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Volumn 77, Issue 3, 2014, Pages 219-225

Cerebrospinal fluid markers of neuroinflammation in delirium: A role for interleukin-1β in delirium after hip fracture

Author keywords

Cerebrospinal fluid; Delirium; Inflammation; Interleukin 1 receptor antagonist; Interleukin 1

Indexed keywords

GAMMA INTERFERON; GLIAL FIBRILLARY ACIDIC PROTEIN; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 1BETA; SOMATOMEDIN C;

EID: 84906790808     PISSN: 00223999     EISSN: 18791360     Source Type: Journal    
DOI: 10.1016/j.jpsychores.2014.06.014     Document Type: Article
Times cited : (100)

References (71)
  • 1
    • 34247569324 scopus 로고    scopus 로고
    • Delirium in older people
    • Young J, Inouye S Delirium in older people. Br Med J 2008, 334:842-846.
    • (2008) Br Med J , vol.334 , pp. 842-846
    • Young, J.1    Inouye, S.2
  • 2
    • 77951957277 scopus 로고    scopus 로고
    • Systemic inflammation induces acute working memory deficits in the primed brain: relevance for delirium
    • Murray C, Sanderson D, Barkus C, Deacon R, Rawlins J, Bannerman D, et al. Systemic inflammation induces acute working memory deficits in the primed brain: relevance for delirium. Neurobiol Aging 2012, 33:603-616.
    • (2012) Neurobiol Aging , vol.33 , pp. 603-616
    • Murray, C.1    Sanderson, D.2    Barkus, C.3    Deacon, R.4    Rawlins, J.5    Bannerman, D.6
  • 3
    • 38649119160 scopus 로고    scopus 로고
    • Neuroinflammation and disruption in working memory in aged mice after acute stimulation of the peripheral innate immune system
    • Chen J, Buchanan JB, Sparkman NL, Godbout JP, Freund GG, Johnson RW Neuroinflammation and disruption in working memory in aged mice after acute stimulation of the peripheral innate immune system. Brain Behav Immun 2008, 22:301-311.
    • (2008) Brain Behav Immun , vol.22 , pp. 301-311
    • Chen, J.1    Buchanan, J.B.2    Sparkman, N.L.3    Godbout, J.P.4    Freund, G.G.5    Johnson, R.W.6
  • 5
    • 84884185767 scopus 로고    scopus 로고
    • Cyclooxygenase-1 dependent prostaglandins mediate susceptibility to systemic inflammation-induced acute cognitive dysfunction
    • Griffin E, Skelly D, Murray C, Cunningham C Cyclooxygenase-1 dependent prostaglandins mediate susceptibility to systemic inflammation-induced acute cognitive dysfunction. J Neurosci 2013, 33:15248-15258.
    • (2013) J Neurosci , vol.33 , pp. 15248-15258
    • Griffin, E.1    Skelly, D.2    Murray, C.3    Cunningham, C.4
  • 8
    • 65449158857 scopus 로고    scopus 로고
    • Cytokines and IGF-1 in delirious and non-delirious acutely ill older medical inpatients
    • Adamis D, Lunn M, Martin FC, Treloar A, Gregson N, Hamilton G, et al. Cytokines and IGF-1 in delirious and non-delirious acutely ill older medical inpatients. Age Ageing 2009, 38:326-332.
    • (2009) Age Ageing , vol.38 , pp. 326-332
    • Adamis, D.1    Lunn, M.2    Martin, F.C.3    Treloar, A.4    Gregson, N.5    Hamilton, G.6
  • 10
    • 79958811522 scopus 로고    scopus 로고
    • Cerebrospinal IL-8 levels are higher in hip fracture patients with delirium versus controls
    • MacLullich A, Edelshain B, Hall R, de Vries A, Howie S, Pearson A, et al. Cerebrospinal IL-8 levels are higher in hip fracture patients with delirium versus controls. J Am Geriatr Soc 2011, 59:1151-1153.
