Peripheral blood dendritic cells and monocytes are differently regulated in the elderly

Clinical Immunology

Volumn 122, Issue 2, 2007, Pages 220-228

  Della Bella, Silvia ^a   Bierti, Luigi ^b   Presicce, Pietro ^a   Arienti, Rossana ^b   Valenti, Marta ^a   Saresella, Marina ^c   Vergani, Carlo ^b   Villa, Maria L ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

^c IRCCS FONDAZIONE DON CARLO GNOCCHI   (Italy)

Author keywords

Ageing; CD34+ cells; Costimulatory molecules; Cytokines; Dendritic cells; Monocytes

Indexed keywords

INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 1BETA; INTERLEUKIN 6; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN;

ADULT; AGED; AGING; ANTIGEN PRESENTING CELL; ARTICLE; BONE MARROW CELL; CD34 SELECTION; CELL COUNT; CELL DIFFERENTIATION; CELL FUNCTION; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOKINE PRODUCTION; DENDRITIC CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; HUMAN; IMMUNE RESPONSE; IMMUNOPHENOTYPING; IMMUNOREGULATION; MALE; MONOCYTE; NORMAL HUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; STEM CELL;

ADULT; AGED; AGED, 80 AND OVER; AGING; ANTIGENS, CD34; BLOOD CELL COUNT; DENDRITIC CELLS; FEMALE; HUMANS; IMMUNOPHENOTYPING; MALE; MIDDLE AGED; MONOCYTES; STEM CELLS;

EID: 33846046984     PISSN: 15216616     EISSN: 15217035     Source Type: Journal    
DOI: 10.1016/j.clim.2006.09.012     Document Type: Article

References (40)

