Sensor systems for bioprocess monitoring

Engineering in Life Sciences

Volumn 15, Issue 5, 2015, Pages 469-488

  Biechele, Philipp ^a   Busse, Christoph ^a   Solle, Dörte ^a   Scheper, Thomas ^a   Reardon, Kenneth ^b  

^a LEIBNIZ UNIVERSITY HANNOVER   (Germany)

^b Engineering Research Center and Hydraulics Laboratory   (United States)

Author keywords

Bioprocess monitoring; Cell culture; Process analytical technology; Process control; Sensor systems

Indexed keywords

BIOREACTORS; CARBON DIOXIDE; CELL CULTURE; CHEMICAL SENSORS; CONTROLLED DRUG DELIVERY; DATA HANDLING; PHASE INTERFACES; SPECTROSCOPIC ANALYSIS;

BIOMASS CONCENTRATIONS; BIOPROCESS MONITORING; CARBON DIOXIDE CONCENTRATIONS; FLOW INJECTION ANALYSIS; PROCESS ANALYTICAL TECHNOLOGY; REAL TIME MEASUREMENTS; SENSOR SYSTEMS; US FOOD AND DRUG ADMINISTRATION;

PROCESS CONTROL;

CARBON DIOXIDE; DISSOLVED OXYGEN; OXYGEN;

BIOACTIVITY; BIOLOGICAL ANALYSIS; BIOREACTOR; CARBON DIOXIDE; CELLS AND CELL COMPONENTS; CONCENTRATION (COMPOSITION); DATA PROCESSING; DRUG; FERMENTATION; LITERATURE REVIEW; MONITORING; PROCESSING; QUALITATIVE ANALYSIS; REAL TIME; SENSOR; TECHNOLOGICAL DEVELOPMENT;

BIOMASS; BIOPROCESS; BIOREACTOR; BIOSENSOR; CALORIMETRY; CARBON DIOXIDE TENSION; CELL CULTURE; CHEMOMETRICS; FIBER OPTICS; FLOW INJECTION ANALYSIS; FLUORESCENCE SPECTROSCOPY; IMPEDANCE; INFORMATION PROCESSING; INFRARED SPECTROSCOPY; MICROSCOPY; NEAR INFRARED SPECTROSCOPY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OPTICAL DENSITY; OXYGEN CONSUMPTION; OXYGEN TENSION; PH; PROCESS MONITORING; RAMAN SPECTROMETRY; REVIEW; TURBIDITY; ULTRAVIOLET SPECTROSCOPY;

EID: 84935722636     PISSN: 16180240     EISSN: 16182863     Source Type: Journal    
DOI: 10.1002/elsc.201500014     Document Type: Review

References (235)