    • (2011) J Am Geriatr Soc , vol.59 , pp. 1151-1153
    • MacLullich, A.1    Edelshain, B.2    Hall, R.3    de Vries, A.4    Howie, S.5    Pearson, A.6
  • 11
    • 0036498510 scopus 로고    scopus 로고
    • Cytokine-induced sickness behaviour: mechanisms and implications
    • Konsman J, Parnet P, Dantzer R Cytokine-induced sickness behaviour: mechanisms and implications. Trends Neurosci 2002, 25:154-159.
    • (2002) Trends Neurosci , vol.25 , pp. 154-159
    • Konsman, J.1    Parnet, P.2    Dantzer, R.3
  • 12
    • 58049190133 scopus 로고    scopus 로고
    • Interleukin-1 (IL-1): a central regulator of stress responses
    • Goshen I, Yirmiya R Interleukin-1 (IL-1): a central regulator of stress responses. Front Neuroendocrinol 2009, 30:30-45.
    • (2009) Front Neuroendocrinol , vol.30 , pp. 30-45
    • Goshen, I.1    Yirmiya, R.2
  • 13
    • 67650674339 scopus 로고    scopus 로고
    • Transport of interleukin-1 across cerebromicrovascular endothelial cells
    • Skinner R, Gibson R, Rothwell N, Pinteaux E, Penny J Transport of interleukin-1 across cerebromicrovascular endothelial cells. Br J Pharmacol 2009, 156:1115-1123.
    • (2009) Br J Pharmacol , vol.156 , pp. 1115-1123
    • Skinner, R.1    Gibson, R.2    Rothwell, N.3    Pinteaux, E.4    Penny, J.5
  • 14
    • 0026334912 scopus 로고
    • Human interleukin (IL) 1 alpha murine IL-1a and murine IL-1b are transported from blood to brain in the mouse by a shared saturable mechanism
    • Banks W, Ortiz L, Plotkin S, Kastin A Human interleukin (IL) 1 alpha murine IL-1a and murine IL-1b are transported from blood to brain in the mouse by a shared saturable mechanism. J Pharmacol Exp Ther 1991, 259:988-996.
    • (1991) J Pharmacol Exp Ther , vol.259 , pp. 988-996
    • Banks, W.1    Ortiz, L.2    Plotkin, S.3    Kastin, A.4
  • 15
    • 84861181394 scopus 로고    scopus 로고
    • Interleukin-ib-induced barrier dysfunction is signaled through pkc-o in human brain microvascular endothelium
    • Rigor R, Beard RJ, Litovka O, Yuan S Interleukin-ib-induced barrier dysfunction is signaled through pkc-o in human brain microvascular endothelium. Am J Physiol Cell Physiol 2012, 302:C1513-C1522.
    • (2012) Am J Physiol Cell Physiol , vol.302
    • Rigor, R.1    Beard, R.J.2    Litovka, O.3    Yuan, S.4
  • 16
    • 30544445602 scopus 로고    scopus 로고
    • Cytokines sing the blues: inflammation and the pathogenesis of depression
    • Raison C, Capuron L, Miller A Cytokines sing the blues: inflammation and the pathogenesis of depression. Trends Immunol 2006, 27:24-31.
    • (2006) Trends Immunol , vol.27 , pp. 24-31
    • Raison, C.1    Capuron, L.2    Miller, A.3
  • 17
    • 27144470284 scopus 로고    scopus 로고
    • Central and systemic endotoxin challenges exacerbate the local inflammatory response and increase neuronal death during chronic neurodegeneration
    • Cunningham C, Wilcockson D, Campion S, Lunnon K, Perry V Central and systemic endotoxin challenges exacerbate the local inflammatory response and increase neuronal death during chronic neurodegeneration. J Neurosci 2005, 25:9275-9284.
