Initiation and synergistic fibrillization of tau and alpha-synuctein

Science

Volumn 300, Issue 5619, 2003, Pages 636-640

  Giasson, Benoit I ^a   Forman, Mark S ^a   Higuchi, Makoto ^a   Golbe, Lawrence I ^b   Graves, Charles L ^a   Kotzbauer, Paul T ^a   Trojanowski, John Q ^a   Lee, Virginia M Y ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INCLUSIONS; POLYMERIZATION; PROTEINS;

FIBRILLIZATION;

DISEASES;

ALPHA SYNUCLEIN; AMYLOID; TAU PROTEIN;

NEUROLOGY; PATHOLOGY; SYNERGISM;

ARTICLE; CELL INCLUSION; DEGENERATIVE DISEASE; HUMAN; NERVE CELL; NONHUMAN; OLIGODENDROGLIA; PATHOGENICITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN POLYMERIZATION; PROTEIN PROTEIN INTERACTION; REACTION ANALYSIS;

ALPHA-SYNUCLEIN; AMYLOID; ANIMALS; BIOPOLYMERS; BRAIN CHEMISTRY; HUMANS; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; MICE, TRANSGENIC; MICROSCOPY, ELECTRON; MICROSCOPY, FLUORESCENCE; MICROSCOPY, IMMUNOELECTRON; NERVE TISSUE PROTEINS; NEURODEGENERATIVE DISEASES; NEURONS; OLIGODENDROGLIA; PROTEIN CONFORMATION; PROTEIN ISOFORMS; SYNUCLEINS; TAU PROTEINS; TAUOPATHIES;

MUS MUSCULUS;

EID: 0037466656     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1082324     Document Type: Article

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34. Supported by grants from the National Institutes on Aging (NIA) and by a Pioneer Award from the Alzheimer's Association. B.I.G. is a Postdoctoral Fellow of the Canadian Institutes of Health Research. M.S.F. is supported by a mentored Clinical Scientist Development Award from the NIA. P.T.K. is a Howard Hughes Medical Institute Physician Postdoctoral Fellow. V.M.Y.L. is the John H. Ware III Chair of Alzheimer's Disease Research at the University of Pennsylvania. We thank L. Kwong for her advice and expertise in the coassembly of Aβ(1-40) and tau and M. Gravel and P. Braun for the expression vector mCNP4.2(Xba I)/SK.