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Volumn 181, Issue 10, 2008, Pages 6747-6756

Aging impairs IFN regulatory factor 7 up-regulation in plasmacytoid dendritic cells during TLR9 activation

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; INTERFERON REGULATORY FACTOR 7; TOLL LIKE RECEPTOR 9; IMMUNOLOGICAL ADJUVANT; IRF7 PROTEIN, MOUSE; REACTIVE OXYGEN METABOLITE; TLR9 PROTEIN, MOUSE; UNCLASSIFIED DRUG;

EID: 58149177781     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.181.10.6747     Document Type: Article
Times cited : (132)

References (55)
  • 2
    • 1142275269 scopus 로고    scopus 로고
    • Age-related changes in lymphocyte development and function
    • DOI 10.1038/ni1033
    • Linton, P.-J., and K. Dorschkind. 2004. Age related changes in lymphocyte development and function. Nat. Immunol. 5: 133-139. (Pubitemid 38208354)
    • (2004) Nature Immunology , vol.5 , Issue.2 , pp. 133-139
    • Linton, P.J.1    Dorshkind, K.2
  • 3
    • 0033845475 scopus 로고    scopus 로고
    • Changes in immune function with age
    • Yung, R. 2000. Changes in immune function with age. Rheum. Dis. Clin. North Am. 26: 455-473.
    • (2000) Rheum. Dis. Clin. North Am. , vol.26 , pp. 455-473
    • Yung, R.1
  • 4
    • 33646546302 scopus 로고    scopus 로고
    • Aging of the immune system: How much can the adaptive immune system adapt?
    • Weng, N. P. 2006. Aging of the immune system: how much can the adaptive immune system adapt? Immunity 24: 495-499.
    • (2006) Immunity , vol.24 , pp. 495-499
    • Weng, N.P.1
  • 5
    • 33744996006 scopus 로고    scopus 로고
    • Why Aging T Cells Fail: Implications for Vaccination
    • DOI 10.1016/j.immuni.2006.06.003, PII S1074761306002706
    • Haynes, L., and S. L. Swain. 2006. Why aging T cells fail: implications for vaccination. Immunity 24: 663-666. (Pubitemid 43867372)
    • (2006) Immunity , vol.24 , Issue.6 , pp. 663-666
    • Haynes, L.1    Swain, S.L.2
  • 6
    • 0035946840 scopus 로고    scopus 로고
    • Severe impairment of primary but not memory responses to influenza viral antigens in aged mice: Costimulation in vivo partially reverses impaired primary immune responses
    • DOI 10.1006/cimm.2001.1799
    • Sambhara, S., A. Kurichh, R. Miranda, O. James, B. Underdown, M. Klein, J. Tartaglia, and D. Burt. 2001. Severe impairment of primary but not memory responses to influenza viral antigens in aged mice: costimulation in vivo partially reverses impaired primary immune responses. Cell. Immunol. 210: 1-4. (Pubitemid 32756935)
    • (2001) Cellular Immunology , vol.210 , Issue.1 , pp. 1-4
    • Sambhara, S.1    Kurichh, A.2    Miranda, R.3    James, O.4    Underdown, B.5    Klein, M.6    Tartaglia, J.7    Burt, D.8
  • 7
  • 8
    • 17644372733 scopus 로고    scopus 로고
