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Volumn 209, Issue 12, 2012, Pages 2149-2156

Anti-apoE immunotherapy inhibits amyloid accumulation in a transgenic mouse model of Aβ amyloidosis

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; APOLIPOPROTEIN E; HJ6.3 ANTIBODY; MONOCLONAL ANTIBODY; UNCLASSIFIED DRUG;

EID: 84871887566     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20121274     Document Type: Article
Times cited : (120)

References (25)
  • 1
    • 0033835996 scopus 로고    scopus 로고
    • Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease
    • Bard, F., C. Cannon, R. Barbour, R.L. Burke, D. Games, H. Grajeda, T.Guido, K. Hu, J. Huang, K. Johnson-Wood, et al. 2000. Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease. Nat. Med. 6:916-919. http://dx.doi.org/10.1038/78682
    • (2000) Nat. Med. , vol.6 , pp. 916-919
    • Bard, F.1    Cannon, C.2    Barbour, R.3    Burke, R.L.4    Games, D.5    Grajeda, H.6    Guido, T.7    Hu, K.8    Huang, J.9    Johnson-Wood, K.10
  • 2
    • 84858423000 scopus 로고    scopus 로고
    • Reducing human apolipoprotein E levels attenuates age-dependent Aβ accumulation in mutant human amyloid precursor protein transgenic mice
    • Bien-Ly, N., A.K. Gillespie, D. Walker, S.Y. Yoon, and Y. Huang. 2012. Reducing human apolipoprotein E levels attenuates age-dependent Aβ accumulation in mutant human amyloid precursor protein transgenic mice. J. Neurosci. 32:4803-4811. http://dx.doi.org/10.1523/JNEUROSCI.0033-12.2012
    • (2012) J. Neurosci. , vol.32 , pp. 4803-4811
    • Bien-Ly, N.1    Gillespie, A.K.2    Walker, D.3    Yoon, S.Y.4    Huang, Y.5
  • 3
    • 47949132196 scopus 로고    scopus 로고
    • Active and passive immunotherapy for neurodegenerative disorders
    • Brody, D.L., and D.M. Holtzman. 2008. Active and passive immunotherapy for neurodegenerative disorders. Annu. Rev. Neurosci. 31:175-193. http://dx.doi.org/10.1146/annurev.neuro.31.060407.125529
    • (2008) Annu. Rev. Neurosci. , vol.31 , pp. 175-193
    • Brody, D.L.1    Holtzman, D.M.2
  • 8
    • 65649091306 scopus 로고    scopus 로고
    • Quantitative and mechanistic studies of Abeta immunotherapy
    • Golde, T.E., P. Das, and Y. Levites. 2009. Quantitative and mechanistic studies of Abeta immunotherapy. CNS Neurol. Disord. Drug Targets. 8:31-49. http://dx.doi.org/10.2174/187152709787601830
    • (2009) Drug Targets , vol.8 , pp. 31-49
    • Golde, T.E.1    Das, P.2    Levites, Y.3
  • 9
    • 78751692575 scopus 로고    scopus 로고
    • Anti-aβ therapeutics in Alzheimer's disease: the need for a paradigm shift
    • Golde, T.E., L.S. Schneider, and E.H. Koo. 2011. Anti-aβ therapeutics in Alzheimer's disease: the need for a paradigm shift. Neuron. 69:203-213. http://dx.doi.org/10.1016/j.neuron.2011.01.002
    • (2009) Neuron , vol.69 , pp. 203-213
    • Golde, T.E.1    Schneider, L.S.2    Koo, E.H.3
  • 10
    • 79953854897 scopus 로고    scopus 로고
    • Alzheimer's disease: the challenge of the second century
    • Holtzman, D.M., J.C. Morris, and A.M. Goate. 2011. Alzheimer's disease: the challenge of the second century. Sci. Transl. Med. 3:sr1.
