Process analytical sensors and image-based techniques for single-use bioreactors

Engineering in Life Sciences

Volumn 11, Issue 6, 2011, Pages 550-553

  Bluma, Arne ^a   Höpfner, Tim ^a   Prediger, Andreas ^a   Glindkamp, Anne ^a   Beutel, Sascha ^a   Scheper, Thomas ^a  

^a LEIBNIZ UNIVERSITY HANNOVER   (Germany)

Author keywords

Disposable sensors; Image based sensors; In situ monitoring; Online estimation; Optical sensors

Indexed keywords

BIO-PRODUCTION; BIOPROCESSES; BIOREACTOR SYSTEM; DISPOSABLE SENSOR SYSTEM; DISPOSABLE SENSORS; EFFICIENT CONTROL; IMAGE-BASED SENSOR; IMAGE-BASED TECHNIQUES; IN SITU MONITORING; MARKET DEMAND; MONITORING AND CONTROL; ON-LINE ESTIMATION; PHARMACEUTICAL INDUSTRY; PLASTIC BAGS; PROCESS ANALYTICAL; PROCESS AND ANALYTICAL TECHNOLOGIES; PROCESS DOCUMENTATION; PROCESS PARAMETERS; PRODUCT YIELDS; PRODUCTION PROCESS; SENSOR COMPONENTS; SENSOR SYSTEMS; TECHNICAL ADVANCES; US FOOD AND DRUG ADMINISTRATION;

BIOCONVERSION; BIOREACTORS; BIOTECHNOLOGY; CHEMICAL SENSORS; ESTIMATION; ONLINE SYSTEMS; OPTICAL SENSORS; PARAMETER ESTIMATION; PLASTIC CONTAINERS;

PROCESS CONTROL;

BIOACTIVITY; BIOREACTOR; BIOTECHNOLOGY; ELECTROCHEMICAL METHOD; IMAGING METHOD; IN SITU MEASUREMENT; OPTICAL INSTRUMENT; PHARMACEUTICAL INDUSTRY; SENSOR; TECHNOLOGICAL DEVELOPMENT;

ANALYTICAL EQUIPMENT; ARTICLE; BIOPROCESS; BIOREACTOR; BIOTECHNOLOGY; CARBON DIOXIDE TENSION; CONDUCTANCE; DOCUMENTATION; DRUG INDUSTRY; ELECTROCHEMICAL ANALYSIS; FLUORESCENCE; NONHUMAN; OXYGEN TENSION; SEMICONDUCTOR; SENSOR; TEMPERATURE;

EID: 80052623593     PISSN: 16180240     EISSN: 16182863     Source Type: Journal    
DOI: 10.1002/elsc.201000191     Document Type: Article

References (18)

1. Bluma, A., Höpfner, T., Lindner, P., Rehbock, C. et al., In-situ imaging sensors for bioprocess monitoring: state of the art. Anal. Bioanal. Chem. 2010, 6, 2429-2438.
2. Rehbock, C., Beutel, S., Brückerhoff, T., Hitzmann, B. et al., Bioprozessanalytik. Chem. Ing. Tech. 2008, 3, 267-286.
3. Tservistas, M., Koneke, R., Comte, A., Scheper, T., Oxygen monitoring in supercritical carbon dioxide using a fibre optic sensor. Enzyme Microb. Technol. 2001, 28, 637-641.
4. Konek, R., Comte, A., Jurgens, H., Kohls, O. et al., Faseroptische Sauerstoffsensoren für Biotechnologie, Umwelt- und Lebensmitteltechnik. Chem. Ing. Tech. 1998, 70, 1611-1617.
5. Kohls, O., Scheper, T., Setup of a fiber optical oxygen multisensor-system and its applications in biotechnology. Sens. Actuat. B Chem. 2000, 70, 121-130.
6. Joeris, K., Scheper, T., Visualizing transport processes at liquid-liquid interfaces - the application of laser-induced fluorescence. J. Colloid Interface Sci. 2003, 267, 369-376.
7. Dremel, B. A. A., Schmid, R. D., Optical sensors for bioprocess control. Chem. Ing. Tech. 1992, 64, 510-517.
8. Wolfbeis, O. S., Kovacs, B., Goswami, K., Klainer, S. M., Fiber-optic fluorescence carbon dioxide sensor for environmental monitoring. Mikrochim. Acta 1998, 129, 181-188.
9. Uttamlal, M., Walt, D. R., A fiberoptic carbon-dioxide sensor for fermentation monitoring. Nat. Biotechnol. 1995, 13, 597-601.
10. 2 determination. J. Appl. Physiol. 1958, 13, 515-520.
11. Bergveld, P., Development of an ion-sensitive solid-state device for neurophysiological measurements. IEEE Trans. Biomed. Eng. 1970, 17, 70-71.
12. Khanna, V. K., Ahmad, A., Jain, Y. K., Ahmad, S., Design and development of a novel high-transconductance pH-ISFET (ion-sensitive-field-effect transistor)-based glucose biosensor. Int. J. Electron. 2006, 93, 81-96.
13. Bittner, C., Wehnert, G., Scheper, T., In situ microscopy for on-line determination of biomass. Biotechnol. Bioeng. 1998, 60, 24-35.
14. Rudolph, G., Brückerhoff, T., Bluma, A., Korb, G. et al., Optical inline measurement procedure for cell count and cell size determination in bioprocess technology. Chem. Ing. Tech. 2007, 79, 42-51.
15. Joeris, K., Frerichs, J. G., Konstantinov, K., Scheper, T., In-situ microscopy: online process monitoring of mammalian cell cultures. Cytotechnology 2002, 38, 129-134.
16. Frerichs, J. G., Joeris, K., Konstantinov, K., Scheper, T., Use of an in-situ microscope for on-line observation of animal cell cultures. Chem. Ing. Tech. 2002, 74, 1629-1633.
17. Rudolph, G., Lindner, P., Gierse, A., Bluma, A. et al., Online monitoring of microcarrier based fibroblast cultivations with in-situ microscopy. Biotechnol. Bioeng. 2007, 99, 136-145.
18. Bluma, A., Höpfner, T., Rudolph, G., Lindner, P. et al., Adaptation of in-situ microscopy for crystallization processes. J. Cryst. Growth 2009, 311, 4193-4198.