The prognostic value of CD147/EMMPRIN is associated with monocarboxylate transporter 1 co-expression in gastric cancer

European Journal of Cancer

Volumn 45, Issue 13, 2009, Pages 2418-2424

  Pinheiro, Céline ^a   Longatto Filho, Adhemar ^a,b   Simões, Kleber ^c   Jacob, Carlos Eduardo ^c   Bresciani, Cláudio José Caldas ^c   Zilberstein, Bruno ^c   Cecconello, Ivan ^c   Alves, Venâncio Avancini Ferreira ^c   Schmitt, Fernando ^d,e   Baltazar, Fátima ^a  

^a UNIVERSITY OF MINHO   (Portugal)

^b INSTITUTO ADOLFO LUTZ   (Brazil)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

^d UNIVERSITY OF PORTO   (Portugal)

^e University of Porto   (Portugal)

Author keywords

CD147 EMMPRIN; Gastric cancer; Immunohistochemistry; Monocarboxylate transporters

Indexed keywords

CD147 ANTIGEN; MONOCARBOXYLATE TRANSPORTER 1; MONOCARBOXYLATE TRANSPORTER 4;

ADVANCED CANCER; ARTICLE; CANCER STAGING; CONTROLLED STUDY; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; STOMACH CARCINOMA;

ANTIGENS, CD147; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; MONOCARBOXYLIC ACID TRANSPORTERS; NEOPLASM PROTEINS; PROGNOSIS; STOMACH NEOPLASMS;

EID: 68749120776     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejca.2009.06.018     Document Type: Article

References (30)

