Real-time in situ monitoring of freely suspended and immobilized cell cultures based on mid-infrared spectroscopic measurements

Biotechnology and Bioengineering

Volumn 77, Issue 2, 2002, Pages 174-185

  Rhiel, Martin ^a   Ducommun, Paul ^a   Bolzonella, Ivan ^a   Marison, Ian ^a   Von Stockar, Urs ^a  

^a EPFL   (Switzerland)

Author keywords

Cell culture monitoring; FTIR; Glucose; Lactate; Spectroscopy

Indexed keywords

BIOREACTORS; BIOSENSORS; CELL IMMOBILIZATION; GLUCOSE; INFRARED SPECTROSCOPY; MATHEMATICAL MODELS; METABOLITES; PROFILOMETRY; REGRESSION ANALYSIS; SUSPENSIONS (FLUIDS);

OVARY CELL CULTURES;

CELL CULTURE;

GLUCOSE; LACTIC ACID;

ANIMAL CELL; ARTICLE; BIOREACTOR; CELL CULTURE; CHO CELL; FOURIER TRANSFORMATION; INFRARED SPECTROSCOPY; NONHUMAN; SENSOR;

ANIMALS; CALIBRATION; CHO CELLS; CRICETINAE; MULTIVARIATE ANALYSIS; SENSITIVITY AND SPECIFICITY; SPECTROSCOPY, FOURIER TRANSFORM INFRARED;

CRICETINAE; CRICETULUS GRISEUS;

EID: 0037137921     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/bit.10134     Document Type: Article

References (67)

1. Off-line monitoring of fermentation samples by FTIR/ATR: A feasibility study for real-time process control
2. Analysis of cell-wall carbohydrates and starch in alfalfa by near infrared reflectance spectroscopy
3. Calibration of spectral reaction data
4. Phantom glucose calibration models from simulated noninvasive human near-infrared spectra
5. Standard practices for infrared, multivariate, quantitative analysis
6. Monitoring of glucose in biological fluids by fourier-transform infrared spectrometry with a cylindrical internal reflectance cell
7. An introduction to multivariate calibration and analysis
8. Fermentation control using ATR and an FT-IR spectrometer
9. Biosensors for monitoring microbial processes
10. Determination of nutrient levels in a bioprocess using near-infrared spectroscopy
11. Biosensors for process control
12. Noninvasive method for monitoring ethanol in fermentation processes using fiber-optic near-infrared spectroscopy
13. Simultaneous measurement of glucose and glutamine in aqueous solutions by near-infrared spectroscopy
14. Simultaneous measurements of glucose, glutamine, ammonia, lactate and glutamate in aqueous solutions by near-infrared spectroscopy
15. Comparison of near-IR, raman, and mid-IR spectroscopies for the determination of BTEX in petroleum fuels
16. In situ monitoring of an Escherichia coli fermentation using a diamond composition ATR probe and mid-infrared spectroscopy
17. On-line determination of animal cell concentration
18. Improved L-lysine yield with corynebacterium-glutamicum use of DAPA resulting in increase flux combined with growth limitation
19. Multiple steady states with distinct cellular metabolism in continuous culture of mammalian cells
20. Whey fermentation: On-line analysis of lactose and lactic-acid by FTIR spectroscopy
21. Monitoring of fermentation processes producing lactic-acid bacteria by midinfrared spectroscopy
22. On-line monitoring of fermentation processes by a new remote dispersive middle-infrared spectrometer
23. Determination of major compounds of alcoholic fermentation by middle-infrared spectroscopy - Study of temperature effects and calibration methods
24. Noninvasive spectroscopy for monitoring cell density in a fermentation process
25. Partial least-squares regression: A tutorial
26. Predicting concentrations of individual sugars in dry mixtures by near-infrared reflectance spectroscopy
27. Partial least-squares methods for spectral analyses. 1. Relation to other quantitative calibration methods and the extraction of qualitative information
28. The use of NIR spectroscopy in monitoring and controlling bioprocesses
29. Near-infrared spectroscopic determination of acetate ammonium, biomass, and glycerol in an industrial Escherichia coli fermentation
30. Determination of recombinant protein in animal-cell culture supernatant by near-infrared spectroscopy
31. A technique for monitoring mammalian cell growth and inhibition in situ via fourier transform infrared sectroscopy
32. Correlation of fermentation yield with yeast extract composition as characterized by near-infrared spectroscopy
33. Control of long-term perfusion chinese hamster ovary cell culture by glucose auxostat
34. On-line monitoring of animal cell cultivation
35. Investigation of near-infrared spectroscopy for periodic determination of glucose in cell culture media in situ
36. At-line control and fault analysis in an industrial high cell density Escherichia coli fementation using NIR spectroscopy
37. Yeast protein measurement using near-infrared reflectance spectroscopy
38. Trends in monitoring, optimization and control of mammalian cell bioprocesses
39. Near-infrared spectroscopy for determination of glucose, lactate, and ammonia in cell culture media
40. Principles and applications of biosensors for bioprocess monitoring and control
41. Vorhersage von bioprozessgrössen aus 2D-floureszenzspektren
42. Determination of 18 amino acids in aqueous solutions by near-infrared spectroscopy
43. Mid-infrared spectroscopic monitoring of animal cell culture bioreactor processes
44. Mid-infrared spectroscopic monitoring of animal cell culture bioreactor processes
45. Matrix enhanced calibration procedure for multivariate calibration models with near-infrared spectra
46. Adaptive calibration scheme for quantification of nutrients and byproducts in insect cell bioreactors by near-infrared spectroscopy
47. The effect of analyte concentration range on measurement error obtained by NIR spectroscopy
48. Simultaneous measurement of 19 components in serum-containing animal cell culture media by Fourier Transform near-infrared spectroscopy
49. Simultaneous measurement of glucose and glutamine in insect cell culture media by near infrared spectroscopy
50. A discussion of recent developments in fermentation monitoring and control from a practical perspective
51. Near-infrared spectroscopy in fermentation and quality-control for amino-acid production
52. FTIR spectroscopy applied to bacterial cells as a novel method for monitoring complex biotechnological processes
53. A multivariate calibration problem in analytical chemistry solved by partial least-squares models in latent variables
54. Development of on-line control system for the cultivation of animal cells in a hollow-fiber reactor using flowing injection analysis and a visual programming language
55. A fourier-transform infrared spectroscopic analysis of organic matter degradation in a bench-scale solid substrate fermentation (composting) system
56. A near-infrared spectroscopy technique for the control of fermentation processes: An application to lactic acid fermentation
57. Critical evaluation of models developed for monitoring an industrial submerged bioprocess for antibiotic production using near-infrared spectroscopy
58. Fourier transform infrared detection of pyruvic acid assimilation by E. Coli
59. Multivariate data analysis in Chemistry
60. Infrared spectroscopy of aqueous antibiotic solutions
61. Prediction of the concentrations of ethanol and acetic-acid in the culture broth of a rice vinegar fermentation using near-infrared spectroscopy
62. Prediction of the concentration of several constituents in a mouse-mouse hybridoma culture by near-infrared spectoscopy
63. The use of infrared spectroscopic techniques in Monitoring and controlling bioreactors
64. Selective measurement of glutamine and asparagine in aqueous media by near-infrared spectroscopy