Real time monitoring of multiple parameters in mammalian cell culture bioreactors using an in-line Raman spectroscopy probe

Biotechnology and Bioengineering

Volumn 108, Issue 5, 2011, Pages 1215-1221

  Abu Absi, Nicholas R ^a   Kenty, Brian M ^a   Cuellar, Maryann Ehly ^b   Borys, Michael C ^a   Sakhamuri, Sivakesava ^a   Strachan, David J ^b   Hausladen, Michael C ^a   Li, Zheng Jian ^a  

^a BRISTOL MYERS SQUIBB COMPANY   (United States)

^b Kaiser Optical Systems Inc   (United States)

Author keywords

Bioprocess monitoring; Chinese hamster ovary; Mammalian cell culture; Process analytical technology; Raman spectroscopy

Indexed keywords

BIOPROCESS MONITORING; CELL DENSITY; CHINESE HAMSTER OVARY; COMPLEX MEDIUM; CULTURE PARAMETERS; IN-LINE; INNOVATIVE IDEAS; MAMMALIAN CELL CULTURE; MULTIPLE COMPONENTS; MULTIPLE PARAMETERS; PROCESS ANALYTICAL TECHNOLOGY; RAMAN PROBE; REAL TIME MONITORING; TECHNICAL FEASIBILITY; VIABLE CELLS;

AMINO ACIDS; AMMONIUM COMPOUNDS; ANIMAL CELL CULTURE; BIOCONVERSION; BIOREACTORS; GLUCOSE; INNOVATION; MAMMALS; MANUFACTURE; PROBES; RAMAN SCATTERING; RAMAN SPECTROSCOPY;

CELL CULTURE;

AMMONIA; ANTIBODY; GLUCOSE; GLUTAMIC ACID; GLUTAMINE; HYBRID PROTEIN; LACTIC ACID;

ANALYSIS; ANIMAL CELL; BIOREACTOR; CARBON DIOXIDE TENSION; CELL COUNT; CELL CULTURE; CELL DENSITY; CELL VIABILITY; CHO CELL; FEASIBILITY STUDY; INLINE ANALYSIS; LETTER; MONITORING; NONHUMAN; OXYGEN TENSION; PARAMETER; PH; PROTEIN EXPRESSION; RAMAN SPECTROMETRY; REAL TIME MONITORING;

BIOREACTORS; CELL CULTURE TECHNIQUES; SPECTRUM ANALYSIS, RAMAN;

CRICETULUS GRISEUS; MAMMALIA;

EID: 79953152705     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.23023     Document Type: Letter

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