Modification of γ-secretase by nitrosative stress links neuronal ageing to sporadic Alzheimer's disease

EMBO Molecular Medicine

Volumn 4, Issue 7, 2012, Pages 660-673

  Guix, Francesc X ^a,b   Wahle, Tina ^a,b   Vennekens, Kristel ^a,b   Snellinx, An ^a,b   Chávez Gutiérrez, Lucía ^a,b   Ill Raga, Gerard ^c   Ramos Fernandez, Eva ^c   Guardia Laguarta, Cristina ^d   Lleó, Alberto ^d   Arimon, Muriel ^e   Berezovska, Oksana ^e   Muñoz, Francisco J ^c   Dotti, Carlos G ^a,b,f   De Strooper, Bart ^a,b  

^a DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^b UNIVERSITY OF LEUVEN   (Belgium)

^c UNIVERSITAT POMPEU FABRA   (Spain)

^d HOSPITAL DE LA SANTA CREU I SANT PAU   (Spain)

^e MASSACHUSETTS GENERAL HOSPITAL   (United States)

^f CENTRO DE BIOLOGÍA MOLECULAR SEVERO OCHOA   (Spain)

Author keywords

Ageing; Alzheimer's disease; Gamma secretase; Peroxynitrite; Presenilin 1

Indexed keywords

AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; GAMMA SECRETASE; MANGANESE SUPEROXIDE DISMUTASE; PEROXYNITRITE; PRESENILIN 1; SUPEROXIDE;

AGING; ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; CATALYSIS; CHEMICAL MODIFICATION; IN VITRO STUDY; NITROSATIVE STRESS; NITROTYROSINATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; BRAIN; CATALYTIC DOMAIN; CELL AGING; CELLS, CULTURED; HUMANS; MICE; NEURONS; PEPTIDE FRAGMENTS; PEROXYNITROUS ACID; PRESENILIN-1; RISK FACTORS; RNA INTERFERENCE; RNA, SMALL INTERFERING; SUPEROXIDE DISMUTASE;

EID: 84862307062     PISSN: 17574676     EISSN: 17574684     Source Type: Journal    
DOI: 10.1002/emmm.201200243     Document Type: Article

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