1. DeVeale B., Brummel T., and Seroude L. Immunity and aging: the enemy within?. Aging Cell 3 (2004) 195-208
2. Linton P.J., Haynes L., Klinman N.R., and Swain S.L. Antigen-independent changes in naive CD4 T cells with aging. J. Exp. Med. 184 (1996) 1891-1900
3. Linton P.J., and Dorshkind K. Age-related changes in lymphocyte development and function. Nat. Immunol. 5 (2004) 133-139
4. Breitbart W., Leka L., Dallal G., Meydani S.N., and Stollar B.D. Altered memory B-cell homeostasis in human aging. J. Gerontol., A, Biol. Sci. Med. Sci. 57 (2002) B304-B311
5. Allman D., and Miller J.P. B cell development and receptor diversity during aging. Curr. Opin. Immunol. 17 (2005) 463-467
6. Trzonkowski P., Szmit E., Mysliwska J., and Mysliwski A. CD4+CD25+ T regulatory cells inhibit cytotoxic activity of CTL and NK cells in humans-Impact of immunosenescence. Clin. Immunol. 119 (2006) 307-316
7. Jentsch-Ullrich K., Koenigsmann M., Mohren M., and Franke A. Lymphocyte subsets' reference ranges in an age- and gender-balanced population of 100 healthy adults-A monocentric German study. Clin. Immunol. 116 (2005) 192-197
8. Plowden J., Renshaw-Hoelscher M., Engleman C., Katz J., and Sambhara S. Innate immunity in aging: impact on macrophage function. Aging Cell 3 (2004) 161-167
9. Mocchegiani E., and Malavolta M. NK and NKT cell functions in immunosenescence. Aging Cell 3 (2004) 177-184
10. Rossi M., and Young J.W. Human dendritic cells: potent antigen-presenting cells at the crossroads of innate and adaptive immunity. J. Immunol. 175 (2005) 1373-1381
11. Inaba K., Metlay J.P., Crowley M.T., and Steinman R.M. Dendritic cells pulsed with protein antigens in vitro can prime antigen-specific, MHC-restricted T cells in situ. J. Exp. Med. 172 (1990) 631-640
12. Steinman R.M., Hawiger D., and Nussenzweig M.C. Tolerogenic dendritic cells. Annu. Rev. Immunol. 21 (2003) 685-711
13. Steinman R.M., and Nussenzweig M.C. Avoiding horror autotoxicus: the importance of dendritic cells in peripheral T cell tolerance. Proc. Natl. Acad. Sci. U. S. A. 99 (2002) 351-358
14. Della Bella S., Nicola S., Timofeeva I., Villa M.L., Santoro A., and Berardi A.C. Are interleukin-16 and thrombopoietin new tools for the in vitro generation of dendritic cells?. Blood 104 (2004) 4020-4028
15. Della Bella S., Gennaro M., Vaccari M., Ferraris C., Nicola S., Riva A., Clerici M., Greco M., and Villa M.L. Altered maturation of peripheral blood dendritic cells in patients with breast cancer. Br. J. Cancer 89 (2003) 1463-1472
16. Della Bella S., Nicola S., Brambilla L., Riva A., Ferrucci S., Presicce P., Boneschi V., Berti E., and Villa M.L. Quantitative and functional defects of dendritic cells in classic Kaposi's sarcoma. Clin. Immunol. 119 (2006) 317-329
17. Lighart G.J., Corberand J.X., Fournier C., Galanaud P., Hijmans W., Kennes B., Mueller-Hermelik H.K., and Steimann G.G. Admission criteria for immunological studies: the SENIEUR protocol. Mech. Ageing Dev. 28 (1984) 47-55
18. Castle S.C., Uyemura K., and Makinodan T. The SENIEUR Protocol after 16 years: a need for a paradigm shift?. Mech. Ageing Dev. 122 (2001) 127-140
19. Rigaud A.S., and Forette B. Hypertension in older adults. J. Gerontol., A, Biol. Sci. Med. Sci. 56 (2001) M217-M225
20. Birrell F.N. Patterns of joint pain: lessons from epidemiology. Rheumatology 43 (2004) 408-409
21. Upham J.W., Lundahl J., Liang H., Denburg J.A., O'Byrne P.M., and Snider D.P. Simplified quantitation of myeloid dendritic cells in peripheral blood using flow cytometry. Cytometry 40 (2000) 50-59
22. Rissoan M.C., Soumelis V., Kadowaki N., Grouard C., Briere F., de Waal Malefyt R., and Liu Y.J. Reciprocal control of T helper cell and dendritic cell differentiation. Science 283 (1999) 1183-1186
23. Pietschmann P., Hahn P., Kudlacek S., Thomas R., and Peterlik M. Surface markers and transendothelial migration of dendritic cells from elderly subjects. Exp. Gerontol. 35 (2000) 213-224
24. Shodell M., and Siegal F.P. Circulating, interferon-producing plasmacytoid dendritic cells decline during aging. Scand. J. Immunol. 56 (2002) 518-521
25. Cella M., Facchetti F., Lanzavecchia A., and Colonna M. Plasmacytoid dendritic cells activated by influenza virus and CD40L drive a potent TH1 polarization. Nat. Immunol. 1 (2000) 305-310
26. Cella M., Jarrossay D., Facchetti F., Alebardi O., Nakajima H., Lanzavecchia A., and Colonna M. Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon. Nat. Med. 5 (1999) 919-923
27. Pascual V., Banchereau J., and Palucka A.K. The central role of dendritic cells and interferon-alpha in SLE. Curr. Opin. Rheumatol. 15 (2003) 548-556
28. Nestle F.O., Conrad C., Tun-Kyi A., Homey B., Gombert M., Boyman O., Burg G., Liu Y.J., and Gilliet M. Plasmacytoid predendritic cells initiate psoriasis through interferon-α production. J. Exp. Med. 202 (2005) 135-143
29. Fortunel N.O., Hatzfeld A., and Hatzfeld J.A. Transforming growth factor-β: pleiotropic role in the regulation of hematopoiesis. Blood 96 (2000) 2022-2036
30. Gabrilovich D.I., Chen H.L., Girgis K.R., Cunningham H.T., Meny G.M., Nadaf S., Kavanaugh D., and Carbone D.P. Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells. Nat. Med. 2 (1996) 1096
31. Kiertscher S., Luo J., Dubinett S.M., and Roth M.D. Tumors promote altered maturation and early apoptosis of monocyte-derived dendritic cells. J. Immunol. 164 (2000) 1269-1276
32. Boos C.J., Goon P.K.Y., and Lip G.Y.H. Endothelial progenitor cells in the vascular pathophysiology of hypertension: arterial stiffness, ageing and more. J. Hum. Hypertens 20 (2006) 1-3
33. Li M.O., Wan Y.Y., Sanjabi S., Robertson A.K.L., and Flavell R.A. Transforming growth factor-β regulation of immune responses. Annu. Rev. Immunol. 24 (2006) 99-146
34. Lin C.M., Wang F.H., and Lee P.K. Activated human CD4+ T cells induced by dendritic cell stimulation are most sensitive to transforming growth factor-β: implications for dendritic cell immunization against cancer. Clin. Immunol. 102 (2002) 96-105
35. Krabbe K.S., Pedersen M., and Bruunsgaard H. Inflammatory mediators in the elderly. Exp. Gerontol. 39 (2004) 687-699
36. Molteni M., Della Bella S., Mascagni B., Coppola C., De Micheli V., Zulian C., Birindelli S., Vanoli M., and Scorza R. Secretion of cytokines upon allogeneic stimulation: effect of aging. J. Biol. Reulg. Homeost. Agents 8 (1994) 41-47
37. Saurwein-Teissl M., Romani N., and Grubeck-Loebenstein B. Dendritic cells in old age-Neglected by gerontology?. Mech. Ageing Dev. 121 (2000) 123-130
38. Mahnke K., and Enk A.H. Dendritic cells: key cells for the induction of regulatory T cells?. Curr. Top. Microbiol. Immunol. 293 (2005) 133-150
39. Rink L., Cakman I., and Kirchner H. Altered cytokine production in the elderly. Mech. Ageing Dev. 102 (1998) 199-209
40. Glaser R., MacCallum R.C., Laskowski B.F., Malarkey W.B., Sheridan J.F., and Kiecolt-Glaser J.K. Evidence for a shift in Th-1 to Th-2 cytokine response associated with chronic stress and aging. J. Gerontol., A, Biol. Sci. Med. Sci. 56 (2001) M477-M482