Epidermal growth factor and hypoxia-induced expression of CXC chemokine receptor 4 on non-small cell lung cancer cells is regulated by the phosphatidylinositol 3-kinase/PTEN/AKT/mammalian target of rapamycin signaling pathway and activation of hypoxia inducible factor-1α

Journal of Biological Chemistry

Volumn 280, Issue 23, 2005, Pages 22473-22481

  Phillips, Roderick J ^a   Mestas, Javier ^a   Gharaee Kermani, Mehrnaz ^a   Burdick, Marie D ^a   Sica, Antonio ^b   Belperio, John A ^a   Keane, Michael P ^a   Strieter, Robert M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; DISEASES; GROWTH KINETICS; SIGNALING; TENSILE TESTING; TUMORS;

CXC CHEMOKINE RECEPTOR 4 (CXCR4); EPIDERMAL GROWTH FACTOR; NON-SMALL CELL LUNG CANCER (NSCLC); SURFACE RECEPTOR;

CELLS;

CHEMOKINE RECEPTOR CXCR4; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; RAPAMYCIN;

ARTICLE; CHEMOTAXIS; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME REGULATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HYPOXIA; LUNG NON SMALL CELL CANCER; OXYGEN TENSION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; UPREGULATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANOXIA; BLOTTING, WESTERN; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SEPARATION; CELL SURVIVAL; CHEMOKINES, CXC; CHEMOTAXIS; DOSE-RESPONSE RELATIONSHIP, DRUG; EPIDERMAL GROWTH FACTOR; FLOW CYTOMETRY; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LUNG NEOPLASMS; NEOPLASM METASTASIS; OXYGEN; PHOSPHORIC MONOESTER HYDROLASES; PROMOTER REGIONS (GENETICS); PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; RECEPTORS, CXCR4; RNA, MESSENGER; SIGNAL TRANSDUCTION; SIROLIMUS; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION; TUMOR SUPPRESSOR PROTEINS; UP-REGULATION;

MAMMALIA;

EID: 20444445920     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M500963200     Document Type: Article

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