메뉴 건너뛰기




Volumn 3, Issue 5, 2011, Pages 1-17

Aging as an event of proteostasis collapse

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; PROTEIN; PROTEOME; SOMATOMEDIN C;

EID: 84863651655     PISSN: None     EISSN: 19430264     Source Type: Journal    
DOI: 10.1101/cshperspect.a004440     Document Type: Article
Times cited : (405)

References (135)
  • 1
    • 84934443868 scopus 로고    scopus 로고
    • Heat shock factor 1 as a coordinator of stress and developmental pathways
    • Anckar J, Sistonen L. 2007. Heat shock factor 1 as a coordinator of stress and developmental pathways. Adv ExpMed Biol 594: 78-88.
    • (2007) Adv ExpMed Biol , vol.594 , pp. 78-88
    • Anckar, J.1    Sistonen, L.2
  • 2
    • 33845972658 scopus 로고    scopus 로고
    • Induction of the heat shock pathway during hypoxia requires regulation of heat shock factor by hypoxia-inducible factor-1
    • BairdNA, TurnbullDW, Johnson EA. 2006. Induction of the heat shock pathway during hypoxia requires regulation of heat shock factor by hypoxia-inducible factor-1. J Biol Chem 281: 38675-38681.
    • (2006) J Biol Chem , vol.281 , pp. 38675-38681
    • Baird, N.A.1    Turnbull, D.W.2    Johnson, E.A.3
  • 3
  • 4
    • 55849132493 scopus 로고    scopus 로고
    • Insulin and aging
    • Bartke A. 2008. Insulin and aging. Cell Cycle 7: 3338-3343.
    • (2008) Cell Cycle , vol.7 , pp. 3338-3343
    • Bartke, A.1
  • 6
    • 70349266064 scopus 로고    scopus 로고
    • Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging
    • Ben-Zvi A, Miller EA, Morimoto RI. 2009. Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging. Proc Natl Acad Sci 106: 14914-14919.
    • (2009) Proc Natl Acad Sci , vol.106 , pp. 14914-14919
    • Ben-Zvi, A.1    Miller, E.A.2    Morimoto, R.I.3
  • 7
    • 0030841350 scopus 로고    scopus 로고
    • Protein oxidation in aging, disease, and oxidative stress
    • Berlett BS, Stadtman ER. 1997. Protein oxidation in aging, disease, and oxidative stress. J Biol Chem 272: 20313-20316.
    • (1997) J Biol Chem , vol.272 , pp. 20313-20316
    • Berlett, B.S.1    Stadtman, E.R.2
  • 9
    • 70350519391 scopus 로고    scopus 로고
    • A kinetic assessment of the C. elegans amyloid disaggregation activity enables uncoupling of disassembly and proteolysis
    • Bieschke J, Cohen E, Murray A, Dillin A, Kelly JW. 2009. A kinetic assessment of the C. elegans amyloid disaggregation activity enables uncoupling of disassembly and proteolysis. Protein Sci 18: 2231-2241.
    • (2009) Protein Sci , vol.18 , pp. 2231-2241
    • Bieschke, J.1    Cohen, E.2    Murray, A.3    Dillin, A.4    Kelly, J.W.5
  • 10
    • 34249891333 scopus 로고    scopus 로고
    • Two neurons mediate dietrestriction-induced longevity in C. elegans
    • Bishop NA, Guarente L. 2007. Two neurons mediate dietrestriction-induced longevity in C. elegans. Nature 447: 545-549.
    • (2007) Nature , vol.447 , pp. 545-549
    • Bishop, N.A.1    Guarente, L.2
  • 11
    • 0036710928 scopus 로고    scopus 로고
    • Lipofuscin: Mechanisms of age-related accumulation and influence on cell function
    • Brunk UT, Terman A. 2002. Lipofuscin: mechanisms of age-related accumulation and influence on cell function. Free Radic Biol Med 33: 611-619.
    • (2002) Free Radic Biol Med , vol.33 , pp. 611-619
    • Brunk, U.T.1    Terman, A.2
  • 12
    • 33646127577 scopus 로고    scopus 로고
    • Molecular chaperones and protein quality control
    • Bukau B, Weissman J, Horwich A. 2006. Molecular chaperones and protein quality control. Cell 125: 443-451.
    • (2006) Cell , vol.125 , pp. 443-451
    • Bukau, B.1    Weissman, J.2    Horwich, A.3
  • 13
    • 0035918148 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase signaling inhibits DAF-16 DNA binding and function via 14-3-3-dependent and 14-3-3-independent pathways
    • Cahill CM, Tzivion G, Nasrin N, Ogg S, Dore J, Ruvkun G, Alexander-Bridges M. 2001. Phosphatidylinositol 3-kinase signaling inhibits DAF-16 DNA binding and function via 14-3-3-dependent and 14-3-3-independent pathways. J Biol Chem 276: 13402-13410.
    • (2001) J Biol Chem , vol.276 , pp. 13402-13410
    • Cahill, C.M.1    Tzivion, G.2    Nasrin, N.3    Ogg, S.4    Dore, J.5    Ruvkun, G.6    Alexander-Bridges, M.7
  • 14
    • 67651004289 scopus 로고    scopus 로고
    • A conserved ubiquitination pathway determines longevity in response to diet restriction
    • Carrano AC, Liu Z, Dillin A, Hunter T. 2009. A conserved ubiquitination pathway determines longevity in response to diet restriction. Nature 460: 396-399.
