficial and adverse effects of chemopreventive agents
    • 12628524
    • BM Lee KK Park 2003 Beneficial and adverse effects of chemopreventive agents Mutat Res. 523-524 265 278 12628524
    • (2003) Mutat Res. , vol.523-524 , pp. 265-278
    • Lee, B.M.1    Park, K.K.2
  • 5
    • 23044435503 scopus 로고    scopus 로고
    • Chemoprevention of colon carcinogenesis by dietary non-nutritive compounds
    • 12718627
    • T Tanaka H Kohno H Mori 2001 Chemoprevention of colon carcinogenesis by dietary non-nutritive compounds Asian Pac J Cancer Prev. 2 165 177 12718627
    • (2001) Asian Pac J Cancer Prev. , vol.2 , pp. 165-177
    • Tanaka, T.1    Kohno, H.2    Mori, H.3
  • 6
    • 58149240953 scopus 로고    scopus 로고
    • Natural products and colon cancer: Current status and future prospects
    • 10.1002/ddr.20276 19884979 1:CAS:528:DC%2BD1MXptVymtQ%3D%3D
    • S Rajamanickam R Agarwal 2008 Natural products and colon cancer: current status and future prospects Drug Dev Res. 69 460 471 10.1002/ddr.20276 19884979 1:CAS:528:DC%2BD1MXptVymtQ%3D%3D
    • (2008) Drug Dev Res. , vol.69 , pp. 460-471
    • Rajamanickam, S.1    Agarwal, R.2
  • 7
    • 34249872201 scopus 로고    scopus 로고
    • Chemopreventive efficacy of silymarin in skin and prostate cancer
    • DOI 10.1177/1534735407301441
    • G Deep R Agarwal 2007 Chemopreventive efficacy of silymarin in skin and prostate cancer Integr Cancer Ther. 6 130 145 10.1177/1534735407301441 17548792 1:CAS:528:DC%2BD2sXnt1Glt7s%3D (Pubitemid 46871840)
    • (2007) Integrative Cancer Therapies , vol.6 , Issue.2 , pp. 130-145
    • Deep, G.1    Agarwal, R.2
  • 8
    • 0142166328 scopus 로고    scopus 로고
    • Cancer chemoprevention with dietary phytochemicals
    • 10.1038/nrc1189 14570043 1:CAS:528:DC%2BD3sXotFChsLw%3D
    • YJ Surh 2003 Cancer chemoprevention with dietary phytochemicals Nat Rev Cancer. 3 768 780 10.1038/nrc1189 14570043 1:CAS:528:DC%2BD3sXotFChsLw%3D
    • (2003) Nat Rev Cancer. , vol.3 , pp. 768-780
    • Surh, Y.J.1
  • 9
  • 10
    • 40949106128 scopus 로고    scopus 로고
    • Silibinin inhibits colorectal cancer growth by inhibiting tumor cell proliferation and angiogenesis
    • DOI 10.1158/0008-5472.CAN-07-6247
    • RP Singh M Gu R Agarwal 2008 Silibinin inhibits colorectal cancer growth by inhibiting tumor cell proliferation and angiogenesis Cancer Res. 68 2043 2050 10.1158/0008-5472.CAN-07-6247 18339887 1:CAS:528:DC%2BD1cXjtFOht7o%3D (Pubitemid 351416592)
    • (2008) Cancer Research , vol.68 , Issue.6 , pp. 2043-2050
    • Singh, R.P.1    Gu, M.2    Agarwal, R.3
  • 11
    • 68849113912 scopus 로고    scopus 로고
    • Silibinin suppresses growth and induces apoptotic death of human colorectal carcinoma LoVo cells in culture and tumor xenograft
    • 10.1158/1535-7163.MCT-09-0304 19638451 1:CAS:528:DC%2BD1MXpvFCms74%3D
    • M Kaur B Velmurugan A Tyagi G Deep S Katiyar C Agarwal R Agarwal 2009 Silibinin suppresses growth and induces apoptotic death of human colorectal carcinoma LoVo cells in culture and tumor xenograft Mol Cancer Ther. 8 2366 2374 10.1158/1535-7163.MCT-09-0304 19638451 1:CAS:528:DC%2BD1MXpvFCms74%3D
    • (2009) Mol Cancer Ther. , vol.8 , pp. 2366-2374
    • Kaur, M.1    Velmurugan, B.2    Tyagi, A.3    Deep, G.4    Katiyar, S.5    Agarwal, C.6    Agarwal, R.7