    • IPC: Professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors
    • DOI 10.1146/annurev.immunol.23.021704.115633
    • Liu, Y. J. 2005. IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors. Annu. Rev. Immunol. 23: 275-306. (Pubitemid 40563171)
    • (2005) Annual Review of Immunology , vol.23 , pp. 275-306
    • Liu, Y.-J.1
  • 10
    • 23944508642 scopus 로고    scopus 로고
    • Production of type I interferons: Plasmacytoid dendritic cells and beyond
    • DOI 10.1084/jem.20051395
    • Asselin-Paturel, C., and G. Trinchieri. 2005. Production of type I interferons: plasmacytoid dendritic cells and beyond. J. Exp. Med. 202: 461-465. (Pubitemid 41186943)
    • (2005) Journal of Experimental Medicine , vol.202 , Issue.4 , pp. 461-465
    • Asselin-Paturel, C.1    Trinchieri, G.2
  • 12
    • 0032773794 scopus 로고    scopus 로고
    • Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon
    • DOI 10.1038/11360
    • Cella, M., D. Jarrossay, F. Facchetti, O. Alebardi, H. Nakajima, A. Lanzavecchia, and M. Colonna. 1999. Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon. Nat. Med. 5: 919-923. (Pubitemid 29372419)
    • (1999) Nature Medicine , vol.5 , Issue.8 , pp. 919-923
    • Cella, M.1    Jarrossay, D.2    Faccheth, F.3    Alebardi, O.4    Nakajima, H.5    Lanzavecchia, A.6    Colonna, M.7
  • 13
    • 2942679083 scopus 로고    scopus 로고
    • The immunobiology of the TLR9 subfamily
    • Wagner, H. 2004. The immunobiology of the TLR9 subfamily. Trends Immunol. 25: 381-386.
    • (2004) Trends Immunol. , vol.25 , pp. 381-386
    • Wagner, H.1
  • 15
    • 34548694962 scopus 로고    scopus 로고
    • Innate recognition of viruses
    • Pichlmair, A., and C. Reis e Sousa. 2007. Innate recognition of viruses. Immunity 27: 370-383.
    • (2007) Immunity , vol.27 , pp. 370-383
    • Pichlmair, A.1    Reis E Sousa, C.2
  • 16
    • 33846000646 scopus 로고    scopus 로고
    • The functional effects of physical interactions among toll-like receptors 7, 8, and 9
    • DOI 10.1074/jbc.M605311200
    • Wang, J., Y. Shao, T. A. Bennett, R. A. Shankar, P. D. Wightman, and L. G. Reddy. 2006. The functional effects of physical interactions among Toll-like receptors 7, 8, and 9. J. Biol. Chem. 281: 37427-37434. (Pubitemid 46042046)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.49 , pp. 37427-37434
    • Wang, J.1    Shao, Y.2    Bennett, T.A.3    Shankar, R.A.4    Wightman, P.D.5    Reddy, L.G.6
  • 17
    • 33947258375 scopus 로고    scopus 로고
    • Cutting edge: Antibody-mediated TLR7-dependent recognition of viral RNA
    • Wang, J. P., D. R. Asher, M. Chan, E. A. Kurt-Jones, and R. W. Finberg. 2007. Cutting edge: antibody-mediated TLR7-dependent recognition of viral RNA. J. Immunol. 178: 3363-3367.
