Evaluation of software sensors for on-line estimation of culture conditions in an Escherichia coli cultivation expressing a recombinant protein

Journal of Biotechnology

Volumn 147, Issue 1, 2010, Pages 37-45

  Warth, Benedikt ^a   Rajkai, György ^b   Mandenius, Carl Fredrik ^a  

^a LINKÖPING UNIVERSITY   (Sweden)

^b Belach Bioteknik AB   (Sweden)

Author keywords

Near infrared spectrometry; On line estimation; PAT; QbD; Software sensor

Indexed keywords

BIOMASS CONCENTRATIONS; BIOPROCESSES; CULTURE CONDITIONS; GAS ANALYZERS; GREEN FLUORESCENT PROTEIN; HARDWARE SENSORS; NEAR INFRARED SPECTROMETRY; ON-LINE ESTIMATION; PROBE SIGNALS; PROCESS ANALYTICAL TECHNOLOGY; PRODUCT-RATE; QUALITY BY DESIGNS; RECOMBINANT PROTEIN; SOFTWARE MODEL; SOFTWARE SENSOR; SPECIFIC GROWTH RATE; STATE VARIABLES; SUBSTRATE UPTAKE;

ESCHERICHIA COLI; ESTIMATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INFRARED DEVICES; INFRARED SPECTROSCOPY; PROBES; PROTEINS; SENSORS; SOFTWARE ARCHITECTURE; SPECTROMETRY; SUBSTRATES;

COMPUTER SOFTWARE SELECTION AND EVALUATION;

GREEN FLUORESCENT PROTEIN; RECOMBINANT PROTEIN;

ARTICLE; BACTERIUM CULTURE; BIOMASS; COMPUTER PROGRAM; CONTROLLED STUDY; ESCHERICHIA COLI; GROWTH RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTERMETHOD COMPARISON; NEAR INFRARED SPECTROSCOPY; NONHUMAN; ONLINE MONITORING; PRIORITY JOURNAL; PROCESS TECHNOLOGY; PROTEIN EXPRESSION; SENSOR; SPECIES CULTIVATION; CULTURE TECHNIQUE; DEVICES; ENZYME SPECIFICITY; EVALUATION STUDY; GENETIC PROCEDURES; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; ONLINE SYSTEM; PROCEDURES;

BIOMASS; BIOSENSING TECHNIQUES; CELL CULTURE TECHNIQUES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ESCHERICHIA COLI; ONLINE SYSTEMS; RECOMBINANT PROTEINS; SOFTWARE; SUBSTRATE SPECIFICITY;

ESCHERICHIA COLI;

EID: 77951975693     PISSN: 01681656     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbiotec.2010.02.023     Document Type: Article

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