-
1
-
-
0025739785
-
Relationship of the expression of the multidrug resistance gene product (P-glycoprotein) in human colon carcinoma to local tumor aggressiveness and lymph node metastasis
-
Weinstein RS, Jakate SM, Dominguez JM. Relationship of the expression of the multidrug resistance gene product (P-glycoprotein) in human colon carcinoma to local tumor aggressiveness and lymph node metastasis. Cancer Res 1991; 51: 2720-2726.
-
(1991)
Cancer Res
, vol.51
, pp. 2720-2726
-
-
Weinstein, R.S.1
Jakate, S.M.2
Dominguez, J.M.3
-
2
-
-
0035300589
-
Progression and enhancement of metastatic potential after exposure of tumor cells to chemotherapeutic agents
-
De Larco JE, Wuertz BR, Manivel JC. Progression and enhancement of metastatic potential after exposure of tumor cells to chemotherapeutic agents. Cancer Res 2001; 61: 2857-2861.
-
(2001)
Cancer Res
, vol.61
, pp. 2857-2861
-
-
De Larco, J.E.1
Wuertz, B.R.2
Manivel, J.C.3
-
3
-
-
0027351189
-
Karnofsky memorial lecture: Ode to methotrexate
-
Bertino JR. Karnofsky memorial lecture: ode to methotrexate. J Clin Oncol 1993; 11: 5-14.
-
(1993)
J Clin Oncol
, vol.11
, pp. 5-14
-
-
Bertino, J.R.1
-
4
-
-
0030462249
-
Molecular therapeutics: Methotrexate and its mechanism of action
-
Cronstein BN. Molecular therapeutics: methotrexate and its mechanism of action. Arthritis Rheum 1996; 39: 1951-1960.
-
(1996)
Arthritis Rheum
, vol.39
, pp. 1951-1960
-
-
Cronstein, B.N.1
-
5
-
-
0021356277
-
Synthesis and properties of 7-hydroxymethotrexate polyglutamyl derivatives in Ehrlich ascites tumor cells in vitro
-
Fabre G, Fabre I, Matherly LH, Cano JP, Goldman ID. Synthesis and properties of 7-hydroxymethotrexate polyglutamyl derivatives in Ehrlich ascites tumor cells in vitro. J Biol Chem 1984; 259: 5066-5072.
-
(1984)
J Biol Chem
, vol.259
, pp. 5066-5072
-
-
Fabre, G.1
Fabre, I.2
Matherly, L.H.3
Cano, J.P.4
Goldman, I.D.5
-
6
-
-
0020565471
-
In vitro formation of polyglutamyl derivatives of methotrexate and 7-hydroxymethotrexate in human lymphoblastic leukemia cells
-
Fabre G, Matherly LH, Favre R, Catalin J, Cano JP. In vitro formation of polyglutamyl derivatives of methotrexate and 7-hydroxymethotrexate in human lymphoblastic leukemia cells. Cancer Res 1983; 43: 4648-4652.
-
(1983)
Cancer Res
, vol.43
, pp. 4648-4652
-
-
Fabre, G.1
Matherly, L.H.2
Favre, R.3
Catalin, J.4
Cano, J.P.5
-
7
-
-
0033754628
-
Classification of ex vivo methotrexate resistance in acute lymphoblastic and myeloid leukemia
-
Rots MG, Pieters R, Kaspers GJ, Veerman AJ, Peters GJ, Jansen G. Classification of ex vivo methotrexate resistance in acute lymphoblastic and myeloid leukemia. Br J Haematol 2000; 110: 791-800.
-
(2000)
Br J Haematol
, vol.110
, pp. 791-800
-
-
Rots, M.G.1
Pieters, R.2
Kaspers, G.J.3
Veerman, A.J.4
Peters, G.J.5
Jansen, G.6
-
8
-
-
0032807982
-
Carrier-mediated membrane transport of folates in mammalian cells
-
Sirotnak FM, Tolner B. Carrier-mediated membrane transport of folates in mammalian cells. Annu Rev Nutr 1999; 19: 91-122.
-
(1999)
Annu Rev Nutr
, vol.19
, pp. 91-122
-
-
Sirotnak, F.M.1
Tolner, B.2
-
9
-
-
0041842584
-
Antifolate resistance associated with loss of MRP1 expression and function in Chinese hamster ovary cells with markedly impaired export of folate and cholate
-
Stark M, Rothem L, Jansen G, Scheffer GL, Goldman ID, Assaraf YG. Antifolate resistance associated with loss of MRP1 expression and function in Chinese hamster ovary cells with markedly impaired export of folate and cholate. Mol Pharmacol 2003; 64: 220-227.