1. Bluma, A., Höpfner, T., Lindner, P., Rehbock, C. et al., In-situ imaging sensors for bioprocess monitoring: State of the art. Anal. Bioanal. Chem. 2010, 398, 2429-2438.
2. Scheper, T. H., Reardon, K. F., Determination of cell concentration and characterization of cells, in: Rehm, H.-J., Reed, G. (Eds.), Biotechnology: Measuring, Modelling, and Control, Volume 4, Wiley-VCH Verlag GmbH, Weinheim 1991.
3. Scheper, T., Hitzmann, B., Stärk, E., Ulber, R. et al., Bioanalytics: Detailed insight into bioprocesses. Analyt. Chim. Acta 1999, 400, 121-134.
4. Glindkamp, A., Riechers, D., Rehbock, C., Hitzmann, B. et al., Sensors in disposable bioreactors status and trends. Adv. Biochem. Eng. Biotechnol. 2009, 115, 145-169.
5. Zhao, L., Hsu-Yuan, F., Weichang, Z., Wei-Shou, H., Advances in process monitoring tools for cell culture bioprocesses. Eng. Life Sci. 2015, 15, 459-468.
6. Kessler, R. W. (Ed.), Prozessanalytik Vol. 1. Wiley-VCH, Weinheim 2006.
7. Bochenkov, V., Sergeev, G., Sensitivity, selectivity, and stability of gas-sensitive metal-oxide nanostructures. Metal Oxide Nanostruct. Appl. 2010, 3, 31-52.
8. Pohlscheidt, M., Charaniya, S., Bork, C., Jenzsch, M. et al., Bioprocess and fermentation monitoring, in: Flickinger, Michael C. (Ed.) Encyclopedia of Industrial Biotechnology John Wiley and Sons, Inc., New York 2013, pp. 1469-1491.
9. Shuk, P., Process zirconia oxygen analyzer-state of art. tm-Technisches Messen Plattform für Methoden. Systeme und Anwendungen der Messtechnik. 2010, 77, 19-23.
10. Suresh, S., Srivastava, V. C., Mishra, I. M., Techniques for oxygen transfer measurement in bioreactors: A review. J. Chem. Technol. Biotechnol. 2009, 84, 1091-1103.
11. Pohlscheidt, M. et al., Bioprocess and Fermentation Monitoring, in Encyclopedia of Industrial Biotechnology, John Wiley & Sons, Inc., New York 2009.
12. Sonnleitner, B., Instrumentation of Biotechnological Processes, in: Sonnleitner, B. (ed.), Bioanalysis and Biosensors for Bioprocess Monitoring, Springer Berlin, Heidelberg 2000, pp. 1-64.
13. 2) sensors for the agri-food industry-a review. Food Bioprocess Technol. 2008, 2, 115-121.
14. Sonnleitner, B., Automated Measurement and Monitoring of Bioprocesses: Key Elements of the M3C Strategy, in: Mandenius, Carl-Fredrik, Titchener-Hooker, Nigel J. (Eds.), Measurement, Monitoring, Modelling and Control of Bioprocesses, Springer, Heidelberg 2013, pp. 1-33.
15. Perez de Vargas-Sansalvador, I. M., Fay, C., Phelan, T., Fernandez-Ramos, M. D. et al., A new light emitting diode-light emitting diode portable carbon dioxide gas sensor based on an interchangeable membrane system for industrial applications. Anal. Chim. Acta 2011, 699, 216-22.
16. Frahm, B., Blank, H. C., Cornand, P., Oelßner, W. et al., Determination of dissolved CO2 concentration and CO2 production rate of mammalian cell suspension culture based on off-gas measurement. J. Biotechnol. 2002, 99, 133-148.
17. Mühlemann, H. M., Bungay, H. R., An ethanol-auxostat with on-line gas sensing. Biotechnol. Techniques 1993, 7, 575-578.
18. Austin, G. D., Sankhe, S. K., Tsao, G. T., Monitoring and control of methanol concentration during polysaccharide fermentation using an on-line methanol sensor. Bioprocess Eng. 1992, 7, 241-247.
19. Hilmer, J. M., Scheper, T., A new version of an in situ sampling system for bioprocess analysis. Acta Biotechnol. 1996, 16, 185-192.
20. Mattiasson, B., Hakanson, H., Sampling and sample handling-crucial steps in process monitoring and control. Trends Biotechnol. 1993, 11, 136-142.
21. Seifert, G. K. E., Matteau, P. P., An automatic aseptic bioreactor sampling system. Biotechnol. Bioeng. 1988, 32, 923-926.
22. Reda, K. D., Thien, M. P., Feygin, I., Marcin, C. S. et al., Automatic whole broth multi-fermentor sampling. J. Ind. Microbiol. 1991, 7, 215-220.
23. Chong, L. Saghafi, M., Knappe, C., Steigmiller, S. et al., Robust on-line sampling and analysis during long-term perfusion cultivation of mammalian cells. J. Biotechnol. 2013, 165, 133-137.
24. Hans, M. A., Heinzle, E., Wittmann, C., Quantification of intracellular amino acids in batch cultures of Saccharomyces cerevisiae. Appl. Microbiol. Biotechnol. 2001, 56, 776-779.
25. Wittmann, C., Krömer, J. O., Kiefer, P., Binz, T. et al., Impact of the cold shock phenomenon on quantification of intracellular metabolites in bacteria. Anal. Biochem. 2004, 327, 135-139.
26. Buchholz, A., Hurlebaus, J., Wandrey, C., Takors, R. et al., Metabolomics: Quantification of intracellular metabolite dynamics. Biomol. Eng. 2002, 19, 5-15.
27. Buchholz, A., Takors, R., Wandrey, C., Quantification of intracellular metabolites in Escherichia coli K12 using liquid chromatographic-electrospray ionization tandem mass spectrometric techniques. Anal. Biochem. 2001, 295, 129-137.
28. Weuster-Botz, D., Sampling tube device for monitoring intracellular metabolite dynamics. Anal. Biochem. 1997, 246, 225-233.
29. da Luz, J. A., Hans, E., Zeng, A.-P., Automated fast filtration and on-filter quenching improve the intracellular metabolite analysis of microorganisms. Eng. Life Sci., 2014, 14, 135-142.
30. Schaefer, U., Boos, W., Takors, R., Weuster-Botz, D., Automated sampling device for monitoring intracellular metabolite dynamics. Anal. Biochem. 1999, 270, 88-96.
31. Hiller, J., Franco-Lara, E., Papaioannou, V., Weuster-Botz, D., Fast sampling and quenching procedures for microbial metabolic profiling. Biotechnol. Lett. 2007, 29, 1161-1167.
32. Lange, H. C., Eman, M., van Zuijlen, G., Visser, D. et al., Improved rapid sampling for in vivo kinetics of intracellular metabolites in Saccharomyces cerevisiae. Biotechnol. Bioeng. 2001, 75, 406-415.
33. Håkanson, H., Nilsson, M., Mattiasson, B., General sampling system for sterile monitoring of biological processes. Anal. Chim. Acta 1991, 249, 61-65.
34. Holzhauer-Rieger, K. W., Zhou, K. Schügerl, On-line high-performance liquid chromatography for the determination of cephalosporin C and by-products in complex fermentation broths. J. Chromatogr. A 1990, 499, 609-615.