  • 12
    • 59449085306 scopus 로고    scopus 로고
    • Silibinin inhibits established prostate tumor growth, progression, invasion, and metastasis and suppresses tumor angiogenesis and epithelial-mesenchymal transition in transgenic adenocarcinoma of the mouse prostate model mice
    • 10.1158/1078-0432.CCR-08-1309 19047104 1:CAS:528:DC%2BD1cXhsVegtrfO
    • RP Singh K Raina G Sharma R Agarwal 2008 Silibinin inhibits established prostate tumor growth, progression, invasion, and metastasis and suppresses tumor angiogenesis and epithelial-mesenchymal transition in transgenic adenocarcinoma of the mouse prostate model mice Clin Cancer Res. 14 7773 7780 10.1158/1078-0432.CCR-08-1309 19047104 1:CAS:528:DC%2BD1cXhsVegtrfO
    • (2008) Clin Cancer Res. , vol.14 , pp. 7773-7780
    • Singh, R.P.1    Raina, K.2    Sharma, G.3    Agarwal, R.4
  • 13
    • 41949087545 scopus 로고    scopus 로고
    • Evaluation of the cancer chemopreventive efficacy of silibinin in genetic mouse models of prostate and intestinal carcinogenesis: Relationship with silibinin levels
    • 10.1016/j.ejca.2008.02.020 18343654 1:CAS:528:DC%2BD1cXks1Gmsrc%3D
    • RD Verschoyle P Greaves K Patel DA Marsden K Brown WP Steward AJ Gescher 2008 Evaluation of the cancer chemopreventive efficacy of silibinin in genetic mouse models of prostate and intestinal carcinogenesis: relationship with silibinin levels Eur J Cancer. 44 898 906 10.1016/j.ejca.2008.02.020 18343654 1:CAS:528:DC%2BD1cXks1Gmsrc%3D
    • (2008) Eur J Cancer. , vol.44 , pp. 898-906
    • Verschoyle, R.D.1    Greaves, P.2    Patel, K.3    Marsden, D.A.4    Brown, K.5    Steward, W.P.6    Gescher, A.J.7
  • 15
    • 0344827261 scopus 로고    scopus 로고
    • Silibinin upregulates the expression of cyclin-dependent kinase inhibitors and causes cell cycle arrest and apoptosis in human colon carcinoma HT-29 cells
    • DOI 10.1038/sj.onc.1207158
    • C Agarwal RP Singh S Dhanalakshmi AK Tyagi M Tecklenburg RA Sclafani R Agarwal 2003 Silibinin upregulates the expression of cyclin-dependent kinase inhibitors and causes cell cycle arrest and apoptosis in human colon carcinoma HT-29 cells Oncogene. 22 8271 8282 10.1038/sj.onc.1207158 14614451 1:CAS:528:DC%2BD3sXovVyms7c%3D (Pubitemid 37485520)
    • (2003) Oncogene , vol.22 , Issue.51 , pp. 8271-8282
    • Agarwal, C.1    Singh, R.P.2    Dhanalakshmi, S.3    Tyagi, A.K.4    Tecklenburg, M.5    Sclafani, R.A.6    Agarwal, R.7
  • 16
    • 35248818831 scopus 로고    scopus 로고
    • Flavonoid, Silibinin, Inhibits Proliferation and Promotes Cell-Cycle Arrest of Human Colon Cancer
    • DOI 10.1016/j.jss.2007.03.080, PII S0022480407002417
    • FS Hogan NK Krishnegowda M Mikhailova MS Kahlenberg 2007 Flavonoid, silibinin, inhibits proliferation and promotes cell-cycle arrest of human colon cancer J Surg Res. 143 58 65 10.1016/j.jss.2007.03.080 17950073 1:CAS:528:DC%2BD2sXhtF2htrfP (Pubitemid 47562449)
    • (2007) Journal of Surgical Research , vol.143 , Issue.1 , pp. 58-65
    • Hogan, F.S.1    Krishnegowda, N.K.2    Mikhailova, M.3    Kahlenberg, M.S.4
  • 17
    • 70449133430 scopus 로고    scopus 로고
    • Silibinin suppresses spontaneous tumorigenesis in APC min/+ mouse model by modulating beta-catenin pathway
    • 10.1007/s11095-009-9968-1 19779968 1:CAS:528:DC%2BD1MXhtlCrtb7K