    • (2009) Nature , vol.460 , pp. 396-399
    • Carrano, A.C.1    Liu, Z.2    Dillin, A.3    Hunter, T.4
  • 16
  • 17
    • 67149107430 scopus 로고    scopus 로고
    • HIF-1 modulates dietary restriction-mediated lifespan extension via IRE-1 in Caenorhabditis elegans
    • Chen D, Thomas EL, Kapahi P. 2009. HIF-1 modulates dietary restriction-mediated lifespan extension via IRE-1 in Caenorhabditis elegans. PLoS Genet 5: e1000486.
    • (2009) PLoS Genet , vol.5
    • Chen, D.1    Thomas, E.L.2    Kapahi, P.3
  • 19
    • 0042467550 scopus 로고    scopus 로고
    • Rationalization of the effects of mutations on peptide and protein aggregation rates
    • Chiti F, Stefani M, Taddei N, Ramponi G, Dobson CM. 2003. Rationalization of the effects of mutations on peptide and protein aggregation rates. Nature 424: 805-808.
    • (2003) Nature , vol.424 , pp. 805-808
    • Chiti, F.1    Stefani, M.2    Taddei, N.3    Ramponi, G.4    Dobson, C.M.5
  • 20
    • 11244309014 scopus 로고    scopus 로고
    • Proteolysis: From the lysosome to ubiquitin and the proteasome
    • Ciechanover A. 2005. Proteolysis: from the lysosome to ubiquitin and the proteasome. Nat Rev Mol Cell Biol 6: 79-87.
    • (2005) Nat Rev Mol Cell Biol , vol.6 , pp. 79-87
    • Ciechanover, A.1
  • 21
    • 52449086907 scopus 로고    scopus 로고
    • The insulin paradox: Aging, proteotoxicity and neurodegeneration
    • Cohen E, Dillin A. 2008. The insulin paradox: aging, proteotoxicity and neurodegeneration. Nat Rev Neurosci 9: 759-767.
    • (2008) Nat Rev Neurosci , vol.9 , pp. 759-767
    • Cohen, E.1    Dillin, A.2
  • 25
    • 56349168452 scopus 로고    scopus 로고
    • Autophagy and aging: Keeping that old broom working
    • Cuervo AM. 2008. Autophagy and aging: keeping that old broom working. Trends Genet 24: 604-612.
    • (2008) Trends Genet , vol.24 , pp. 604-612
    • Cuervo, A.M.1
  • 26
    • 0034613294 scopus 로고    scopus 로고
    • Age-related decline in chaperonemediated autophagy
    • Cuervo AM, Dice JF. 2000. Age-related decline in chaperonemediated autophagy. J Biol Chem 275: 31505-31513.
    • (2000) J Biol Chem , vol.275 , pp. 31505-31513
    • Cuervo, A.M.1    Dice, J.F.2
  • 27
    • 34548658230 scopus 로고    scopus 로고
    • Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis
    • Dai C, Whitesell L, Rogers AB, Lindquist S. 2007. Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis. Cell 130: 1005-1018.
    • (2007) Cell , vol.130 , pp. 1005-1018
    • Dai, C.1    Whitesell, L.2    Rogers, A.B.3    Lindquist, S.4
  • 28
    • 0037174629 scopus 로고    scopus 로고
    • Timing requirements for insulin/IGF-1 signaling in C. elegans
    • Dillin A, Crawford DK, Kenyon C. 2002a. Timing requirements for insulin/IGF-1 signaling in C. elegans. Science 298: 830-834.
    • (2002) Science , vol.298 , pp. 830-834
    • Dillin, A.1    Crawford, D.K.2    Kenyon, C.3
  • 30
    • 9744223523 scopus 로고    scopus 로고
    • Proteasome inhibition increases DNA and RNA oxidation in astrocyte and neuron cultures
    • Ding Q, Dimayuga E, Markesbery WR, Keller JN. 2004. Proteasome inhibition increases DNA and RNA oxidation in astrocyte and neuron cultures. J Neurochem 91: 1211-1218.
    • (2004) J Neurochem , vol.91 , pp. 1211-1218
    • Ding, Q.1    Dimayuga, E.2    Markesbery, W.R.3    Keller, J.N.4
  • 32
    • 50949086260 scopus 로고    scopus 로고
    • Effect of aging and anti-aging caloric restriction on the endocrine regulation of rat liver autophagy
    • Donati A, Recchia G, Cavallini G, Bergamini E. 2008. Effect of aging and anti-aging caloric restriction on the endocrine regulation of rat liver autophagy. J Gerontol A Biol Sci Med Sci 63: 550-555.
    • (2008) J Gerontol A Biol Sci Med Sci , vol.63 , pp. 550-555
    • Donati, A.1    Recchia, G.2    Cavallini, G.3    Bergamini, E.4
  • 34
    • 47549097539 scopus 로고    scopus 로고
    • Mistranslation-induced protein misfolding as a dominant constraint on codingsequence evolution
    • Drummond DA, Wilke CO. 2008. Mistranslation-induced protein misfolding as a dominant constraint on codingsequence evolution. Cell 134: 341-352.
    • (2008) Cell , vol.134 , pp. 341-352
    • Drummond, D.A.1    Wilke, C.O.2
  • 36
    • 0035515923 scopus 로고    scopus 로고
    • Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans
    • Feng J, Bussiere F, Hekimi S. 2001. Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans. Dev Cell 1: 633-644.