    • (2005) J Neurosci , vol.25 , pp. 9275-9284
    • Cunningham, C.1    Wilcockson, D.2    Campion, S.3    Lunnon, K.4    Perry, V.5
  • 18
    • 49149119577 scopus 로고    scopus 로고
    • Unravelling the pathophysiology of delirium: a focus on the role of aberrant stress responses
    • MacLullich A, Ferguson K, Miller T, de Rooij S, Cunningham C Unravelling the pathophysiology of delirium: a focus on the role of aberrant stress responses. J Psychosom Res 2008, 65:229-238.
    • (2008) J Psychosom Res , vol.65 , pp. 229-238
    • MacLullich, A.1    Ferguson, K.2    Miller, T.3    de Rooij, S.4    Cunningham, C.5
  • 19
    • 33846585119 scopus 로고    scopus 로고
    • Systemic infections and inflammation affect chronic neurodegeneration
    • Perry V, Cunningham C, Holmes C Systemic infections and inflammation affect chronic neurodegeneration. Nat Rev Immunol 2007, 7:161-167.
    • (2007) Nat Rev Immunol , vol.7 , pp. 161-167
    • Perry, V.1    Cunningham, C.2    Holmes, C.3
  • 20
    • 84906789681 scopus 로고    scopus 로고
    • Association, American Psychiatric: [dsm iv tr].
    • Association, American Psychiatric: [dsm iv tr], 2000.
    • (2000)
  • 21
    • 0025667229 scopus 로고
    • Clarifying confusion - the confusion assessment method - a new method for detection of delirium
    • Inouye S, Vandyck C, Alessi C, Balkin S, Siegal A, Horowitz R Clarifying confusion - the confusion assessment method - a new method for detection of delirium. Ann Intern Med 1990, 113.
    • (1990) Ann Intern Med , vol.113
    • Inouye, S.1    Vandyck, C.2    Alessi, C.3    Balkin, S.4    Siegal, A.5    Horowitz, R.6
  • 22
    • 0024362650 scopus 로고
    • The informant questionnaire on cognitive decline in the elderly (iqcode) - socio-demographic correlates, reliability, validity and some norms
    • Jorm A, Jacomb P The informant questionnaire on cognitive decline in the elderly (iqcode) - socio-demographic correlates, reliability, validity and some norms. Psychol Med 1989, 19:1015-1022.
    • (1989) Psychol Med , vol.19 , pp. 1015-1022
    • Jorm, A.1    Jacomb, P.2
  • 23
    • 0031002614 scopus 로고    scopus 로고
    • Cognitive impairment in medical inpatients. I: screening for dementia - is history better than mental state?
    • Harwood D, Hope T, Jacoby R Cognitive impairment in medical inpatients. I: screening for dementia - is history better than mental state?. Age Ageing 1997, 26:31-35.
    • (1997) Age Ageing , vol.26 , pp. 31-35
    • Harwood, D.1    Hope, T.2    Jacoby, R.3
  • 24
    • 0023092594 scopus 로고
    • A new method of classifying prognostic comorbidity in longitudinal studies: development and validation
    • Charlson M, Pompei P, Ales K, MacKenzie C A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 1987, 40:373-383.
    • (1987) J Chronic Dis , vol.40 , pp. 373-383
    • Charlson, M.1    Pompei, P.2    Ales, K.3    MacKenzie, C.4
  • 25
    • 0031035885 scopus 로고    scopus 로고
    • Increased levels of interleukin-1b and soluble intercellular adhesion molecule-1 in cerebrospinal fluid of patients with subacute sclerosing panencephalitis
    • Mehta P, Kulczycki J, Mehta S, Coyle P, Wisniewski H Increased levels of interleukin-1b and soluble intercellular adhesion molecule-1 in cerebrospinal fluid of patients with subacute sclerosing panencephalitis. J Infect Dis 1997, 175:689-692.
    • (1997) J Infect Dis , vol.175 , pp. 689-692
    • Mehta, P.1    Kulczycki, J.2    Mehta, S.3    Coyle, P.4    Wisniewski, H.5
  • 26
    • 60349120175 scopus 로고    scopus 로고
    • The analysis of IL-1 beta and its naturally occurring inhibitors in multiple sclerosis: the elevation of IL-1 receptor antagonist and IL-1 receptor type ii after steroid therapy
    • Dujmovic I, Mangano K, Pekmezovic T, Quattrocchi C, Mesaros S, Stojsavljevic N, et al. The analysis of IL-1 beta and its naturally occurring inhibitors in multiple sclerosis: the elevation of IL-1 receptor antagonist and IL-1 receptor type ii after steroid therapy. J Neuroimmunol 2009, 207:101-106.