    • S Rajamanickam M Kaur B Velmurugan RP Singh R Agarwal 2009 Silibinin suppresses spontaneous tumorigenesis in APC min/+ mouse model by modulating beta-catenin pathway Pharm Res. 26 2558 2567 10.1007/s11095-009-9968-1 19779968 1:CAS:528:DC%2BD1MXhtlCrtb7K
    • (2009) Pharm Res. , vol.26 , pp. 2558-2567
    • Rajamanickam, S.1    Kaur, M.2    Velmurugan, B.3    Singh, R.P.4    Agarwal, R.5
  • 18
    • 61549128686 scopus 로고    scopus 로고
    • Inhibition of azoxymethane-induced colonic aberrant crypt foci formation by silibinin in male Fisher 344 rats
    • 1:CAS:528:DC%2BC3cXptFOit7w%3D
    • B Velmurugan RP Singh A Tyagi R Agarwal 2008 Inhibition of azoxymethane-induced colonic aberrant crypt foci formation by silibinin in male Fisher 344 rats Cancer Prev Res (Phila Pa) 1 376 384 1:CAS:528: DC%2BC3cXptFOit7w%3D
    • (2008) Cancer Prev Res (Phila Pa) , vol.1 , pp. 376-384
    • Velmurugan, B.1    Singh, R.P.2    Tyagi, A.3    Agarwal, R.4
  • 19
    • 69749108159 scopus 로고    scopus 로고
    • Silibinin modulates biotransforming microbial enzymes and prevents 1, 2-dimethylhydrazine-induced preneoplastic changes in experimental colon cancer
    • 10.1097/CEJ.0b013e32832d1b4f 19654488 1:CAS:528:DC%2BD1MXhtV2itLnO
    • N Sangeetha AJ Felix N Nalini 2009 Silibinin modulates biotransforming microbial enzymes and prevents 1, 2-dimethylhydrazine-induced preneoplastic changes in experimental colon cancer Eur J Cancer Prev. 18 385 394 10.1097/CEJ.0b013e32832d1b4f 19654488 1:CAS:528:DC%2BD1MXhtV2itLnO
    • (2009) Eur J Cancer Prev. , vol.18 , pp. 385-394
    • Sangeetha, N.1    Felix, A.J.2    Nalini, N.3
  • 20
    • 34447646653 scopus 로고    scopus 로고
    • Wnt signaling as a therapeutic target for cancer
    • 17172707 1:CAS:528:DC%2BD2sXmslChtw%3D%3D
    • A Herbst FT Kolligs 2007 Wnt signaling as a therapeutic target for cancer Methods Mol Biol. 361 63 91 17172707 1:CAS:528:DC%2BD2sXmslChtw%3D%3D
    • (2007) Methods Mol Biol. , vol.361 , pp. 63-91
    • Herbst, A.1    Kolligs, F.T.2
  • 21
    • 0345708286 scopus 로고    scopus 로고
    • Colon cancer: Prevalence, screening, gene expression and mutation, and risk factors and assessment
    • 15845222
    • FE Ahmed 2003 Colon cancer: prevalence, screening, gene expression and mutation, and risk factors and assessment J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 21 65 131 15845222
    • (2003) J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. , vol.21 , pp. 65-131
    • Ahmed, F.E.1
  • 22
    • 33751306998 scopus 로고    scopus 로고
    • Min/+ mouse
    • DOI 10.1111/j.1349-7006.2006.00348.x
    • Y Yamada H Mori 2007 Multistep carcinogenesis of the colon in Apc(Min/+) mouse Cancer Sci. 98 6 10 10.1111/j.1349-7006.2006.00348.x 17052257 1:CAS:528:DC%2BD2sXht1Gisrg%3D (Pubitemid 44803913)
    • (2007) Cancer Science , vol.98 , Issue.1 , pp. 6-10
    • Yamada, Y.1    Mori, H.2
  • 23
    • 33847755702 scopus 로고    scopus 로고
    • WNT signaling in the normal intestine and colorectal cancer
    • DOI 10.2741/2076
    • W de Lau N Barker H Clevers 2007 WNT signaling in the normal intestine and colorectal cancer Front Biosci. 12 471 491 10.2741/2076 17127311 (Pubitemid 46852800)
    • (2007) Frontiers in Bioscience , vol.12 , Issue.2 , pp. 471-491