35. Wilkens, E., Ringel, A., Hortig, D., Willke, T. et al., High-level production of 1, 3-propanediol from crude glycerol by Clostridium butyricum AKR102 a. Appl. Microbiol. Biotechnol. 2012, 93, 1057-1063.
36. Mandenius, C. F., Danielsson, B., Mattiasson, B., Evaluation of a dialysis probe for continuous sampling in fermentors and in complex media. Anal. Chim. Acta 1984, 163, 135-141.
37. Buttler, T., Nilsson, C., Gorton, L., Marko-Varga, G. et al., Membrane characterisation and performance of microdialysis probes intended for use as bioprocess sampling units. J. Chromatogr. A 1996, 725, 41-56.
38. Mulchandani, A., Bassi, A. S., Principles and applications of biosensors for bioprocess monitoring and control. Crit. Rev. Biotechnol. 1995, 15, 105-124.
39. Borisov, S. M., Wolfbeis, O. S., Optical biosensors. Chem. Rev. 2008, 108, 423-61.
40. Rhee, J., Ritzka, A., Scheper, T., On-line monitoring and control of substrate concentrations in biological processes by flow injection analysis systems. Biotechnol. Bioprocess Eng. 2004, 9, 156-165.
41. Bracewell, D. G., Gill, A., Hoare, M., An in-line flow injection optical biosensor for real-time bioprocess monitoring. Food Bioproduct. Processing 2002, 80, 71-77.
42. Becker, T., Hitzmann, B., Muffler, K., Pörtner, R. et al., Future aspects of bioprocess monitoring. White Biotechnol. 2007, 105, 249-293.
43. Grieshaber, D., MacKenzie, R., Vörös, J., Reimhult, E. et al., Electrochemical biosensors - sensor principles and architectures. Sensors 2008. 8, 1400-1458.
44. Thevenot, D. R., Toth, K., Durst, R. A., Wilson, G. S., Electrochemical biosensors: recommended definitions and classification. Biosens. Bioelectron. 2001, 16, 121-31.
45. Song, S., Wang, L., Li, J., Fan, C. et al., Aptamer-based biosensors. TrAC Trends Anal. Chem. 2008, 27, 108-117.
46. Lönne, M., Zhu, G., Stahl, F., Walter, J. G. et al., Aptamer-modified nanoparticles as biosensors. Adv. Biochem. Eng. Biotechnol. 2014, 140, 121-154.
47. Walter, J. G., Kokpinar, O., Friehs, K., Stahl, F. et al., Systematic investigation of optimal aptamer immobilization for protein-microarray applications. Anal. Chem. 2008, 80, 7372-7378.
48. Walter, J. G., Heilkenbrinker, A., Austerjost, J., Timur, S. et al., Aptasensors for small molecule detection. Zeitschrift fur Naturforschung B-Journal of Chemical Sciences 2012, 67(10), 976-986.
49. Strehlitz, B., Nikolaus, N., Stoltenburg, R., Protein detection with aptamer biosensors. Sensors 2008, 8, 4296-4307.
50. Cleland, N., Enfors, S.-O., Control of glucose-fed batch cultivations of E. coli by means of an oxygen stabilized enzyme electrode. Eur. J. Appl. Microbiol. Biotechnol. 1983, 18, 141-147.
51. Park, J.-K., Kim, H.-S., A new biosensor for specific determination of glucose or fructose using an oxidoreductase of Zymomonas mobilis. Biotechnol. Bioeng. 1990, 36, 744-749.
52. Scheper, T. H. et al., Biosensors in bioprocess monitoring. J. Chromatogr. A 1996, 725, 3-12.
53. Scheper, T. (Ed.), Bioanalytik, Vieweg+Teubner Verlag 1991, pp. 156-315.
54. Scheper, T., Brandes, W., Grau, C., Hundeck, H. G. et al., Applications of biosensor systems for bioprocess monitoring. Anal. Chim. Acta 1991 (b), 249, 25-34.
55. Hundeck, H. G., Sauerbrei, A., Hübner, U., Scheper, T. et al., Four-channel enzyme thermistor system for process monitoring and control in biotechnology. Anal. Chim. Acta 1990, 238, 211-221.
56. Yakovleva, M., Bhand, S., Danielsson, B., The enzyme thermistor - A realistic biosensor concept. A critical review. Anal. Chim. Acta 2013, 766, 1-12.
57. Lammers, F., Scheper, T., Thermal biosensors in biotechnology. Adv. Biochem. Eng. Biotechnol. 1999, 64, 35-67.
58. Karube, I., Mitsuda, S., Suzuki, S., Glucose sensor using immobilized whole cells of Pseudomonas fluorescens. Eur. J. Appl. Microbiol. Biotechnol. 1979, 7, 343-350.
59. Wang, J., Electrochemical glucose biosensors. Chem. Rev. 2008, 108, 814-825.
60. Scheper, T., Reardon, K. F., Bioprocess analysis, in: Townshend, A., Haswell, S., Lederer, M., Wilson, I., Worsfold, P. (eds.), Encyclopedia of Analytical Science, Academic Press, London 2005, pp. 358-365.
61. Forman, L. W., Thomas, B. D., Jacobson, F. S., On-line monitoring and control of fermentation processes by flow-injection analysis. Anal. Chim. Acta 1991, 249, 101-111.
62. Garn, M., Gisin, M., Thommen, C., Cevey, P., Flow injection analysis system for fermentation monitoring and control. Biotechnol. Bioeng. 1989, 34, 423-428.
63. Ruzicka, J., Hansen E. H., Flow injection analysis, in: Winefordner, J. D. (Ed.), Chemical Analysis Vol. 62, John Wiley & Sons, New York 1988.
64. Ruzicka, J., Hansen, E. H., Flow injection analyses. Part I. A new concept of fast continuous flow analysis. Anal. Chim. Acta 1975, 78, 145-157.
65. Scheper, T., Brandes, W., Maschke, H., Plötz, F. et al., Two FIA-based biosensor systems studied for bioprocess monitoring. J. Biotechnol. 1993, 31, 345-356.
66. Haouz, A., Stieg, S., Continuous monitoring of D-glucose and L-lactate by flow injection analysis. Enzyme Microb. Technol. 2002, 30, 129-133.
67. Bäcker, M., Rakowski, D., Poghossian, A., Biselli, M. et al., Chip-based amperometric enzyme sensor system for monitoring of bioprocesses by flow-injection analysis. J. Biotechnol. 2013, 163, 371-376.
68. Brooks, S. L., Ashby, R. E., Turner, A. P. F., Calder, M. R. et al., Development of an on-line glucose sensor for fermentation monitoring. Biosensors 1987, 3, 45-56.
69. Yuksel, M., Akin, M., Geyik, C., Demirkol, D. O. et al., Offline glucose biomonitoring in yeast culture by polyamidoamine/ cysteamine-modified gold electrodes. Biotechnol. Progress. 2011, 27, 530-538.
70. Akin, M., Prediger, A., Yuksel, M., Höpfner, T. et al., A new set up for multi-analyte sensing: At-line bio-process monitoring. Biosens. Bioelectron. 2011, 26, 4532-4537.
71. Akin, M., Yuksel, M., Geyik, C., Odaci, D. et al., Alcohol biosensing by polyamidoamine (PAMAM)/cysteamine/alcohol oxidase-modified gold electrode. Biotechnol. Progress. 2010, 26, 896-906.
