Semisynthetic model calibration for monitoring glucose in mammalian cell culture with in situ near infrared spectroscopy

Biotechnology and Bioengineering

Volumn 111, Issue 5, 2014, Pages 896-903

  Milligan, Michael ^a   Lewin Koh, Nicholas ^a   Coleman, Daniel ^a   Arroyo, Adeyma ^a   Saucedo, Victor ^a  

^a GENENTECH INC   (United States)

Author keywords

CHO cell culture; Glucose; In situ; Model calibration; Near infrared spectroscopy

Indexed keywords

CALIBRATION; FORECASTING; GLUCOSE; INFRARED DEVICES; LEAST SQUARES APPROXIMATIONS; MEAN SQUARE ERROR; NEAR INFRARED SPECTROSCOPY; PRODUCTION ENGINEERING; REGRESSION ANALYSIS;

CHINESE HAMSTER OVARY CELLS; CHO CELL CULTURES; GLUCOSE CONCENTRATION; IN-SITU; MAMMALIAN CELL CULTURE; MODEL CALIBRATION; PARTIAL LEAST-SQUARES REGRESSION; ROOT-MEAN-SQUARE ERROR OF PREDICTIONS;

CELL CULTURE;

AMINO ACID; GLUCOSE; INORGANIC SALT; LACTIC ACID; LIPID; PEPTONE; TRACE ELEMENT; VITAMIN;

ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; BIOLOGICAL MODEL; CALIBRATION; CELL CULTURE MONITORING; CELL DENSITY; CELL VIABILITY; CHO CELL; NEAR INFRARED SPECTROSCOPY; NONHUMAN; PARTIAL LEAST SQUARES REGRESSION; PREDICTION; SEMISYNTHETIC MODEL CALIBRATION;

CRICETULUS GRISEUS; MAMMALIA;

CHO CELL CULTURE; GLUCOSE; IN-SITU; MODEL CALIBRATION; NEAR INFRARED SPECTROSCOPY;

ANIMALS; CALIBRATION; CELL CULTURE TECHNIQUES; CHO CELLS; CRICETINAE; CRICETULUS; CULTURE MEDIA; GLUCOSE; LEAST-SQUARES ANALYSIS; MODELS, BIOLOGICAL; SPECTROSCOPY, NEAR-INFRARED;

EID: 84897029909     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.25161     Document Type: Article

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