    • (2011) Sci. Transl. Med. , vol.3
    • Holtzman, D.M.1    Morris, J.C.2    Goate, A.M.3
  • 11
    • 1642555780 scopus 로고    scopus 로고
    • Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase
    • Jankowsky, J.L., D.J. Fadale, J. Anderson, G.M. Xu, V. Gonzales, N.A. Jenkins, N.G. Copeland, M.K. Lee, L.H. Younkin, S.L. Wagner, et al.2004. Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase. Hum. Mol. Genet. 13:159-170. http://dx.doi.org/10.1093/hmg/ddh019
    • (2004) Hum. Mol. Genet. , vol.13 , pp. 159-170
    • Jankowsky, J.L.1    Fadale, D.J.2    Anderson, J.3    Xu, G.M.4    Gonzales, V.5    Jenkins, N.A.6    Copeland, N.G.7    Lee, M.K.8    Younkin, L.H.9    Wagner, S.L.10
  • 13
    • 68249134074 scopus 로고    scopus 로고
    • The role of apolipo-protein E in Alzheimer's disease
    • Kim, J., J.M. Basak, and D.M. Holtzman. 2009a. The role of apolipo-protein E in Alzheimer's disease. Neuron. 63:287-303. http://dx.doi.org/10.1016/j.neuron.2009.06.026
    • (2009) Neuron. , vol.63 , pp. 287-303
    • Kim, J.1    Basak, J.M.2    Holtzman, D.M.3
  • 14
    • 71449125786 scopus 로고    scopus 로고
    • Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance
    • Kim, J., J.M. Castellano, H. Jiang, J.M. Basak, M. Parsadanian, V. Pham, S.M. Mason, S.M. Paul, and D.M. Holtzman. 2009b. Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance. Neuron. 64:632-644. http://dx.doi.org/10.1016/j.neuron.2009.11.013
    • (2009) Neuron , vol.64 , pp. 632-644
    • Kim, J.1    Castellano, J.M.2    Jiang, H.3    Basak, J.M.4    Parsadanian, M.5    Pham, V.6    Mason, S.M.7    Paul, S.M.8    Holtzman, D.M.9
  • 15
    • 83055160869 scopus 로고    scopus 로고
    • Haploinsufficiency of human APOE reduces amyloid deposition in a mouse model of amyloid-β amyloidosis
    • Kim, J., H. Jiang, S. Park, A.E. Eltorai, F.R. Stewart, H. Yoon, J.M. Basak, M.B. Finn, and D.M. Holtzman. 2011. Haploinsufficiency of human APOE reduces amyloid deposition in a mouse model of amyloid-β amyloidosis. J. Neurosci. 31:18007-18012. http://dx.doi .org/10.1523/JNEUROSCI.3773-11.2011
    • (2011) J. Neurosci. , vol.31 , pp. 18007-18012
    • Kim, J.1    Jiang, H.2    Park, S.3    Eltorai, A.E.4    Stewart, F.R.5    Yoon, H.6    Basak, J.M.7    Finn, M.B.8    Holtzman, D.M.9
  • 17
    • 70349807619 scopus 로고    scopus 로고
    • Immune activation in brain aging and neurodegeneration: too much or too little?