    • (2009) J Neuroimmunol , vol.207 , pp. 101-106
    • Dujmovic, I.1    Mangano, K.2    Pekmezovic, T.3    Quattrocchi, C.4    Mesaros, S.5    Stojsavljevic, N.6
  • 27
    • 84864524213 scopus 로고    scopus 로고
    • Peripheral inflammatory disease associated with centrally activated IL-1 system in humans and mice
    • Lampa J, Westman M, Kadetoff D, Nordenstedt Agreus A, Le Maitre E, Gillis-Haegerstrand C, et al. Peripheral inflammatory disease associated with centrally activated IL-1 system in humans and mice. PNAS 2012, 109:12728-12733.
    • (2012) PNAS , vol.109 , pp. 12728-12733
    • Lampa, J.1    Westman, M.2    Kadetoff, D.3    Nordenstedt Agreus, A.4    Le Maitre, E.5    Gillis-Haegerstrand, C.6
  • 28
    • 66749088001 scopus 로고    scopus 로고
    • Interleukin-1beta is increased in the cerebrospinal fluid of patients with small infarcts
    • Sun Y, Lu C-J, Lin C-H, Wen L-L Interleukin-1beta is increased in the cerebrospinal fluid of patients with small infarcts. Eur J Neurol 2009, 16:858-863.
    • (2009) Eur J Neurol , vol.16 , pp. 858-863
    • Sun, Y.1    Lu, C.-J.2    Lin, C.-H.3    Wen, L.-L.4
  • 29
    • 0032406078 scopus 로고    scopus 로고
    • Longitudinal study of inflammatory factors in serum, cerebrospinal fluid, and brain tissue in Alzheimer disease: interleukin-1beta, interleukin-6, interleukin-1 receptor antagonist, tumour necrosis factor-alpha, the soluble tumour necrosis factor receptors i and ii, and alpha1-antichymotrypsin
    • Lanzrein A-S, Johnston C, Perry V, Jobst K, King E, Smith A Longitudinal study of inflammatory factors in serum, cerebrospinal fluid, and brain tissue in Alzheimer disease: interleukin-1beta, interleukin-6, interleukin-1 receptor antagonist, tumour necrosis factor-alpha, the soluble tumour necrosis factor receptors i and ii, and alpha1-antichymotrypsin. Alzheimer Dis Assoc Disord 1998, 12:215-227.
    • (1998) Alzheimer Dis Assoc Disord , vol.12 , pp. 215-227
    • Lanzrein, A.-S.1    Johnston, C.2    Perry, V.3    Jobst, K.4    King, E.5    Smith, A.6
  • 31
    • 0032868874 scopus 로고    scopus 로고
    • Intracerebral production of tumor necrosis factor-a, a local neuroprotective agent, in Alzheimer disease and vascular dementia
    • Tarkowski E, Blennow K, Wallin A, Tarkowski A Intracerebral production of tumor necrosis factor-a, a local neuroprotective agent, in Alzheimer disease and vascular dementia. J Clin Immunol 1999, 19:223-230.
    • (1999) J Clin Immunol , vol.19 , pp. 223-230
    • Tarkowski, E.1    Blennow, K.2    Wallin, A.3    Tarkowski, A.4
  • 32
    • 0042421736 scopus 로고    scopus 로고
    • Cerebrospinal fluid markers in dementia with lewy bodies compared with Alzheimer disease
    • Gomez-Tortosa E, Gonzalo I, Fanjul S, Sainz M, Cantarero S, Cemillan C, et al. Cerebrospinal fluid markers in dementia with lewy bodies compared with Alzheimer disease. Arch Neurol 2003, 60:1218-1222.