1. Globocan 2002, http://www-dep.iarc.fr/ [accessed December 2008]
2. Vauhkonen M., Vauhkonen H., and Sipponen P. Pathology and molecular biology of gastric cancer. Best Pract Res Clin Gastroenterol 20 (2006) 651-674
3. Dicken B.J., Bigam D.L., Cass C., Mackey J.R., Joy A.A., and Hamilton S.M. Gastric adenocarcinoma: review and considerations for future directions. Ann Surg 241 (2005) 27-39
4. Vecchi M., Nuciforo P., Romagnoli S., et al. Gene expression analysis of early and advanced gastric cancers. Oncogene 26 (2007) 4284-4294
5. Gatenby R.A., and Gillies R.J. Why do cancers have high aerobic glycolysis?. Nat Rev Cancer 4 (2004) 891-899
6. Gatenby R.A., Gawlinski E.T., Gmitro A.F., Kaylor B., and Gillies R.J. Acid-mediated tumor invasion: a multidisciplinary study. Cancer Res 66 (2006) 5216-5223
7. Rofstad E.K., Mathiesen B., Kindem K., and Galappathi K. Acidic extracellular pH promotes experimental metastasis of human melanoma cells in athymic nude mice. Cancer Res 66 (2006) 6699-6707
8. Izumi H., Torigoe T., Ishiguchi H., et al. Cellular pH regulators: potentially promising molecular targets for cancer chemotherapy. Cancer Treat Rev 29 (2003) 541-549
9. Mathupala S.P., Parajuli P., and Sloan A.E. Silencing of monocarboxylate transporters via small interfering ribonucleic acid inhibits glycolysis and induces cell death in malignant glioma: an in vitro study. Neurosurgery 55 (2004) 1410-1419
10. Fang J., Quinones Q.J., Holman T.L., et al. The H+-linked monocarboxylate transporter (MCT1/SLC16A1): a potential therapeutic target for high-risk neuroblastoma. Mol Pharmacol 70 (2006) 2108-2115
11. Koukourakis M.I., Giatromanolaki A., Harris A.L., and Sivridis E. Comparison of metabolic pathways between cancer cells and stromal cells in colorectal carcinomas: a metabolic survival role for tumor-associated stroma. Cancer Res 66 (2006) 632-637
12. Pinheiro C., Longatto-Filho A., Scapulatempo C., et al. Increased expression of monocarboxylate transporters 1, 2 and 4 in colorectal carcinomas. Virchows Arch 452 (2008) 139-146
13. Pinheiro C., Longatto-Filho A., Ferreira L., et al. Increasing expression of monocarboxylate transporters 1 and 4 along progression to invasive cervical carcinoma. Int J Gynec Pathol 27 (2008) 568-574
14. Koukourakis M.I., Giatromanolaki A., Bougioukas G., and Sivridis E. Lung cancer: a comparative study of metabolism related protein expression in cancer cells and tumor associated stroma. Cancer Biol Ther 6 (2007) 1476-1479
15. Kirk P., Wilson M.C., Heddle C., Brown M.H., Barclay A.N., and Halestrap A.P. CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression. EMBO J 19 (2000) 3896-3904
16. Wilson M.C., Meredith D., Fox J.E., Manoharan C., Davies A.J., and Halestrap A.P. Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: the ancillary protein for the insensitive MCT2 is EMBIGIN (gp70). J Biol Chem 280 (2005) 27213-27221
17. Philp N.J., Ochrietor J.D., Rudoy C., Muramatsu T., and Linser P.J. Loss of MCT1, MCT3, and MCT4 expression in the retinal pigment epithelium and neural retina of the 5A11/basigin-null mouse. Invest Ophthalmol Vis Sci 44 (2003) 1305-1311
18. Gallagher S.M., Castorino J.J., Wang D., and Philp N.J. Monocarboxylate transporter 4 regulates maturation and trafficking of CD147 to the plasma membrane in the metastatic breast cancer cell line MDA-MB-231. Cancer Res 67 (2007) 4182-4189
19. Deora A.A., Philp N., Hu J., Bok D., and Rodriguez-Boulan E. Mechanisms regulating tissue-specific polarity of monocarboxylate transporters and their chaperone CD147 in kidney and retinal epithelia. Proc Natl Acad Sci USA 102 (2005) 16245-16250
20. Pinheiro C, Longatto-Filho A, Pereira SMM et al. Monocarboxylate transporters 1 and 4 are associated with CD147 in cervical carcinoma. Dis Markers In press
21. Nabeshima K., Iwasaki H., Koga K., Hojo H., Suzumiya J., and Kikuchi M. Emmprin (basigin/CD147): matrix metalloproteinase modulator and multifunctional cell recognition molecule that plays a critical role in cancer progression. Pathol Int 56 (2006) 359-367
22. Gabison E.E., Hoang-Xuan T., Mauviel A., and Menashi S. EMMPRIN/CD147, an MMP modulator in cancer, development and tissue repair. Biochimie 87 (2005) 361-368
23. Riethdorf S., Reimers N., Assmann V., et al. High incidence of EMMPRIN expression in human tumors. Int J Cancer 19 (2006) 1800-1810
24. Zheng H.C., Takahashi H., Murai Y., et al. Upregulated EMMPRIN/CD147 might contribute to growth and angiogenesis of gastric carcinoma: a good marker for local invasion and prognosis. Br J Cancer 95 (2006) 1371-1378
25. Kononem J., Bubendorf L., Kallioniemi A., et al. Tissue microarrays for high-throughput molecular profiling of tumor specimens. Nat Med 4 (1998) 844-847
26. Lambert D.W., Wood I.S., Ellis A., and Shirazi-Beechey S.P. Molecular changes in the expression of human colonic nutrient transporters during the transition from normality to malignancy. Br J Cancer 86 (2002) 1262-1269
27. Asada K., Miyamoto K., Fukutomi T., et al. Reduced expression of GNA11 and silencing of MCT1 in human breast cancers. Oncology 64 (2003) 380-388
28. Leppilampi M., Saarnio J., Karttunen T.J., et al. Carbonic anhydrase isozymes IX and XII in gastric tumors. World J Gastroenterol 9 (2003) 1398-1403
29. Ullah M.S., Davies A.J., and Halestrap A.P. The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism. J Biol Chem 281 (2006) 9030-9037
30. Zheng H., Takahashi H., Murai Y., et al. Pathobiological characteristics of intestinal and diffuse-type gastric carcinoma in Japan: an immunostaining study on the tissue microarray. J Clin Pathol 60 (2007) 273-277