Increased mtDNA mutations with aging promotes amyloid accumulation and brain atrophy in the APP/Ld transgenic mouse model of Alzheimer's disease

Molecular Neurodegeneration

Volumn 9, Issue 1, 2014, Pages

  Kukreja, Lokesh ^a   Kujoth, Gregory C ^b   Prolla, Tomas A ^b   Van Leuven, Fred ^c   Vassar, Robert ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

^c UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Alzheimer's disease; Amyloid; APP Ld; A ; Brain atrophy; Insulin degrading enzyme; mitochondrial dysfunction; Neurodegeneration; PolgA D257A

Indexed keywords

AMYLOID; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-42]; CASPASE 3; INSULINASE; MITOCHONDRIAL DNA; PROTEIN P25;

ALZHEIMER DISEASE; AMYLOID PLAQUE; ANIMAL CELL; ANIMAL MODEL; ARTICLE; BIOENERGY; BRAIN ATROPHY; BRAIN HOMOGENATE; BRAIN NERVE CELL; CELL STRUCTURE; CONTROLLED STUDY; DISEASE SEVERITY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENZYME METABOLISM; GENE MUTATION; HUMAN; HUMAN TISSUE; IN VIVO STUDY; MOUSE; NERVE DEGENERATION; NEUROPATHOLOGY; NONHUMAN; PHENOTYPE; PREMATURE AGING; PROTEIN SYNTHESIS; TRANSGENE; TRANSGENIC MOUSE;

MUS; MUS MUSCULUS;

AGING; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; ATROPHY; BRAIN; DISEASE MODELS, ANIMAL; DNA, MITOCHONDRIAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLUORESCENT ANTIBODY TECHNIQUE; GENE KNOCK-IN TECHNIQUES; HUMANS; IMMUNOBLOTTING; MICE; MICE, TRANSGENIC; MUTATION; PLAQUE, AMYLOID;

EID: 84901294948     PISSN: None     EISSN: 17501326     Source Type: Journal    
DOI: 10.1186/1750-1326-9-16     Document Type: Article

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