    • De Lau, W.1    Barker, N.2    Clevers, H.3
  • 25
    • 33847397617 scopus 로고    scopus 로고
    • The canonical Wnt signalling pathway and its APC partner in colon cancer development
    • DOI 10.1136/gut.2006.093310
    • J Schneikert J Behrens 2007 The canonical Wnt signalling pathway and its APC partner in colon cancer development Gut. 56 417 425 10.1136/gut.2006.093310 16840506 1:CAS:528:DC%2BD2sXksVCqs70%3D (Pubitemid 46579774)
    • (2007) Gut , vol.56 , Issue.3 , pp. 417-425
    • Schneikert, J.1    Behrens, J.2
  • 26
    • 33745809820 scopus 로고    scopus 로고
    • Adenomatous polyposis coli (APC) differentially regulates β-catenin phosphorylation and ubiquitination in colon cancer cells
    • DOI 10.1074/jbc.M600831200
    • J Yang W Zhang PM Evans X Chen X He C Liu 2006 Adenomatous polyposis coli (APC) differentially regulates beta-catenin phosphorylation and ubiquitination in colon cancer cells J Biol Chem. 281 17751 17757 10.1074/jbc.M600831200 16798748 1:CAS:528:DC%2BD28XmtFyksbs%3D (Pubitemid 44035574)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.26 , pp. 17751-17757
    • Yang, J.1    Zhang, W.2    Evans, P.M.3    Chen, X.4    He, X.5    Liu, C.6
  • 27
    • 21644441458 scopus 로고    scopus 로고
    • DNA polymerase lambda directly binds to proliferating cell nuclear antigen through its confined C-terminal region
    • DOI 10.1111/j.1365-2443.2005.00868.x
    • N Shimazaki T Yazaki T Kubota A Sato A Nakamura S Kurei S Toji K Tamai O Koiwai 2005 DNA polymerase lambda directly binds to proliferating cell nuclear antigen through its confined C-terminal region Genes Cells. 10 705 715 10.1111/j.1365-2443.2005.00868.x 15966901 1:CAS:528:DC%2BD2MXpvF2ltr0%3D (Pubitemid 40932350)
    • (2005) Genes to Cells , vol.10 , Issue.7 , pp. 705-715
    • Shimazaki, N.1    Yazaki, T.2    Kubota, T.3    Sato, A.4    Nakamura, A.5    Kurei, S.6    Toji, S.7    Tamai, K.8    Koiwai, O.9
  • 28
    • 33745818640 scopus 로고    scopus 로고
    • ROS-triggered caspase 2 activation and feedback amplification loop in β-carotene-induced apoptosis
    • DOI 10.1016/j.freeradbiomed.2006.03.009, PII S0891584906001833
    • V Prasad A Chandele JC Jagtap P Sudheer Kumar P Shastry 2006 ROS-triggered caspase 2 activation and feedback amplification loop in beta-carotene-induced apoptosis Free Radic Biol Med. 41 431 442 10.1016/j.freeradbiomed.2006.03.009 16843824 1:CAS:528:DC%2BD28XntFWru7s%3D (Pubitemid 44056011)
    • (2006) Free Radical Biology and Medicine , vol.41 , Issue.3 , pp. 431-442
    • Prasad, V.1    Chandele, A.2    Jagtap, J.C.3    Kumar, P.S.4    Shastry, P.5
  • 31
    • 33746864818 scopus 로고    scopus 로고
    • Regulation of human nitric oxide synthase 2 expression by Wnt β-catenin signaling
    • DOI 10.1158/0008-5472.CAN-05-4110
    • Q Du KS Park Z Guo P He M Nagashima L Shao R Sahai DA Geller SP Hussain 2006 Regulation of human nitric oxide synthase 2 expression by Wnt beta-catenin signaling Cancer Res. 66 7024 7031 10.1158/0008-5472.CAN-05-4110 16849547 1:CAS:528:DC%2BD28XmvFGktrg%3D (Pubitemid 44197678)
    • (2006) Cancer Research , vol.66 , Issue.14 , pp. 7024-7031
    • Du, Q.1    Park, K.S.2    Guo, Z.3    He, P.4    Nagashima, M.5    Shao, L.6    Sahai, R.7    Geller, D.A.8    Hussain, S.P.9
  • 32
    • 0035893568 scopus 로고    scopus 로고