72. Romette, J. L., Cooney, C. L., L-glutamine enzyme electrode for on-line mammalian cell culture process control. Anal. Lett. 1987, 20, 1069-1081.
73. Schügerl, K., Brandes, L., Dullau, T., Holzhauer-Rieger, K. et al., Fermentation monitoring and control by on-line flow injection and liquid chromatography. Anal. Chim. Acta 1991, 249, 87-100.
74. Hikuma, M., Obana, H., Yasuda, T., Karube, I. et al., Amperometric determination of total assimilable sugars in fermentation broths with use of immobilized whole cells. Enzyme Microbial Technol. 1980, 2, 234-238.
75. Dremel, B. A. A., Li, S. Y., Schmid, R. D., On-line determination of glucose and lactate concentrations in animal cell culture based on fibre optic detection of oxygen in flow-injection analysis. Biosens. Bioelectron. 1992, 7, 133-139.
76. Lee, S.-J., Saleemuddin, M., Scheper, T., Loos, H. et al., A fluorometric fiber-optic biosensor for dual analysis of glucose and fructose using glucose-fructose-oxidoreductase isolated from Zymomonas mobilis. J. Biotechnol. 1994, 36, 39-44.
77. Ogbomo, I., Kittsteiner-Eberle, R., Englbrecht, U., Prinzing, U. et al., Flow-injection systems for the determination of oxidoreductase substrates: Applications in food quality control and process monitoring. Anal. Chim. Acta 1991, 249, 137-143.
78. Cattaneo, M. V., Luong, J. H., Monitoring glutamine in animal cell cultures using a chemiluminescence fiber optic biosensor. Biotechnol. Bioeng. 1993, 41, 659-665.
79. Wehnert, G., Sauerbrei, A., Bayer, T., Scheper, T. et al., Application of an enzyme thermistor for the determination of glucose in complex fermentation media. Anal. Chim. Acta 1987, 200, 73-78.
80. Rank, M., Gram, J., Danielsson, B., Industrial on-line monitoring of penicillin V, glucose and ethanol using a split-flow modified thermal biosensor. Anal. Chim. Acta 1993, 281, 521-526.
81. Muramatsu, H., Dicks, J. M., Tamiya, E., Karube, I., Piezoelectric crystal biosensor modified with protein A for determination of immunoglobulins. Anal. Chem. 1987, 59, 2760-2763.
82. Ulber, R., Hitzmann, B., Scheper, T., Reardon, K., Bioreactor Monitoring and Control, Academic Press, Enyclopedia of Microbiology, 2000, Vol. 1, pages 567-578.
83. Harms, P., Kostov, Y., Rao, G., Bioprocess monitoring. Curr. Opin. Biotechnol. 2002, 13, 124-127.
84. Clark, L. C., Jr. et al., Continuous recording of blood oxygen tensions by polarography. J. Appl. Physiol. 1953, 6, 189-93.
85. Henkel, S., Beutel, S., Messung des pH-Werts in der Biotechnologie. Chem. Ing. Tech. 2013, 85, 872-885.
86. Zafar, S., D'Emic, C., Afzali, A., Flechter, B. et al., Optimization of pH sensing using silicon nanowire field effect transistors with HfO2 as the sensing surface. Nanotechnology 2011, 22, 1-6.
87. Knopfmacher, O., Tarasov, A., Fu, W., Wipf, M. et al., Nernst limit in dual-gated Si-nanowire FET sensors. Nano Lett. 2010, 10, 2268-2274.
88. Bergveld, P., Thirty years of ISFETOLOGY: What happened in the past 30 years and what may happen in the next 30 years. Sens. Actuators B 2003, 88, 1-20.
89. Beutel, S., Henkel, S., In situ sensor techniques in modern bioprocess monitoring. Appl. Microbiol. Biotechnol. 2011, 91, 1493-1505.
90. Rehbock, C., Beutel, S., Brückerhoff, T., Hitzmann, B. et al., Bioprozessanalytik. Chem. Ing. Tech. 2008, 80, 267-286.
91. Lam, H. and Kostov, Y., Optical Instrumentation for Bioprocess Monitoring, in: Rao G. (Ed.), Optical Sensor Systems in Biotechnology, Springer Verlag, Heidelberg 2010, pp. 125-142.
92. Bambot, S. B., Holavanahali, R., Lakowicz, J. R., Carter, G. M. Phase fluorometric sterilizable optical oxygen sensor. Biotechnol. Bioeng. 1994, 43, 1139-1145.
93. Amao, Y., Probes and polymers for optical sensing of oxygen. Microchim. Acta 2003, 143, 1-12.
94. Ulber, R., Frerichs, J.-G., Beutel, S., Optical sensor systems for bioprocess monitoring. Anal. Bioanal. Chem. 2003, 376, 342-348.
95. Hanson, M. A., Ge, X., Kostov, Y., Brorson, K. A. et al., Comparisons of optical pH and dissolved oxygen sensors with traditional electrochemical probes during mammalian cell culture. Biotechnol. Bioeng. 2007, 97, 833-841.
96. Mills, A., Chang, Q., McMurray, N., Equilibrium studies on colorimetric plastic film sensors for carbon dioxide. Anal. Chem. 1992, 64, 1383-1389.
97. Gupta, B. D., Sharma, S., A long-range fiber optic pH sensor prepared by dye doped sol-gel immobilization technique. Optics Commun. 1998, 154, 282-284.
98. Lin, J., Recent development and applications of optical and fiber-optic pH sensors. TrAC Trends Anal. Chem. 2000, 19, 541-552.
99. Glindkamp, A., Riechers, D., Rehbock, C., Hitzmann, B. et al., Sensors in disposable bioreactors status and trends. Adv. Biochem. Eng. Biotechnol. 2009, 115, 145-169.
100. Ali, R., Saleh, S. M., Meier, R. J., Azab, H. A. et al., Upconverting nanoparticle based optical sensor for carbon dioxide. Sens. Actuators B 2010, 150, 126-131.
101. Neurauter, G., Klimant, I., Wolfbeis, O. S., Microsecond lifetime-based optical carbon dioxide sensor using luminescence resonance energy transfer. Anal. Chim. Acta 1999, 382, 67-75.
102. Ge, X., Kostov, Y., Rao, G., High-stability non-invasive autoclavable naked optical CO2 sensor. Biosens. Bioelectron. 2003, 18, 857-865.
103. Rhiel, M., Ducommun, P., Bolzonella, I., Marison, I. et al., Real-time in situ monitoring of freely suspended and immobilized cell cultures based on mid-infrared spectroscopic measurements. Biotechnol. Bioeng. 2002, 77, 174-85.
104. Sandor, M., Rüdinger, F., Bienert, R., Grimm, C. et al., Comparative study of non-invasive monitoring via infrared spectroscopy for mammalian cell cultivations. J. Biotechnol. 2013, 168, 636-645.
105. Sellick, C. A., Hansen, R., Jarvis, R. M., Maqsood, A. R. et al., Rapid monitoring of recombinant antibody production by mammalian cell cultures using fourier transform infrared spectroscopy and chemometrics. Biotechnol. Bioeng. 2010, 106, 432-442.
106. Schenk, J., Marison, I. W., vonStockar, U., pH prediction and control in bioprocesses using mid-infrared spectroscopy. Biotechnol. Bioeng. 2008, 100, 82-93.