    • (2007) J. Immunol. , vol.178 , pp. 3363-3367
    • Wang, J.P.1    Asher, D.R.2    Chan, M.3    Kurt-Jones, E.A.4    Finberg, R.W.5
  • 19
    • 1542317578 scopus 로고    scopus 로고
    • Species-Specific Recognition of Single-Stranded RNA via Till-like Receptor 7 and 8
    • DOI 10.1126/science.1093620
    • Heil, F., H. Hemmi, H. Hochrein, F. Ampenberger, C. Kirschning, S. Akira, G. Lipford, H. Wagner, and S. Bauer. 2004. Species-specific recognition of single-stranded RNA via Toll-like receptor 7 and 8. Science 303: 1526-1529. (Pubitemid 38314424)
    • (2004) Science , vol.303 , Issue.5663 , pp. 1526-1529
    • Heil, F.1    Hemmi, H.2    Hochrein, H.3    Ampenberger, F.4    Kirschning, C.5    Akira, S.6    Lipford, G.7    Wagner, H.8    Bauer, S.9
  • 21
    • 0042123694 scopus 로고    scopus 로고
    • Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells
    • DOI 10.1084/jem.20030162
    • Lund, J., A. Sato, S. Akira, R. Medzhitov, and A. Iwasaki. 2003. Toll-like receptor 9-mediated recognition of herpes simplex virus-2 by plasmacytoid dendritic cells. J. Exp. Med. 198: 513-520. (Pubitemid 36976063)
    • (2003) Journal of Experimental Medicine , vol.198 , Issue.3 , pp. 513-520
    • Lund, J.1    Sato, A.2    Akira, S.3    Medzhitov, R.4    Iwasaki, A.5
  • 25
    • 33745813175 scopus 로고    scopus 로고
    • Activation of plasmacytoid dendritic cells with TLR9 agonists initiates invariant NKT cell-mediated cross-talk with myeloid dendritic cells
    • Montoya, C. J., H. B. Jie, L. Al-Harthi, C. Mulder, P. J. Patino, M. T. Rugeles, A. M. Krieg, A. L. Landay, and S. B. Wilson. 2006. Activation of plasmacytoid dendritic cells with TLR9 agonists initiates invariant NKT cell-mediated cross-talk with myeloid dendritic cells. J. Immunol. 177: 1028-1039.
    • (2006) J. Immunol. , vol.177 , pp. 1028-1039
    • Montoya, C.J.1    Jie, H.B.2    Al-Harthi, L.3    Mulder, C.4    Patino, P.J.5    Rugeles, M.T.6    Krieg, A.M.7    Landay, A.L.8    Wilson, S.B.9
  • 26
    • 27644480499 scopus 로고    scopus 로고
    • Aging negatively skews macrophage TLR2- And TLR4-mediated pro-inflammatory responses without affecting the IL-2-stimulated pathway
    • Boehmer, E. D., M. J. Meehan, B. T. Cutro, and E. J. Kovacs. 2005. Aging negatively skews macrophage TLR2- and TLR4-mediated pro-inflammatory responses without affecting the IL-2-stimulated pathway. Mech. Ageing Dev. 126: 1305.
    • (2005) Mech. Ageing Dev. , vol.126 , pp. 1305
    • Boehmer, E.D.1    Meehan, M.J.2    Cutro, B.T.3    Kovacs, E.J.4
  • 29
    • 0036243137 scopus 로고    scopus 로고
    • Age-related changes in human blood dendritic cell subpopulations
    • DOI 10.1046/j.1365-3083.2002.01068.x
    • Teig, N., D. Moses, S. Gieseler, and U. Schauer. 2002. Age-related changes in human blood dendritic cell subpopulations. Scand. J. Immunol. 55: 453-457. (Pubitemid 34451230)
    • (2002) Scandinavian Journal of Immunology , vol.55 , Issue.5 , pp. 453-457
    • Teig, N.1    Moses, D.2    Gieseler, S.3    Schauer, U.4
  • 30
    • 0021272260 scopus 로고
    • Age-related decline of human interferon alpha and interferon gamma production
    • Abb, J., H. Abb, and F. Deinhardt. 1984. Age-related decline of human interferon α and interferon γ production. Blut 48: 285-289. (Pubitemid 14104893)
    • (1984) Blut , vol.48 , Issue.5 , pp. 285-289
    • Abb, J.1    Abb, H.2    Deinhardt, F.3
  • 31
    • 0036436469 scopus 로고    scopus 로고
    • Circulating, interferon-producing plasmacytoid dendritic cells decline during human ageing
    • DOI 10.1046/j.1365-3083.2002.01148.x
    • Shodell, M., and F. Siegal. 2002. Circulating, interferon-producing plasmacytoid dendritic cells decline during human ageing. Scand. J. Immunol. 56: 518-521. (Pubitemid 35373689)
    • (2002) Scandinavian Journal of Immunology , vol.56 , Issue.5 , pp. 518-521
    • Shodell, M.1    Siegal, F.P.2
  • 32
    • 23844558266 scopus 로고    scopus 로고
    • A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: A dawn for evolutionary medicine
    • Wallace, D. C. 2005. A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine. Annu. Rev. Genet. 39: 359-407.
