메뉴 건너뛰기




Volumn 33, Issue 9, 2013, Pages 3765-3779

Reversible pathologic and cognitive phenotypes in an inducible model of Alzheimer-amyloidosis

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN [1-42]; AMYLOID PRECURSOR PROTEIN; UNCLASSIFIED DRUG;

EID: 84874605021     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4251-12.2013     Document Type: Article
Times cited : (43)

References (61)
  • 1
    • 0035830686 scopus 로고    scopus 로고
    • Progressive, age-related behavioral impairments in transgenic mice carrying both mutant amyloid precursor protein and presenilin-1 transgenes
    • CrossRef Medline
    • Arendash GW, King DL, Gordon MN, Morgan D, Hatcher JM, Hope CE, Diamond DM (2001) Progressive, age-related behavioral impairments in transgenic mice carrying both mutant amyloid precursor protein and presenilin-1 transgenes. Brain Res 891:42-53. CrossRef Medline
    • (2001) Brain Res , vol.891 , pp. 42-53
    • Arendash, G.W.1    King, D.L.2    Gordon, M.N.3    Morgan, D.4    Hatcher, J.M.5    Hope, C.E.6    Diamond, D.M.7
  • 4
    • 0033586449 scopus 로고    scopus 로고
    • Impairments in learning and memory accompanied by neurodegeneration in mice transgenic for the carboxyl-terminus of the amyloid precursor protein
    • Medline
    • Berger-Sweeney J, McPhie DL, Arters JA, Greenan J, Oster-Granite ML, Neve RL (1999) Impairments in learning and memory accompanied by neurodegeneration in mice transgenic for the carboxyl-terminus of the amyloid precursor protein. Brain Res Mol Brain Res 66:150-162. Medline
    • (1999) Brain Res Mol Brain Res , vol.66 , pp. 150-162
    • Berger-Sweeney, J.1    McPhie, D.L.2    Arters, J.A.3    Greenan, J.4    Oster-Granite, M.L.5    Neve, R.L.6
  • 5
    • 0037388574 scopus 로고    scopus 로고
    • Switching memory systems during learning: Changes in patterns of brain acetylcholine release in the hippocampus and striatum in rats
    • Medline
    • Chang Q, Gold PE (2003) Switching memory systems during learning: changes in patterns of brain acetylcholine release in the hippocampus and striatum in rats. J Neurosci 23:3001-3005. Medline
    • (2003) J Neurosci , vol.23 , pp. 3001-3005
    • Chang, Q.1    Gold, P.E.2
  • 6
    • 79551633353 scopus 로고    scopus 로고
    • β-Secretase inhibitor GRL-8234 rescues age-related cognitive decline in APP transgenic mice
    • CrossRef Medline
    • Chang WP, Huang X, Downs D, Cirrito JR, Koelsch G, Holtzman DM, Ghosh AK, Tang J (2011) β-Secretase inhibitor GRL-8234 rescues age-related cognitive decline in APP transgenic mice. FASEB J 25:775-784. CrossRef Medline
    • (2011) FASEB J , vol.25 , pp. 775-784
    • Chang, W.P.1    Huang, X.2    Downs, D.3    Cirrito, J.R.4    Koelsch, G.5    Holtzman, D.M.6    Ghosh, A.K.7    Tang, J.8
  • 8
    • 16944362157 scopus 로고    scopus 로고
    • Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice
    • CrossRef Medline
    • Citron M, Westaway D, Xia W, Carlson G, Diehl T, Levesque G, Johnson-Wood K, Lee M, Seubert P, Davis A, et al. (1997) Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice. Nat Med 3:67-72. CrossRef Medline
    • (1997) Nat Med , vol.3 , pp. 67-72
    • Citron, M.1    Westaway, D.2    Xia, W.3    Carlson, G.4    Diehl, T.5    Levesque, G.6    Johnson-Wood, K.7    Lee, M.8    Seubert, P.9    Davis, A.10
  • 11
    • 0030447110 scopus 로고    scopus 로고
    • Chronic stress impairs rat spatial memory on the Y maze, and this effect is blocked by tianeptine pretreatment
    • CrossRef Medline
