Human and murine apoE markedly alters Aβ metabolism before and after plaque formation in a mouse model of Alzheimer's Disease

Neurobiology of Disease

Volumn 9, Issue 3, 2002, Pages 305-318

  Fagan, Anne M ^a   Watson, Melanie ^a   Parsadanian, Maia ^a   Bales, Kelly R ^c   Paul, Steven M ^c,d   Holtzman, David M ^a,b  

^a Center for the Study of Nervous System Injury   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c ELI LILLY AND COMPANY   (United States)

^d INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; APOLIPOPROTEIN E2; APOLIPOPROTEIN E3; APOLIPOPROTEIN E4;

AGING; ALLELE; ALZHEIMER DISEASE; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; IN VIVO STUDY; MOUSE; NEUROFIBRILLARY TANGLE; NEUROFILAMENT; NONHUMAN; PATHOGENESIS; PLAQUE FORMING CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN METABOLISM; RISK FACTOR; TRANSGENIC MOUSE;

EID: 0036233168     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1006/nbdi.2002.0483     Document Type: Article

References (68)

1. Lipid binding to amyloid beta-peptide aggregates: Preferential binding of cholesterol as compared with phosphatidylcholine and fatty acids
2. V717F transgenic mouse model of Alzheimer's disease
3. Lack of apolipoprotein E dramatically reduces amyloid β-peptide deposition
4. Apolipoprotein E isoform-specific reduction of extracellular amyloid in neuronal cultures
5. Flotillin and epidermal surface antigen define a new family of caveolae-associated integral membrane proteins
6. Co-expression of beta-amyloid precursor protein (betaAPP) and apolipoprotein E in cell culture: Analysis of betaAPP processing
7. Human apolipoprotein E4 accelerates β-amyloid deposition in APPsw transgenic mouse brain
8. Fibrillogenesis in Alzheimer's disease of amyloid beta peptides and apolipoprotein E
9. Acceleration of amyloid fibril formation by specific binding of Aβ-(1-40) peptide to ganglioside-containing membrane vesicles
10. Influence of lipoproteins on microglial degradation of Alzheimer's amyloid beta-protein
11. Alzheimer's A beta (1-42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells
12. Protective effect of apolipoprotein E type 2 allele decreases risk of late onset Alzheimer disease
13. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families
14. Astrocyte lipoproteins, effects of apoE on neuronal function, and role for apoE in amyloid-β deposition in vivo
15. The regions of the Fe65 protein homologous to the phosphotyrosine interaction/phosphotyrosine binding domain of Shc bind the intracellular domain of the Alzheimer's amyloid precursor protein
16. Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein
17. Intraneuronal Aβ42 accumulation in human brain
18. Association of a novel human FE65-like protein with the cytoplasmic domain of the beta-amyloid precursor protein
19. Distinct sites of intracellular production of Alzheimer's disease Abeta 40/42 amyloid peptides
20. The LDL Receptor gene family: (Un)expected signal transducers in the brain
21. Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease
22. Expression of human apolipoprotein E reduces amyloid-β deposition in a mouse model of Alzheimer's disease
23. ApoE is required for neuritic and cerebrovascular plaque formation ion the APPsw mouse model of Alzheimer's disease
24. Perforant pathway changes and the memory impairment of Alzheimer's disease
25. V717F transgenic mice
26. Aβ deposition is associated with neuropil changes, but not with overt neuronal loss in the human amyloid precursor protein V717F (PDAPP) transgenic mouse
27. Amyloid precursor protein processing and Aβ42 deposition in a transgenic mouse model of Alzheimer's disease
28. Isoform-specific effect of apolipoprotein E on cell survival and beta-amyloid-induced toxicity in rat hippocampal pyramidal neuronal cultures
29. Cell surface APP751 forms complexes with protease nexin 2 ligands and is internalized via the low density lipoprotein receptor-related protein (LRP)
30. Evidence that production and release of amyloid β-protein involves the endocytic pathway
31. LDL-receptor-related protein, a multifunctional apoE receptor, binds secreted β-amyloid precursor protein and mediates its degradation