    • (2001) Dev Cell , vol.1 , pp. 633-644
    • Feng, J.1    Bussiere, F.2    Hekimi, S.3
  • 37
    • 16344363800 scopus 로고    scopus 로고
    • Altered proteasome structure, function, and oxidation in aged muscle
    • Ferrington DA, Husom AD, Thompson LV. 2005. Altered proteasome structure, function, and oxidation in aged muscle. FASEB J 19: 644-646.
    • (2005) FASEB J , vol.19 , pp. 644-646
    • Ferrington, D.A.1    Husom, A.D.2    Thompson, L.V.3
  • 38
    • 35848955910 scopus 로고    scopus 로고
    • Decreased insulin-receptor signaling promotes the autophagic degradation of β-amyloid peptide in C. elegans
    • Florez-McClure ML, Hohsfield LA, Fonte G, Bealor MT, Link CD. 2007. Decreased insulin-receptor signaling promotes the autophagic degradation of β-amyloid peptide in C. elegans. Autophagy 3: 569-580.
    • (2007) Autophagy , vol.3 , pp. 569-580
    • Florez-McClure, M.L.1    Hohsfield, L.A.2    Fonte, G.3    Bealor, M.T.4    Link, C.D.5
  • 39
    • 5044229348 scopus 로고    scopus 로고
    • Molecular mechanisms of translational control
    • Gebauer F, Hentze MW. 2004. Molecular mechanisms of translational control. Nat Rev Mol Cell Biol 5: 827-835.
    • (2004) Nat Rev Mol Cell Biol , vol.5 , pp. 827-835
    • Gebauer, F.1    Hentze, M.W.2
  • 40
    • 33644850056 scopus 로고    scopus 로고
    • Progressive disruption of cellular protein folding in models of polyglutamine diseases
    • Gidalevitz T, Ben-Zvi A, Ho KH, Brignull HR, Morimoto RI. 2006. Progressive disruption of cellular protein folding in models of polyglutamine diseases. Science 311: 1471-1474.
    • (2006) Science , vol.311 , pp. 1471-1474
    • Gidalevitz, T.1    Ben-Zvi, A.2    Ho, K.H.3    Brignull, H.R.4    Morimoto, R.I.5
  • 41
    • 62149129690 scopus 로고    scopus 로고
    • Destabilizing protein polymorphisms in the genetic background direct phenotypic expression of mutant SOD1 toxicity
    • Gidalevitz T, Krupinski T, Garcia S, Morimoto RI. 2009. Destabilizing protein polymorphisms in the genetic background direct phenotypic expression of mutant SOD1 toxicity. PLoS Genet 5: e1000399.
    • (2009) PLoS Genet , vol.5
    • Gidalevitz, T.1    Krupinski, T.2    Garcia, S.3    Morimoto, R.I.4
  • 42
    • 72949117234 scopus 로고    scopus 로고
    • Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila
    • Grandison RC, Piper MD, Partridge L. 2009. Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila. Nature 462: 1061-1064.
    • (2009) Nature , vol.462 , pp. 1061-1064
    • Grandison, R.C.1    Piper, M.D.2    Partridge, L.3
  • 46
    • 77953020414 scopus 로고    scopus 로고
    • A photoconvertible reporter of the ubiquitin-proteasome system in vivo
    • Hamer G, Matilainen O, Holmberg CI. 2010. A photoconvertible reporter of the ubiquitin-proteasome system in vivo. Nat Methods 7: 473-478.
    • (2010) Nat Methods , vol.7 , pp. 473-478
    • Hamer, G.1    Matilainen, O.2    Holmberg, C.I.3
  • 47
    • 40149105890 scopus 로고    scopus 로고
    • A role for autophagy in the extension of lifespan by dietary restriction in C. elegans
    • Hansen M, Chandra A, Mitic LL, Onken B, Driscoll M, Kenyon C. 2008. A role for autophagy in the extension of lifespan by dietary restriction in C. elegans. PLoS Genet 4: e24.
    • (2008) PLoS Genet , vol.4
    • Hansen, M.1    Chandra, A.2    Mitic, L.L.3    Onken, B.4    Driscoll, M.5    Kenyon, C.6
  • 48
    • 33846423520 scopus 로고    scopus 로고
    • Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans
    • Hansen M, Taubert S, Crawford D, Libina N, Lee SJ, Kenyon C. 2007. Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans. Aging Cell 6: 95-110.
    • (2007) Aging Cell , vol.6 , pp. 95-110
    • Hansen, M.1    Taubert, S.2    Crawford, D.3    Libina, N.4    Lee, S.J.5    Kenyon, C.6
  • 50
    • 0037470539 scopus 로고    scopus 로고
    • Genetics and the specificity of the aging process
    • Hekimi S, Guarente L. 2003. Genetics and the specificity of the aging process. Science 299: 1351-1354.
    • (2003) Science , vol.299 , pp. 1351-1354
    • Hekimi, S.1    Guarente, L.2
  • 51
    • 0035846604 scopus 로고    scopus 로고
    • daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans
    • Henderson ST, Johnson TE. 2001. daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans. Curr Biol 11: 1975-1980.