    • (2005) Annu. Rev. Genet. , vol.39 , pp. 359-407
    • Wallace, D.C.1
  • 33
    • 8344282655 scopus 로고    scopus 로고
    • The role of oxidative damage and stress in aging
    • DOI 10.1016/j.mad.2004.07.009, PII S004763740400171X
    • Bokov, A., A. Chaudhuri, and A. Richardson. 2004. The role of oxidative damage and stress in aging. Mech. Ageing Dev. 125: 811. (Pubitemid 39482409)
    • (2004) Mechanisms of Ageing and Development , vol.125 , Issue.10-11 SPEC. ISS , pp. 811-826
    • Bokov, A.1    Chaudhuri, A.2    Richardson, A.3
  • 34
    • 33751566350 scopus 로고    scopus 로고
    • Cutting edge: Plasmacytoid dendritic cells provide innate immune protection against mucosal viral infection in situ
    • Lund, J. M., M. M. Linehan, N. Iijima, and A. Iwasaki. 2006. Cutting edge: plasmacytoid dendritic cells provide innate immune protection against mucosal viral infection in situ. J. Immunol. 177: 7510-7514.
    • (2006) J. Immunol. , vol.177 , pp. 7510-7514
    • Lund, J.M.1    Linehan, M.M.2    Iijima, N.3    Iwasaki, A.4
  • 37
    • 0030589104 scopus 로고    scopus 로고
    • Fibronectin fragment mediated cartilage chondrolysis. I. Suppression by anti-oxidants
    • DOI 10.1016/S0925-4439(96)00046-4, PII S0925443996000464
    • Homandberg, G. A., F. Hui, and C. Wen. 1996. Fibronectin fragment mediated cartilage chondrolysis: I. Suppression by anti-oxidants. Biochim. Biophys. Acta 1317: 134-142. (Pubitemid 26388783)
    • (1996) Biochimica et Biophysica Acta - Molecular Basis of Disease , vol.1317 , Issue.2 , pp. 134-142
    • Homandberg, G.A.1    Hui, F.2    Wen, C.3
  • 40
    • 4544363652 scopus 로고    scopus 로고
    • Detection of intracellular superoxide formation in endothelial cells and intact tissues using dihydroethidium and an HPLC-based assay
    • DOI 10.1152/ajpcell.00028.2004
    • Fink, B., K. Laude, L. McCann, A. Doughan, D. G. Harrison, and S. Dikalov. 2004. Detection of intracellular superoxide formation in endothelial cells and intact tissues using dihydroethidium and an HPLC-based assay. Am. J. Physiol. 287: C895-C902. (Pubitemid 39238312)
    • (2004) American Journal of Physiology - Cell Physiology , vol.287 , Issue.4
    • Fink, B.1    Laude, K.2    McCann, L.3    Doughan, A.4    Harrison, D.G.5    Dikalov, S.6
  • 41
    • 3142683548 scopus 로고    scopus 로고
    • TLR9-dependent recognition of MCMV by IPC and DC generates coordinated cytokine responses that activate antiviral NK cell function
    • DOI 10.1016/j.immuni.2004.06.007, PII S1074761304001621
    • Krug, A., A. R. French, W. Barchet, J. A. A. Fischer, A. Dzionek, J. T. Pingel, M. M. Orihuela, S. Akira, W. M. Yokoyama, and M. Colonna. 2004. TLR9-dependent recognition of MCMV by IPC and DC generates coordinated cytokine responses that activate antiviral NK cell function. Immunity 21: 107-119. (Pubitemid 38925271)
    • (2004) Immunity , vol.21 , Issue.1 , pp. 107-119
    • Krug, A.1    French, A.R.2    Barchet, W.3    Fischer, J.A.A.4    Dzionek, A.5    Pingel, J.T.6    Orihuela, M.M.7    Akira, S.8    Yokoyama, W.M.9    Colonna, M.10