    • (2003) Arch Neurol , vol.60 , pp. 1218-1222
    • Gomez-Tortosa, E.1    Gonzalo, I.2    Fanjul, S.3    Sainz, M.4    Cantarero, S.5    Cemillan, C.6
  • 33
    • 84865173281 scopus 로고    scopus 로고
    • The diagnostic value of cytokine and nitric oxide concentrations in cerebrospinal fluid for the differential diagnosis of meningitis
    • Bociaga-Jasik M, Garlicki A, Ciesla A, Kalinowska-Nowak A, Sobczyk-Krupiarz I, Mach T The diagnostic value of cytokine and nitric oxide concentrations in cerebrospinal fluid for the differential diagnosis of meningitis. Adv Med Sci 2012, 57:142-147.
    • (2012) Adv Med Sci , vol.57 , pp. 142-147
    • Bociaga-Jasik, M.1    Garlicki, A.2    Ciesla, A.3    Kalinowska-Nowak, A.4    Sobczyk-Krupiarz, I.5    Mach, T.6
  • 35
    • 1142299541 scopus 로고    scopus 로고
    • Non-herpetic acute limbic encephalitis: cerebrospinal fluid cytokines and magnetic resonance imaging findings
    • Asaoka K, Shoji H, Nishizaka S, Ayabe M, Abe T, Ohori N, et al. Non-herpetic acute limbic encephalitis: cerebrospinal fluid cytokines and magnetic resonance imaging findings. Intern Med 2004, 43:42-48.
    • (2004) Intern Med , vol.43 , pp. 42-48
    • Asaoka, K.1    Shoji, H.2    Nishizaka, S.3    Ayabe, M.4    Abe, T.5    Ohori, N.6
  • 37
    • 77950627059 scopus 로고    scopus 로고
    • Cytokines and chemokines in viral encephalitis: a clinicoradiological correlation
    • Kalita J, Srivastava R, Mishra M, Basu A, Misra U Cytokines and chemokines in viral encephalitis: a clinicoradiological correlation. Neurosci Lett 2010, 473:48-51.
    • (2010) Neurosci Lett , vol.473 , pp. 48-51
    • Kalita, J.1    Srivastava, R.2    Mishra, M.3    Basu, A.4    Misra, U.5
  • 38
    • 0033983153 scopus 로고    scopus 로고
    • "Inflammatory" cytokines: neuromodulators in normal brain?
    • Vitkovic L, Bockaert J, Jacque C "Inflammatory" cytokines: neuromodulators in normal brain?. J Neurochem 2000, 74:457-471.
    • (2000) J Neurochem , vol.74 , pp. 457-471
    • Vitkovic, L.1    Bockaert, J.2    Jacque, C.3
  • 40
    • 0033103979 scopus 로고    scopus 로고
    • Temporal and spatial relationships between lipopolysaccharide-induced expression of fos, interleukin-1 beta and inducible nitric oxide synthase in rat brain
    • Konsman J, Kelley K, Dantzer R Temporal and spatial relationships between lipopolysaccharide-induced expression of fos, interleukin-1 beta and inducible nitric oxide synthase in rat brain. Neuroscience 1999, 89:535-548.
    • (1999) Neuroscience , vol.89 , pp. 535-548
    • Konsman, J.1    Kelley, K.2    Dantzer, R.3
  • 41
    • 0032978333 scopus 로고    scopus 로고
    • The progression and topographic distribution of interleukin-1beta expression after permanent middle cerebral artery occlusion in the rat
    • Davies C, Loddick S, Toulmond S, Stroemer R, Hunt J, Rothwell N The progression and topographic distribution of interleukin-1beta expression after permanent middle cerebral artery occlusion in the rat. J Cereb Blood Flow Metab 1999, 19:87-98.