    • Conrad CD, Galea LA, Kuroda Y, McEwen BS (1996) Chronic stress impairs rat spatial memory on the Y maze, and this effect is blocked by tianeptine pretreatment. Behav Neurosci 110:1321-1334. CrossRef Medline
    • (1996) Behav Neurosci , vol.110 , pp. 1321-1334
    • Conrad, C.D.1    Galea, L.A.2    Kuroda, Y.3    McEwen, B.S.4
  • 12
    • 0024003321 scopus 로고
    • Caudate nucleus and memory for egocentric localization
    • CrossRef Medline
    • Cook D, Kesner RP (1988) Caudate nucleus and memory for egocentric localization. Behav Neural Biol 49:332-343. CrossRef Medline
    • (1988) Behav Neural Biol , vol.49 , pp. 332-343
    • Cook, D.1    Kesner, R.P.2
  • 14
    • 0031104085 scopus 로고    scopus 로고
    • Extension of a new two trial memory task in the rat: Influence of environmental context on recognition processes
    • CrossRef Medline
    • Dellu F, Fauchey V, Le Moal M, Simon H (1997) Extension of a new two trial memory task in the rat: influence of environmental context on recognition processes. Neurobiol Learn Mem 67:112-120. CrossRef Medline
    • (1997) Neurobiol Learn Mem , vol.67 , pp. 112-120
    • Dellu, F.1    Fauchey, V.2    Le Moal, M.3    Simon, H.4
  • 15
    • 84863403423 scopus 로고    scopus 로고
    • Novel GαS-protein signaling associated with membranetethered amyloid precursor protein intracellular domain 1
    • CrossRef Medline
    • Deyts C, Vetrivel KS, Das S, Shepherd YM, Dupré DJ, Thinakaran G, Parent AT (2012) Novel GαS-protein signaling associated with membranetethered amyloid precursor protein intracellular domain 1. J Neurosci 32:1714-1729. CrossRef Medline
    • (2012) J Neurosci , vol.32 , pp. 1714-1729
    • Deyts, C.1    Vetrivel, K.S.2    Das, S.3    Shepherd, Y.M.4    Dupré, D.J.5    Thinakaran, G.6    Parent, A.T.7
  • 17
    • 0033501744 scopus 로고    scopus 로고
    • Behavioral disturbances in transgenic mice overexpressing the V717F β-amyloid precursor protein
    • CrossRef Medline
    • Dodart JC, Meziane H, Mathis C, Bales KR, Paul SM, Ungerer A (1999) Behavioral disturbances in transgenic mice overexpressing the V717F β-amyloid precursor protein. Behav Neurosci 113:982-990. CrossRef Medline
    • (1999) Behav Neurosci , vol.113 , pp. 982-990
    • Dodart, J.C.1    Meziane, H.2    Mathis, C.3    Bales, K.R.4    Paul, S.M.5    Ungerer, A.6
  • 18
    • 0023691166 scopus 로고
    • A new one-trial test for neurobiological studies of memory in rats. 1: Behavioral data
    • CrossRef Medline
    • Ennaceur A, Delacour J (1988) A new one-trial test for neurobiological studies of memory in rats. 1: Behavioral data. Behav Brain Res 31:47-59. CrossRef Medline
    • (1988) Behav Brain Res , vol.31 , pp. 47-59
    • Ennaceur, A.1    Delacour, J.2
  • 19
    • 33846466652 scopus 로고    scopus 로고
    • Plaques, tangles, and memory loss in mouse models of neurodegeneration
    • CrossRef Medline
    • Eriksen JL, Janus CG (2007) Plaques, tangles, and memory loss in mouse models of neurodegeneration. Behav Genet 37:79-100. CrossRef Medline
    • (2007) Behav Genet , vol.37 , pp. 79-100
    • Eriksen, J.L.1    Janus, C.G.2
  • 22
    • 0026569388 scopus 로고
    • An improved thioflavine S method for staining neurofibrillary tangles and senile plaques in Alzheimer's disease
    • CrossRef Medline
    • Guntern R, Bouras C, Hof PR, Vallet PG (1992) An improved thioflavine S method for staining neurofibrillary tangles and senile plaques in Alzheimer's disease. Experientia 48:8-10. CrossRef Medline
    • (1992) Experientia , vol.48 , pp. 8-10