107. Kornmann, H., Rhiel, M., Cannizzaro, C., Marison, I. et al., Methodology for real-time, multianalyte monitoring of fermentations using an in-situ mid-infrared sensor. Biotechnol. Bioeng. 2003, 82, 702-709.
108. Mazarevica, G., Diewok, J., Baena, J. R., Rosenberg, E. et al., On-line fermentation monitoring by mid-infrared spectroscopy. Appl. Spectrosc. 2004, 58, 804-810.
109. Arnold, S. A., Crowley, J., Woods, N., Harvey, L. M. et al., In-situ near infrared spectroscopy to monitor key analytes in mammalian cell cultivation. Biotechnol. Bioeng. 2003, 84, 13-19.
110. Henriques, J. G., Buziol, S., Stocker, E., Voogd, A. et al., Monitoring Mammalian Cell Cultivations for Monoclonal Antibody Production Using Near-Infrared Spectroscopy, in: Rao G. (Ed.), Optical Sensor Systems in Biotechnology, Springer Verlag, Heidelberg 2010, pp. 29-72.
111. Clavaud, M., Roggo, Y., Von Daeniken, R., Liebler, A. et al., Chemometrics and in-line near infrared spectroscopic monitoring of a biopharmaceutical Chinese hamster ovary cell culture: Prediction of multiple cultivation variables. Talanta 2013, 111, 28-38.
112. Card, C., Hunsaker, B., Smith, T., Hirsch, J. et al., Near-infrared spectroscopy for rapid, simultaneous monitoring. BioProcess Int. 2008, 6, 58-67.
113. Kiviharju, K., Salonen, K., Moilanen, U., Meskanen, E. et al., On-line biomass measurements in bioreactor cultivations: Comparison study of two on-line probes. J. Ind. Microbiol. Biotechnol. 2007, 34, 561-566.
114. Noui, L., Hill, J., Keay, P. J., Wang, R. Y. et al., Development of a high resolution UV spectrophotometer for at-line monitoring of bioprocesses. Chem. Eng. Processing 2002, 41, 107-114.
115. Pons, M.-N., Bonté, S. L., Potier, O., Spectral analysis and fingerprinting for biomedia characterisation. J. Biotechnol. 2004, 113, 211-230.
116. Duysens, L. N. M., Amesz, J., Fluorescence spectrophotometry of reduced phosphopyridine nucleotide in intact cells in the near-ultraviolet and visible region. Biochim. Biophys. Acta 1957, 24, 19-26.
117. Hantelmann, K., Kollecker, M., Hüll, D., Hitzmann, B. et al., Two-dimensional fluorescence spectroscopy: A novel approach for controlling fed-batch cultivations. J. Biotechnol. 2006, 121, 410-417.
118. Haack, M. B., Eliasson, A., Olsson, L., On-line cell mass monitoring of Saccharomyces cerevisiae cultivations by multi-wavelength fluorescence. J. Biotechnol. 2004, 114, 199-208.
119. Lee, H. L. T., Boccazzi, P., Gorret, N., Ram, R. J. et al., In situ bioprocess monitoring of Escherichia coli bioreactions using Raman spectroscopy. Vibrational Spectrosc. 2004, 35, 131-137.
120. Cannizzaro, C., Rhiel, M., Marison, I., von Stockar, U., On-line monitoring of Phaffia rhodozyma fed-batch process with in situ dispersive Raman spectroscopy. Biotechnol. Bioeng. 2003, 83, 668-680.
121. Roychoudhury, P., Harvey, L. M., McNeil, B., The potential of mid infrared spectroscopy (MIRS) for real time bioprocess monitoring. Anal. Chim. Acta 2006, 571, 159-166.
122. Landgrebe, D., Haake, C., Höpfner, T., Beutel, S. et al., On-line infrared spectroscopy for bioprocess monitoring. Appl. Microbiol. Biotechnol. 2010, 88, 11-22.
123. Scarff, M., Arnold, S. A., Harvey, L. M., McNeil, B., Near infrared spectroscopy for bioprocess monitoring and control: Current status and future trends. Crit. Rev. Biotechnol. 2006, 26, 17-39.
124. Haake, C., Landgrebe, D., Scheper, T., Rhiel, M., Online-Infrarotspektroskopie in der Bioprozessanalytik. Chem. Ing. Tech. 2009, 81, 1385-1396.
125. Hakemeyer, C., Strauss, U., Werz, S., Jose, G. E. et al., At-line NIR spectroscopy as effective PAT monitoring technique in Mab cultivations during process development and manufacturing. Talanta 2012, 90, 12-21.
126. Liauw, M. A., Baylor, L. C. and O'Rourke, P. E., UV-Visible Spectroscopy for On-Line Analysis, in: Bakeev, K.A., (ed.) Process Analytical Technology: Spectroscopic Tools and Implementation Strategies for the Chemical and Pharmaceutical Industries, Second Edition, John Wiley & Sons, Ltd., Chichester UK 2010, pp. 81-106.
127. Vojinovic, V., Cabral, J. M. S., Fonseca, L. P., Real-time bioprocess monitoring: Part I: In situ sensors. Sens. Actuators B 2006, 114, 1083-1091.
128. Tartakovsky, B., Sheintuch, M., Hilmer, J. M., Scheper, T., Application of scanning fluorometry for monitoring of a fermentation process. Biotechnol. Prog. 1996, 12, 126-31.
129. Scheper, T., Lorenz, T. H., Schmidt, W., Schügerl, K., On-line measurement of culture fluorescence for process monitoring and control of biotechnological processes. Ann. N Y Acad. Sci. 1987, 506, 431-445.
130. Anders, K. D., Wehnert, G., Thordsen, O., Scheper, T., Biotechnological applications of fiber-optic sensing: Multiple uses of a fiber-optic fluorimeter. Sens. Actuators B 1993, 11, 395-403.
131. Sato, K., Yoshida, Y., Hirahara, T., Ohba, T., On-line measurement of intracellular ATP of Saccharomyces cerevisiae and pyruvate during sake mashing. J. Biosci. Bioeng. 2000, 90, 294-301.
132. Marose, S., Lindemann, C., Scheper, T., Two-dimensional fluorescence spectroscopy: A new tool for on-line bioprocess monitoring. Biotechnol. Progress 1998, 14, 63-74.
133. Rhee, J. I., Kang, T.-H., On-line process monitoring and chemometric modeling with 2 D fluorescence spectra obtained in recombinant E. coli fermentations. Process Biochem. 2007, 42, 1124-1134.
134. Boehl, D., Solle, D., Hitzmann, B., Scheper, T., Chemometric modelling with two-dimensional fluorescence data for Claviceps purpurea bioprocess characterization. J. Biotechnol. 2003, 105, 179-188.
135. Vankeirsbilck, T., Vercauteren, A., Baeyens, W., Van der Weken, G. et al., Applications of Raman spectroscopy in pharmaceutical analysis. TrAC Trends Anal. Chem. 2002, 21, 869-877.
136. Abu-Absi, N. R., Kenty, B. M., Cuellar, M. E., Borys, M. C. et al., Real time monitoring of multiple parameters in mammalian cell culture bioreactors using an in-line Raman spectroscopy probe. Biotechnol. Bioeng. 2011, 108, 1215-1221.
137. Tensmeyer, L. G., Heathman, M. A., Analytical applications of Raman spectroscopy in the pharmaceutical field. TrAC Trends Anal. Chem. 1989, 8, 19-24.
