Dutch, Flemish, Italian, and Arctic mutations of APP and resistance of Aβ to physiologically relevant proteolytic degradation

Lancet

Volumn 361, Issue 9373, 2003, Pages 1957-1958

  Tsubuki, Satoshi ^a   Takaki, Yoshie ^a   Saido, Takaomi C ^a  

^a RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOIDOSIS; ARTICLE; BIOACCUMULATION; CONTROLLED STUDY; FIBROGENESIS; GENE MUTATION; GENE SEQUENCE; GENETIC CODE; GENETIC RESISTANCE; HALF LIFE TIME; HUMAN; ITALY; NETHERLANDS; PATHOGENICITY; PHYSIOLOGY; PRIORITY JOURNAL; PROTEIN DEGRADATION;

EID: 0038204547     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(03)13555-6     Document Type: Article

References (5)

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2. Saito T, Takaki, Y, Iwata, N, Trojanowski, J, Saido TC. Perspectives: Alzheimer's disease, neuropeptide, neuropeptidase, and amyloid β peptide metabolism. Science SAGE-KE. Jan 22, 2003; http://sageke.sciencemag.org/cgi/content/full/sageke;2003/3/pe1 (accessed Jan 23, 2003).
3. Oefner C., D'Arcy A., Hennig M., Winkler F.K., Dale G.E. Structure of human neutral endopeptidase (neprilysin) complexed with phosphoramidon. J Mol Biol. 296:2000;341-349.
4. Perez A., Morelli L., Cresto J.C., Castano E.M. Degradation of soluble amyloid beta-peptides 1-40, 1-42, and the Dutch variant 1-40Q by insulin degrading enzyme from Alzheimer disease and control brains. Neurochem Res. 25:2000;247-255.
5. Kumar-Singh S., Dewachter I., Moechars D., et al. Behavioral disturbances without amyloid deposits in mice overexpressing human amyloid precursor protein with Flemish (A692G) or Dutch (E693Q) mutation. Neurobiol Dis. 7:2000;9-22.