    • Guntern, R.1    Bouras, C.2    Hof, P.R.3    Vallet, P.G.4
  • 25
    • 0029742199 scopus 로고    scopus 로고
    • Correlative memory deficts, Aβ elevation and amyloid plaques in transgenic mice
    • CrossRef Medline
    • Hsiao K, Chapman P, Nilsen S, Eckman C, Harigaya Y, Younkin S, Yang F, Cole G (1996) Correlative memory deficts, Aβ elevation and amyloid plaques in transgenic mice. Science 274:99-102. CrossRef Medline
    • (1996) Science , vol.274 , pp. 99-102
    • Hsiao, K.1    Chapman, P.2    Nilsen, S.3    Eckman, C.4    Harigaya, Y.5    Younkin, S.6    Yang, F.7    Cole, G.8
  • 26
    • 0028169925 scopus 로고
    • Visualization ofAβ42(43)-positive andAβ40-positive senile plaques with end-specific Aβ-monoclonal antibodies: Evidence that an initially deposited Aβ species is Aβ1-42(43)
    • CrossRef Medline
    • Iwatsubo T, Odaka A, Suzuki N, Mizusawa H, Nukina N, Ihara Y (1994) Visualization ofAβ42(43)-positive andAβ40-positive senile plaques with end-specific Aβ-monoclonal antibodies: evidence that an initially deposited Aβ species is Aβ1-42(43). Neuron 13:45-53. CrossRef Medline
    • (1994) Neuron , vol.13 , pp. 45-53
    • Iwatsubo, T.1    Odaka, A.2    Suzuki, N.3    Mizusawa, H.4    Nukina, N.5    Ihara, Y.6
  • 27
    • 0036727402 scopus 로고    scopus 로고
    • Transgenic mouse models of neurodegenerative disease: Opportunities for therapeutic development
    • CrossRef Medline
    • Jankowsky JL, Savonenko A, Schilling G, Wang J, Xu G, Borchelt DR (2002) Transgenic mouse models of neurodegenerative disease: opportunities for therapeutic development. Curr Neurol Neurosci Rep 2:457-464. CrossRef Medline
    • (2002) Curr Neurol Neurosci Rep , vol.2 , pp. 457-464
    • Jankowsky, J.L.1    Savonenko, A.2    Schilling, G.3    Wang, J.4    Xu, G.5    Borchelt, D.R.6
  • 30
    • 0026443727 scopus 로고
    • Deposition of β/A4 immunoreactivity and neuronal pathology in transgenic mice expressing the carboxyterminal fragment of the Alzheimer amyloid precursor in the brain
    • CrossRef Medline
    • Kammesheidt A, Boyce FM, Spanoyannis AF, Cummings BJ, Ortegón M, Cotman C, Vaught JL, Neve RL (1992) Deposition of β/A4 immunoreactivity and neuronal pathology in transgenic mice expressing the carboxyterminal fragment of the Alzheimer amyloid precursor in the brain. Proc Natl Acad Sci U S A 89:10857-10861. CrossRef Medline
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 10857-10861
    • Kammesheidt, A.1    Boyce, F.M.2    Spanoyannis, A.F.3    Cummings, B.J.4    Ortegón, M.5    Cotman, C.6    Vaught, J.L.7    Neve, R.L.8
  • 31
    • 0035863055 scopus 로고    scopus 로고
    • Age-dependent changes in brain, CSF, and plasma amyloid (β) protein in the Tg2576 transgenic mouse model of Alzheimer's disease
    • Medline
    • Kawarabayashi T, Younkin LH, Saido TC, Shoji M, Ashe KH, Younkin SG (2001) Age-dependent changes in brain, CSF, and plasma amyloid (β) protein in the Tg2576 transgenic mouse model of Alzheimer's disease. J Neurosci 21:372-381. Medline
    • (2001) J Neurosci , vol.21 , pp. 372-381
    • Kawarabayashi, T.1    Younkin, L.H.2    Saido, T.C.3    Shoji, M.4    Ashe, K.H.5    Younkin, S.G.6
  • 35
    • 0033966705 scopus 로고    scopus 로고
    • Novel Leu723Pro amyloid precursor protein mutation increases amyloid β42(43) peptide levels and induces apoptosis
    • CrossRef Medline
    • Kwok JB, Li QX, Hallupp M, Whyte S, Ames D, Beyreuther K, Masters CL, Schofield PR (2000) Novel Leu723Pro amyloid precursor protein mutation increases amyloid β42(43) peptide levels and induces apoptosis. Ann Neurol 47:249-253. CrossRef Medline