    • (1999) J Cereb Blood Flow Metab , vol.19 , pp. 87-98
    • Davies, C.1    Loddick, S.2    Toulmond, S.3    Stroemer, R.4    Hunt, J.5    Rothwell, N.6
  • 42
    • 68949122506 scopus 로고    scopus 로고
    • Il-1/il-1ra balance in the brain revisited - evidence from transgenic mouse models
    • Spulber S, Bartfai T, Schultzberg M Il-1/il-1ra balance in the brain revisited - evidence from transgenic mouse models. Brain Behav Immun 2009, 23:573-579.
    • (2009) Brain Behav Immun , vol.23 , pp. 573-579
    • Spulber, S.1    Bartfai, T.2    Schultzberg, M.3
  • 44
    • 0034534995 scopus 로고    scopus 로고
    • Interleukin 1 in the brain: biology, pathology and therapeutic target
    • Rothwell N, Luheshi G Interleukin 1 in the brain: biology, pathology and therapeutic target. Trends Neurosci 2000, 23:618-625.
    • (2000) Trends Neurosci , vol.23 , pp. 618-625
    • Rothwell, N.1    Luheshi, G.2
  • 45
    • 61649120189 scopus 로고    scopus 로고
    • Central inhibition of interleukin-1 beta ameliorates sickness behavior in aged mice
    • Abraham J, Johnson RW Central inhibition of interleukin-1 beta ameliorates sickness behavior in aged mice. Brain Behav Immun 2009, 23:396-401.
    • (2009) Brain Behav Immun , vol.23 , pp. 396-401
    • Abraham, J.1    Johnson, R.W.2
  • 46
    • 33845955692 scopus 로고    scopus 로고
    • Twenty years of research on cytokine-induced sickness behavior
    • Dantzer R, Kelley K Twenty years of research on cytokine-induced sickness behavior. Brain Behav Immun 2007, 21:153-160.
    • (2007) Brain Behav Immun , vol.21 , pp. 153-160
    • Dantzer, R.1    Kelley, K.2
  • 47
    • 84872199548 scopus 로고    scopus 로고
    • At the extreme end of the psychoneuroimmunological spectrum: delirium as a maladaptive sickness behaviour response
    • Cunningham C, MacLullich A At the extreme end of the psychoneuroimmunological spectrum: delirium as a maladaptive sickness behaviour response. Brain Behav Immun 2013, 28:1-13.
    • (2013) Brain Behav Immun , vol.28 , pp. 1-13
    • Cunningham, C.1    MacLullich, A.2
  • 48
    • 51449117700 scopus 로고    scopus 로고
    • Exaggerated sickness behavior and brain proinflammatory cytokine expression in aged mice in response to intracerebroventricular lipopolysaccharide
    • Huang Y, Henry CJ, Dantzer R, Johnson RW, Godbout JP Exaggerated sickness behavior and brain proinflammatory cytokine expression in aged mice in response to intracerebroventricular lipopolysaccharide. Neurobiol Aging 2008, 29:1744-1753.
    • (2008) Neurobiol Aging , vol.29 , pp. 1744-1753
    • Huang, Y.1    Henry, C.J.2    Dantzer, R.3    Johnson, R.W.4    Godbout, J.P.5
  • 51
    • 0001360461 scopus 로고
    • Brain interleukin 1 and s-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease
    • Griffin W, Stanley L, Ling C, White L, MacLeod V, Perrot L, et al. Brain interleukin 1 and s-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease. Proc Natl Acad Sci U S A 1989, 86:7611-7615.
    • (1989) Proc Natl Acad Sci U S A , vol.86 , pp. 7611-7615
    • Griffin, W.1    Stanley, L.2    Ling, C.3    White, L.4    MacLeod, V.5    Perrot, L.6
  • 52
    • 0036697305 scopus 로고    scopus 로고
    • Interleukin-1 in the genesis and progression of and risk for development of neuronal degeneration in Alzheimer's disease
    • Griffin W, Mrak R Interleukin-1 in the genesis and progression of and risk for development of neuronal degeneration in Alzheimer's disease. J Leukoc Biol 2002, 72:233-238.