  • 42
    • 0037387403 scopus 로고    scopus 로고
    • Dendritic cell responses to early murine cytomegalovirus infection: Subset functional specialization and differential regulation by interferon α/β
    • DOI 10.1084/jem.20021522
    • Dalod, M., T. Hamilton, R. Salomon, T. P. Salazar-Mather, S. C. Henry, J. D. Hamilton, and C. A. Biron. 2003. Dendritic cell responses to early murine cytomegalovirus infection: subset functional specialization and differential regulation by interferon α/β. J. Exp. Med. 197: 885-898. (Pubitemid 36437865)
    • (2003) Journal of Experimental Medicine , vol.197 , Issue.7 , pp. 885-898
    • Dalod, M.1    Hamilton, T.2    Salomon, R.3    Salazar-Mather, T.P.4    Henry, S.C.5    Hamilton, J.D.6    Biron, C.A.7
  • 43
    • 44449165607 scopus 로고    scopus 로고
    • Cutting edge: Overlapping functions of TLR7 and TLR9 for innate defense against a herpesvirus infection
    • Zucchini, N., G. Bessou, S. Traub, S. H. Robbins, S. Uematsu, S. Akira, L. Alexopoulou, and M. Dalod. 2008. Cutting edge: overlapping functions of TLR7 and TLR9 for innate defense against a herpesvirus infection. J. Immunol. 180: 5799-5803.
    • (2008) J. Immunol. , vol.180 , pp. 5799-5803
    • Zucchini, N.1    Bessou, G.2    Traub, S.3    Robbins, S.H.4    Uematsu, S.5    Akira, S.6    Alexopoulou, L.7    Dalod, M.8
  • 45
    • 1542317550 scopus 로고    scopus 로고
    • Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA
    • Diebold, S. S., T. Kaisho, H. Hemmi, S. Akira, and C. Reis e Sousa. 2004. Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science 303: 1529-1531.
    • (2004) Science , vol.303 , pp. 1529-1531
    • Diebold, S.S.1    Kaisho, T.2    Hemmi, H.3    Akira, S.4    Reis E Sousa, C.5
  • 48
    • 39549116503 scopus 로고    scopus 로고
    • PI3K is critical for the nuclear translocation of IRF-7 and type I IFN production by human plasmacytoid predendritic cells in response to TLR activation
    • DOI 10.1084/jem.20070763
    • Guiducci, C., C. Ghirelli, M.-A. Marloie-Provost, T. Matray, R. L. Coffman, Y.-J. Liu, F. J. Barrat, and V. Soumelis. 2008. PI3K is critical for the nuclear translocation of IRF-7 and type I IFN production by human plasmacytoid predendritic cells in response to TLR activation. J. Exp. Med. 205: 315-322. (Pubitemid 351281597)
    • (2008) Journal of Experimental Medicine , vol.205 , Issue.2 , pp. 315-322
    • Guiducci, C.1    Ghirelli, C.2    Marloie-Provost, M.-A.3    Matray, T.4    Coffman, R.L.5    Liu, Y.-J.6    Barrat, F.J.7    Soumelis, V.8
  • 49
    • 34249775503 scopus 로고    scopus 로고
    • Altered innate immune functioning of dendritic cells in elderly humans: A role of phosphoinositide 3-kinase-signaling pathway
    • Agrawal, A., S. Agrawal, J.-N. Cao, H. Su, K. Osann, and S. Gupta. 2007. Altered innate immune functioning of dendritic cells in elderly humans: a role of phosphoinositide 3-kinase-signaling pathway. J. Immunol. 178: 6912-6922. (Pubitemid 46847417)
