메뉴 건너뛰기




Volumn 24, Issue , 2015, Pages 40-53

Innate immune perturbations, accumulating DAMPs and inflammasome dysregulation: A ticking time bomb in ageing

Author keywords

Autophagy; DAMPs; Inflammasome; Inflammation; Nod like receptors; Pattern recognition receptors

Indexed keywords

ADENOSINE TRIPHOSPHATE; AMYLIN; AMYLOID BETA PROTEIN; DAMAGE ASSOCIATED MOLECULAR PATTERN; HIGH MOBILITY GROUP B1 PROTEIN; INFLAMMASOME; INTERLEUKIN 1BETA; OXIDIZED LOW DENSITY LIPOPROTEIN; PATTERN RECOGNITION RECEPTOR; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; URATE; URIC ACID;

EID: 84936962136     PISSN: 15681637     EISSN: 18729649     Source Type: Journal    
DOI: 10.1016/j.arr.2015.02.005     Document Type: Review
Times cited : (55)

References (227)
  • 1
    • 77956663452 scopus 로고    scopus 로고
    • Cholesterol crystals piercing the arterial plaque and intima trigger local and systemic inflammation
    • Abela G.S. Cholesterol crystals piercing the arterial plaque and intima trigger local and systemic inflammation. J. Clin. Lipidol. 2010, 4:156-164.
    • (2010) J. Clin. Lipidol. , vol.4 , pp. 156-164
    • Abela, G.S.1
  • 3
    • 0014318652 scopus 로고
    • Mast cells in health and disease
    • Asboe-Hansen G. Mast cells in health and disease. Bull. N. Y. Acad. Med. 1968, 44:1048-1056.
    • (1968) Bull. N. Y. Acad. Med. , vol.44 , pp. 1048-1056
    • Asboe-Hansen, G.1
  • 4
    • 0000730374 scopus 로고
    • Cytoplasmic components in hepatic cell lysosomes
    • Ashford T.P., Porter K.R. Cytoplasmic components in hepatic cell lysosomes. J. Cell Biol. 1962, 12:198-202.
    • (1962) J. Cell Biol. , vol.12 , pp. 198-202
    • Ashford, T.P.1    Porter, K.R.2
  • 6
    • 59849086158 scopus 로고    scopus 로고
    • Macrophages generate reactive oxygen species in response to minimally oxidized low-density lipoprotein: toll-like receptor 4- and spleen tyrosine kinase-dependent activation of NADPH oxidase 2
    • Bae Y.S., Lee J.H., Choi S.H., Kim S., Almazan F., Witztum J.L., Miller Y.I. Macrophages generate reactive oxygen species in response to minimally oxidized low-density lipoprotein: toll-like receptor 4- and spleen tyrosine kinase-dependent activation of NADPH oxidase 2. Circ. Res. 2009, 104:210-218. 21p following 218.
    • (2009) Circ. Res. , vol.104 , pp. 210-218
    • Bae, Y.S.1    Lee, J.H.2    Choi, S.H.3    Kim, S.4    Almazan, F.5    Witztum, J.L.6    Miller, Y.I.7
  • 10
    • 79960542894 scopus 로고    scopus 로고
    • Cutting edge: reactive oxygen species inhibitors block priming, but not activation, of the NLRP3 inflammasome
    • Bauernfeind F., Bartok E., Rieger A., Franchi L., Nunez G., Hornung V. Cutting edge: reactive oxygen species inhibitors block priming, but not activation, of the NLRP3 inflammasome. J. Immunol. 2011, 187:613-617.
    • (2011) J. Immunol. , vol.187 , pp. 613-617
    • Bauernfeind, F.1    Bartok, E.2    Rieger, A.3    Franchi, L.4    Nunez, G.5    Hornung, V.6
  • 13
    • 0016893747 scopus 로고
    • Crystal shedding and acute pseudogout. An hypothesis based on a therapeutic failure
    • Bennett R.M., Lehr J.R., McCarty D.J. Crystal shedding and acute pseudogout. An hypothesis based on a therapeutic failure. Arthritis Rheum. 1976, 19:93-97.
    • (1976) Arthritis Rheum. , vol.19 , pp. 93-97
    • Bennett, R.M.1    Lehr, J.R.2    McCarty, D.J.3
  • 14
    • 54549093803 scopus 로고    scopus 로고
    • Ageing, oxidative stress and cancer: paradigms in parallax
    • Benz C.C., Yau C. Ageing, oxidative stress and cancer: paradigms in parallax. Nat. Rev. Cancer 2008, 8:875-879.
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 875-879
    • Benz, C.C.1    Yau, C.2
  • 15
    • 70149084792 scopus 로고    scopus 로고
    • HMGB1 loves company
    • Bianchi M.E. HMGB1 loves company. J. Leukoc. Biol. 2009, 86:573-576.
    • (2009) J. Leukoc. Biol. , vol.86 , pp. 573-576
    • Bianchi, M.E.1
  • 17
    • 0038509116 scopus 로고    scopus 로고
    • Effects of C-reactive protein on the release of von Willebrand factor, E-selectin, thrombomodulin and intercellular adhesion molecule-1 from human umbilical vein endothelial cells
    • Blann A.D., Lip G.Y. Effects of C-reactive protein on the release of von Willebrand factor, E-selectin, thrombomodulin and intercellular adhesion molecule-1 from human umbilical vein endothelial cells. Blood Coagul. Fibrinolysis 2003, 14:335-340.
    • (2003) Blood Coagul. Fibrinolysis , vol.14 , pp. 335-340
    • Blann, A.D.1    Lip, G.Y.2
  • 19
    • 0842309938 scopus 로고    scopus 로고
    • Age-dependent decrease in Toll-like receptor 4-mediated proinflammatory cytokine production and mitogen-activated protein kinase expression
    • Boehmer E.D., Goral J., Faunce D.E., Kovacs E.J. Age-dependent decrease in Toll-like receptor 4-mediated proinflammatory cytokine production and mitogen-activated protein kinase expression. J. Leukoc. Biol. 2004, 75:342-349.
    • (2004) J. Leukoc. Biol. , vol.75 , pp. 342-349
    • Boehmer, E.D.1    Goral, J.2    Faunce, D.E.3    Kovacs, E.J.4
  • 21
    • 0032933203 scopus 로고    scopus 로고
    • CD69 is a stimulatory receptor for natural killer cell and its cytotoxic effect is blocked by CD94 inhibitory receptor
    • Borrego F., Robertson M.J., Ritz J., Pena J., Solana R. CD69 is a stimulatory receptor for natural killer cell and its cytotoxic effect is blocked by CD94 inhibitory receptor. Immunology 1999, 97:159-165.
    • (1999) Immunology , vol.97 , pp. 159-165
    • Borrego, F.1    Robertson, M.J.2    Ritz, J.3    Pena, J.4    Solana, R.5
  • 24
    • 0036467447 scopus 로고    scopus 로고
    • Chlamydial heat shock protein 60 activates macrophages and endothelial cells through Toll-like receptor 4 and MD2 in a MyD88-dependent pathway
    • Bulut Y., Faure E., Thomas L., Karahashi H., Michelsen K.S., Equils O., Morrison S.G., Morrison R.P., Arditi M. Chlamydial heat shock protein 60 activates macrophages and endothelial cells through Toll-like receptor 4 and MD2 in a MyD88-dependent pathway. J. Immunol. 2002, 168:1435-1440.
    • (2002) J. Immunol. , vol.168 , pp. 1435-1440
    • Bulut, Y.1    Faure, E.2    Thomas, L.3    Karahashi, H.4    Michelsen, K.S.5    Equils, O.6    Morrison, S.G.7    Morrison, R.P.8    Arditi, M.9
  • 28
    • 0038369150 scopus 로고    scopus 로고
    • Insulin-like growth factor I and interleukin-6 contribute synergistically to disability and mortality in older women
    • Cappola A.R., Xue Q.L., Ferrucci L., Guralnik J.M., Volpato S., Fried L.P. Insulin-like growth factor I and interleukin-6 contribute synergistically to disability and mortality in older women. J. Clin. Endocrinol. Metab. 2003, 88:2019-2025.
    • (2003) J. Clin. Endocrinol. Metab. , vol.88 , pp. 2019-2025
    • Cappola, A.R.1    Xue, Q.L.2    Ferrucci, L.3    Guralnik, J.M.4    Volpato, S.5    Fried, L.P.6
  • 30
    • 16844363815 scopus 로고    scopus 로고
    • The unresponsiveness of aged mice to polysaccharide antigens is a result of a defect in macrophage function
    • Chelvarajan R.L., Collins S.M., Van Willigen J.M., Bondada S. The unresponsiveness of aged mice to polysaccharide antigens is a result of a defect in macrophage function. J. Leukoc. Biol. 2005, 77:503-512.
    • (2005) J. Leukoc. Biol. , vol.77 , pp. 503-512
    • Chelvarajan, R.L.1    Collins, S.M.2    Van Willigen, J.M.3    Bondada, S.4
  • 31
    • 33746747096 scopus 로고    scopus 로고
    • MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals
    • Chen C.J., Shi Y., Hearn A., Fitzgerald K., Golenbock D., Reed G., Akira S., Rock K.L. MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals. J. Clin. Invest. 2006, 116:2262-2271.