138. Whelan, J., Craven, S., Glennon, B., In situ Raman spectroscopy for simultaneous monitoring of multiple process parameters in mammalian cell culture bioreactors. Biotechnol. Prog. 2012, 28, 1355-1362.
139. Moretto, J., Smelko, J. P., Cuellar, M., Berry, B. et al., Process Raman spectroscopy for in-line CHO cell culture monitoring. Am. Pharmaceut. Rev. 2011, 14, 18-25.
140. Lottspeich, F., Engels, J. W., (Eds.) Bioanalytik, Spektrum Akademischer Verlag, Heidelberg 2006.
141. Hesse, M., Meier, H., Zeeh, B., (Eds.) Spektroskopische Methoden in Der Organischen Chemie. Vol. 8, Georg Thieme Verlag, Stuttgart, New York 2012.
142. Abu-Absi, N. R., Martel, R. P., Lanza, A. M., Clements, S. J. et al., Application of spectroscopic methods for monitoring of bioprocesses and the implications for the manufacture of biologics. Pharmaceut. Bioprocess. 2014, 2, 267-284.
143. Reardon, K. F., Scheper, T. H., Determination of cell concentration and characterization of cells. Biotechnol. Set, Second Edition 1991, 4, 179-223.
144. Kiviharju, K., Salonen, K., Moilanen, U., Eerikäinen, T., Biomass measurement online: The performance of in situ measurements and software sensors. J. Ind. Microbiol. Biotechnol. 2008, 35, 657-665.
145. Junker, B. H., Reddy, J., Gbewonyo, K., Greasham, R., On-line and in-situ monitoring technology for cell density measurement in microbial and animal cell cultures. Bioprocess Eng. 1994, 10, 195-207.
146. Janelt, G., Gerbsch, N., Buchholz, R., A novel fiber optic probe for on-line monitoring of biomass concentrations. Bioprocess Eng. 2000, 22, 275-279.
147. Merten, O. W., Palfi, G. E., Staheli, J., Steiner, J., Invasive infrared sensor for the determination of the cell number in a continuous fermentation of hybridomas. Dev. Biol. Stand. 1987, 66, 357-360.
148. Wu, P., Ozturk, S. S., Blackie, J. D., Thrift, J. C., Evaluation and applications of optical cell density probes in mammalian cell bioreactors. Biotechnol. Bioeng. 1995, 45, 495-502.
149. Carvell, J., Dowd, J., On-line measurements and control of viable cell density in cell culture manufacturing processes using radio-frequency impedance. Cytotechnology 2006, 50, 35-48.
150. Palmer, S. M., Kunji, E. R., Online monitoring of biomass accumulation in recombinant yeast cultures. Methods Mol. Biol. 2012, 866, 165-179.
151. Bill, R. M., Recombinant protein production in yeast: Methods and protocols. Methods Mol. Biol. 2012, 866.
152. Kaiser, C., Pototzki, T., Ellert, A., Luttmann, R., Applications of PAT-process analytical technology in recombinant protein processes with Escherichia coli. Eng. Life Sci. 2008, 8, 132-138.
153. Sarrafzadeh, M. H. et al., Growth, sporulation, delta-endotoxins synthesis, and toxicity during culture of bacillus thuringiensis H14. Curr. Microbiol. 2005, 51, 75-81.
154. Ansorge, S., Esteban, G., Schmid, G., On-line monitoring of responses to nutrient feed additions by multi-frequency permittivity measurements in fed-batch cultivations of CHO cells. Cytotechnology 2010, 62, 121-132.
155. Logan, D. W., Carvell, J. P., Lee, M. P., Creating new opportunities in process control through radio frequency impedance spectroscopy. BMC Proc. 2011, 5, P57.
156. Björnsen, P. K., Automatic determination of bacterioplankton biomass by image analysis. Appl. Environ. Microbiol. 1986, 51, 1199-1204.
157. Joeris, K., Frerichs, J.-G., Konstantinov, K., Scheper, T., In-situ microscopy: Online process monitoring of mammalian cell cultures. Cytotechnology 2002, 38, 129-134.
158. Bittner, C., Wehnert, G., Scheper, T., In situ microscopy for on-line determination of biomass. Biotechnol. Bioeng. 1998, 60, 24-35.
159. Guez, J. S., Cassar, J. P., Wartelle, F., Dhulster, P. et al., Real time in situ microscopy for animal cell-concentration monitoring during high density culture in bioreactor. J. Biotechnol. 2004, 111, 335-343.
160. Camisard, V., Brienne, J. P., Baussart, H., Hammann, J. et al., Inline characterization of cell concentration and cell volume in agitated bioreactors using in situ microscopy: Application to volume variation induced by osmotic stress. Biotechnol. Bioeng. 2002, 78, 73-80.
161. Wiedemann, P., Guez, J. S., Wiegemann, H. B., Egner, F. et al., In situ microscopic cytometry enables noninvasive viability assessment of animal cells by measuring entropy states. Biotechnol. Bioeng. 2011, 108, 2884-2893.
162. Suhr, H., Wehnert, G., Schneider, K., Bittner, C. et al., In situ microscopy for on-line characterization of cell-populations in bioreactors, including cell-concentration measurements by depth from focus. Biotechnol. Bioeng. 1995, 47. 106-116.
163. Lüder, C., Lindner, P., Bulnes-Abundis, D., Lu, S. M. et al., In situ microscopy and MIR-spectroscopy as non-invasive optical sensors for cell cultivation process monitoring. Pharmaceut. Bioprocess. 2014, 2, 157-166.
164. Maskow, T., Rollich, A., Fetzer, I., Ackermann, J. U. et al., On-line monitoring of lipid storage in yeasts using impedance spectroscopy. J. Biotechnol. 2008, 135, 64-70.
165. Sivaprakasam, S., Schuler, M. M., Hama, A., Hughes, K.-M. et al., Biocalorimetry as a process analytical technology process analyser; robust in-line monitoring and control of aerobic fed-batch cultures of crabtree-negative yeast cells. J. Therm. Analysis Calorimet. 2011, 104, 75-85.
166. Birou, B., Marison, I. W., Stockar, U. V., Calorimetric investigation of aerobic fermentations. Biotechnol. Bioeng. 1987, 30, 650-660.
167. Von Stockar, U., Marison, I., The Use of Calorimetry in Biotechnology, in: Fiechter, A. (Ed.), Bioprocesses and Engineering, Springer Verlag Heidelberg 1989, Vol. 40, pp. 93-136.
168. Von Stockar, U., Duboc, P., Menoud, L., Marison, I. W., On-line calorimetry as a technique for process monitoring and control in biotechnology. Thermochim. Acta 1997, 300, 225-236.
169. Von Stockar, U., Marison, I. W., Large-scale calorimetry and biotechnology. Thermochim. Acta 1991, 193, 215-242.