    • (2002) J Leukoc Biol , vol.72 , pp. 233-238
    • Griffin, W.1    Mrak, R.2
  • 56
    • 84906791575 scopus 로고    scopus 로고
    • Clinical Trials Register E
    • Clinical Trials Register E https://www.Clinicaltrialsregister.Eu/ctr-search/search?Query=il-1ra.
  • 57
    • 79551687466 scopus 로고    scopus 로고
    • Intravenous anakinra can achieve experimentally effective concentrations in the central nervous system within a therapeutic time window: results of a dose-ranging study
    • Galea J, Ogungbenro K, Hulme S, Greenhalgh A, Aarons L, Scarth S, et al. Intravenous anakinra can achieve experimentally effective concentrations in the central nervous system within a therapeutic time window: results of a dose-ranging study. J Cereb Blood Flow Metab 2011, 31:439-447.
    • (2011) J Cereb Blood Flow Metab , vol.31 , pp. 439-447
    • Galea, J.1    Ogungbenro, K.2    Hulme, S.3    Greenhalgh, A.4    Aarons, L.5    Scarth, S.6
  • 58
    • 2342505985 scopus 로고    scopus 로고
    • A comparative study of the inhibitory effects of interleukin-1 receptor antagonist following administration as a recombinant protein or by gene transfer
    • Gouze J-G, Gouze E, Palmer G, Liew V, Pascher A, Betz O, et al. A comparative study of the inhibitory effects of interleukin-1 receptor antagonist following administration as a recombinant protein or by gene transfer. Arthritis Res Ther 2003, 5:R301-R309.
    • (2003) Arthritis Res Ther , vol.5
    • Gouze, J.-G.1    Gouze, E.2    Palmer, G.3    Liew, V.4    Pascher, A.5    Betz, O.6
  • 59
    • 0025288396 scopus 로고
    • Biological properties of recombinant human monocyte-derived interleukin 1 receptor antagonist
    • Arend W, Welgus H, Thompson R, Eisenberg S Biological properties of recombinant human monocyte-derived interleukin 1 receptor antagonist. J Clin Investig 1990, 85:1694-1697.
    • (1990) J Clin Investig , vol.85 , pp. 1694-1697
    • Arend, W.1    Welgus, H.2    Thompson, R.3    Eisenberg, S.4
  • 60
    • 77949912530 scopus 로고    scopus 로고
    • Expression of insulin-like growth factor-1 and insulin-like growth factor binding proteins in the serum and cerebrospinal fluid of patients with Parkinson's disease
    • Mashayekhi F, Mirzajani E, Naji M, Azari M Expression of insulin-like growth factor-1 and insulin-like growth factor binding proteins in the serum and cerebrospinal fluid of patients with Parkinson's disease. J Clin Neurosci 2010, 17:623-627.
    • (2010) J Clin Neurosci , vol.17 , pp. 623-627
    • Mashayekhi, F.1    Mirzajani, E.2    Naji, M.3    Azari, M.4
  • 61
    • 65949096494 scopus 로고    scopus 로고
    • Insulin like growth factor-1 and insulin like growth factor binding proteins in the cerebrospinal fluid and serum from patients with Alzheimer's disease
    • Salehi Z, Mashayekhi F, Naji M Insulin like growth factor-1 and insulin like growth factor binding proteins in the cerebrospinal fluid and serum from patients with Alzheimer's disease. Biofactors 2008, 33:99-106.
    • (2008) Biofactors , vol.33 , pp. 99-106
    • Salehi, Z.1    Mashayekhi, F.2    Naji, M.3
  • 63
    • 0033595448 scopus 로고    scopus 로고
    • Interferon-gamma-inducing factor (IL-18) and interferon-gamma in inflammatory CNS diseases
    • Fassbender K, Mielke O, Bertsch T, Muehlhauser F, Hennerici M, Kurimoto M, et al. Interferon-gamma-inducing factor (IL-18) and interferon-gamma in inflammatory CNS diseases. Neurology 1999, 53:1104-1106.