    • (2001) Curr Biol , vol.11 , pp. 1975-1980
    • Henderson, S.T.1    Johnson, T.E.2
  • 53
    • 0038826959 scopus 로고    scopus 로고
    • Lifespan extension of Drosophila melanogaster through hormesis by repeated mild heat stress
    • Hercus MJ, Loeschcke V, Rattan SI. 2003. Lifespan extension of Drosophila melanogaster through hormesis by repeated mild heat stress. Biogerontology 4: 149-156.
    • (2003) Biogerontology , vol.4 , pp. 149-156
    • Hercus, M.J.1    Loeschcke, V.2    Rattan, S.I.3
  • 54
    • 11144355021 scopus 로고    scopus 로고
    • Celegans SGK-1 is the critical component in the Akt/PKB kinase complex to control stress response and life span
    • Hertweck M, Gobel C, Baumeister R. 2004. Celegans SGK-1 is the critical component in the Akt/PKB kinase complex to control stress response and life span. Dev Cell 6: 577-588.
    • (2004) Dev Cell , vol.6 , pp. 577-588
    • Hertweck, M.1    Gobel, C.2    Baumeister, R.3
  • 55
    • 8344265219 scopus 로고    scopus 로고
    • Akt/PKB and pp38 MAPK signaling, translational initiation and longevity in Snell dwarf mouse livers
    • Hsieh CC, Papaconstantinou J. 2004. Akt/PKB and pp38 MAPK signaling, translational initiation and longevity in Snell dwarf mouse livers. Mech Ageing Dev 125: 785-798.
    • (2004) Mech Ageing Dev , vol.125 , pp. 785-798
    • Hsieh, C.C.1    Papaconstantinou, J.2
  • 56
    • 0038701745 scopus 로고    scopus 로고
    • Regulation of aging and age-related disease byDAF-16 and heat-shock factor
    • Hsu AL, Murphy CT, Kenyon C. 2003. Regulation of aging and age-related disease byDAF-16 and heat-shock factor. Science 300: 1142-1145.
    • (2003) Science , vol.300 , pp. 1142-1145
    • Hsu, A.L.1    Murphy, C.T.2    Kenyon, C.3
  • 57
    • 35848937781 scopus 로고    scopus 로고
    • Autophagy is required for dietary restriction-mediated life span extension in C. elegans
    • Jia K, Levine B. 2007. Autophagy is required for dietary restriction-mediated life span extension in C. elegans. Autophagy 3: 597-599.
    • (2007) Autophagy , vol.3 , pp. 597-599
    • Jia, K.1    Levine, B.2
  • 58
    • 4544311861 scopus 로고    scopus 로고
    • The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span
    • Jia K, Chen D, Riddle DL. 2004. The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span. Development 131: 3897-3906.
    • (2004) Development , vol.131 , pp. 3897-3906
    • Jia, K.1    Chen, D.2    Riddle, D.L.3
  • 59
    • 33846210657 scopus 로고    scopus 로고
    • Autophagy genes protect against disease caused by polyglutamine expansion proteins in Caenorhabditis elegans
    • Jia K, Hart AC, Levine B. 2007. Autophagy genes protect against disease caused by polyglutamine expansion proteins in Caenorhabditis elegans. Autophagy 3: 21-25.
    • (2007) Autophagy , vol.3 , pp. 21-25
    • Jia, K.1    Hart, A.C.2    Levine, B.3
  • 60
    • 77955292017 scopus 로고    scopus 로고
    • Role of autophagy in diabetes and mitochondria
    • Jung HS, Lee MS. 2010. Role of autophagy in diabetes and mitochondria. Ann N Y Acad Sci 1201: 79-83.
    • (2010) Ann N Y Acad Sci , vol.1201 , pp. 79-83
    • Jung, H.S.1    Lee, M.S.2
  • 62
    • 20844451123 scopus 로고    scopus 로고
    • AMPactivated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism
    • Kahn BB, Alquier T, Carling D, Hardie DG. 2005. AMPactivated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab 1: 15-25.
    • (2005) Cell Metab , vol.1 , pp. 15-25
    • Kahn, B.B.1    Alquier, T.2    Carling, D.3    Hardie, D.G.4
  • 63
    • 16644365353 scopus 로고    scopus 로고
    • TOR pathway: Linking nutrient sensing to life span
    • Kapahi P, Zid B. 2004. TOR pathway: linking nutrient sensing to life span. Sci Aging Knowledge Environ 2004: PE34.
    • (2004) Sci Aging Knowledge Environ , vol.2004
    • Kapahi, P.1    Zid, B.2
  • 64
    • 3042648746 scopus 로고    scopus 로고
    • Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway
    • Kapahi P, Zid BM, Harper T, Koslover D, Sapin V, Benzer S. 2004. Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway. Curr Biol 14: 885-890.
    • (2004) Curr Biol , vol.14 , pp. 885-890
    • Kapahi, P.1    Zid, B.M.2    Harper, T.3    Koslover, D.4    Sapin, V.5    Benzer, S.6
  • 68
    • 13944262937 scopus 로고    scopus 로고
    • Understanding the odd science of aging
    • Kirkwood TB. 2005. Understanding the odd science of aging. Cell 120: 437-447.
    • (2005) Cell , vol.120 , pp. 437-447
    • Kirkwood, T.B.1
  • 69
    • 0032573178 scopus 로고    scopus 로고
    • The genetics of caloric restriction in Caenorhabditis elegans
    • Lakowski B, Hekimi S. 1998. The genetics of caloric restriction in Caenorhabditis elegans. Proc Natl Acad Sci 95: 13091-13096.