    • (2006) J. Clin. Invest. , vol.116 , pp. 2262-2271
    • Chen, C.J.1    Shi, Y.2    Hearn, A.3    Fitzgerald, K.4    Golenbock, D.5    Reed, G.6    Akira, S.7    Rock, K.L.8
  • 32
    • 47949085624 scopus 로고    scopus 로고
    • Cutting edge: TLR2 is a functional receptor for acute-phase serum amyloid A
    • Cheng N., He R., Tian J., Ye P.P., Ye R.D. Cutting edge: TLR2 is a functional receptor for acute-phase serum amyloid A. J. Immunol. 2008, 181:22-26.
    • (2008) J. Immunol. , vol.181 , pp. 22-26
    • Cheng, N.1    He, R.2    Tian, J.3    Ye, P.P.4    Ye, R.D.5
  • 33
    • 34047261260 scopus 로고    scopus 로고
    • ATP activates a reactive oxygen species-dependent oxidative stress response and secretion of proinflammatory cytokines in macrophages
    • Cruz C.M., Rinna A., Forman H.J., Ventura A.L., Persechini P.M., Ojcius D.M. ATP activates a reactive oxygen species-dependent oxidative stress response and secretion of proinflammatory cytokines in macrophages. J. Biol. Chem. 2007, 282:2871-2879.
    • (2007) J. Biol. Chem. , vol.282 , pp. 2871-2879
    • Cruz, C.M.1    Rinna, A.2    Forman, H.J.3    Ventura, A.L.4    Persechini, P.M.5    Ojcius, D.M.6
  • 34
    • 0034613294 scopus 로고    scopus 로고
    • Age-related decline in chaperone-mediated autophagy
    • Cuervo A.M., Dice J.F. Age-related decline in chaperone-mediated autophagy. J. Biol. Chem. 2000, 275:31505-31513.
    • (2000) J. Biol. Chem. , vol.275 , pp. 31505-31513
    • Cuervo, A.M.1    Dice, J.F.2
  • 36
    • 0342289468 scopus 로고
    • Promotion of wound repair in old mice by local injection of macrophages
    • Danon D., Kowatch M.A., Roth G.S. Promotion of wound repair in old mice by local injection of macrophages. Proc. Natl. Acad. Sci. U. S. A. 1989, 86:2018-2020.
    • (1989) Proc. Natl. Acad. Sci. U. S. A. , vol.86 , pp. 2018-2020
    • Danon, D.1    Kowatch, M.A.2    Roth, G.S.3
  • 39
    • 84886797274 scopus 로고    scopus 로고
    • Autophagy in infection, inflammation and immunity
    • Deretic V., Saitoh T., Akira S. Autophagy in infection, inflammation and immunity. Nat. Rev. Immunol. 2013, 13:722-737.
    • (2013) Nat. Rev. Immunol. , vol.13 , pp. 722-737
    • Deretic, V.1    Saitoh, T.2    Akira, S.3
  • 40
    • 77953854915 scopus 로고    scopus 로고
    • Leukocyte function in the aging immune system
    • Desai A., Grolleau-Julius A., Yung R. Leukocyte function in the aging immune system. J. Leukoc. Biol. 2010, 87:1001-1009.
    • (2010) J. Leukoc. Biol. , vol.87 , pp. 1001-1009
    • Desai, A.1    Grolleau-Julius, A.2    Yung, R.3
  • 42
    • 33644854500 scopus 로고    scopus 로고
    • Interleukin 1 and interleukin 18 as mediators of inflammation and the aging process
    • Dinarello C.A. Interleukin 1 and interleukin 18 as mediators of inflammation and the aging process. Am. J. Clin. Nutr. 2006, 83:447S-455S.
    • (2006) Am. J. Clin. Nutr. , vol.83 , pp. 447S-455S
    • Dinarello, C.A.1
  • 45
    • 43249125839 scopus 로고    scopus 로고
    • Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica
    • Dostert C., Petrilli V., Van Bruggen R., Steele C., Mossman B.T., Tschopp J. Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica. Science 2008, 320:674-677.
    • (2008) Science , vol.320 , pp. 674-677
    • Dostert, C.1    Petrilli, V.2    Van Bruggen, R.3    Steele, C.4    Mossman, B.T.5    Tschopp, J.6
  • 46
    • 84903279324 scopus 로고    scopus 로고
    • Urinary kidney injury molecule 1 (KIM-1) and interleukin 18 (IL-18) as risk markers for heart failure in older adults: the Health, Aging, and Body Composition (Health ABC) Study
    • Health ABC Study
    • Driver T.H., Katz R., Ix J.H., Magnani J.W., Peralta C.A., Parikh C.R., Fried L., Newman A.B., Kritchevsky S.B., Sarnak M.J., Shlipak M.G. Urinary kidney injury molecule 1 (KIM-1) and interleukin 18 (IL-18) as risk markers for heart failure in older adults: the Health, Aging, and Body Composition (Health ABC) Study. Am. J. Kidney Dis. 2014, 64:49-56. Health ABC Study.
    • (2014) Am. J. Kidney Dis. , vol.64 , pp. 49-56
    • Driver, T.H.1    Katz, R.2    Ix, J.H.3    Magnani, J.W.4    Peralta, C.A.5    Parikh, C.R.6    Fried, L.7    Newman, A.B.8    Kritchevsky, S.B.9    Sarnak, M.J.10    Shlipak, M.G.11
  • 48
    • 0019979669 scopus 로고
    • The inhibitory effect of polymyxin B on endotoxin-induced endogenous pyrogen production
    • Duff G.W., Atkins E. The inhibitory effect of polymyxin B on endotoxin-induced endogenous pyrogen production. J. Immunol. Methods 1982, 52:333-340.
    • (1982) J. Immunol. Methods , vol.52 , pp. 333-340
    • Duff, G.W.1    Atkins, E.2
  • 49
    • 0027503291 scopus 로고
    • Interleukin-6: a cytokine for gerontologists
    • Ershler W.B. Interleukin-6: a cytokine for gerontologists. J. Am. Geriatr. Soc. 1993, 41:176-181.
    • (1993) J. Am. Geriatr. Soc. , vol.41 , pp. 176-181
    • Ershler, W.B.1
  • 50
    • 0034051068 scopus 로고    scopus 로고
    • Age-associated increased interleukin-6 gene expression, late-life diseases, and frailty
    • Ershler W.B., Keller E.T. Age-associated increased interleukin-6 gene expression, late-life diseases, and frailty. Annu. Rev. Med. 2000, 51:245-270.
    • (2000) Annu. Rev. Med. , vol.51 , pp. 245-270
    • Ershler, W.B.1    Keller, E.T.2
  • 51
    • 76549115951 scopus 로고    scopus 로고
    • Evolution in health and medicine Sackler colloquium: evolution of the human lifespan and diseases of aging: roles of infection, inflammation, and nutrition
    • Finch C.E. Evolution in health and medicine Sackler colloquium: evolution of the human lifespan and diseases of aging: roles of infection, inflammation, and nutrition. Proc. Natl. Acad. Sci. U. S. A. 2010, 107(Suppl. 1):1718-1724.
    • (2010) Proc. Natl. Acad. Sci. U. S. A. , vol.107 , pp. 1718-1724
    • Finch, C.E.1
  • 54
    • 0033982070 scopus 로고    scopus 로고
    • Mucosal vaccination and immune responses in the elderly
    • Fujihashi K., Koga T., McGhee J.R. Mucosal vaccination and immune responses in the elderly. Vaccine 2000, 18:1675-1680.
    • (2000) Vaccine , vol.18 , pp. 1675-1680
    • Fujihashi, K.1    Koga, T.2    McGhee, J.R.3
  • 55
    • 0037928705 scopus 로고    scopus 로고
    • Recombinant human heat shock protein 60 does not induce the release of tumor necrosis factor alpha from murine macrophages
    • Gao B., Tsan M.F. Recombinant human heat shock protein 60 does not induce the release of tumor necrosis factor alpha from murine macrophages. J. Biol. Chem. 2003, 278:22523-22529.
    • (2003) J. Biol. Chem. , vol.278 , pp. 22523-22529
    • Gao, B.1    Tsan, M.F.2
  • 56
    • 33748867575 scopus 로고    scopus 로고
    • The heat sensitivity of cytokine-inducing effect of lipopolysaccharide
    • Gao B., Wang Y., Tsan M.F. The heat sensitivity of cytokine-inducing effect of lipopolysaccharide. J. Leukoc. Biol. 2006, 80:359-366.
    • (2006) J. Leukoc. Biol. , vol.80 , pp. 359-366
    • Gao, B.1    Wang, Y.2    Tsan, M.F.3
  • 57
    • 0024354775 scopus 로고
    • Oxygen radical chemistry of polyunsaturated fatty acids
    • Gardner H.W. Oxygen radical chemistry of polyunsaturated fatty acids. Free Radic. Biol. Med. 1989, 7:65-86.
    • (1989) Free Radic. Biol. Med. , vol.7 , pp. 65-86
    • Gardner, H.W.1
  • 58
    • 33947322314 scopus 로고    scopus 로고
    • Review article: bacterial translocation in the critically ill - evidence and methods of prevention
    • Gatt M., Reddy B.S., MacFie J. Review article: bacterial translocation in the critically ill - evidence and methods of prevention. Aliment. Pharmacol. Ther. 2007, 25:741-757.