170. Marison, I. W., Von Stockar, U., The application of a novel heat flux calorimeter for studying growth of Escherichia coli W in aerobic batch culture. Biotechnol. Bioeng. 1986, 28, 1780-1793.
171. Grivet, J.-P., Delort, A.-M., NMR for microbiology: In vivo and in situ applications. Progress Nucl. Magn. Reson. Spectrosc. 2009, 54, 1-53.
172. Hemminga, M. A., Visser, J., NMR in biotechnology. J. Biotechnol. 2000, 77, 1-3.
173. Brecker, L., Weber, H., Griengl, H., Ribbons, D. W. et al., In situ proton-NMR analyses of Escherichia coli HB101 fermentations in 1H2O and in D2O. Microbiology 1999, 145, 3389-3397.
174. Bradley, S. A., Ouyang, A., Purdie, J., Smitka, T. A. et al., Fermentanomics: monitoring mammalian cell cultures with NMR spectroscopy. J. Am. Chem. Soc. 2010, 132, 9531-9533.
175. Majors, P. D., McLean, J. S., Scholten, J. C., NMR bioreactor development for live in-situ microbial functional analysis. J. Magn. Reson. 2008, 192, 159-166.
176. Garcia-Ochoa, F., Gomez, E., Bioreactor scale-up and oxygen transfer rate in microbial processes: an overview. Biotechnol. Adv. 2009, 27, 153-176.
177. Palomares, L., Ramirez, O., The effect of dissolved oxygen tension and the utility of oxygen uptake rate in insect cell culture. Cytotechnology 1996, 22, 225-237.
178. Zou, X., Hang, H. F., Chu, J., Zhuang, Y. P. et al., Oxygen uptake rate optimization with nitrogen regulation for erythromycin production and scale-up from 50 L to 372 m3 scale. Bioresour. Technol. 2009, 100, 1406-1412.
179. Garcia-Ochoa, F. et al., Oxygen uptake rate in microbial processes: an overview. Biochem. Eng. J. 2010, 49, 289-307.
180. Ruffieux, P. A., vonStockar, U., Marison, I. W., Measurement of volumetric (OUR) and determination of specific (qO2) oxygen uptake rates in animal cell cultures. J. Biotechnol. 1998, 63, 85-95.
181. Berrios, J., Altamirano, C., Osses, N., Gonzalez, R. et al., Continuous CHO cell cultures with improved recombinant protein productivity by using mannose as carbon source: metabolic analysis and scale-up simulation. Chem. Eng. Sci. 2011, 66, 2431-2439.
182. Xiong, Z.-Q., Guo, M.-J., Guo, Y.-X., Chu, J. et al., RQ feedback control for simultaneous improvement of GSH yield and GSH content in Saccharomyces cerevisiae T65. Enzyme Microb. Technol. 2010, 46, 598-602.
183. Brückerhoff, T., Frerichs, J.-G., Joeris, K., Konstantinov, K., Image analysis based real time-control of glucose concentration, in: Godia, F., Fussenegger, M. M., (Eds.), Animal Cell Technology Meets Genomics, Proceedings of the 18th ESACT Meeting. Vol. 2, 2005, pp. 589-592.
184. Rudolph, G., Lindner, P., Bluma, A., Joeris, K. et al., Optical inline measurement procedures for counting and sizing cells in bioprocess technology. Adv. Biochem. Eng. Biotechnol. 2009, 116, 125-142.
185. Sarrafzadeh, M. H. et al., Dielectric monitoring of growth and sporulation of Bacillus thuringiensis. Biotechnol. Lett. 2005, 27, 511-517.
186. Kamen, A. A., Bedard, C., Tom, R., Perret, S. et al., On-line monitoring of respiration in recombinant-baculovirus infected and uninfected insect cell bioreactor cultures. Biotechnol. Bioeng. 1996, 50, 36-48.
187. Hao, X., Wang, Q., Zhang, X., Cao, Y. et al., Experimental evaluation of decrease in bacterial activity due to cell death and activity decay in activated sludge. Water Res. 2009. 43, 3604-3612.
188. Geladi, P., Chemometrics in spectroscopy. Part 1. Classical chemometrics. Spectrochim. Acta B 2003, 58, 767-782.
189. Rathore, A. S., Bhushan, N., Hadpe, S., Chemometrics applications in biotech processes: A review. Biotechnol. Prog. 2011, 27, 307-315.
190. Martens, H., Nielsen, J. P., Engelsen, S. B., Light scattering and light absorbance separated by extended multiplicative signal correction. Application to near-infrared transmission analysis of powder mixtures. Anal. Chem. 2003, 75, 394-404.
191. Sivakesava, S., Irudayaraj, J., Ali, D., Simultaneous determination of multiple components in lactic acid fermentation using FT-MIR, NIR, and FT-Raman spectroscopic techniques. Process Biochem. 2001, 37, 371-378.
192. Rodrigues, L. O., Vieira, L., Cardoso, J. P., Menezes, J. C. et al., The use of NIR as a multi-parametric in situ monitoring technique in filamentous fermentation systems. Talanta 2008, 75, 1356-1361.
193. Soons, Z. I. T. A., Streefland, M., van Straten, G., van Boxtel, A. J. B. et al., Assessment of near infrared and "software sensor" for biomass monitoring and control. Chemometrics Int. Lab. Syst. 2008, 94, 166-174.
194. Rinnan, A., vanden Berg, F., Engelsen, S. B., Review of the most common pre-processing techniques for near-infrared spectra. TrAC Trends Anal. Chem. 2009, 28, 1201-1222.
195. Lourenço, N. D., Lopes, J. A., Almeida, C. F., Sarraguça, M. C., Bioreactor monitoring with spectroscopy and chemometrics: A review. Anal. Bioanal. Chem. 2012, 404, 1211-1237.
196. Kjeldahl, K., Bro, R., Some common misunderstandings in chemometrics. J. Chemometrics 2010, 24, 558-564.
197. Defernez, M., Kemsley, E. K., The use and misuse of chemometrics for treating classification problems. Trends Anal. Chem. 1997, 16, 216-221.
198. Desai, K., Badhe, Y., Tambe, S. S., Kulkarni, B. D. Soft-sensor development for fed-batch bioreactors using support vector regression. Biochem. Eng. J. 2006, 27, 225-239.
199. Liu, G., Zhou, D., Xu, H., Mei, C., Model optimization of SVM for a fermentation soft sensor. Exp. Syst. Appl. 2010, 37, 2708-2713.
200. Kessler, W., Kessler, R., Multivariate Curve Resolution - Integration von Wissen in Chemometrische Modelle. Chemie Ingenieur Technik, 2010, 82, 441-451.
201. Pomerantsev, A. L., Rodionova, O. Y., Process analytical technology: A critical view of the chemometricians. J. Chemometrics 2012, 26, 299-310.
202. Potumarthi, S. C. R., Chemometrics-based process analytical technology (PAT) tools: Applications and adaptation in pharmaceutical and biopharmaceutical industries. Appl. Biochem. Biotechnol. 2013, 169, 66-76.
203. Alves-Rausch, J., Bienert, R., Grimm, C., Bergmaier, D., Real time in-line monitoring of large scale Bacillus fermentations with near-infrared spectroscopy. J. Biotechnol. 2014, 189, 120-128.