    • Evidence that APC regulates survivin expression: A possible mechanism contributing to the stem cell origin of colon cancer
    • 11751382 1:CAS:528:DC%2BD38Xht1OgsQ%3D%3D
    • T Zhang T Otevrel Z Gao SM Ehrlich JZ Fields BM Boman 2001 Evidence that APC regulates survivin expression: a possible mechanism contributing to the stem cell origin of colon cancer Cancer Res. 61 8664 8667 11751382 1:CAS:528:DC%2BD38Xht1OgsQ%3D%3D
    • (2001) Cancer Res. , vol.61 , pp. 8664-8667
    • Zhang, T.1    Otevrel, T.2    Gao, Z.3    Ehrlich, S.M.4    Fields, J.Z.5    Boman, B.M.6
  • 33
    • 41549115361 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling: New (and old) players and new insights
    • 10.1016/j.ceb.2008.01.009 18339531 1:CAS:528:DC%2BD1cXks1Gnur8%3D
    • H Huang X He 2008 Wnt/beta-catenin signaling: new (and old) players and new insights Curr Opin Cell Biol. 20 119 125 10.1016/j.ceb.2008.01.009 18339531 1:CAS:528:DC%2BD1cXks1Gnur8%3D
    • (2008) Curr Opin Cell Biol. , vol.20 , pp. 119-125
    • Huang, H.1    He, X.2
  • 34
    • 69949153738 scopus 로고    scopus 로고
    • DcR3 and survivin are highly expressed in colorectal carcinoma and closely correlated to its clinicopathologic parameters
    • 10.1631/jzus.B0920077 19735100 1:CAS:528:DC%2BD1MXhtVygsr%2FJ
    • QL Liang BR Wang GH Li 2009 DcR3 and survivin are highly expressed in colorectal carcinoma and closely correlated to its clinicopathologic parameters J Zhejiang Univ Sci B. 10 675 682 10.1631/jzus.B0920077 19735100 1:CAS:528:DC%2BD1MXhtVygsr%2FJ
    • (2009) J Zhejiang Univ Sci B. , vol.10 , pp. 675-682
    • Liang, Q.L.1    Wang, B.R.2    Li, G.H.3
  • 35
    • 19644373254 scopus 로고    scopus 로고
    • Wnt signaling in disease and in development
    • DOI 10.1038/sj.cr.7290260
    • R Nusse 2005 Wnt signaling in disease and in development Cell Res. 15 28 32 10.1038/sj.cr.7290260 15686623 1:CAS:528:DC%2BD2MXkslGisb0%3D (Pubitemid 41653961)
    • (2005) Cell Research , vol.15 , Issue.1 , pp. 28-32
    • Nusse, R.1
  • 36
    • 0033551378 scopus 로고    scopus 로고
    • The role of c-myc in cellular growth control
    • DOI 10.1038/sj.onc.1202751
    • EV Schmidt 1999 The role of c-myc in cellular growth control Oncogene. 18 2988 2996 10.1038/sj.onc.1202751 10378694 1:CAS:528:DyaK1MXjs12qtLo%3D (Pubitemid 29276538)
    • (1999) Oncogene , vol.18 , Issue.19 , pp. 2988-2996
    • Schmidt, E.V.1
  • 37
    • 0035126561 scopus 로고    scopus 로고
    • Expression of survivin in normal, hyperplastic, and neoplastic colonic mucosa
    • DOI 10.1053/hupa.2001.21897
    • R Gianani E Jarboe D Orlicky M Frost J Bobak R Lehner KR Shroyer 2001 Expression of survivin in normal, hyperplastic, and neoplastic colonic mucosa Hum Pathol. 32 119 125 10.1053/hupa.2001.21897 11172305 1:CAS:528: DC%2BD3MXjslKmtbs%3D (Pubitemid 32150638)
    • (2001) Human Pathology , vol.32 , Issue.1 , pp. 119-125
    • Gianani, R.1    Jarboe, E.2    Orlicky, D.3    Frost, M.4    Bobak, J.5    Lehner, R.6    Shroyer, K.R.7
  • 38
    • 34547124062 scopus 로고    scopus 로고
    • Hypoxia: A key regulator of angiogenesis in cancer
    • DOI 10.1007/s10555-007-9066-y, Special issue on Hypoxia and Cancer, Guest Editor: Gregg L. Semenza