    • (2007) Aliment. Pharmacol. Ther. , vol.25 , pp. 741-757
    • Gatt, M.1    Reddy, B.S.2    MacFie, J.3
  • 59
    • 84901358607 scopus 로고    scopus 로고
    • Monocytes and macrophages: developmental pathways and tissue homeostasis
    • Ginhoux F., Jung S. Monocytes and macrophages: developmental pathways and tissue homeostasis. Nat. Rev. Immunol. 2014, 14:392-404.
    • (2014) Nat. Rev. Immunol. , vol.14 , pp. 392-404
    • Ginhoux, F.1    Jung, S.2
  • 60
    • 80054736885 scopus 로고    scopus 로고
    • Interleukin-6, C-reactive protein, and tumor necrosis factor-alpha as predictors of mortality in frail, community-living elderly individuals
    • Giovannini S., Onder G., Liperoti R., Russo A., Carter C., Capoluongo E., Pahor M., Bernabei R., Landi F. Interleukin-6, C-reactive protein, and tumor necrosis factor-alpha as predictors of mortality in frail, community-living elderly individuals. J. Am. Geriatr. Soc. 2011, 59:1679-1685.
    • (2011) J. Am. Geriatr. Soc. , vol.59 , pp. 1679-1685
    • Giovannini, S.1    Onder, G.2    Liperoti, R.3    Russo, A.4    Carter, C.5    Capoluongo, E.6    Pahor, M.7    Bernabei, R.8    Landi, F.9
  • 61
    • 2342527293 scopus 로고    scopus 로고
    • Aging, autoimmunity and arthritis: T-cell senescence and contraction of T-cell repertoire diversity - catalysts of autoimmunity and chronic inflammation
    • Goronzy J.J., Weyand C.M. Aging, autoimmunity and arthritis: T-cell senescence and contraction of T-cell repertoire diversity - catalysts of autoimmunity and chronic inflammation. Arthritis Res. Ther. 2003, 5:225-234.
    • (2003) Arthritis Res. Ther. , vol.5 , pp. 225-234
    • Goronzy, J.J.1    Weyand, C.M.2
  • 62
    • 0343095229 scopus 로고
    • Concepts of aging: an historical review
    • Grant R.L. Concepts of aging: an historical review. Perspect. Biol. Med. 1963, 6:443-478.
    • (1963) Perspect. Biol. Med. , vol.6 , pp. 443-478
    • Grant, R.L.1
  • 63
    • 79959354999 scopus 로고    scopus 로고
    • Mitochondria and the autophagy-inflammation-cell death axis in organismal aging
    • Green D.R., Galluzzi L., Kroemer G. Mitochondria and the autophagy-inflammation-cell death axis in organismal aging. Science 2011, 333:1109-1112.
    • (2011) Science , vol.333 , pp. 1109-1112
    • Green, D.R.1    Galluzzi, L.2    Kroemer, G.3
  • 64
    • 0030775322 scopus 로고    scopus 로고
    • Oxidative stress and cardiovascular disease
    • Griendling K.K., Alexander R.W. Oxidative stress and cardiovascular disease. Circulation 1997, 96:3264-3265.
    • (1997) Circulation , vol.96 , pp. 3264-3265
    • Griendling, K.K.1    Alexander, R.W.2
  • 65
    • 84884185767 scopus 로고    scopus 로고
    • Cyclooxygenase-1-dependent prostaglandins mediate susceptibility to systemic inflammation-induced acute cognitive dysfunction
    • Griffin E.W., Skelly D.T., Murray C.L., Cunningham C. Cyclooxygenase-1-dependent prostaglandins mediate susceptibility to systemic inflammation-induced acute cognitive dysfunction. J. Neurosci. 2013, 33:15248-15258.
    • (2013) J. Neurosci. , vol.33 , pp. 15248-15258
    • Griffin, E.W.1    Skelly, D.T.2    Murray, C.L.3    Cunningham, C.4
  • 68
    • 84907546578 scopus 로고    scopus 로고
    • Dysfunction of dendritic cells in aged C57BL/6 mice leads to failure of natural killer cell activation and of tumor eradication
    • Guo Z., Tilburgs T., Wong B., Strominger J.L. Dysfunction of dendritic cells in aged C57BL/6 mice leads to failure of natural killer cell activation and of tumor eradication. Proc. Natl. Acad. Sci. U. S. A. 2014, 111:14199-14204.
    • (2014) Proc. Natl. Acad. Sci. U. S. A. , vol.111 , pp. 14199-14204
    • Guo, Z.1    Tilburgs, T.2    Wong, B.3    Strominger, J.L.4
  • 69
    • 84883790050 scopus 로고    scopus 로고
    • Cytoplasmic LPS activates caspase-11: implications in TLR4-independent endotoxic shock
    • Hagar J.A., Powell D.A., Aachoui Y., Ernst R.K., Miao E.A. Cytoplasmic LPS activates caspase-11: implications in TLR4-independent endotoxic shock. Science 2013, 341:1250-1253.
    • (2013) Science , vol.341 , pp. 1250-1253
    • Hagar, J.A.1    Powell, D.A.2    Aachoui, Y.3    Ernst, R.K.4    Miao, E.A.5
  • 74
    • 0032751559 scopus 로고    scopus 로고
    • Age-related changes in dermal mast cell prevalence in BALB/c mice: functional importance and correlation with dermal mast cell expression of Kit
    • Hart P.H., Grimbaldeston M.A., Hosszu E.K., Swift G.J., Noonan F.P., Finlay-Jones J.J. Age-related changes in dermal mast cell prevalence in BALB/c mice: functional importance and correlation with dermal mast cell expression of Kit. Immunology 1999, 98:352-356.
    • (1999) Immunology , vol.98 , pp. 352-356
    • Hart, P.H.1    Grimbaldeston, M.A.2    Hosszu, E.K.3    Swift, G.J.4    Noonan, F.P.5    Finlay-Jones, J.J.6
  • 75
    • 84904903325 scopus 로고    scopus 로고
    • Impaired neutrophil extracellular trap formation: a novel defect in the innate immune system of aged individuals
    • Hazeldine J., Harris P., Chapple I.L., Grant M., Greenwood H., Livesey A., Sapey E., Lord J.M. Impaired neutrophil extracellular trap formation: a novel defect in the innate immune system of aged individuals. Aging Cell 2014, 13:690-698.
    • (2014) Aging Cell , vol.13 , pp. 690-698
    • Hazeldine, J.1    Harris, P.2    Chapple, I.L.3    Grant, M.4    Greenwood, H.5    Livesey, A.6    Sapey, E.7    Lord, J.M.8
  • 76
    • 58849134296 scopus 로고    scopus 로고
    • Serum amyloid A induces G-CSF expression and neutrophilia via Toll-like receptor 2
    • He R.L., Zhou J., Hanson C.Z., Chen J., Cheng N., Ye R.D. Serum amyloid A induces G-CSF expression and neutrophilia via Toll-like receptor 2. Blood 2009, 113:429-437.
    • (2009) Blood , vol.113 , pp. 429-437
    • He, R.L.1    Zhou, J.2    Hanson, C.Z.3    Chen, J.4    Cheng, N.5    Ye, R.D.6
  • 77
    • 84887446052 scopus 로고    scopus 로고
    • Mitochondrial reactive oxygen species induces NLRP3-dependent lysosomal damage and inflammasome activation
    • Heid M.E., Keyel P.A., Kamga C., Shiva S., Watkins S.C., Salter R.D. Mitochondrial reactive oxygen species induces NLRP3-dependent lysosomal damage and inflammasome activation. J. Immunol. 2013, 191:5230-5238.
    • (2013) J. Immunol. , vol.191 , pp. 5230-5238
    • Heid, M.E.1    Keyel, P.A.2    Kamga, C.3    Shiva, S.4    Watkins, S.C.5    Salter, R.D.6
  • 79
    • 0035116898 scopus 로고    scopus 로고
    • IFN-gamma-dependent transcription of MHC class II IA is impaired in macrophages from aged mice
    • Herrero C., Marques L., Lloberas J., Celada A. IFN-gamma-dependent transcription of MHC class II IA is impaired in macrophages from aged mice. J. Clin. Invest. 2001, 107:485-493.
    • (2001) J. Clin. Invest. , vol.107 , pp. 485-493
    • Herrero, C.1    Marques, L.2    Lloberas, J.3    Celada, A.4
  • 83
    • 84879013380 scopus 로고    scopus 로고
    • Innate lymphoid cells in immunity and disease
    • Hwang Y.Y., McKenzie A.N. Innate lymphoid cells in immunity and disease. Adv. Exp. Med. Biol. 2013, 785:9-26.
    • (2013) Adv. Exp. Med. Biol. , vol.785 , pp. 9-26
    • Hwang, Y.Y.1    McKenzie, A.N.2
  • 85
    • 10244265881 scopus 로고    scopus 로고
    • Peritoneal macrophages function modulation by L-carnitine in aging rats
    • Izgut-Uysal V.N., Agac A., Karadogan I., Derin N. Peritoneal macrophages function modulation by L-carnitine in aging rats. Aging Clin. Exp. Res. 2004, 16:337-341.