-
(2003)
Mol Pharmacol
, vol.64
, pp. 220-227
-
-
Stark, M.1
Rothem, L.2
Jansen, G.3
Scheffer, G.L.4
Goldman, I.D.5
Assaraf, Y.G.6
-
10
-
-
0142166328
-
Cancer chemoprevention with dietary phytochemicals
-
Surh YJ. Cancer chemoprevention with dietary phytochemicals. Nat Rev Cancer 2003; 3: 768-780.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 768-780
-
-
Surh, Y.J.1
-
11
-
-
0024321992
-
Randomized controlled trial of silymarin treatment in patients with cirrhosis of the liver
-
Ferenci P, Dragosics B, Dittrich H, Frank H, Benda L, Lochs H, et al. Randomized controlled trial of silymarin treatment in patients with cirrhosis of the liver. J Hepatol 1989; 9: 105-113.
-
(1989)
J Hepatol
, vol.9
, pp. 105-113
-
-
Ferenci, P.1
Dragosics, B.2
Dittrich, H.3
Frank, H.4
Benda, L.5
Lochs, H.6
-
12
-
-
28544439164
-
Silibinin efficacy against human hepatocellular carcinoma
-
Varghese L, Agarwal C, Tyagi A. Silibinin efficacy against human hepatocellular carcinoma. Clin Cancer Res 2005; 11: 8441-8448.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 8441-8448
-
-
Varghese, L.1
Agarwal, C.2
Tyagi, A.3
-
13
-
-
33244472101
-
Silymarin and silibinin cause G1 and G2-M cell cycle arrest via distinct circuitries in human prostate cancer PC3 cells: A comparison of flavanone silibinin with flavanolignan mixture silymarin
-
Deep G, Singh RP, Agarwal C, Kroll DJ, Agarwal R. Silymarin and silibinin cause G1 and G2-M cell cycle arrest via distinct circuitries in human prostate cancer PC3 cells: a comparison of flavanone silibinin with flavanolignan mixture silymarin. Oncogene 2006; 25: 1053-1069.
-
(2006)
Oncogene
, vol.25
, pp. 1053-1069
-
-
Deep, G.1
Singh, R.P.2
Agarwal, C.3
Kroll, D.J.4
Agarwal, R.5
-
14
-
-
3242786628
-
Synergistic anti-cancer effects of silibinin with conventional cytotoxic agents doxorubicin, cisplatin and carboplatin against human breast carcinoma MCF-7 and MDA-MB468 cells
-
Tyagi AK, Agarwal C, Chan DC, Agarwal R. Synergistic anti-cancer effects of silibinin with conventional cytotoxic agents doxorubicin, cisplatin and carboplatin against human breast carcinoma MCF-7 and MDA-MB468 cells. Oncol Rep 2004; 11: 493-499.
-
(2004)
Oncol Rep
, vol.11
, pp. 493-499
-
-
Tyagi, A.K.1
Agarwal, C.2
Chan, D.C.3
Agarwal, R.4
-
15
-
-
0043025262
-
Silibinin sensitizes human prostate carcinoma DU145 cells to cisplatin and carboplatin-induced growth inhibition and apoptotic death
-
Dhanalakshmi S, Agarwal P, Glode LM, Agarwal R. Silibinin sensitizes human prostate carcinoma DU145 cells to cisplatin and carboplatin-induced growth inhibition and apoptotic death. Int J Cancer 2003; 106: 699-705.
-
(2003)
Int J Cancer
, vol.106
, pp. 699-705
-
-
Dhanalakshmi, S.1
Agarwal, P.2
Glode, L.M.3
Agarwal, R.4
-
16
-
-
0036847718
-
Silibinin strongly synergizes human prostate carcinoma DU145 cells to doxorubicin-induced growth inhibition, G2-M arrest, and apoptosis
-
Tyagi AK, Singh RP, Agarwal C, Chan DC, Agarwal R. Silibinin strongly synergizes human prostate carcinoma DU145 cells to doxorubicin-induced growth inhibition, G2-M arrest, and apoptosis. Clin Cancer Res 2002; 8: 3512-3519.
-
(2002)
Clin Cancer Res
, vol.8
, pp. 3512-3519
-
-
Tyagi, A.K.1
Singh, R.P.2
Agarwal, C.3
Chan, D.C.4
Agarwal, R.5
-
17
-
-
33947195450
-
Silibinin synergizes with mitoxantrone to inhibit cell growth and induce apoptosis in human prostate cancer cells
-
Flaig TW, Su LJ, Harrison G, Agarwal R, Glode LM. Silibinin synergizes with mitoxantrone to inhibit cell growth and induce apoptosis in human prostate cancer cells. Int J Cancer 2007; 120: 2028-2033.