    • (2000) Ann Neurol , vol.47 , pp. 249-253
    • Kwok, J.B.1    Li, Q.X.2    Hallupp, M.3    Whyte, S.4    Ames, D.5    Beyreuther, K.6    Masters, C.L.7    Schofield, P.R.8
  • 37
    • 61449208917 scopus 로고    scopus 로고
    • Toward structural elucidation of the γ-secretase complex
    • CrossRef Medline
    • Li H, Wolfe MS, Selkoe DJ (2009) Toward structural elucidation of the γ-secretase complex. Structure 17:326-334. CrossRef Medline
    • (2009) Structure , vol.17 , pp. 326-334
    • Li, H.1    Wolfe, M.S.2    Selkoe, D.J.3
  • 38
    • 79955663580 scopus 로고    scopus 로고
    • Regulated intramembrane proteolysis: Lessons from amyloid precursor protein processing
    • CrossRef Medline
    • Lichtenthaler SF, Haass C, Steiner H (2011) Regulated intramembrane proteolysis: lessons from amyloid precursor protein processing. J Neurochem 117:779-796. CrossRef Medline
    • (2011) J Neurochem , vol.117 , pp. 779-796
    • Lichtenthaler, S.F.1    Haass, C.2    Steiner, H.3
  • 39
    • 77951928742 scopus 로고    scopus 로고
    • The presence of sodium dodecyl sulphate-stable Abeta dimers is strongly associated with Alzheimer-type dementia
    • CrossRef Medline
    • McDonald JM, Savva GM, Brayne C, Welzel AT, Forster G, Shankar GM, Selkoe DJ, Ince PG, Walsh DM (2010) The presence of sodium dodecyl sulphate-stable Abeta dimers is strongly associated with Alzheimer-type dementia. Brain 133:1328-1341. CrossRef Medline
    • (2010) Brain , vol.133 , pp. 1328-1341
    • McDonald, J.M.1    Savva, G.M.2    Brayne, C.3    Welzel, A.T.4    Forster, G.5    Shankar, G.M.6    Selkoe, D.J.7    Ince, P.G.8    Walsh, D.M.9
  • 41
    • 33746433950 scopus 로고    scopus 로고
    • Cycloxygenase-2 activity promotes cognitive deficits but not increased amyloid burden in a model of Alzheimer's disease in a sex-dimorphic pattern
    • CrossRef Medline
    • Melnikova T, Savonenko A, Wang Q, Liang X, Hand T, WuL, Kaufmann WE, Vehmas A, Andreasson KI (2006) Cycloxygenase-2 activity promotes cognitive deficits but not increased amyloid burden in a model of Alzheimer's disease in a sex-dimorphic pattern. Neuroscience 141:1149-1162. CrossRef Medline
    • (2006) Neuroscience , vol.141 , pp. 1149-1162
    • Melnikova, T.1    Savonenko, A.2    Wang, Q.3    Liang, X.4    Hand, T.5    Wu, L.6    Kaufmann, W.E.7    Vehmas, A.8    Andreasson, K.I.9
  • 42
    • 84857020179 scopus 로고    scopus 로고
    • Differential effects between γ-secretase inhibitors and modulators on cognitive function in amyloid precursor proteintransgenic and nontransgenic mice
    • CrossRef Medline
    • Mitani Y, Yarimizu J, Saita K, Uchino H, Akashiba H, Shitaka Y, Ni K, Matsuoka N (2012) Differential effects between γ-secretase inhibitors and modulators on cognitive function in amyloid precursor proteintransgenic and nontransgenic mice. J Neurosci 32:2037-2050. CrossRef Medline
    • (2012) J Neurosci , vol.32 , pp. 2037-2050
    • Mitani, Y.1    Yarimizu, J.2    Saita, K.3    Uchino, H.4    Akashiba, H.5    Shitaka, Y.6    Ni, K.7    Matsuoka, N.8
  • 45
    • 0029972847 scopus 로고    scopus 로고
    • Inactivation of hippocampus or caudate nucleus with lidocaine differentially affects expression of place and response learning
    • CrossRef Medline
    • Packard MG, McGaugh JL (1996) Inactivation of hippocampus or caudate nucleus with lidocaine differentially affects expression of place and response learning. Neurobiol Learn Mem 65:65-72. CrossRef Medline