    • (2004) Aging Clin. Exp. Res. , vol.16 , pp. 337-341
    • Izgut-Uysal, V.N.1    Agac, A.2    Karadogan, I.3    Derin, N.4
  • 86
    • 84905383255 scopus 로고    scopus 로고
    • IL-2/CD40-activated macrophages rescue age and tumor-induced T cell dysfunction in elderly mice
    • Jackaman C., Dye D.E., Nelson D.J. IL-2/CD40-activated macrophages rescue age and tumor-induced T cell dysfunction in elderly mice. Age (Dordr) 2014, 36:9655.
    • (2014) Age (Dordr) , vol.36 , pp. 9655
    • Jackaman, C.1    Dye, D.E.2    Nelson, D.J.3
  • 87
    • 84898787733 scopus 로고    scopus 로고
    • Are macrophages, myeloid derived suppressor cells and neutrophils mediators of local suppression in healthy and cancerous tissues in aging hosts?
    • Jackaman C., Nelson D.J. Are macrophages, myeloid derived suppressor cells and neutrophils mediators of local suppression in healthy and cancerous tissues in aging hosts?. Exp. Gerontol. 2014, 54:53-57.
    • (2014) Exp. Gerontol. , vol.54 , pp. 53-57
    • Jackaman, C.1    Nelson, D.J.2
  • 89
    • 84865348839 scopus 로고    scopus 로고
    • Oxidized low-density lipoprotein induces secretion of interleukin-1beta by macrophages via reactive oxygen species-dependent NLRP3 inflammasome activation
    • Jiang Y., Wang M., Huang K., Zhang Z., Shao N., Zhang Y., Wang W., Wang S. Oxidized low-density lipoprotein induces secretion of interleukin-1beta by macrophages via reactive oxygen species-dependent NLRP3 inflammasome activation. Biochem. Biophys. Res. Commun. 2012, 425:121-126.
    • (2012) Biochem. Biophys. Res. Commun. , vol.425 , pp. 121-126
    • Jiang, Y.1    Wang, M.2    Huang, K.3    Zhang, Z.4    Shao, N.5    Zhang, Y.6    Wang, W.7    Wang, S.8
  • 90
    • 70349303199 scopus 로고    scopus 로고
    • Aging is associated with a numerical and functional decline in plasmacytoid dendritic cells, whereas myeloid dendritic cells are relatively unaltered in human peripheral blood
    • Jing Y., Shaheen E., Drake R.R., Chen N., Gravenstein S., Deng Y. Aging is associated with a numerical and functional decline in plasmacytoid dendritic cells, whereas myeloid dendritic cells are relatively unaltered in human peripheral blood. Hum. Immunol. 2009, 70:777-784.
    • (2009) Hum. Immunol. , vol.70 , pp. 777-784
    • Jing, Y.1    Shaheen, E.2    Drake, R.R.3    Chen, N.4    Gravenstein, S.5    Deng, Y.6
  • 91
    • 84947036646 scopus 로고    scopus 로고
    • Activation of the NLRP3 Inflammasome in association with Calcium Oxalate crystal-induced Reactive Oxygen Species in kidneys
    • Joshi S., Wang W., Peck A.B., Khan S.R. Activation of the NLRP3 Inflammasome in association with Calcium Oxalate crystal-induced Reactive Oxygen Species in kidneys. J. Urol. 2014.
    • (2014) J. Urol.
    • Joshi, S.1    Wang, W.2    Peck, A.B.3    Khan, S.R.4
  • 92
    • 36849021043 scopus 로고    scopus 로고
    • Atg7-dependent autophagy promotes neuronal health, stress tolerance, and longevity but is dispensable for metamorphosis in Drosophila
    • Juhasz G., Erdi B., Sass M., Neufeld T.P. Atg7-dependent autophagy promotes neuronal health, stress tolerance, and longevity but is dispensable for metamorphosis in Drosophila. Genes Dev. 2007, 21:3061-3066.
    • (2007) Genes Dev. , vol.21 , pp. 3061-3066
    • Juhasz, G.1    Erdi, B.2    Sass, M.3    Neufeld, T.P.4
  • 93
    • 84867770402 scopus 로고    scopus 로고
    • Non-transcriptional priming and deubiquitination regulate NLRP3 inflammasome activation
    • Juliana C., Fernandes-Alnemri T., Kang S., Farias A., Qin F., Alnemri E.S. Non-transcriptional priming and deubiquitination regulate NLRP3 inflammasome activation. J. Biol. Chem. 2012, 287:36617-36622.
    • (2012) J. Biol. Chem. , vol.287 , pp. 36617-36622
    • Juliana, C.1    Fernandes-Alnemri, T.2    Kang, S.3    Farias, A.4    Qin, F.5    Alnemri, E.S.6
  • 95
    • 28244459680 scopus 로고    scopus 로고
    • Potentiation of caspase-1 activation by the P2X7 receptor is dependent on TLR signals and requires NF-kappaB-driven protein synthesis
    • Kahlenberg J.M., Lundberg K.C., Kertesy S.B., Qu Y., Dubyak G.R. Potentiation of caspase-1 activation by the P2X7 receptor is dependent on TLR signals and requires NF-kappaB-driven protein synthesis. J. Immunol. 2005, 175:7611-7622.
    • (2005) J. Immunol. , vol.175 , pp. 7611-7622
    • Kahlenberg, J.M.1    Lundberg, K.C.2    Kertesy, S.B.3    Qu, Y.4    Dubyak, G.R.5
  • 104
    • 0033557202 scopus 로고    scopus 로고
    • Chlamydial and human heat shock protein 60s activate human vascular endothelium, smooth muscle cells, and macrophages
    • Kol A., Bourcier T., Lichtman A.H., Libby P. Chlamydial and human heat shock protein 60s activate human vascular endothelium, smooth muscle cells, and macrophages. J. Clin. Invest. 1999, 103:571-577.
    • (1999) J. Clin. Invest. , vol.103 , pp. 571-577
    • Kol, A.1    Bourcier, T.2    Lichtman, A.H.3    Libby, P.4
  • 105
    • 27144529078 scopus 로고    scopus 로고
    • Age-related differences in phenotype and function of CD4+ T cells are due to a phenotypic shift from naive to memory effector CD4+ T cells
    • Kovaiou R.D., Weiskirchner I., Keller M., Pfister G., Cioca D.P., Grubeck-Loebenstein B. Age-related differences in phenotype and function of CD4+ T cells are due to a phenotypic shift from naive to memory effector CD4+ T cells. Int. Immunol. 2005, 17:1359-1366.
    • (2005) Int. Immunol. , vol.17 , pp. 1359-1366
    • Kovaiou, R.D.1    Weiskirchner, I.2    Keller, M.3    Pfister, G.4    Cioca, D.P.5    Grubeck-Loebenstein, B.6
  • 108
    • 78751560494 scopus 로고    scopus 로고
    • Pathogen recognition by the innate immune system
    • Kumar H., Kawai T., Akira S. Pathogen recognition by the innate immune system. Int. Rev. Immunol. 2011, 30:16-34.
    • (2011) Int. Rev. Immunol. , vol.30 , pp. 16-34
    • Kumar, H.1    Kawai, T.2    Akira, S.3
  • 109
    • 0036786928 scopus 로고    scopus 로고
    • Effect of aging on serum uric acid levels: longitudinal changes in a large Japanese population group
    • Kuzuya M., Ando F., Iguchi A., Shimokata H. Effect of aging on serum uric acid levels: longitudinal changes in a large Japanese population group. J. Gerontol. A Biol. Sci. Med. Sci. 2002, 57:M660-M664.
    • (2002) J. Gerontol. A Biol. Sci. Med. Sci. , vol.57 , pp. M660-M664
    • Kuzuya, M.1    Ando, F.2    Iguchi, A.3    Shimokata, H.4
  • 110
    • 84878237993 scopus 로고    scopus 로고
    • Activation and regulation of the inflammasomes
    • Latz E., Xiao T.S., Stutz A. Activation and regulation of the inflammasomes. Nat. Rev. Immunol. 2013, 13:397-411.
    • (2013) Nat. Rev. Immunol. , vol.13 , pp. 397-411
    • Latz, E.1    Xiao, T.S.2    Stutz, A.3
  • 113
  • 114
    • 0014436078 scopus 로고
    • Clottable protein in Limulus; its localization and kinetics of its coagulation by endotoxin
    • Levin J., Bang F.B. Clottable protein in Limulus; its localization and kinetics of its coagulation by endotoxin. Thromb. Diath. Haemorrh. 1968, 19:186-197.
    • (1968) Thromb. Diath. Haemorrh. , vol.19 , pp. 186-197
    • Levin, J.1    Bang, F.B.2
  • 115
    • 0033966340 scopus 로고    scopus 로고
    • Increased plasma levels of interleukin-1, interleukin-6 and alpha-1-antichymotrypsin in patients with Alzheimer's disease: peripheral inflammation or signals from the brain?
    • Licastro F., Pedrini S., Caputo L., Annoni G., Davis L.J., Ferri C., Casadei V., Grimaldi L.M. Increased plasma levels of interleukin-1, interleukin-6 and alpha-1-antichymotrypsin in patients with Alzheimer's disease: peripheral inflammation or signals from the brain?. J. Neuroimmunol. 2000, 103:97-102.