-
(2007)
Int J Cancer
, vol.120
, pp. 2028-2033
-
-
Flaig, T.W.1
Su, L.J.2
Harrison, G.3
Agarwal, R.4
Glode, L.M.5
-
18
-
-
0033936288
-
Characterization and modulation of drug resistance of human pediatric rhabdomyosarcoma cell lines
-
Cocker HA, Pinkerton CR, Kelland LR. Characterization and modulation of drug resistance of human pediatric rhabdomyosarcoma cell lines. Br J Cancer 2000; 83: 338-345.
-
(2000)
Br J Cancer
, vol.83
, pp. 338-345
-
-
Cocker, H.A.1
Pinkerton, C.R.2
Kelland, L.R.3
-
19
-
-
37349121900
-
Transcriptional regulation of aldo-ketoreductase 1C1 in HT29 human colon cancer cells resistant to methotrexate: Role in the cell cycle and apoptosis
-
Selga E, Noe V, Ciudad CJ. Transcriptional regulation of aldo-ketoreductase 1C1 in HT29 human colon cancer cells resistant to methotrexate: role in the cell cycle and apoptosis. Biochem Pharmacol 2008; 75: 414-426.
-
(2008)
Biochem Pharmacol
, vol.75
, pp. 414-426
-
-
Selga, E.1
Noe, V.2
Ciudad, C.J.3
-
20
-
-
0021061819
-
Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
-
Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 1983; 65: 55-63.
-
(1983)
J Immunol Methods
, vol.65
, pp. 55-63
-
-
Mosmann, T.1
-
21
-
-
33846981552
-
Improvement in histologic response but not survival in osteosarcoma patients treated with intensified chemotherapy: A randomized phase III trial of the European Osteosarcoma Intergroup
-
Lewis IJ, Nooij MA, Whelan J, Sydes MR, Grimer R, Hogendoorn PC, et al. Improvement in histologic response but not survival in osteosarcoma patients treated with intensified chemotherapy: a randomized phase III trial of the European Osteosarcoma Intergroup. J Natl Cancer Inst 2007; 99: 112-128.
-
(2007)
J Natl Cancer Inst
, vol.99
, pp. 112-128
-
-
Lewis, I.J.1
Nooij, M.A.2
Whelan, J.3
Sydes, M.R.4
Grimer, R.5
Hogendoorn, P.C.6
-
23
-
-
35248859158
-
Effects and mechanisms of Silibinin on human hepatoma cell lines
-
Lah JJ, Cui W, Hu KQ. Effects and mechanisms of Silibinin on human hepatoma cell lines. World J Gastroenterol 2007; 13: 5299-5305.
-
(2007)
World J Gastroenterol
, vol.13
, pp. 5299-5305
-
-
Lah, J.J.1
Cui, W.2
Hu, K.Q.3
-
24
-
-
33646739493
-
Pilot study of oral silibinin, a putative chemopreventive agent, in colorectal cancer patients: Silibinin levels in plasma, colorectum, and liver and their pharmacodynamic consequences
-
Hoh C, Boocock D, Marczylo T, Singh R, Berry DP, Dennison AR, et al. Pilot study of oral silibinin, a putative chemopreventive agent, in colorectal cancer patients: silibinin levels in plasma, colorectum, and liver and their pharmacodynamic consequences. Clin Cancer Res 2006; 12: 2944-2950.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 2944-2950
-
-
Hoh, C.1
Boocock, D.2
Marczylo, T.3
Singh, R.4
Berry, D.P.5
Dennison, A.R.6
-
25
-
-
82955187812
-
Silibinin triggers apoptotic signaling pathways and autophagic survival response in human colon adenocarcinoma cells and their derived metastatic cells
-
Kauntz H, Bousserouel S, Gosse F, Raul F. Silibinin triggers apoptotic signaling pathways and autophagic survival response in human colon adenocarcinoma cells and their derived metastatic cells. Apoptosis 2011; 16: 1042-1053.
-
(2011)
Apoptosis
, vol.16
, pp. 1042-1053
-
-
Kauntz, H.1
Bousserouel, S.2
Gosse, F.3
Raul, F.4
-
26
-
-
4544287556
-
Silibinin causes cell cycle arrest and apoptosis in human bladder transitional cell carcinoma cells by regulating CDKI-CDK-cyclin cascade, and caspase 3 and PARP cleavages
-
Tyagi A, Agarwal C, Harrison G, Glode LM, Agarwal R. Silibinin causes cell cycle arrest and apoptosis in human bladder transitional cell carcinoma cells by regulating CDKI-CDK-cyclin cascade, and caspase 3 and PARP cleavages. Carcinogenesis 2004; 25: 1711-1720.