    • (1996) Neurobiol Learn Mem , vol.65 , pp. 65-72
    • Packard, M.G.1    McGaugh, J.L.2
  • 46
    • 0035808416 scopus 로고    scopus 로고
    • A novel γ-secretase assay based on detection of the putative C-terminal fragment-γ of amyloid beta protein precursor
    • CrossRef Medline
    • Pinnix I, Musunuru U, Tun H, Sridharan A, Golde T, Eckman C, Ziani-Cherif C, Onstead L, Sambamurti K (2001) A novel γ-secretase assay based on detection of the putative C-terminal fragment-γ of amyloid beta protein precursor. J Biol Chem 276:481-487. CrossRef Medline
    • (2001) J Biol Chem , vol.276 , pp. 481-487
    • Pinnix, I.1    Musunuru, U.2    Tun, H.3    Sridharan, A.4    Golde, T.5    Eckman, C.6    Ziani-Cherif, C.7    Onstead, L.8    Sambamurti, K.9
  • 47
    • 84862264187 scopus 로고    scopus 로고
    • Transgenic APP expression during postnatal development causes persistent locomotor hyperactivity in the adult
    • CrossRef Medline
    • Rodgers SP, Born HA, Das P, Jankowsky JL (2012) Transgenic APP expression during postnatal development causes persistent locomotor hyperactivity in the adult. Mol Neurodegener 7:28. CrossRef Medline
    • (2012) Mol Neurodegener , vol.7 , pp. 28
    • Rodgers, S.P.1    Born, H.A.2    Das, P.3    Jankowsky, J.L.4
  • 48
    • 0029101491 scopus 로고
    • Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene
    • CrossRef Medline
    • Rogaev EI, Sherrington R, Rogaeva EA, Levesque G, Ikeda M, Liang Y, Chi H, Lin C, Holman K, Tsuda T, et al. (1995) Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene. Nature 376:775-778. CrossRef Medline
    • (1995) Nature , vol.376 , pp. 775-778
    • Rogaev, E.I.1    Sherrington, R.2    Rogaeva, E.A.3    Levesque, G.4    Ikeda, M.5    Liang, Y.6    Chi, H.7    Lin, C.8    Holman, K.9    Tsuda, T.10
  • 50
    • 0038755949 scopus 로고    scopus 로고
    • Normal cognitive behavior in two distinct lines of transgenic mice hyperexpressing mutant APPswe
    • CrossRef Medline
    • Savonenko AV, Xu GM, Price DL, Borchelt DR, Markowska AL (2003) Normal cognitive behavior in two distinct lines of transgenic mice hyperexpressing mutant APPswe. Neurobiol Dis 12:194-211. CrossRef Medline
    • (2003) Neurobiol Dis , vol.12 , pp. 194-211
    • Savonenko, A.V.1    Xu, G.M.2    Price, D.L.3    Borchelt, D.R.4    Markowska, A.L.5
  • 51
    • 20044383377 scopus 로고    scopus 로고
    • Episodic-like memory deficits in the APPswe/PS1dE9 mouse model of Alzheimer's disease: Relationships toβ-amyloid deposition and neurotransmitter abnormalities
    • CrossRef Medline
    • Savonenko A, Xu GM, Melnikova T, Morton JL, Gonzales V, Wong MP, Price DL, Tang F, Markowska AL, Borchelt DR (2005) Episodic-like memory deficits in the APPswe/PS1dE9 mouse model of Alzheimer's disease: relationships toβ-amyloid deposition and neurotransmitter abnormalities. Neurobiol Dis 18:602-617. CrossRef Medline
    • (2005) Neurobiol Dis , vol.18 , pp. 602-617
    • Savonenko, A.1    Xu, G.M.2    Melnikova, T.3    Morton, J.L.4    Gonzales, V.5    Wong, M.P.6    Price, D.L.7    Tang, F.8    Markowska, A.L.9    Borchelt, D.R.10
  • 52
    • 16044373524 scopus 로고    scopus 로고
    • Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease
    • CrossRef Medline
    • Scheuner D, Eckman C, Jensen M, Song X, Citron M, Suzuki N, Bird TD, Hardy J, Hutton M, Kukull W, et al. (1996) Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nat Med 2:864-870. CrossRef Medline