    • (2007) Journal of Immunology , vol.178 , Issue.11 , pp. 6912-6922
    • Agrawal, A.1    Agrawal, S.2    Cao, J.-N.3    Su, H.4    Osann, K.5    Gupta, S.6
  • 50
    • 46849115807 scopus 로고    scopus 로고
    • The molecular mechanisms of the attenuation of cisplatin-induced acute renal failure by N-acetylcysteine in rats
    • DOI 10.1093/ndt/gfn090
    • Luo, J., T. Tsuji, H. Yasuda, Y. Sun, Y. Fujigaki, and A. Hishida. 2008. The molecular mechanisms of the attenuation of cisplatin-induced acute renal failure by N-acetylcysteine in rats. Nephrol. Dial. Transplant. 23: 2198-2205. (Pubitemid 351957613)
    • (2008) Nephrology Dialysis Transplantation , vol.23 , Issue.7 , pp. 2198-2205
    • Luo, J.1    Tsuji, T.2    Yasuda, H.3    Sun, Y.4    Fujigaki, Y.5    Hishida, A.6
  • 51
    • 0034679566 scopus 로고    scopus 로고
    • Natural interferon α/β-producing cells link innate and adaptive immunity
    • DOI 10.1084/jem.192.2.219
    • Kadowaki, N., S. Antonenko, J. Y.-N. Lau, and Y.-J. Liu. 2000. Natural interferon α/β-producing cells link innate and adaptive immunity. J. Exp. Med. 192: 219-226. (Pubitemid 30470304)
    • (2000) Journal of Experimental Medicine , vol.192 , Issue.2 , pp. 219-225
    • Kadowaki, N.1    Antonenko, S.2    Lau, J.Y.-N.3    Liu, Y.-J.4
  • 52
    • 0036926154 scopus 로고    scopus 로고
    • Natural type I interferon-producing cells as a link between innate and adaptive immunity
    • DOI 10.1016/S0198-8859(02)00751-6, PII S0198885902007516
    • Kadowaki, N., and Y.-J. Liu. 2002. Natural type I interferon-producing cells as a link between innate and adaptive immunity. Hum. Immunol. 63: 1126-1132. (Pubitemid 36025987)
    • (2002) Human Immunology , vol.63 , Issue.12 , pp. 1126-1132
    • Kadowaki, N.1    Liu, Y.-J.2
  • 53
    • 0034044735 scopus 로고    scopus 로고
    • The function of type I interferons in antimicrobial immunity
    • DOI 10.1016/S0952-7915(00)00111-4
    • Bogdan, C. 2000. The function of type I interferons in antimicrobial immunity. Curr. Opin. Immunol. 12: 419-424. (Pubitemid 30410347)
    • (2000) Current Opinion in Immunology , vol.12 , Issue.4 , pp. 419-424
    • Bogdan, C.1
  • 54
    • 22544457163 scopus 로고    scopus 로고
    • Depletion of T cells by type I interferon: Differences between young and aged mice
    • Jiang, J., D. Gross, S. Nogusa, P. Elbaum, and D. M. Murasko. 2005. Depletion of T cells by type I interferon: differences between young and aged mice. J. Immunol. 175: 1820-1826. (Pubitemid 41023087)
    • (2005) Journal of Immunology , vol.175 , Issue.3 , pp. 1820-1826
    • Jiang, J.1    Gross, D.2    Nogusa, S.3    Elbaum, P.4    Murasko, D.M.5
  • 55
    • 33746895106 scopus 로고    scopus 로고
    • Antiviral defense: Interferons and beyond
    • Stetson, D. B., and R. Medzhitov. 2006. Antiviral defense: interferons and beyond. J. Exp. Med. 203: 1837-1841.
    • (2006) J. Exp. Med. , vol.203 , pp. 1837-1841
    • Stetson, D.B.1    Medzhitov, R.2


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