    • (2000) J. Neuroimmunol. , vol.103 , pp. 97-102
    • Licastro, F.1    Pedrini, S.2    Caputo, L.3    Annoni, G.4    Davis, L.J.5    Ferri, C.6    Casadei, V.7    Grimaldi, L.M.8
  • 116
    • 84889580268 scopus 로고    scopus 로고
    • Increased Th17 differentiation in aged mice is significantly associated with high IL-1beta level and low IL-2 expression
    • Lim M.A., Lee J., Park J.S., Jhun J.Y., Moon Y.M., Cho M.L., Kim H.Y. Increased Th17 differentiation in aged mice is significantly associated with high IL-1beta level and low IL-2 expression. Exp. Gerontol. 2014, 49:55-62.
    • (2014) Exp. Gerontol. , vol.49 , pp. 55-62
    • Lim, M.A.1    Lee, J.2    Park, J.S.3    Jhun, J.Y.4    Moon, Y.M.5    Cho, M.L.6    Kim, H.Y.7
  • 118
    • 1142275269 scopus 로고    scopus 로고
    • Age-related changes in lymphocyte development and function
    • Linton P.J., Dorshkind K. Age-related changes in lymphocyte development and function. Nat. Immunol. 2004, 5:133-139.
    • (2004) Nat. Immunol. , vol.5 , pp. 133-139
    • Linton, P.J.1    Dorshkind, K.2
  • 120
    • 84941055651 scopus 로고    scopus 로고
    • Relationship between red cell distribution width and serum uric acid in patients with untreated essential hypertension
    • Luo M., Li Z.Z., Li Y.Y., Chen L.Z., Yan S.P., Chen P., Hu Y.Y. Relationship between red cell distribution width and serum uric acid in patients with untreated essential hypertension. Sci. Rep. 2014, 4:7291.
    • (2014) Sci. Rep. , vol.4 , pp. 7291
    • Luo, M.1    Li, Z.Z.2    Li, Y.Y.3    Chen, L.Z.4    Yan, S.P.5    Chen, P.6    Hu, Y.Y.7
  • 121
    • 0026747632 scopus 로고
    • Effect of aging and caloric restriction on intestinal permeability
    • Ma T.Y., Hollander D., Dadufalza V., Krugliak P. Effect of aging and caloric restriction on intestinal permeability. Exp. Gerontol. 1992, 27:321-333.
    • (1992) Exp. Gerontol. , vol.27 , pp. 321-333
    • Ma, T.Y.1    Hollander, D.2    Dadufalza, V.3    Krugliak, P.4
  • 122
    • 84858342119 scopus 로고    scopus 로고
    • Lifelong rapamycin administration ameliorates age-dependent cognitive deficits by reducing IL-1beta and enhancing NMDA signaling
    • Majumder S., Caccamo A., Medina D.X., Benavides A.D., Javors M.A., Kraig E., Strong R., Richardson A., Oddo S. Lifelong rapamycin administration ameliorates age-dependent cognitive deficits by reducing IL-1beta and enhancing NMDA signaling. Aging Cell 2012, 11:326-335.
    • (2012) Aging Cell , vol.11 , pp. 326-335
    • Majumder, S.1    Caccamo, A.2    Medina, D.X.3    Benavides, A.D.4    Javors, M.A.5    Kraig, E.6    Strong, R.7    Richardson, A.8    Oddo, S.9
  • 123
    • 0034855409 scopus 로고    scopus 로고
    • Evaluation of phagocytosis and arachidonate metabolism by alveolar macrophages and recruited neutrophils from F344xBN rats of different ages
    • Mancuso P., McNish R.W., Peters-Golden M., Brock T.G. Evaluation of phagocytosis and arachidonate metabolism by alveolar macrophages and recruited neutrophils from F344xBN rats of different ages. Mech. Ageing Dev. 2001, 122:1899-1913.
    • (2001) Mech. Ageing Dev. , vol.122 , pp. 1899-1913
    • Mancuso, P.1    McNish, R.W.2    Peters-Golden, M.3    Brock, T.G.4
  • 126
    • 0030814756 scopus 로고    scopus 로고
    • Incidence of community-acquired pneumonia requiring hospitalization. Results of a population-based active surveillance Study in Ohio. The Community-Based Pneumonia Incidence Study Group
    • Marston B.J., Plouffe J.F., File T.M., Hackman B.A., Salstrom S.J., Lipman H.B., Kolczak M.S., Breiman R.F. Incidence of community-acquired pneumonia requiring hospitalization. Results of a population-based active surveillance Study in Ohio. The Community-Based Pneumonia Incidence Study Group. Arch. Intern. Med. 1997, 157:1709-1718.
    • (1997) Arch. Intern. Med. , vol.157 , pp. 1709-1718
    • Marston, B.J.1    Plouffe, J.F.2    File, T.M.3    Hackman, B.A.4    Salstrom, S.J.5    Lipman, H.B.6    Kolczak, M.S.7    Breiman, R.F.8
  • 127
    • 0036671894 scopus 로고    scopus 로고
    • The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta
    • Martinon F., Burns K., Tschopp J. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol. Cell 2002, 10:417-426.
    • (2002) Mol. Cell , vol.10 , pp. 417-426
    • Martinon, F.1    Burns, K.2    Tschopp, J.3
  • 128
    • 32944468985 scopus 로고    scopus 로고
    • Gout-associated uric acid crystals activate the NALP3 inflammasome
    • Martinon F., Petrilli V., Mayor A., Tardivel A., Tschopp J. Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 2006, 440:237-241.
    • (2006) Nature , vol.440 , pp. 237-241
    • Martinon, F.1    Petrilli, V.2    Mayor, A.3    Tardivel, A.4    Tschopp, J.5
  • 131
    • 39449099608 scopus 로고    scopus 로고
    • Age-related changes in eosinophil function in human subjects
    • Mathur S.K., Schwantes E.A., Jarjour N.N., Busse W.W. Age-related changes in eosinophil function in human subjects. Chest 2008, 133:412-419.
    • (2008) Chest , vol.133 , pp. 412-419
    • Mathur, S.K.1    Schwantes, E.A.2    Jarjour, N.N.3    Busse, W.W.4
  • 134
    • 70349899283 scopus 로고    scopus 로고
    • The intestinal epithelial barrier: does it become impaired with age?
    • Meier J., Sturm A. The intestinal epithelial barrier: does it become impaired with age?. Dig. Dis. 2009, 27:240-245.
    • (2009) Dig. Dis. , vol.27 , pp. 240-245
    • Meier, J.1    Sturm, A.2
  • 135
    • 0042691506 scopus 로고    scopus 로고
    • Autophagy genes are essential for dauer development and life-span extension in C. elegans
    • Melendez A., Talloczy Z., Seaman M., Eskelinen E.L., Hall D.H., Levine B. Autophagy genes are essential for dauer development and life-span extension in C. elegans. Science 2003, 301:1387-1391.
    • (2003) Science , vol.301 , pp. 1387-1391
    • Melendez, A.1    Talloczy, Z.2    Seaman, M.3    Eskelinen, E.L.4    Hall, D.H.5    Levine, B.6
  • 137
    • 0042931219 scopus 로고    scopus 로고
    • The decline in B lymphopoiesis in aged mice reflects loss of very early B-lineage precursors
    • Miller J.P., Allman D. The decline in B lymphopoiesis in aged mice reflects loss of very early B-lineage precursors. J. Immunol. 2003, 171:2326-2330.
    • (2003) J. Immunol. , vol.171 , pp. 2326-2330
    • Miller, J.P.1    Allman, D.2
  • 138
    • 0037449723 scopus 로고    scopus 로고
    • Minimally modified LDL binds to CD14, induces macrophage spreading via TLR4/MD-2, and inhibits phagocytosis of apoptotic cells
    • Miller Y.I., Viriyakosol S., Binder C.J., Feramisco J.R., Kirkland T.N., Witztum J.L. Minimally modified LDL binds to CD14, induces macrophage spreading via TLR4/MD-2, and inhibits phagocytosis of apoptotic cells. J. Biol. Chem. 2003, 278:1561-1568.
    • (2003) J. Biol. Chem. , vol.278 , pp. 1561-1568
    • Miller, Y.I.1    Viriyakosol, S.2    Binder, C.J.3    Feramisco, J.R.4    Kirkland, T.N.5    Witztum, J.L.6
  • 139
    • 84910648789 scopus 로고    scopus 로고
    • Emerging role of selective autophagy in human diseases
    • Mizumura K., Choi A.M., Ryter S.W. Emerging role of selective autophagy in human diseases. Front. Pharmacol. 2014, 5:244.
    • (2014) Front. Pharmacol. , vol.5 , pp. 244
    • Mizumura, K.1    Choi, A.M.2    Ryter, S.W.3
  • 140
    • 11344283120 scopus 로고    scopus 로고
    • NK and NKT cell functions in immunosenescence
    • Mocchegiani E., Malavolta M. NK and NKT cell functions in immunosenescence. Aging Cell 2004, 3:177-184.