    • (1998) Proc Natl Acad Sci , vol.95 , pp. 13091-13096
    • Lakowski, B.1    Hekimi, S.2
  • 70
    • 0035846601 scopus 로고    scopus 로고
    • Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway
    • Lee RY, Hench J, Ruvkun G. 2001. Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway. Curr Biol 11: 1950-1957.
    • (2001) Curr Biol , vol.11 , pp. 1950-1957
    • Lee, R.Y.1    Hench, J.2    Ruvkun, G.3
  • 72
    • 0037228016 scopus 로고    scopus 로고
    • A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity
    • Lee SS, Lee RY, Fraser AG, Kamath RS, Ahringer J, Ruvkun G. 2003. A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity. Nat Genet 33: 40-48.
    • (2003) Nat Genet , vol.33 , pp. 40-48
    • Lee, S.S.1    Lee, R.Y.2    Fraser, A.G.3    Kamath, R.S.4    Ahringer, J.5    Ruvkun, G.6
  • 73
    • 33846596646 scopus 로고    scopus 로고
    • RLE-1, an E3 ubiquitin ligase, regulates C. elegans aging by catalyzing DAF-16 polyubiquitination
    • LiW, Gao B, Lee SM, Bennett K, FangD. 2007. RLE-1, an E3 ubiquitin ligase, regulates C. elegans aging by catalyzing DAF-16 polyubiquitination. Dev Cell 12: 235-246.
    • (2007) Dev Cell , vol.12 , pp. 235-246
    • Li, W.1    Gao, B.2    Lee, S.M.3    Bennett, K.4    Fang, D.5
  • 74
    • 0030657540 scopus 로고    scopus 로고
    • daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans
    • Lin K, Dorman JB, Rodan A, Kenyon C. 1997. daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans. Science 278: 1319-1322.
    • (1997) Science , vol.278 , pp. 1319-1322
    • Lin, K.1    Dorman, J.B.2    Rodan, A.3    Kenyon, C.4
  • 75
    • 0034967720 scopus 로고    scopus 로고
    • Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling
    • Lin K, Hsin H, Libina N, Kenyon C. 2001. Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling. Nat Genet 28: 139-145.
    • (2001) Nat Genet , vol.28 , pp. 139-145
    • Lin, K.1    Hsin, H.2    Libina, N.3    Kenyon, C.4
  • 76
    • 0028981288 scopus 로고
    • Expression of human β-amyloid peptide in transgenic Caenorhabditis elegans
    • Link CD. 1995. Expression of human β-amyloid peptide in transgenic Caenorhabditis elegans. Proc Natl Acad Sci 92: 9368-9372.
    • (1995) Proc Natl Acad Sci , vol.92 , pp. 9368-9372
    • Link, C.D.1
  • 77
    • 0029123058 scopus 로고
    • Thermotolerance and extended life-span conferred by singlegene mutations and induced by thermal stress
    • Lithgow GJ, White TM, Melov S, Johnson TE. 1995. Thermotolerance and extended life-span conferred by singlegene mutations and induced by thermal stress. Proc Natl Acad Sci 92: 7540-7544.
    • (1995) Proc Natl Acad Sci , vol.92 , pp. 7540-7544
    • Lithgow, G.J.1    White, T.M.2    Melov, S.3    Johnson, T.E.4
  • 78
    • 26944501617 scopus 로고    scopus 로고
    • Evolutionary conservation of the clk-1-dependent mechanism of longevity: Loss of mclk1 increases cellular fitness and lifespan in mice
    • Liu X, Jiang N, Hughes B, Bigras E, Shoubridge E, Hekimi S. 2005. Evolutionary conservation of the clk-1-dependent mechanism of longevity: loss of mclk1 increases cellular fitness and lifespan in mice. Genes Dev 19: 2424-2434.
    • (2005) Genes Dev , vol.19 , pp. 2424-2434
    • Liu, X.1    Jiang, N.2    Hughes, B.3    Bigras, E.4    Shoubridge, E.5    Hekimi, S.6
  • 79
    • 50649099122 scopus 로고    scopus 로고
    • Aging and survival: The genetics of life span extension by dietary restriction
    • Mair W, Dillin A. 2008. Aging and survival: the genetics of life span extension by dietary restriction. Annu Rev Biochem 77: 727-754.
    • (2008) Annu Rev Biochem , vol.77 , pp. 727-754
    • Mair, W.1    Dillin, A.2
  • 80
    • 0141766912 scopus 로고    scopus 로고
    • Demography of dietary restriction and death in Drosophila
    • MairW, Goymer P, Pletcher SD, Partridge L. 2003. Demography of dietary restriction and death in Drosophila. Science 301: 1731-1733.
    • (2003) Science , vol.301 , pp. 1731-1733
    • Mair, W.1    Goymer, P.2    Pletcher, S.D.3    Partridge, L.4
  • 81
    • 8444224619 scopus 로고    scopus 로고
    • Balancing Akt with S6K: Implications for both metabolic diseases and tumorigenesis
    • Manning BD. 2004. Balancing Akt with S6K: implications for both metabolic diseases and tumorigenesis. J Cell Biol 167: 399-403.