    • D Liao RS Johnson 2007 Hypoxia: a key regulator of angiogenesis in cancer Cancer Metastasis Rev. 26 281 290 10.1007/s10555-007-9066-y 17603752 1:CAS:528:DC%2BD2sXotFWrtLw%3D (Pubitemid 47101669)
    • (2007) Cancer and Metastasis Reviews , vol.26 , Issue.2 , pp. 281-290
    • Liao, D.1    Johnson, R.S.2
  • 39
    • 33750231566 scopus 로고    scopus 로고
    • Clinical trials of natural products as chemopreventive agents for prostate cancer
    • DOI 10.1517/13543784.15.10.1191
    • DL Bemis AE Katz R Buttyan 2006 Clinical trials of natural products as chemopreventive agents for prostate cancer Expert Opin Investig Drugs. 15 1191 1200 10.1517/13543784.15.10.1191 16989596 1:CAS:528:DC%2BD28XpvVeisLc%3D (Pubitemid 44608259)
    • (2006) Expert Opinion on Investigational Drugs , vol.15 , Issue.10 , pp. 1191-1200
    • Bemis, D.L.1    Katz, A.E.2    Buttyan, R.3
  • 40
    • 0032533494 scopus 로고    scopus 로고
    • Inhibition of apoptosis by survivin predicts shorter survival rates in colorectal cancer
    • 9823313 1:CAS:528:DyaK1cXnsFSmt78%3D
    • H Kawasaki DC Altieri CD Lu M Toyoda T Tenjo N Tanigawa 1998 Inhibition of apoptosis by survivin predicts shorter survival rates in colorectal cancer Cancer Res. 58 5071 5074 9823313 1:CAS:528:DyaK1cXnsFSmt78%3D
    • (1998) Cancer Res. , vol.58 , pp. 5071-5074
    • Kawasaki, H.1    Altieri, D.C.2    Lu, C.D.3    Toyoda, M.4    Tenjo, T.5    Tanigawa, N.6
  • 41
    • 33947732977 scopus 로고    scopus 로고
    • Angiogenesis: An organizing principle for drug discovery?
    • DOI 10.1038/nrd2115, PII NRD2115
    • J Folkman 2007 Angiogenesis: an organizing principle for drug discovery? Nat Rev Drug Discov. 6 273 286 10.1038/nrd2115 17396134 1:CAS:528: DC%2BD2sXjs1SisL4%3D (Pubitemid 46505878)
    • (2007) Nature Reviews Drug Discovery , vol.6 , Issue.4 , pp. 273-286
    • Folkman, J.1
  • 42
    • 0034648765 scopus 로고    scopus 로고
    • Angiogenesis in cancer and other diseases
    • 10.1038/35025220 11001068 1:CAS:528:DC%2BD3cXmvVSls74%3D
    • P Carmeliet RK Jain 2000 Angiogenesis in cancer and other diseases Nature. 407 249 257 10.1038/35025220 11001068 1:CAS:528:DC%2BD3cXmvVSls74%3D
    • (2000) Nature. , vol.407 , pp. 249-257
    • Carmeliet, P.1    Jain, R.K.2
  • 43
    • 49149124199 scopus 로고    scopus 로고
    • Mechanisms of angiogenesis
    • 10.1134/S0006297908070031 1:CAS:528:DC%2BD1cXpt12rtLw%3D
    • AF Karamysheva 2008 Mechanisms of angiogenesis Biochemistry (Mosc) 73 751 762 10.1134/S0006297908070031 1:CAS:528:DC%2BD1cXpt12rtLw%3D
    • (2008) Biochemistry (Mosc) , vol.73 , pp. 751-762
    • Karamysheva, A.F.1
  • 44
    • 0033998238 scopus 로고    scopus 로고
    • Vascular endothelial growth factor in human colon cancer: Biology and therapeutic implications
    • 10.1634/theoncologist.5-suppl-1-11 10804085 1:CAS:528: DC%2BD3cXjsFartr0%3D
    • LM Ellis Y Takahashi W Liu RM Shaheen 2000 Vascular endothelial growth factor in human colon cancer: biology and therapeutic implications Oncologist 5 Suppl 1 11 15 10.1634/theoncologist.5-suppl-1-11 10804085 1:CAS:528: DC%2BD3cXjsFartr0%3D
    • (2000) Oncologist , vol.5 , Issue.SUPPL. 1 , pp. 11-15
    • Ellis, L.M.1    Takahashi, Y.2    Liu, W.3    Shaheen, R.M.4
  • 45
    • 0028935608 scopus 로고
    • Regulation by vascular endothelial growth factor of human colon cancer tumorigenesis in a mouse model of experimental liver metastasis