    • (2004) Aging Cell , vol.3 , pp. 177-184
    • Mocchegiani, E.1    Malavolta, M.2
  • 142
    • 84862688241 scopus 로고    scopus 로고
    • Innate lymphoid cells: critical regulators of allergic inflammation and tissue repair in the lung
    • Monticelli L.A., Sonnenberg G.F., Artis D. Innate lymphoid cells: critical regulators of allergic inflammation and tissue repair in the lung. Curr. Opin. Immunol. 2012, 24:284-289.
    • (2012) Curr. Opin. Immunol. , vol.24 , pp. 284-289
    • Monticelli, L.A.1    Sonnenberg, G.F.2    Artis, D.3
  • 145
    • 84879596906 scopus 로고    scopus 로고
    • K(+) efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter
    • Munoz-Planillo R., Kuffa P., Martinez-Colon G., Smith B.L., Rajendiran T.M., Nunez G. K(+) efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter. Immunity 2013, 38:1142-1153.
    • (2013) Immunity , vol.38 , pp. 1142-1153
    • Munoz-Planillo, R.1    Kuffa, P.2    Martinez-Colon, G.3    Smith, B.L.4    Rajendiran, T.M.5    Nunez, G.6
  • 146
    • 58249093939 scopus 로고    scopus 로고
    • How mitochondria produce reactive oxygen species
    • Murphy M.P. How mitochondria produce reactive oxygen species. Biochem. J. 2009, 417:1-13.
    • (2009) Biochem. J. , vol.417 , pp. 1-13
    • Murphy, M.P.1
  • 147
    • 84930176006 scopus 로고    scopus 로고
    • Associations between serum uric acid levels and the incidence of hypertension and metabolic syndrome: a 4-year follow-up study of a large screened cohort in Okinawa, Japan
    • Nagahama K., Inoue T., Kohagura K., Kinjo K., Ohya Y. Associations between serum uric acid levels and the incidence of hypertension and metabolic syndrome: a 4-year follow-up study of a large screened cohort in Okinawa, Japan. Hypertens. Res. 2014.
    • (2014) Hypertens. Res.
    • Nagahama, K.1    Inoue, T.2    Kohagura, K.3    Kinjo, K.4    Ohya, Y.5
  • 148
    • 33644689929 scopus 로고    scopus 로고
    • Lipopolysaccharide (LPS) contamination plays the real role in C-reactive protein-induced IL-6 secretion from human endothelial cells in vitro
    • Nerurkar S.S., McDevitt P.J., Scott G.F., Johanson K.O., Willette R.N., Yue T.L. Lipopolysaccharide (LPS) contamination plays the real role in C-reactive protein-induced IL-6 secretion from human endothelial cells in vitro. Arterioscler. Thromb. Vasc. Biol. 2005, 25:e136.
    • (2005) Arterioscler. Thromb. Vasc. Biol. , vol.25 , pp. e136
    • Nerurkar, S.S.1    McDevitt, P.J.2    Scott, G.F.3    Johanson, K.O.4    Willette, R.N.5    Yue, T.L.6
  • 149
    • 27144517418 scopus 로고    scopus 로고
    • Age-induced reprogramming of mast cell degranulation
    • Nguyen M., Pace A.J., Koller B.H. Age-induced reprogramming of mast cell degranulation. J. Immunol. 2005, 175:5701-5707.
    • (2005) J. Immunol. , vol.175 , pp. 5701-5707
    • Nguyen, M.1    Pace, A.J.2    Koller, B.H.3
  • 151
    • 46249132015 scopus 로고    scopus 로고
    • Ageing and life-long maintenance of T-cell subsets in the face of latent persistent infections
    • Nikolich-Zugich J. Ageing and life-long maintenance of T-cell subsets in the face of latent persistent infections. Nat. Rev. Immunol. 2008, 8:512-522.
    • (2008) Nat. Rev. Immunol. , vol.8 , pp. 512-522
    • Nikolich-Zugich, J.1
  • 152
    • 0034916891 scopus 로고    scopus 로고
    • Association between natural killer cell activity and infection in immunologically normal elderly people
    • Ogata K., An E., Shioi Y., Nakamura K., Luo S., Yokose N., Minami S., Dan K. Association between natural killer cell activity and infection in immunologically normal elderly people. Clin. Exp. Immunol. 2001, 124:392-397.
    • (2001) Clin. Exp. Immunol. , vol.124 , pp. 392-397
    • Ogata, K.1    An, E.2    Shioi, Y.3    Nakamura, K.4    Luo, S.5    Yokose, N.6    Minami, S.7    Dan, K.8
  • 153
    • 0034650427 scopus 로고    scopus 로고
    • Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex
    • Ohashi K., Burkart V., Flohe S., Kolb H. Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex. J. Immunol. 2000, 164:558-561.
    • (2000) J. Immunol. , vol.164 , pp. 558-561
    • Ohashi, K.1    Burkart, V.2    Flohe, S.3    Kolb, H.4
  • 154
    • 33745726073 scopus 로고    scopus 로고
    • Development, migration, and survival of mast cells
    • Okayama Y., Kawakami T. Development, migration, and survival of mast cells. Immunol. Res. 2006, 34:97-115.
    • (2006) Immunol. Res. , vol.34 , pp. 97-115
    • Okayama, Y.1    Kawakami, T.2
  • 155
    • 84870051439 scopus 로고    scopus 로고
    • Removal of endotoxins from plasmid DNA: analysis of aggregative interaction of mobile divalent metal cations with endotoxins and plasmid DNA
    • Ongkudon C.M., Hodges E., Murphy K., Danquah M.K. Removal of endotoxins from plasmid DNA: analysis of aggregative interaction of mobile divalent metal cations with endotoxins and plasmid DNA. J. Sep. Sci. 2012, 35:3208-3216.
    • (2012) J. Sep. Sci. , vol.35 , pp. 3208-3216
    • Ongkudon, C.M.1    Hodges, E.2    Murphy, K.3    Danquah, M.K.4
  • 156
    • 0016184131 scopus 로고
    • Neutralization of the hemodynamic effects of endotoxin by polymyxin B
    • Palmer J.D., Rifkind D. Neutralization of the hemodynamic effects of endotoxin by polymyxin B. Surg. Gynecol. Obstet. 1974, 138:755-759.
    • (1974) Surg. Gynecol. Obstet. , vol.138 , pp. 755-759
    • Palmer, J.D.1    Rifkind, D.2
  • 157
    • 58149107469 scopus 로고    scopus 로고
    • Impact of oxidative stress on lung diseases
    • Park H.S., Kim S.R., Lee Y.C. Impact of oxidative stress on lung diseases. Respirology 2009, 14:27-38.
    • (2009) Respirology , vol.14 , pp. 27-38
    • Park, H.S.1    Kim, S.R.2    Lee, Y.C.3
  • 159
    • 1542380035 scopus 로고    scopus 로고
    • Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein
    • Park J.S., Svetkauskaite D., He Q., Kim J.Y., Strassheim D., Ishizaka A., Abraham E. Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein. J. Biol. Chem. 2004, 279:7370-7377.
    • (2004) J. Biol. Chem. , vol.279 , pp. 7370-7377
    • Park, J.S.1    Svetkauskaite, D.2    He, Q.3    Kim, J.Y.4    Strassheim, D.5    Ishizaka, A.6    Abraham, E.7
  • 161
    • 0034739462 scopus 로고    scopus 로고
    • Direct proinflammatory effect of C-reactive protein on human endothelial cells
    • Pasceri V., Willerson J.T., Yeh E.T. Direct proinflammatory effect of C-reactive protein on human endothelial cells. Circulation 2000, 102:2165-2168.
    • (2000) Circulation , vol.102 , pp. 2165-2168
    • Pasceri, V.1    Willerson, J.T.2    Yeh, E.T.3
  • 165
    • 4944231755 scopus 로고    scopus 로고
    • Impaired antigen-induced CD8+ T cell clonal expansion in aging is due to defects in antigen presenting cell function
    • Plowden J., Renshaw-Hoelscher M., Gangappa S., Engleman C., Katz J.M., Sambhara S. Impaired antigen-induced CD8+ T cell clonal expansion in aging is due to defects in antigen presenting cell function. Cell. Immunol. 2004, 229:86-92.
    • (2004) Cell. Immunol. , vol.229 , pp. 86-92
    • Plowden, J.1    Renshaw-Hoelscher, M.2    Gangappa, S.3    Engleman, C.4    Katz, J.M.5    Sambhara, S.6
  • 166
    • 0030003411 scopus 로고    scopus 로고
    • Effect of recombinant granulocyte colony-stimulating factor on neutrophil kinetics in normal young and elderly humans
    • Price T.H., Chatta G.S., Dale D.C. Effect of recombinant granulocyte colony-stimulating factor on neutrophil kinetics in normal young and elderly humans. Blood 1996, 88:335-340.
    • (1996) Blood , vol.88 , pp. 335-340
    • Price, T.H.1    Chatta, G.S.2    Dale, D.C.3
  • 168
    • 79955001064 scopus 로고    scopus 로고
    • Impaired interferon signaling in dendritic cells from older donors infected in vitro with West Nile virus
    • Qian F., Wang X., Zhang L., Lin A., Zhao H., Fikrig E., Montgomery R.R. Impaired interferon signaling in dendritic cells from older donors infected in vitro with West Nile virus. J. Infect. Dis. 2011, 203:1415-1424.
