Comparative study of non-invasive monitoring via infrared spectroscopy for mammalian cell cultivations

Journal of Biotechnology

Volumn 168, Issue 4, 2013, Pages 636-645

  Sandor, M ^a   Rudinger F ^a   Bienert, R ^b   Grimm, C ^b   Solle, D ^a   Scheper, T ^a  

^a LEIBNIZ UNIVERSITY HANNOVER   (Germany)

^b SARTORIUS STEDIM BIOTECH GMBH   (Germany)

Author keywords

CHO cell cultivation; Infrared spectroscopy; Multivariate data analysis; Online monitoring

Indexed keywords

CHO CELL; CRITICAL PROCESS PARAMETERS; MAMMALIAN CELL CULTIVATIONS; MULTIVARIATE DATA ANALYSIS; ONLINE MONITORING; PARTIAL LEAST-SQUARES REGRESSION; PROCESS ANALYTICAL TECHNOLOGY; ROOT-MEAN-SQUARE ERROR OF PREDICTIONS;

CALIBRATION; GLUCOSE; INFRARED SPECTROSCOPY; MEAN SQUARE ERROR; MULTIVARIANT ANALYSIS;

FORECASTING;

AMMONIA; GLUCOSE; GLUTAMIC ACID; GLUTAMINE; LACTIC ACID;

ACCURACY; ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; CALIBRATION; CELL DENSITY; CELL VIABILITY; CHO CELL; COMPARATIVE STUDY; CONCENTRATION (PARAMETERS); INFRARED SPECTROSCOPY; NON INVASIVE PROCEDURE; NONHUMAN; ONLINE MONITORING; PARTIAL LEAST SQUARES REGRESSION; PREDICTION; PRIORITY JOURNAL; PROCESS ANALYTICAL TECHNOLOGY; PROCESS OPTIMIZATION; PROCESS TECHNOLOGY; VALIDATION STUDY;

ANIMALIA; MAMMALIA;

CHO CELL CULTIVATION; INFRARED SPECTROSCOPY; MULTIVARIATE DATA ANALYSIS; ONLINE MONITORING;

ANIMALS; CELL COUNT; CELL CULTURE TECHNIQUES; GLUCOSE; INTERNET; LACTIC ACID; MAMMALS; SPECTROPHOTOMETRY, INFRARED;

EID: 84888824939     PISSN: 01681656     EISSN: 18734863     Source Type: Journal    
DOI: 10.1016/j.jbiotec.2013.08.002     Document Type: Article

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