    • 10.1172/JCI117857 7535799 1:CAS:528:DyaK2MXkslyktb4%3D
    • RS Warren H Yuan MR Matli NA Gillett N Ferrara 1995 Regulation by vascular endothelial growth factor of human colon cancer tumorigenesis in a mouse model of experimental liver metastasis J Clin Invest. 95 1789 1797 10.1172/JCI117857 7535799 1:CAS:528:DyaK2MXkslyktb4%3D
    • (1995) J Clin Invest. , vol.95 , pp. 1789-1797
    • Warren, R.S.1    Yuan, H.2    Matli, M.R.3    Gillett, N.A.4    Ferrara, N.5
  • 46
    • 33646063560 scopus 로고    scopus 로고
    • Tumour overexpression of inducible nitric oxide synthase (iNOS) increases angiogenesis and may modulate the anti-tumour effects of the vascular disrupting agent ZD6126
    • 10.1016/j.mvr.2006.01.004 16530791 1:CAS:528:DC%2BD28XjvVGlsrg%3D
    • ER Cullis TL Kalber SE Ashton JE Cartwright JR Griffiths AJ Ryan SP Robinson 2006 Tumour overexpression of inducible nitric oxide synthase (iNOS) increases angiogenesis and may modulate the anti-tumour effects of the vascular disrupting agent ZD6126 Microvasc Res. 71 76 84 10.1016/j.mvr.2006.01.004 16530791 1:CAS:528:DC%2BD28XjvVGlsrg%3D
    • (2006) Microvasc Res. , vol.71 , pp. 76-84
    • Cullis, E.R.1    Kalber, T.L.2    Ashton, S.E.3    Cartwright, J.E.4    Griffiths, J.R.5    Ryan, A.J.6    Robinson, S.P.7
  • 48
    • 26944502030 scopus 로고    scopus 로고
    • Colorectal cancer: Lifestyle and dietary factors
    • 16045124 1:STN:280:DC%2BD2Mzos12ktA%3D%3D
    • MP Correa Lima MH Gomes-da-Silva 2005 Colorectal cancer: lifestyle and dietary factors Nutr Hosp. 20 235 241 16045124 1:STN:280:DC%2BD2Mzos12ktA%3D%3D
    • (2005) Nutr Hosp. , vol.20 , pp. 235-241
    • Correa Lima, M.P.1    Gomes-Da-Silva, M.H.2
  • 49
    • 0038012718 scopus 로고    scopus 로고
    • Milk thistle: Is there a role for its use as an adjunct therapy in patients with cancer?
    • 10.1089/107555303765551633 12816629
    • EJ Ladas KM Kelly 2003 Milk thistle: is there a role for its use as an adjunct therapy in patients with cancer? J Altern Complement Med. 9 411 416 10.1089/107555303765551633 12816629
    • (2003) J Altern Complement Med. , vol.9 , pp. 411-416
    • Ladas, E.J.1    Kelly, K.M.2
  • 50
    • 33646739493 scopus 로고    scopus 로고
    • Pilot study of oral silibinin, a putative chemopreventive agent, in colorectal cancer patients: Silibinin levels in plasma, colorectum, and liver and their pharmacodynamic consequences
    • 10.1158/1078-0432.CCR-05-2724 16675592 1:CAS:528:DC%2BD28Xltlamurs%3D
    • C Hoh D Boocock T Marczylo R Singh DP Berry AR Dennison D Hemingway A Miller K West S Euden G Garcea PB Farmer WP Steward AJ Gescher 2006 Pilot study of oral silibinin, a putative chemopreventive agent, in colorectal cancer patients: silibinin levels in plasma, colorectum, and liver and their pharmacodynamic consequences Clin Cancer Res. 12 2944 2950 10.1158/1078-0432. CCR-05-2724 16675592 1:CAS:528:DC%2BD28Xltlamurs%3D
    • (2006) Clin Cancer Res. , vol.12 , pp. 2944-2950
    • Hoh, C.1    Boocock, D.2    Marczylo, T.3    Singh, R.4    Berry, D.P.5    Dennison, A.R.6    Hemingway, D.7    Miller, A.8    West, K.9    Euden, S.10    Garcea, G.11    Farmer, P.B.12    Steward, W.P.13    Gescher, A.J.14


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.