A three-dimensional human neural cell culture model of Alzheimer's disease

Nature

Volumn 515, Issue 7526, 2014, Pages 274-278

  Choi, Se Hoon ^a   Kim, Young Hye ^a,b   Hebisch, Matthias ^a,c   Sliwinski, Christopher ^a   Lee, Seungkyu ^d   D'Avanzo, Carla ^a   Chen, Hechao ^a   Hooli, Basavaraj ^a   Asselin, Caroline ^a   Muffat, Julien ^e   Klee, Justin B ^a   Zhang, Can ^a   Wainger, Brian J ^d   Peitz, Michael ^c   Kovacs, Dora M ^a   Woolf, Clifford J ^d   Wagner, Steven L ^f   Tanzi, Rudolph E ^a   Kim, Doo Yeon ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b Korea Basic Science Institute (KBSI)   (South Korea)

^c UNIVERSITY OF BONN   (Germany)

^d BOSTON CHILDREN S HOSPITAL   (United States)

^e WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE INHIBITOR; DETERGENT; FLAVINE ADENINE NUCLEOTIDE; GAMMA SECRETASE INHIBITOR; GLYCOGEN SYNTHASE KINASE 3; PRESENILIN 1; SILVER; TAU PROTEIN; MAP2 PROTEIN, HUMAN; MICROTUBULE ASSOCIATED PROTEIN; PRESENILIN 1, MOUSE;

BIOACCUMULATION; DISEASE PREVALENCE; ENZYME ACTIVITY; MUTATION; NEUROLOGY; NUMERICAL MODEL; PATHOLOGY; THREE-DIMENSIONAL MODELING; TOXICITY;

ALZHEIMER DISEASE; ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; EXTRACELLULAR MATRIX; GENE EXPRESSION; GENE MUTATION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNOELECTRON MICROSCOPY; MEDIATOR; NERVE CELL CULTURE; NERVE CELL DIFFERENTIATION; NEURITE; NEUROPATHOLOGY; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN PHOSPHORYLATION; SOMATIC CELL; TAUOPATHY; BIOLOGICAL MODEL; CELL DIFFERENTIATION; CHEMISTRY; CULTURE TECHNIQUE; DRUG SCREENING; EXTRACELLULAR SPACE; GENETICS; METABOLISM; NEURAL STEM CELL; PATHOLOGY; PHOSPHORYLATION; PROCEDURES; PROTEINOSIS; REPRODUCIBILITY;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; DRUG EVALUATION, PRECLINICAL; EXTRACELLULAR SPACE; GLYCOGEN SYNTHASE KINASE 3; HUMANS; MICROTUBULE-ASSOCIATED PROTEINS; MODELS, BIOLOGICAL; NEURAL STEM CELLS; NEURITES; PHOSPHORYLATION; PRESENILIN-1; PROTEIN AGGREGATION, PATHOLOGICAL; REPRODUCIBILITY OF RESULTS; TAU PROTEINS;

EID: 84912064761     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature13800     Document Type: Article

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