32. Association of human, rat, and rabbit apolipoprotein E with β-amyloid
33. A detergent-insoluble membrane compartment contains Aβ in vivo
34. Characterization of caveolin-rich membrane domains isolated from an endothelial-rich source: Implication for human disease
35. Amyloid-associated proteins alpha-1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer beta-protein into filaments
36. The presence of amyloid β-protein in the detergent-insoluble membrane compartment of human neuroblastoma cells
37. Tangles and plaques in nondemented aging and "preclinical" Alzheimer's disease
38. Apolipoprotein E in sporadic Alzheimer's disease: Allelic variation and receptor interactions
39. Localization of apolipoprotein E receptor 2 to caveolae in the plasma membrane
40. Association of apolipoprotein E allele ε4 with late-onset familial and sporadic Alzheimer's disease
41. Increased amyloid β-peptide deposition in cerebral cortex as a consequence of apolipoprotein genotype in late-onset Alzheimer disease
42. Familial dysbetalipoproteinemia. Abnormal binding of mutant apoprotein E to low density lipoprotein receptors of human fibroblasts and membranes from liver and adrenal of rats, rabbits, and cows
43. 1-40 peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier
44. Detection of a novel intraneuronal pool of insoluble amyloid β protein that accumulates with time in culture
45. Apolipoprotein E: High avidity binding to β-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease
46. GFAP-apoE transgenic mice: Astrocyte specific expression and differing biological effects of astrocyte-secreted apoE3 and apoE4 lipoproteins
47. Presence of soluble amyloid β-peptide precedes amyloid plaque formation in Down's syndrome
48. Apolipoprotein E isotype-specific effects in neurodegeneration
49. Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein
50. Modulation of β-amyloid precursor protein processing by the low density lipoprotein receptor-related protein (LRP): Evidence that LRP contributes to the pathogenesis of Alzheimer's disease
51. Cerebrovascular smooth muscle cells internalize Alzheimer amyloid beta protein via a lipoprotein pathway: Implications for cerebral amyloid angiopathy
52. Astrocytes down-regulate neuronal β-amyloid precursor protein expression and modify its processing in an apolipoprotein E isoform-specific manner
53. Cholesterol dependent γ-secretase activity in buoyant cholesterol-rich membrane microdomains
54. The levels of soluble versus insoluble brain Aβ distinguish Alzheimer's disease from normal and pathologic aging
55. Abnormal lipoprotein receptor-binding activity of the human E apoprotein due to cysteine-arginine interchange at a single site
56. Frequency of the apolipoprotein E ε2 allele is diminished in sporadic Alzheimer's disease
57. New stereological methods for counting neurons
58. Intracellular generation and accumulation of amyloid-β peptide terminating at amino acid 42
59. Biology of Aβ amyloid in Alzheimer's disease
60. Generation of Alzheimer β-amyloid protein in the trans-Golgi network in the apparent absence of vesicle formation
61. Isolation and characterization of apolipoproteins from murine microglia: Identification of a low density lipoprotein-like apolipoprotein J-rich but apoE-poor spherical particle
62. Amyloid β protein (Aβ) starts to deposit as plasma membrane-bound form in diffuse plaques of brains from hereditary cerebral hemorrhage with amyloidosis-Dutch type, Alzheimer disease and non-demented aged subjects
63. Accumulation and aggregation of amyloid β-protein in late endosomes of Niemann-pick type C cells
64. GM1 ganglioside-bound amyloid beta-protein (A beta): A possible form of preamyloid in Alzheimer's disease
65. Intracellular accumulation of insoluble, newly synthesized A-beta n-42 in amyloid precursor protein-transfected cells that have been treated with Abeta 1-42
66. Characterization of the binding of amyloid-β peptide to cell culture-derived native apolipoprotein E2, E3, and E4 isoforms and to isoforms from human plasma
67. Glycoprotein 330/megalin: Probable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer's disease amyloid β at the blood-brain and blood-cerebrospinal fluid barriers