Oxygen uptake rate optimization with nitrogen regulation for erythromycin production and scale-up from 50 L to 372 m3 scale

Bioresource Technology

Volumn 100, Issue 3, 2009, Pages 1406-1412

  Zou, Xiang ^a,b   Hang, Hai feng ^a   Chu, Ju ^a   Zhuang, Ying ping ^a   Zhang, Si liang ^a  

^a EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b SOUTHWEST UNIVERSITY   (China)

Author keywords

Erythromycin; Industrial scale; Metabolic flux; Oxygen uptake rate; Scale up

Indexed keywords

AMINES; AMINO ACIDS; BIOCHEMICAL ENGINEERING; BIOCHEMISTRY; BIOSYNTHESIS; CITRIC ACID; CONCENTRATION (PROCESS); ENZYME ACTIVITY; FATTY ACIDS; FERMENTERS; GRAIN (AGRICULTURAL PRODUCT); LACTIC ACID; METABOLISM; ORGANIC ACIDS; ORGANIC COMPOUNDS; OXYGEN;

ERYTHROMYCIN; INDUSTRIAL SCALE; METABOLIC FLUX; OXYGEN UPTAKE RATE; SCALE-UP;

NONMETALS;

ALANINE; CITRIC ACID; ERYTHROMYCIN; GLYCINE; LACTIC ACID; NITROGEN; OXYGEN; PHENYLALANINE; PROPIONIC ACID; PYRUVIC ACID; SERINE; THREONINE;

ANTIBIOTICS; FERMENTATION; INDUSTRIAL PRODUCTION; MAIZE; METABOLISM; MICROBIAL ACTIVITY; MONITORING SYSTEM; NITROGEN; OPTIMIZATION; ORGANIC ACID; OXYGEN; SOYBEAN;

ARTICLE; BIOREACTOR; BIOSYNTHESIS; CULTURE MEDIUM; FERMENTATION; MICROBIAL METABOLISM; NONHUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; SOYBEAN;

BIOREACTORS; CELL CULTURE TECHNIQUES; COMPUTER SIMULATION; ERYTHROMYCIN; FEEDBACK; MODELS, BIOLOGICAL; NITROGEN; OXYGEN; OXYGEN CONSUMPTION; PILOT PROJECTS; SACCHAROPOLYSPORA;

GLYCINE MAX; ZEA MAYS;

EID: 55549083820     PISSN: 09608524     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biortech.2008.09.017     Document Type: Article

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