    • (2004) J Cell Biol , vol.167 , pp. 399-403
    • Manning, B.D.1
  • 83
    • 0042631524 scopus 로고    scopus 로고
    • Transcriptional outputs of the Caenorhabditis elegans forkhead protein DAF-16
    • McElwee J, Bubb K, Thomas JH. 2003. Transcriptional outputs of the Caenorhabditis elegans forkhead protein DAF-16. Aging Cell 2: 111-121.
    • (2003) Aging Cell , vol.2 , pp. 111-121
    • McElwee, J.1    Bubb, K.2    Thomas, J.H.3
  • 84
    • 0032571397 scopus 로고    scopus 로고
    • Targeted disruption of heat shock transcription factor 1 abolishes thermotolerance and protection against heatinducible apoptosis
    • McMillan DR, Xiao X, Shao L, Graves K, Benjamin IJ. 1998. Targeted disruption of heat shock transcription factor 1 abolishes thermotolerance and protection against heatinducible apoptosis. J Biol Chem 273: 7523-7528.
    • (1998) J Biol Chem , vol.273 , pp. 7523-7528
    • McMillan, D.R.1    Xiao, X.2    Shao, L.3    Graves, K.4    Benjamin, I.J.5
  • 86
    • 0042691506 scopus 로고    scopus 로고
    • Autophagy genes are essential for dauer development and life-span extension in C. elegans
    • Melendez A, Talloczy Z, Seaman M, Eskelinen EL, Hall DH, Levine B. 2003. Autophagy genes are essential for dauer development and life-span extension in C. elegans. Science 301: 1387-1391.
    • (2003) Science , vol.301 , pp. 1387-1391
    • Melendez, A.1    Talloczy, Z.2    Seaman, M.3    Eskelinen, E.L.4    Hall, D.H.5    Levine, B.6
  • 87
    • 44849094781 scopus 로고    scopus 로고
    • Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging
    • Morimoto RI. 2008. Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging. Genes Dev 22: 1427-1438.
    • (2008) Genes Dev , vol.22 , pp. 1427-1438
    • Morimoto, R.I.1
  • 88
    • 0742323000 scopus 로고    scopus 로고
    • Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones
    • Morley JF, Morimoto RI. 2004. Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones. Mol Biol Cell 15: 657-664.
    • (2004) Mol Biol Cell , vol.15 , pp. 657-664
    • Morley, J.F.1    Morimoto, R.I.2
  • 89
    • 0036678146 scopus 로고    scopus 로고
    • The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans
    • Morley JF, Brignull HR, Weyers JJ, Morimoto RI. 2002. The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans. Proc Natl Acad Sci 99: 10417-10422.
    • (2002) Proc Natl Acad Sci , vol.99 , pp. 10417-10422
    • Morley, J.F.1    Brignull, H.R.2    Weyers, J.J.3    Morimoto, R.I.4
  • 90
    • 0029768753 scopus 로고    scopus 로고
    • A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans
    • Morris JZ, Tissenbaum HA, Ruvkun G. 1996. A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans. Nature 382: 536-539.
    • (1996) Nature , vol.382 , pp. 536-539
    • Morris, J.Z.1    Tissenbaum, H.A.2    Ruvkun, G.3
  • 91
    • 2442649342 scopus 로고    scopus 로고
    • Overexpression of the small mitochondrial Hsp22 extends Drosophila life span and increases resistance to oxidative stress
    • Morrow G, Samson M, Michaud S, Tanguay RM. 2004. Overexpression of the small mitochondrial Hsp22 extends Drosophila life span and increases resistance to oxidative stress. FASEB J 18: 598-599.
    • (2004) FASEB J , vol.18 , pp. 598-599
    • Morrow, G.1    Samson, M.2    Michaud, S.3    Tanguay, R.M.4
  • 92
    • 0037274713 scopus 로고    scopus 로고
    • Positive selection of Caenorhabditis elegans mutants with increased stress resistance and longevity
    • Muñoz MJ, Riddle DL. 2003. Positive selection of Caenorhabditis elegans mutants with increased stress resistance and longevity. Genetics 163: 171-180.
    • (2003) Genetics , vol.163 , pp. 171-180
    • Muñoz, M.J.1    Riddle, D.L.2
  • 95
    • 0032238299 scopus 로고    scopus 로고
    • The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway
    • Ogg S, Ruvkun G. 1998. The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway. Mol Cell 2: 887-893.
    • (1998) Mol Cell , vol.2 , pp. 887-893
    • Ogg, S.1    Ruvkun, G.2
  • 96
    • 0030659557 scopus 로고    scopus 로고
    • The Fork head transcription factorDAF-16 transduces insulin-like metabolic and longevity signals in C. elegans
    • Ogg S, Paradis S, Gottlieb S, Patterson GI, Lee L, Tissenbaum HA, Ruvkun G. 1997. The Fork head transcription factorDAF-16 transduces insulin-like metabolic and longevity signals in C. elegans. Nature 389: 994-999.
    • (1997) Nature , vol.389 , pp. 994-999
    • Ogg, S.1    Paradis, S.2    Gottlieb, S.3    Patterson, G.I.4    Lee, L.5    Tissenbaum, H.A.6    Ruvkun, G.7
  • 97
    • 31744438846 scopus 로고    scopus 로고
    • Identification of direct DAF-16 targets controlling longevity, metabolism and diapause by chromatin immunoprecipitation
    • Oh SW, Mukhopadhyay A, Dixit BL, Raha T, Green MR, Tissenbaum HA. 2006. Identification of direct DAF-16 targets controlling longevity, metabolism and diapause by chromatin immunoprecipitation. Nat Genet 38: 251-257.