-
(2004)
Carcinogenesis
, vol.25
, pp. 1711-1720
-
-
Tyagi, A.1
Agarwal, C.2
Harrison, G.3
Glode, L.M.4
Agarwal, R.5
-
27
-
-
79960009760
-
Quercetin induces apoptosis in the methotrexate-resistant osteosarcoma cell line U2-OS/MTX300 via mitochondrial dysfunction and dephosphorylation of Akt
-
Xie X, Yin J, Jia Q, Wang J, Zou C, Brewer KJ, et al. Quercetin induces apoptosis in the methotrexate-resistant osteosarcoma cell line U2-OS/MTX300 via mitochondrial dysfunction and dephosphorylation of Akt. Oncol Rep 2011; 26: 687-693.
-
(2011)
Oncol Rep
, vol.26
, pp. 687-693
-
-
Xie, X.1
Yin, J.2
Jia, Q.3
Wang, J.4
Zou, C.5
Brewer, K.J.6
-
28
-
-
44649155314
-
New combination therapies with cell-cycle agents
-
Deep G, Agarwal R. New combination therapies with cell-cycle agents. Curr Opin Invest Drugs 2008; 9: 591-604.
-
(2008)
Curr Opin Invest Drugs
, vol.9
, pp. 591-604
-
-
Deep, G.1
Agarwal, R.2
-
29
-
-
4644220793
-
Oxidised derivatives of Silybin and their antiradical and antioxidant activity
-
Gazak R, Svobodova A, Psotova J, Sedmera P, Prikrylova V, Walterova D, et al. Oxidised derivatives of Silybin and their antiradical and antioxidant activity. Bioorg Med Chem 2004; 12: 5677-5687.
-
(2004)
Bioorg Med Chem
, vol.12
, pp. 5677-5687
-
-
Gazak, R.1
Svobodova, A.2
Psotova, J.3
Sedmera, P.4
Prikrylova, V.5
Walterova, D.6
-
30
-
-
77957598340
-
Antimetastatic efficacy of silibinin: Molecular mechanisms and therapeutic potential against cancer
-
Deep G, Agarwal R. Antimetastatic efficacy of silibinin: molecular mechanisms and therapeutic potential against cancer. Cancer Metastasis Rev 2010; 29: 447-463.
-
(2010)
Cancer Metastasis Rev
, vol.29
, pp. 447-463
-
-
Deep, G.1
Agarwal, R.2
-
31
-
-
0029861534
-
Influence of methotrexate dose intensity on outcome of patients with high-grade osteogenic osteosarcoma. Analysis of the literature
-
Delepine N, Delepine G, Bacci G, Rosen G, Desbois JC. Influence of methotrexate dose intensity on outcome of patients with high-grade osteogenic osteosarcoma. Analysis of the literature. Cancer 1996; 78: 2127-2135.
-
(1996)
Cancer
, vol.78
, pp. 2127-2135
-
-
Delepine, N.1
Delepine, G.2
Bacci, G.3
Rosen, G.4
Desbois, J.C.5
-
32
-
-
27644439523
-
Mechanisms and preclinical efficacy of silibinin in preventing skin cancer
-
Singh RP, Agarwal R. Mechanisms and preclinical efficacy of silibinin in preventing skin cancer. Eur J Cancer 2005; 41: 1969-1979.
-
(2005)
Eur J Cancer
, vol.41
, pp. 1969-1979
-
-
Singh, R.P.1
Agarwal, R.2
-
33
-
-
33845899681
-
A phase I and pharmacokinetic study of silybinphytosome in prostate cancer patients
-
Flaig TW, Gustafson DL, Su LJ, Zirrolli JA, Crighton F, Harrison GS. A phase I and pharmacokinetic study of silybinphytosome in prostate cancer patients. Invest New Drugs 2007; 25: 139-146.
-
(2007)
Invest New Drugs
, vol.25
, pp. 139-146
-
-
Flaig, T.W.1
Gustafson, D.L.2
Su, L.J.3
Zirrolli, J.A.4
Crighton, F.5
Harrison, G.S.6
-
34
-
-
0034576945
-
Milk thistle: Effects on liver disease and cirrhosis and clinical adverse effects
-
Mulrow C, Lawrence V, Jacobs B, Dennehy C, Sapp J, Ramirez G, et al. Milk thistle: effects on liver disease and cirrhosis and clinical adverse effects. Evid Rep Technol Assess 2000; 21: 1-3.