204. Waldraff, W., King, R., Gilles, E. D., Optimal feeding strategies by adaptive mesh selection for fed-batch bioprocesses. Bioprocess Eng. 1997, 17, 221-227.
205. Navrátil, M., Cimander, C., Mandenius, C.-F., On-line multisensor monitoring of yogurt and filmjölk fermentations on production scale. J. Agric. Food Chem. 2004, 52(3), 415-420.
206. Cervera, A. E., Petersen, N., Lantz, A. E., Larsen, A. et al., Application of near-infrared spectroscopy for monitoring and control of cell culture and fermentation. Biotechnology Progress, 2009, 25, 1561-1581.
207. Roggo, Y., Chalus, P., Maurer, L., Lema-Martinez, C. et al., A review of near infrared spectroscopy and chemometrics in pharmaceutical technologies. J. Pharmaceut. Biomed. Anal. 2007, 44, 683-700.
208. Clementschitsch, F., Kern, J., Pötschacher, F., Bayer, K., Sensor combination and chemometric modelling for improved process monitoring in recombinant E. coli fed-batch cultivations. J. Biotechnol. 2005, 120, 183-196.
209. Odman, P., Johansen, C. L., Olsson, L., Gernaey, K. V. et al., On-line estimation of biomass, glucose and ethanol in Saccharomyces cerevisiae cultivations using in-situ multi-wavelength fluorescence and software sensors. J. Biotechnol. 2009, 144, 102-112.
210. Roychoudhury, P., Harvey, L. M., McNeil, B., At-line monitoring of ammonium, glucose, methyl oleate and biomass in a complex antibiotic fermentation process using attenuated total reflectance-mid-infrared (ATR-MIR) spectroscopy. Anal. Chim. Acta 2006, 561, 218-224.
211. Solle, D., Geissler, D., Stärk, E., Scheper, T. et al., Chemometric modelling based on 2 D-fluorescence spectra without a calibration measurement. Bioinformatics 2003, 19, 173-177.
212. Ghosh, P. K., Jayas, D. S., Use of spectroscopic data for automation in food processing industry. Sens. Instrumen. Food Qual. 2009, 3, 3-11.
213. Koch, C., Posch, A. E., Goicoechea, H. C., Herwig, C. et al., Multi-analyte quantification in bioprocesses by Fourier-transform-infrared spectroscopy by partial least squares regression and multivariate curve resolution. Anal. Chim. Acta 2014, 807, 103-110.
214. Milligan, M., Lewin-Koh, N., Coleman, D., Arroyo, A. et al., Semisynthetic model calibration for monitoring glucose in mammalian cell culture with in situ near infrared spectroscopy. Biotechnol. Bioeng. 2014, 111, 896-903.
215. Shaw, A. D., Winson, M. K., Woodward, A. M., McGovern, A. C. et al., Rapid analysis of high-dimensional bioprocesses using multivariate spectroscopies and advanced chemometrics, in: Scheper, T. (Ed.), Advances in Biochemical Engineering and Biotechnology, Springer Verlag, Heidelberg, 1999, Vol. 66, pp. 83-113.
216. Dieterle, F., Gauglitz, G., Busche, S., Different approaches to multivariate calibration of nonlinear sensor data. Anal. Bioanal. Chem. 2004, 380, 383-396.
217. Isermann, R., Advanced methods of process computer control for industrial processes. Computers Ind. 1981, 2, 59-72.
218. Navratil, M., Norberg, A., Lembren, L., Mandenius, C. F., On-line multi-analyzer monitoring of biomass, glucose and acetate for growth rate control of a Vibrio cholerae fed-batch cultivation. J. Biotechnol. 2005, 115, 67-79.
219. Gnoth, S., Jenzsch, M., Simutis, R., Lübbert, A., Process analytical technology (PAT): Batch-to-batch reproducibility of fermentation processes by robust process operational design and control. J. Biotechnol. 2007, 132, 180-186.
220. Hu, K., Yuan, J., Multivariate statistical process control based on multiway locality preserving projections. J. Process Control 2008, 18, 797-807.
221. Teixeira, A. P., Portugal, C. A., Carinhas, N., Dias, J. M. et al., In situ 2 D fluorometry and chemometric monitoring of mammalian cell cultures. Biotechnol. Bioeng. 2009, 102, 1098-1106.
222. Chéruy, A., Software sensors in bioprocess engineering. J. Biotechnol. 1997, 52, 193-199.
223. Luttmann, R. et al., Soft sensors in bioprocessing: a status report and recommendations. Biotechnol. J. 2012, 7, 1040-1048.
224. Warth, B., Rajkai, G., Mandenius, C. F., Evaluation of software sensors for on-line estimation of culture conditions in an Escherichia coli cultivation expressing a recombinant protein. J. Biotechnol. 2010, 147, 37-45.
225. Sundström, H., Enfors, S.-O., Software sensors for fermentation processes. Bioprocess Biosyst. Eng. 2008, 31, 145-152.
226. Odman, P., Johansen, C. L., Olsson, L., Gernaey, K. V. et al., Sensor combination and chemometric variable selection for online monitoring of Streptomyces coelicolor fed-batch cultivations. Appl. Microbiol. Biotechnol. 2010, 86, 1745-1759.
227. Jenzsch, M., Simutis, R., Eisbrenner, G., Stuckrath, I. et al., Estimation of biomass concentrations in fermentation processes for recombinant protein production. Bioprocess Biosyst. Eng. 2006, 29, 19-27.
228. Kadlec, P., Gabrys, B., Strandt, S., Data-driven soft sensors in the process industry. Comput. Chem. Eng. 2009, 33, 795-814.
229. Jenzsch, M., Simutis, R., Luebbert, A., Generic model control of the specific growth rate in recombinant Escherichia coli cultivations. J. Biotechnol. 2006, 122, 483-493.
230. Bogaerts, P., A hybrid asymptotic-Kalman observer for bioprocesses. Bioprocess Eng. 1999, 20, 249-255.
231. Lin, B., Recke, B., Knudsen, J. K. H., Jørgensen, S. B., A systematic approach for soft sensor development. Computers Chem. Eng. 2007, 31, 419-425.
232. Kaneko, H., Arakawa, M., Funatsu, K., Development of a new soft sensor method using independent component analysis and partial least squares. AIChE J. 2009, 55, 87-98.
233. Park, S., Han, C., A nonlinear soft sensor based on multivariate smoothing procedure for quality estimation in distillation columns. Computers Chem. Eng. 2000, 24, 871-877.
234. Kadlec, P., Grbic, R., Gabrys, B., Review of adaptation mechanisms for data-driven soft sensors. Computers Chem. Eng. 2011, 35, 1-24.
235. Bluma, A., Höpfner, T., Prediger, A., Glindkamp, A., Process analytical sensors and image-based techniques for single-use bioreactors. Eng. Life Sci. 2011, 11, 550-553.