    • (2006) Nat Genet , vol.38 , pp. 251-257
    • Oh, S.W.1    Mukhopadhyay, A.2    Dixit, B.L.3    Raha, T.4    Green, M.R.5    Tissenbaum, H.A.6
  • 100
    • 68149169938 scopus 로고    scopus 로고
    • Signals of youth: Endocrine regulation of aging in Caenorhabditis elegans
    • Panowski SH, Dillin A. 2009. Signals of youth: Endocrine regulation of aging in Caenorhabditis elegans. Trends Endocrinol Metab 20: 259-264.
    • (2009) Trends Endocrinol Metab , vol.20 , pp. 259-264
    • Panowski, S.H.1    Dillin, A.2
  • 101
    • 34249888736 scopus 로고    scopus 로고
    • PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans
    • Panowski SH, Wolff S, Aguilaniu H, Durieux J, Dillin A. 2007. PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans. Nature 447: 550-555.
    • (2007) Nature , vol.447 , pp. 550-555
    • Panowski, S.H.1    Wolff, S.2    Aguilaniu, H.3    Durieux, J.4    Dillin, A.5
  • 102
    • 0032529189 scopus 로고    scopus 로고
    • Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor
    • Paradis S, Ruvkun G. 1998. Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor. Genes Dev 12: 2488-2498.
    • (1998) Genes Dev , vol.12 , pp. 2488-2498
    • Paradis, S.1    Ruvkun, G.2
  • 103
    • 13944282128 scopus 로고    scopus 로고
    • Sex and death:What is the connection?
    • Partridge L, GemsD, Withers DJ. 2005. Sex and death:What is the connection? Cell 120: 461-472.
    • (2005) Cell , vol.120 , pp. 461-472
    • Partridge, L.1    Gems, D.2    Withers, D.J.3
  • 104
    • 17744372861 scopus 로고    scopus 로고
    • Roles of the heat shock transcription factors in regulation of the heat shock response and beyond
    • Pirkkala L, Nykanen P, Sistonen L. 2001. Roles of the heat shock transcription factors in regulation of the heat shock response and beyond. FASEB J 15: 1118-1131.
    • (2001) FASEB J , vol.15 , pp. 1118-1131
    • Pirkkala, L.1    Nykanen, P.2    Sistonen, L.3
  • 105
    • 0042161896 scopus 로고    scopus 로고
    • Control of cell number by Drosophila FOXO: Downstream and feedback regulation of the insulin receptor pathway
    • Puig O, Marr MT, Ruhf ML, Tjian R. 2003. Control of cell number by Drosophila FOXO: Downstream and feedback regulation of the insulin receptor pathway. Genes Dev 17: 2006-2020.
    • (2003) Genes Dev , vol.17 , pp. 2006-2020
    • Puig, O.1    Marr, M.T.2    Ruhf, M.L.3    Tjian, R.4
  • 106
    • 13444259647 scopus 로고    scopus 로고
    • Regulation of cap-dependent translation by eIF4E inhibitory proteins
    • Richter JD, Sonenberg N. 2005. Regulation of cap-dependent translation by eIF4E inhibitory proteins. Nature 433: 477-480.
    • (2005) Nature , vol.433 , pp. 477-480
    • Richter, J.D.1    Sonenberg, N.2
  • 108
    • 36248964713 scopus 로고    scopus 로고
    • Gene activities that mediate increased life span of C. elegans insulin-like signaling mutants
    • Samuelson AV, Carr CE, Ruvkun G. 2007. Gene activities that mediate increased life span of C. elegans insulin-like signaling mutants. Genes Dev 21: 2976-2994.
    • (2007) Genes Dev , vol.21 , pp. 2976-2994
    • Samuelson, A.V.1    Carr, C.E.2    Ruvkun, G.3
  • 109
    • 22244446505 scopus 로고    scopus 로고
    • The mammalian unfolded protein response
    • Schroder M, Kaufman RJ. 2005. The mammalian unfolded protein response. Annu Rev Biochem 74: 739-789.
    • (2005) Annu Rev Biochem , vol.74 , pp. 739-789
    • Schroder, M.1    Kaufman, R.J.2
  • 111
    • 18244379033 scopus 로고    scopus 로고
    • Evidence for down-regulation of phosphoinositide 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR)-dependent translation regulatory signaling pathways in Ames dwarf mice
    • Sharp ZD, Bartke A. 2005. Evidence for down-regulation of phosphoinositide 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR)-dependent translation regulatory signaling pathways in Ames dwarf mice. J Gerontol A Biol Sci Med Sci 60: 293-300.
    • (2005) J Gerontol A Biol Sci Med Sci , vol.60 , pp. 293-300
    • Sharp, Z.D.1    Bartke, A.2
  • 112
    • 2942722444 scopus 로고    scopus 로고
    • Hsp104 catalyzes formation and elimination of self-replicating Sup35 prion conformers
    • Shorter J, Lindquist S. 2004. Hsp104 catalyzes formation and elimination of self-replicating Sup35 prion conformers. Science 304: 1793-1797.
