Comparisons of optical pH and dissolved oxygen sensors with traditional electrochemical probes during mammalian cell culture

Biotechnology and Bioengineering

Volumn 97, Issue 4, 2007, Pages 833-841

  Hanson, Michael A ^a,b   Ge, Xudong ^a   Kostov, Yordan ^a   Brorson, Kurt A ^b   Moreira, Antonio R ^a   Rao, Govind ^a  

^a University of Marylandw Baltimore County   (United States)

^b CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

Electrochemical probe; Mammalian cell culture; Optical sensor; Process monitoring; Scale up

Indexed keywords

ELECTROCHEMICAL PROBES; MAMMALIAN CELL CULTURE; PROCESS PARAMETERS;

DISSOLVED OXYGEN; ELECTROCHEMISTRY; MAMMALS; OPTICAL SENSORS; PH EFFECTS; PROCESS MONITORING;

CELL CULTURE;

DISSOLVED OXYGEN;

ARTICLE; CELL CULTURE; CONTROLLED STUDY; CORRELATION COEFFICIENT; ELECTRICAL CONDUCTIVITY PARAMETERS; ELECTROCHEMICAL ANALYSIS; FED BATCH REACTOR; INTERMETHOD COMPARISON; MAMMAL CELL; NEISSERIA MENINGITIDIS; NONHUMAN; OPTICAL BIOSENSOR; OSMOLALITY; OXYGEN SENSING; PH MEASUREMENT;

ANIMALS; ANTIBODIES, MONOCLONAL; BIOREACTORS; BIOSENSING TECHNIQUES; CALIBRATION; CELL CULTURE TECHNIQUES; CELL LINE, TUMOR; CELL SURVIVAL; CULTURE MEDIA; ELECTROCHEMISTRY; HYBRIDOMAS; HYDROGEN-ION CONCENTRATION; IMMUNOGLOBULIN G; MICE; MULTIPLE MYELOMA; OPTICS; OSMOLAR CONCENTRATION; OXYGEN;

MAMMALIA;

EID: 34447334530     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.21320     Document Type: Article

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