    • (2011) J. Infect. Dis. , vol.203 , pp. 1415-1424
    • Qian, F.1    Wang, X.2    Zhang, L.3    Lin, A.4    Zhao, H.5    Fikrig, E.6    Montgomery, R.R.7
  • 169
    • 84859717206 scopus 로고    scopus 로고
    • Innate immunity in the central nervous system
    • Ransohoff R.M., Brown M.A. Innate immunity in the central nervous system. J. Clin. Invest. 2012, 122:1164-1171.
    • (2012) J. Clin. Invest. , vol.122 , pp. 1164-1171
    • Ransohoff, R.M.1    Brown, M.A.2
  • 170
  • 171
    • 0024266283 scopus 로고
    • Do mitochondrial DNA fragments promote cancer and aging?
    • Richter C. Do mitochondrial DNA fragments promote cancer and aging?. FEBS Lett. 1988, 241:1-5.
    • (1988) FEBS Lett. , vol.241 , pp. 1-5
    • Richter, C.1
  • 172
    • 0026743031 scopus 로고
    • Reactive oxygen and DNA damage in mitochondria
    • Richter C. Reactive oxygen and DNA damage in mitochondria. Mutat. Res. 1992, 275:249-255.
    • (1992) Mutat. Res. , vol.275 , pp. 249-255
    • Richter, C.1
  • 173
    • 0023811053 scopus 로고
    • Normal oxidative damage to mitochondrial and nuclear DNA is extensive
    • Richter C., Park J.W., Ames B.N. Normal oxidative damage to mitochondrial and nuclear DNA is extensive. Proc. Natl. Acad. Sci. U. S. A. 1988, 85:6465-6467.
    • (1988) Proc. Natl. Acad. Sci. U. S. A. , vol.85 , pp. 6465-6467
    • Richter, C.1    Park, J.W.2    Ames, B.N.3
  • 178
    • 84863329778 scopus 로고    scopus 로고
    • Inflammaging: disturbed interplay between autophagy and inflammasomes
    • Salminen A., Kaarniranta K., Kauppinen A. Inflammaging: disturbed interplay between autophagy and inflammasomes. Aging (Albany, NY) 2012, 4:166-175.
    • (2012) Aging (Albany, NY) , vol.4 , pp. 166-175
    • Salminen, A.1    Kaarniranta, K.2    Kauppinen, A.3
  • 180
    • 84892640743 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase inhibition restores neutrophil accuracy in the elderly: toward targeted treatments for immunosenescence
    • Sapey E., Greenwood H., Walton G., Mann E., Love A., Aaronson N., Insall R.H., Stockley R.A., Lord J.M. Phosphoinositide 3-kinase inhibition restores neutrophil accuracy in the elderly: toward targeted treatments for immunosenescence. Blood 2014, 123:239-248.
    • (2014) Blood , vol.123 , pp. 239-248
    • Sapey, E.1    Greenwood, H.2    Walton, G.3    Mann, E.4    Love, A.5    Aaronson, N.6    Insall, R.H.7    Stockley, R.A.8    Lord, J.M.9
  • 181
    • 0026650438 scopus 로고
    • Isolation and characterization of two binding proteins for advanced glycosylation end products from bovine lung which are present on the endothelial cell surface
    • Schmidt A.M., Vianna M., Gerlach M., Brett J., Ryan J., Kao J., Esposito C., Hegarty H., Hurley W., Clauss M., et al. Isolation and characterization of two binding proteins for advanced glycosylation end products from bovine lung which are present on the endothelial cell surface. J. Biol. Chem. 1992, 267:14987-14997.
    • (1992) J. Biol. Chem. , vol.267 , pp. 14987-14997
    • Schmidt, A.M.1    Vianna, M.2    Gerlach, M.3    Brett, J.4    Ryan, J.5    Kao, J.6    Esposito, C.7    Hegarty, H.8    Hurley, W.9    Clauss, M.10
  • 183
    • 77950362382 scopus 로고    scopus 로고
    • The inflammasomes
    • Schroder K., Tschopp J. The inflammasomes. Cell 2010, 140:821-832.
    • (2010) Cell , vol.140 , pp. 821-832
    • Schroder, K.1    Tschopp, J.2
  • 185
    • 77953669656 scopus 로고    scopus 로고
    • Age-dependent alterations of monocyte subsets and monocyte-related chemokine pathways in healthy adults
    • Seidler S., Zimmermann H.W., Bartneck M., Trautwein C., Tacke F. Age-dependent alterations of monocyte subsets and monocyte-related chemokine pathways in healthy adults. BMC Immunol. 2010, 11:30.
    • (2010) BMC Immunol. , vol.11 , pp. 30
    • Seidler, S.1    Zimmermann, H.W.2    Bartneck, M.3    Trautwein, C.4    Tacke, F.5
  • 187
    • 84857195479 scopus 로고    scopus 로고
    • Activation of autophagy by inflammatory signals limits IL-1beta production by targeting ubiquitinated inflammasomes for destruction
    • Shi C.S., Shenderov K., Huang N.N., Kabat J., Abu-Asab M., Fitzgerald K.A., Sher A., Kehrl J.H. Activation of autophagy by inflammatory signals limits IL-1beta production by targeting ubiquitinated inflammasomes for destruction. Nat. Immunol. 2012, 13:255-263.
    • (2012) Nat. Immunol. , vol.13 , pp. 255-263
    • Shi, C.S.1    Shenderov, K.2    Huang, N.N.3    Kabat, J.4    Abu-Asab, M.5    Fitzgerald, K.A.6    Sher, A.7    Kehrl, J.H.8
  • 188
    • 84906571225 scopus 로고    scopus 로고
    • Inflammatory caspases are innate immune receptors for intracellular LPS
    • Shi J., Zhao Y., Wang Y., Gao W., Ding J., Li P., Hu L., Shao F. Inflammatory caspases are innate immune receptors for intracellular LPS. Nature 2014, 514:187-192.
    • (2014) Nature , vol.514 , pp. 187-192
    • Shi, J.1    Zhao, Y.2    Wang, Y.3    Gao, W.4    Ding, J.5    Li, P.6    Hu, L.7    Shao, F.8
  • 190
    • 38949099761 scopus 로고    scopus 로고
    • Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila
    • Simonsen A., Cumming R.C., Brech A., Isakson P., Schubert D.R., Finley K.D. Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila. Autophagy 2008, 4:176-184.
    • (2008) Autophagy , vol.4 , pp. 176-184
    • Simonsen, A.1    Cumming, R.C.2    Brech, A.3    Isakson, P.4    Schubert, D.R.5    Finley, K.D.6
  • 191
    • 34047174085 scopus 로고    scopus 로고
    • A pilot study of IL-1 inhibition by anakinra in acute gout
    • So A., De Smedt T., Revaz S., Tschopp J. A pilot study of IL-1 inhibition by anakinra in acute gout. Arthritis Res. Ther. 2007, 9:R28.
    • (2007) Arthritis Res. Ther. , vol.9 , pp. R28
    • So, A.1    De Smedt, T.2    Revaz, S.3    Tschopp, J.4
  • 192
    • 0033951533 scopus 로고    scopus 로고
    • NK and NK/T cells in human senescence
    • Solana R., Mariani E. NK and NK/T cells in human senescence. Vaccine 2000, 18:1613-1620.
    • (2000) Vaccine , vol.18 , pp. 1613-1620
    • Solana, R.1    Mariani, E.2
  • 193
    • 84906840499 scopus 로고    scopus 로고
    • Regulation of intestinal health and disease by innate lymphoid cells
    • Sonnenberg G.F. Regulation of intestinal health and disease by innate lymphoid cells. Int. Immunol. 2014, 26:501-507.
    • (2014) Int. Immunol. , vol.26 , pp. 501-507
    • Sonnenberg, G.F.1
  • 194
    • 80655125143 scopus 로고    scopus 로고
    • Age-associated impaired plasmacytoid dendritic cell functions lead to decreased CD4 and CD8 T cell immunity
    • Sridharan A., Esposo M., Kaushal K., Tay J., Osann K., Agrawal S., Gupta S., Agrawal A. Age-associated impaired plasmacytoid dendritic cell functions lead to decreased CD4 and CD8 T cell immunity. Age (Dordr) 2011, 33:363-376.
    • (2011) Age (Dordr) , vol.33 , pp. 363-376
    • Sridharan, A.1    Esposo, M.2    Kaushal, K.3    Tay, J.4    Osann, K.5    Agrawal, S.6    Gupta, S.7    Agrawal, A.8
  • 195
    • 0025674536 scopus 로고
    • Metal ion-catalyzed oxidation of proteins: biochemical mechanism and biological consequences
    • Stadtman E.R. Metal ion-catalyzed oxidation of proteins: biochemical mechanism and biological consequences. Free Radic. Biol. Med. 1990, 9:315-325.
    • (1990) Free Radic. Biol. Med. , vol.9 , pp. 315-325
    • Stadtman, E.R.1
  • 196
    • 0029822246 scopus 로고    scopus 로고
    • Morphologically and functionally intact dendritic cells can be derived from the peripheral blood of aged individuals
    • Steger M.M., Maczek C., Grubeck-Loebenstein B. Morphologically and functionally intact dendritic cells can be derived from the peripheral blood of aged individuals. Clin. Exp. Immunol. 1996, 105:544-550.