-
(2000)
Evid Rep Technol Assess
, vol.21
, pp. 1-3
-
-
Mulrow, C.1
Lawrence, V.2
Jacobs, B.3
Dennehy, C.4
Sapp, J.5
Ramirez, G.6
-
35
-
-
42549155669
-
Silibinin restores paclitaxel sensitivity to paclitaxel-resistant human ovarian carcinoma cells
-
Zhou L, Liu P, Chen B, Wang Y, Wang X, Internati MC, et al. Silibinin restores paclitaxel sensitivity to paclitaxel-resistant human ovarian carcinoma cells. Anticancer Res 2008; 28: 1119-1127.
-
(2008)
Anticancer Res
, vol.28
, pp. 1119-1127
-
-
Zhou, L.1
Liu, P.2
Chen, B.3
Wang, Y.4
Wang, X.5
Internati, M.C.6
-
36
-
-
84875344694
-
Chemoprevention utility of silibinin and Cdk4 pathway inhibition in Apc-/+ mice
-
Karim BO, Rhee KJ, Liu G, Zheng D, Huso DL. Chemoprevention utility of silibinin and Cdk4 pathway inhibition in Apc-/+ mice. BMC Cancer 2013; 13: 157-167.
-
(2013)
BMC Cancer
, vol.13
, pp. 157-167
-
-
Karim, B.O.1
Rhee, K.J.2
Liu, G.3
Zheng, D.4
Huso, D.L.5
-
37
-
-
37549017366
-
Chemopreventive effects of silymarin and silibinin on N-butyl-N-(4-hydroxybutyl) nitrosamine induced urinary bladder carcinogenesis in male ICR mice
-
Tyagi A, Raina K, Singh RP, Gu M, Agarwal C, Harrison G, et al. Chemopreventive effects of silymarin and silibinin on N-butyl-N-(4-hydroxybutyl) nitrosamine induced urinary bladder carcinogenesis in male ICR mice. Mol Cancer Ther 2007; 6: 3248-3255.
-
(2007)
Mol Cancer Ther
, vol.6
, pp. 3248-3255
-
-
Tyagi, A.1
Raina, K.2
Singh, R.P.3
Gu, M.4
Agarwal, C.5
Harrison, G.6
-
38
-
-
37549009050
-
Oral silibinin inhibits in vivo human bladder tumor xenograft growth involving down-regulation of survivin
-
Singh RP, Tyagi A, Sharma G, Mohan S, Agarwal R. Oral silibinin inhibits in vivo human bladder tumor xenograft growth involving down-regulation of survivin. Clin Cancer Res 2008; 14: 300-308.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 300-308
-
-
Singh, R.P.1
Tyagi, A.2
Sharma, G.3
Mohan, S.4
Agarwal, R.5
-
39
-
-
78751525898
-
Chemopreventive and chemotherapeutic effects of intravesical silibinin against bladder cancer by acting on mitochondria
-
Zeng J, Sun Y, Wu K, Li L, Zhang G, Yang Z, et al. Chemopreventive and chemotherapeutic effects of intravesical silibinin against bladder cancer by acting on mitochondria. Mol Cancer Ther 2011; 10: 104-116.
-
(2011)
Mol Cancer Ther
, vol.10
, pp. 104-116
-
-
Zeng, J.1
Sun, Y.2
Wu, K.3
Li, L.4
Zhang, G.5
Yang, Z.6
-
40
-
-
30344487254
-
Use of P-glycoprotein and BCRP inhibitors to improve oral bioavailability and CNS penetration of anticancer drugs
-
Breedveld P, Beijnen JH, Schellens JH. Use of P-glycoprotein and BCRP inhibitors to improve oral bioavailability and CNS penetration of anticancer drugs. Trends Pharmacol Sci 2006; 27: 17-24.
-
(2006)
Trends Pharmacol Sci
, vol.27
, pp. 17-24
-
-
Breedveld, P.1
Beijnen, J.H.2
Schellens, J.H.3
-
41
-
-
69949106198
-
Emerging significance of flavonoids as P-glycoprotein inhibitors in cancer chemotherapy
-
Bansal T, Jaggi M, Khar RK, Talegaonkar S. Emerging significance of flavonoids as P-glycoprotein inhibitors in cancer chemotherapy. J Pharm Pharm Sci 2009; 12: 46-78.
-
(2009)
J Pharm Pharm Sci
, vol.12
, pp. 46-78
-
-
Bansal, T.1
Jaggi, M.2
Khar, R.K.3
Talegaonkar, S.4
|