    • (1999) Neurology , vol.53 , pp. 1104-1106
    • Fassbender, K.1    Mielke, O.2    Bertsch, T.3    Muehlhauser, F.4    Hennerici, M.5    Kurimoto, M.6
  • 64
    • 33745252827 scopus 로고    scopus 로고
    • Increased intrathecal TGF-beta1, but not IL-12, IFN-gamma and IL-10 levels in Alzheimer's disease patients
    • Rota E, Bellone G, Rocca P, Bergamasco B, Emanuelli G, Ferrero P Increased intrathecal TGF-beta1, but not IL-12, IFN-gamma and IL-10 levels in Alzheimer's disease patients. Neurol Sci 2006, 27:33-39.
    • (2006) Neurol Sci , vol.27 , pp. 33-39
    • Rota, E.1    Bellone, G.2    Rocca, P.3    Bergamasco, B.4    Emanuelli, G.5    Ferrero, P.6
  • 67
    • 79959967979 scopus 로고    scopus 로고
    • Glial fibrillary acidic protein: a potential biomarker for progression in multiple sclerosis
    • Axelsson M, Malmestrom C, Nilsson S, Haghighi S, Rosengren L, Lycke J Glial fibrillary acidic protein: a potential biomarker for progression in multiple sclerosis. J Neurol 2011, 258:882-888.
    • (2011) J Neurol , vol.258 , pp. 882-888
    • Axelsson, M.1    Malmestrom, C.2    Nilsson, S.3    Haghighi, S.4    Rosengren, L.5    Lycke, J.6
  • 68
    • 75749128242 scopus 로고    scopus 로고
    • Consecutive analyses of cerebrospinal fluid axonal and glial markers in Parkinson's disease and atypical Parkinsonian disorders
    • Constantinescu R, Rosengren L, Johnels B, Zetterberg H, Holmberg B Consecutive analyses of cerebrospinal fluid axonal and glial markers in Parkinson's disease and atypical Parkinsonian disorders. Parkinsonism Relat Disord 2010, 16:142-145.
    • (2010) Parkinsonism Relat Disord , vol.16 , pp. 142-145
    • Constantinescu, R.1    Rosengren, L.2    Johnels, B.3    Zetterberg, H.4    Holmberg, B.5
  • 69
    • 79955919374 scopus 로고    scopus 로고
    • Neuron-specific enolase, s100b, and glial fibrillary acidic protein levels as outcome predictors in patients with severe traumatic brain injury
    • Bohmer A, Oses J, Schmidt A, Peron C, Krebs C, Oppitz P, et al. Neuron-specific enolase, s100b, and glial fibrillary acidic protein levels as outcome predictors in patients with severe traumatic brain injury. Neurosurgery 2011, 68:1624-1631.
    • (2011) Neurosurgery , vol.68 , pp. 1624-1631
    • Bohmer, A.1    Oses, J.2    Schmidt, A.3    Peron, C.4    Krebs, C.5    Oppitz, P.6
  • 70
    • 77649218035 scopus 로고    scopus 로고
    • Neurobiochemical markers of brain damage in cerebrospinal fluid of acute ischaemic stroke patients
    • Brouns R, De Vil B, Cras P, De Surgeloose D, Marien P, De Deyn P Neurobiochemical markers of brain damage in cerebrospinal fluid of acute ischaemic stroke patients. Clin Chem 2010, 56:451-458.
    • (2010) Clin Chem , vol.56 , pp. 451-458
    • Brouns, R.1    De Vil, B.2    Cras, P.3    De Surgeloose, D.4    Marien, P.5    De Deyn, P.6
  • 71
    • 0028294845 scopus 로고
    • A sensitive elisa for glial fibrillary acidic protein: application in CSF of adults
    • Rosengren L, Wikkelso C, Hagberg L A sensitive elisa for glial fibrillary acidic protein: application in CSF of adults. J Neurosci Methods 1994, 51:197-204.
    • (1994) J Neurosci Methods , vol.51 , pp. 197-204
    • Rosengren, L.1    Wikkelso, C.2    Hagberg, L.3


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