    • Lucin, K.M., and T. Wyss-Coray. 2009. Immune activation in brain aging and neurodegeneration: too much or too little? Neuron. 64:110-122. http://dx.doi.org/10.1016/j.neuron.2009.08.039
    • (2009) Neuron. , vol.64 , pp. 110-122
    • Lucin, K.M.1    Wyss-Coray, T.2
  • 18
    • 0028173205 scopus 로고
    • Amyloid-associated proteins alpha 1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer beta-protein into filaments
    • Ma, J., A. Yee, H.B. Brewer Jr., S. Das, and H. Potter. 1994. Amyloid-associated proteins alpha 1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer beta-protein into filaments. Nature. 372:92-94. http://dx.doi.org/10.1038/372092a0
    • (1994) Nature , vol.372 , pp. 92-94
    • Ma, J.1    Yee, A.2    Brewer Jr., H.B.3    Das, S.4    Potter, H.5
  • 19
    • 0025971426 scopus 로고
    • Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease
    • Namba, Y., M. Tomonaga, H. Kawasaki, E. Otomo, and K. Ikeda. 1991. Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease. Brain Res. 541:163-166. http://dx.doi.org/10.1016/0006-8993(91)91092-F
    • (1991) Brain Res. , vol.541 , pp. 163-166
    • Namba, Y.1    Tomonaga, M.2    Kawasaki, H.3    Otomo, E.4    Ikeda, K.5
  • 20
    • 33845484383 scopus 로고    scopus 로고
    • Blocking the apolipoprotein E/amyloid-beta interaction as a potential therapeutic approach for Alzheimer's disease
    • USA
    • Sadowski, M.J., J. Pankiewicz, H. Scholtzova, P.D. Mehta, F. Prelli, D. Quartermain, and T. Wisniewski. 2006. Blocking the apolipoprotein E/amyloid-beta interaction as a potential therapeutic approach for Alzheimer's disease. Proc. Natl. Acad. Sci. USA. 103:18787-18792. http://dx.doi.org/10.1073/pnas.0604011103
    • (2006) Proc. Natl. Acad. Sci. , vol.103 , pp. 18787-18792
    • Sadowski, M.J.1    Pankiewicz, J.2    Scholtzova, H.3    Mehta, P.D.4    Prelli, F.5    Quartermain, D.6    Wisniewski, T.7
  • 22
    • 79952775194 scopus 로고    scopus 로고
    • Robust amyloid clearance in a mouse model of Alzheimer's disease provides novel insights into the mechanism of amyloid-β immunotherapy
    • Wang, A., P. Das, R.C. Switzer III, T.E. Golde, and J.L. Jankowsky. 2011. Robust amyloid clearance in a mouse model of Alzheimer's disease provides novel insights into the mechanism of amyloid-β immunotherapy. J. Neurosci. 31:4124-4136. http://dx.doi.org/10.1523/JNEUROSCI.5077-10.2011
    • (2011) J. Neurosci. , vol.31 , pp. 4124-4136
    • Wang, A.1    Das, P.2    Switzer III, R.C.3    Golde, T.E.4    Jankowsky, J.L.5
  • 23
    • 1642497601 scopus 로고    scopus 로고
    • Microglial activation facilitates Abeta plaque removal following intracranial anti-Abeta antibody administration
    • Wilcock, D.M., S.K. Munireddy, A. Rosenthal, K.E. Ugen, M.N. Gordon, and D. Morgan. 2004. Microglial activation facilitates Abeta plaque removal following intracranial anti-Abeta antibody administration. Neurobiol. Dis. 15:11-20. http://dx.doi.org/10.1016/j.nbd .2003.09.015
    • (2004) Neurobiol. Dis. , vol.15 , pp. 11-20
    • Wilcock, D.M.1    Munireddy, S.K.2    Rosenthal, A.3    Ugen, K.E.4    Gordon, M.N.5    Morgan, D.6
  • 24
    • 0026542786 scopus 로고
    • Apolipoprotein E: a pathological chaperone protein in patients with cerebral and systemic amyloid
    • Wisniewski, T., and B. Frangione. 1992. Apolipoprotein E: a pathological chaperone protein in patients with cerebral and systemic amyloid. Neurosci. Lett. 135:235-238. http://dx.doi.org/10.1016/0304-3940 (92)90444-C
    • (1992) Neurosci. Lett. , vol.135 , pp. 235-238
    • Wisniewski, T.1    Frangione, B.2
  • 25
    • 0027970307 scopus 로고
    • Acceleration of Alzheimer's fibril formation by apolipoprotein E in vitro
    • Wisniewski, T., E.M. Castão, A. Golabek, T. Vogel, and B. Frangione. 1994. Acceleration of Alzheimer's fibril formation by apolipoprotein E in vitro. Am. J. Pathol. 145:1030-1035.
    • (1994) Am. J. Pathol. , vol.145 , pp. 1030-1035
    • Wisniewski, T.1    Castão, E.M.2    Golabek, A.3    Vogel, T.4    Frangione, E.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.