    • (1996) Clin. Exp. Immunol. , vol.105 , pp. 544-550
    • Steger, M.M.1    Maczek, C.2    Grubeck-Loebenstein, B.3
  • 198
    • 58149177781 scopus 로고    scopus 로고
    • Aging impairs IFN regulatory factor 7 up-regulation in plasmacytoid dendritic cells during TLR9 activation
    • Stout-Delgado H.W., Yang X., Walker W.E., Tesar B.M., Goldstein D.R. Aging impairs IFN regulatory factor 7 up-regulation in plasmacytoid dendritic cells during TLR9 activation. J. Immunol. 2008, 181:6747-6756.
    • (2008) J. Immunol. , vol.181 , pp. 6747-6756
    • Stout-Delgado, H.W.1    Yang, X.2    Walker, W.E.3    Tesar, B.M.4    Goldstein, D.R.5
  • 201
    • 0033398390 scopus 로고    scopus 로고
    • Impaired wound repair and delayed angiogenesis in aged mice
    • Swift M.E., Kleinman H.K., DiPietro L.A. Impaired wound repair and delayed angiogenesis in aged mice. Lab. Invest. 1999, 79:1479-1487.
    • (1999) Lab. Invest. , vol.79 , pp. 1479-1487
    • Swift, M.E.1    Kleinman, H.K.2    DiPietro, L.A.3
  • 203
    • 20144377088 scopus 로고    scopus 로고
    • C-reactive protein-induced in vitro endothelial cell activation is an artefact caused by azide and lipopolysaccharide
    • Taylor K.E., Giddings J.C., van den Berg C.W. C-reactive protein-induced in vitro endothelial cell activation is an artefact caused by azide and lipopolysaccharide. Arterioscler. Thromb. Vasc. Biol. 2005, 25:1225-1230.
    • (2005) Arterioscler. Thromb. Vasc. Biol. , vol.25 , pp. 1225-1230
    • Taylor, K.E.1    Giddings, J.C.2    van den Berg, C.W.3
  • 204
    • 0034862568 scopus 로고    scopus 로고
    • Age-related changes in wound healing
    • Thomas D.R. Age-related changes in wound healing. Drugs Aging 2001, 18:607-620.
    • (2001) Drugs Aging , vol.18 , pp. 607-620
    • Thomas, D.R.1
  • 205
    • 0037425564 scopus 로고    scopus 로고
    • Mortality associated with influenza and respiratory syncytial virus in the United States
    • Thompson W.W., Shay D.K., Weintraub E., Brammer L., Cox N., Anderson L.J., Fukuda K. Mortality associated with influenza and respiratory syncytial virus in the United States. JAMA 2003, 289:179-186.
    • (2003) JAMA , vol.289 , pp. 179-186
    • Thompson, W.W.1    Shay, D.K.2    Weintraub, E.3    Brammer, L.4    Cox, N.5    Anderson, L.J.6    Fukuda, K.7
  • 208
    • 34547116858 scopus 로고    scopus 로고
    • Pathogen-associated molecular pattern contamination as putative endogenous ligands of Toll-like receptors
    • Tsan M.F., Gao B. Pathogen-associated molecular pattern contamination as putative endogenous ligands of Toll-like receptors. J. Endotoxin Res. 2007, 13:6-14.
    • (2007) J. Endotoxin Res. , vol.13 , pp. 6-14
    • Tsan, M.F.1    Gao, B.2
  • 209
    • 84864378864 scopus 로고    scopus 로고
    • Innate immune dysfunctions in aged mice facilitate the systemic dissemination of methicillin-resistant S. aureus
    • Tseng C.W., Kyme P.A., Arruda A., Ramanujan V.K., Tawackoli W., Liu G.Y. Innate immune dysfunctions in aged mice facilitate the systemic dissemination of methicillin-resistant S. aureus. PLOS ONE 2012, 7:e41454.
    • (2012) PLOS ONE , vol.7 , pp. e41454
    • Tseng, C.W.1    Kyme, P.A.2    Arruda, A.3    Ramanujan, V.K.4    Tawackoli, W.5    Liu, G.Y.6
  • 210
    • 84871209287 scopus 로고    scopus 로고
    • Age-related decline of mast cell regeneration in senescence-accelerated mice (SAMP1) after chemical myeloablation due to senescent stromal cell impairment
    • Tsuboi I., Harada T., Hirabayashi Y., Kanno J., Inoue T., Aizawa S. Age-related decline of mast cell regeneration in senescence-accelerated mice (SAMP1) after chemical myeloablation due to senescent stromal cell impairment. Exp. Biol. Med. (Maywood) 2012, 237:1289-1297.
    • (2012) Exp. Biol. Med. (Maywood) , vol.237 , pp. 1289-1297
    • Tsuboi, I.1    Harada, T.2    Hirabayashi, Y.3    Kanno, J.4    Inoue, T.5    Aizawa, S.6
  • 212
    • 7944228661 scopus 로고    scopus 로고
    • Age and caloric restriction diets are confounding factors that modify the response to lipopolysaccharide by peritoneal macrophages in C57BL/6 mice
    • Vega V.L., De Cabo R., De Maio A. Age and caloric restriction diets are confounding factors that modify the response to lipopolysaccharide by peritoneal macrophages in C57BL/6 mice. Shock 2004, 22:248-253.
    • (2004) Shock , vol.22 , pp. 248-253
    • Vega, V.L.1    De Cabo, R.2    De Maio, A.3
  • 213
    • 0037126012 scopus 로고    scopus 로고
    • Demonstration that C-reactive protein decreases eNOS expression and bioactivity in human aortic endothelial cells
    • Venugopal S.K., Devaraj S., Yuhanna I., Shaul P., Jialal I. Demonstration that C-reactive protein decreases eNOS expression and bioactivity in human aortic endothelial cells. Circulation 2002, 106:1439-1441.
    • (2002) Circulation , vol.106 , pp. 1439-1441
    • Venugopal, S.K.1    Devaraj, S.2    Yuhanna, I.3    Shaul, P.4    Jialal, I.5
  • 216
    • 2542505678 scopus 로고    scopus 로고
    • Oxidative stress and mitochondrial DNA mutations in human aging
    • Wei Y.H. Oxidative stress and mitochondrial DNA mutations in human aging. Proc. Soc. Exp. Biol. Med. 1998, 217:53-63.
    • (1998) Proc. Soc. Exp. Biol. Med. , vol.217 , pp. 53-63
    • Wei, Y.H.1
  • 220
    • 0002707375 scopus 로고
    • On gouty and urinary concretions
    • Wollaston W.H. On gouty and urinary concretions. Philos. Trans. 1797, 87:386-400.
    • (1797) Philos. Trans. , vol.87 , pp. 386-400
    • Wollaston, W.H.1
  • 221
    • 41249098290 scopus 로고    scopus 로고
    • Aging up-regulates expression of inflammatory mediators in mouse adipose tissue
    • Wu D., Ren Z., Pae M., Guo W., Cui X., Merrill A.H., Meydani S.N. Aging up-regulates expression of inflammatory mediators in mouse adipose tissue. J. Immunol. 2007, 179:4829-4839.
    • (2007) J. Immunol. , vol.179 , pp. 4829-4839
    • Wu, D.1    Ren, Z.2    Pae, M.3    Guo, W.4    Cui, X.5    Merrill, A.H.6    Meydani, S.N.7
  • 224
    • 44449162626 scopus 로고    scopus 로고
    • High mobility group box 1 protein binding to lipopolysaccharide facilitates transfer of lipopolysaccharide to CD14 and enhances lipopolysaccharide-mediated TNF-alpha production in human monocytes
    • Youn J.H., Oh Y.J., Kim E.S., Choi J.E., Shin J.S. High mobility group box 1 protein binding to lipopolysaccharide facilitates transfer of lipopolysaccharide to CD14 and enhances lipopolysaccharide-mediated TNF-alpha production in human monocytes. J. Immunol. 2008, 180:5067-5074.
    • (2008) J. Immunol. , vol.180 , pp. 5067-5074
    • Youn, J.H.1    Oh, Y.J.2    Kim, E.S.3    Choi, J.E.4    Shin, J.S.5
  • 225
    • 84903135154 scopus 로고    scopus 로고
    • MtDNA mutations and their role in aging, diseases and forensic sciences
    • Zapico S.C., Ubelaker D.H. mtDNA mutations and their role in aging, diseases and forensic sciences. Aging Dis. 2013, 4:364-380.
    • (2013) Aging Dis. , vol.4 , pp. 364-380
    • Zapico, S.C.1    Ubelaker, D.H.2
  • 226
    • 78651393239 scopus 로고    scopus 로고
    • A role for mitochondria in NLRP3 inflammasome activation
    • Zhou R., Yazdi A.S., Menu P., Tschopp J. A role for mitochondria in NLRP3 inflammasome activation. Nature 2011, 469:221-225.
    • (2011) Nature , vol.469 , pp. 221-225
    • Zhou, R.1    Yazdi, A.S.2    Menu, P.3    Tschopp, J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.