    • (1996) Nat Med , vol.2 , pp. 864-870
    • Scheuner, D.1    Eckman, C.2    Jensen, M.3    Song, X.4    Citron, M.5    Suzuki, N.6    Bird, T.D.7    Hardy, J.8    Hutton, M.9    Kukull, W.10
  • 53
    • 0036403702 scopus 로고    scopus 로고
    • Deciphering the genetic basis of Alzheimer's disease
    • CrossRef Medline
    • Selkoe DJ, Podlisny MB (2002) Deciphering the genetic basis of Alzheimer's disease. Annu Rev Genomics Hum Genet 3:67-99. CrossRef Medline
    • (2002) Annu Rev Genomics Hum Genet , vol.3 , pp. 67-99
    • Selkoe, D.J.1    Podlisny, M.B.2
  • 55
    • 78049286290 scopus 로고    scopus 로고
    • Ameliorative effects of a non-competitive BACE1 inhibitor TAK-070 on Abeta peptide levels and impaired learning behavior in aged rats
    • CrossRef Medline
    • Takahashi H, Fukumoto H, Maeda R, Terauchi J, Kato K, Miyamoto M (2010) Ameliorative effects of a non-competitive BACE1 inhibitor TAK-070 on Abeta peptide levels and impaired learning behavior in aged rats. Brain Res 1361:146-156. CrossRef Medline
    • (2010) Brain Res , vol.1361 , pp. 146-156
    • Takahashi, H.1    Fukumoto, H.2    Maeda, R.3    Terauchi, J.4    Kato, K.5    Miyamoto, M.6
  • 56
    • 84862161020 scopus 로고    scopus 로고
    • Inhibition of γ-secretase worsens memory deficits in a genetically congruous mouse model of Danish dementia
    • CrossRef Medline
    • Tamayev R, D'Adamio L (2012) Inhibition of γ-secretase worsens memory deficits in a genetically congruous mouse model of Danish dementia. Mol Neurodegener 7:19. CrossRef Medline
    • (2012) Mol Neurodegener , vol.7 , pp. 19
    • Tamayev, R.1    D'Adamio, L.2
  • 57
    • 84858123000 scopus 로고    scopus 로고
    • β-but not γ-secretase proteolysis of APP causes synaptic and memory deficits in a mouse model of dementia
    • CrossRef Medline
    • Tamayev R, Matsuda S, Arancio O, D'Adamio L (2012) β-but not γ-secretase proteolysis of APP causes synaptic and memory deficits in a mouse model of dementia. EMBO Mol Med 4:171-179. CrossRef Medline
    • (2012) EMBO Mol Med , vol.4 , pp. 171-179
    • Tamayev, R.1    Matsuda, S.2    Arancio, O.3    D'Adamio, L.4
  • 59
    • 60549107033 scopus 로고    scopus 로고
    • A specific enzyme-linked immunosorbent assay for measuringβ-amyloid protein oligomers in human plasma and brain tissue of patients with Alzheimer disease
    • CrossRef Medline
    • Xia W, Yang T, Shankar G, Smith IM, Shen Y, Walsh DM, Selkoe DJ (2009) A specific enzyme-linked immunosorbent assay for measuringβ-amyloid protein oligomers in human plasma and brain tissue of patients with Alzheimer disease. Arch Neurol 66:190-199. CrossRef Medline
    • (2009) Arch Neurol , vol.66 , pp. 190-199
    • Xia, W.1    Yang, T.2    Shankar, G.3    Smith, I.M.4    Shen, Y.5    Walsh, D.M.6    Selkoe, D.J.7
  • 60
    • 84860165507 scopus 로고    scopus 로고
    • Reduction of lowdensity lipoprotein receptor-related protein (LRP1) in hippocampal neurons does not proportionately reduce, or otherwise alter, amyloid deposition in APPswe/PS1dE9 transgenic mice
    • CrossRef Medline
    • Xu G, Green CC, Fromholt SE, Borchelt DR (2012) Reduction of lowdensity lipoprotein receptor-related protein (LRP1) in hippocampal neurons does not proportionately reduce, or otherwise alter, amyloid deposition in APPswe/PS1dE9 transgenic mice. Alzheimers Res Ther 4:12. CrossRef Medline
    • (2012) Alzheimers Res Ther , vol.4 , pp. 12
    • Xu, G.1    Green, C.C.2    Fromholt, S.E.3    Borchelt, D.R.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.