    • (2004) Science , vol.304 , pp. 1793-1797
    • Shorter, J.1    Lindquist, S.2
  • 113
    • 38949099761 scopus 로고    scopus 로고
    • Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila
    • Simonsen A, Cumming RC, Brech A, Isakson P, Schubert DR, Finley KD. 2008. Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila. Autophagy 4: 176-184.
    • (2008) Autophagy , vol.4 , pp. 176-184
    • Simonsen, A.1    Cumming, R.C.2    Brech, A.3    Isakson, P.4    Schubert, D.R.5    Finley, K.D.6
  • 114
    • 40649129442 scopus 로고    scopus 로고
    • Nonenzymatic posttranslational protein modifications in ageing
    • Soskic V, Groebe K, Schrattenholz A. 2008. Nonenzymatic posttranslational protein modifications in ageing. Exp Gerontol 43: 247-257.
    • (2008) Exp Gerontol , vol.43 , pp. 247-257
    • Soskic, V.1    Groebe, K.2    Schrattenholz, A.3
  • 115
    • 0344944630 scopus 로고    scopus 로고
    • Protein aggregation and aggregate toxicity: New insights into protein folding, misfolding diseases and biological evolution
    • Stefani M, Dobson CM. 2003. Protein aggregation and aggregate toxicity: New insights into protein folding, misfolding diseases and biological evolution. J Mol Med 81: 678-699.
    • (2003) J Mol Med , vol.81 , pp. 678-699
    • Stefani, M.1    Dobson, C.M.2
  • 118
    • 33847199335 scopus 로고    scopus 로고
    • eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans
    • Syntichaki P, Troulinaki K, Tavernarakis N. 2007. eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans. Nature 445: 922-926.
    • (2007) Nature , vol.445 , pp. 922-926
    • Syntichaki, P.1    Troulinaki, K.2    Tavernarakis, N.3
  • 119
    • 0029560552 scopus 로고
    • The effect of age on formation and elimination of autophagic vacuoles in mouse hepatocytes
    • Terman A. 1995. The effect of age on formation and elimination of autophagic vacuoles in mouse hepatocytes. Gerontology 41 Suppl 2: 319-326.
    • (1995) Gerontology , vol.41 , Issue.SUPPL. 2 , pp. 319-326
    • Terman, A.1
  • 120
    • 0035826271 scopus 로고    scopus 로고
    • Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
    • Tissenbaum HA, Guarente L. 2001. Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature 410: 227-230.
    • (2001) Nature , vol.410 , pp. 227-230
    • Tissenbaum, H.A.1    Guarente, L.2
  • 124
    • 0041507039 scopus 로고    scopus 로고
    • Lifespan extension in C. elegans by a molecular chaperone dependent upon insulinlike signals
    • Walker GA, Lithgow GJ. 2003. Lifespan extension in C. elegans by a molecular chaperone dependent upon insulinlike signals. Aging Cell 2: 131-139.
    • (2003) Aging Cell , vol.2 , pp. 131-139
    • Walker, G.A.1    Lithgow, G.J.2
  • 125
    • 0035881470 scopus 로고    scopus 로고
    • Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase
    • Wang X, LiW, Williams M, Terada N, Alessi DR, Proud CG. 2001. Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase. EMBO J 20: 4370-4379.
    • (2001) EMBO J , vol.20 , pp. 4370-4379
    • Wang, X.1    Li, W.2    Williams, M.3    Terada, N.4    Alessi, D.R.5    Proud, C.G.6
  • 127
    • 33751431218 scopus 로고    scopus 로고
    • The trifecta of aging in Caenorhabditis elegans
    • Wolff S, Dillin A. 2006. The trifecta of aging in Caenorhabditis elegans. Exp Gerontol 41: 894-903.
    • (2006) Exp Gerontol , vol.41 , pp. 894-903
    • Wolff, S.1    Dillin, A.2
  • 128
    • 33644750381 scopus 로고    scopus 로고
    • SMK-1, an essential regulator of DAF-16-mediated longevity
    • Wolff S, Ma H, Burch D, Maciel GA, Hunter T, Dillin A. 2006. SMK-1, an essential regulator of DAF-16-mediated longevity. Cell 124: 1039-1053.
    • (2006) Cell , vol.124 , pp. 1039-1053
    • Wolff, S.1    Ma, H.2    Burch, D.3    Maciel, G.A.4    Hunter, T.5    Dillin, A.6
  • 129
    • 0346668317 scopus 로고    scopus 로고
    • Insulin receptor substrate and pp55 orthologous adaptor proteins function in the Caenorhabditis elegans daf-2/insulin-like signaling pathway
    • Wolkow CA, Munoz MJ, Riddle DL, Ruvkun G. 2002. Insulin receptor substrate and pp55 orthologous adaptor proteins function in the Caenorhabditis elegans daf-2/insulin-like signaling pathway. J Biol Chem 277: 49591-49597.
    • (2002) J Biol Chem , vol.277 , pp. 49591-49597
    • Wolkow, C.A.1    Munoz, M.J.2    Riddle, D.L.3    Ruvkun, G.4
  • 130
    • 32044465506 scopus 로고    scopus 로고
    • TORsignaling in growth and metabolism
    • Wullschleger S, Loewith R, Hall MN. 2006. TORsignaling in growth and metabolism. Cell 124: 471-484.
    • (2006) Cell , vol.124 , pp. 471-484
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 131
    • 33644540193 scopus 로고    scopus 로고
    • Autophagymediated clearance of huntingtin aggregates triggered by the insulin-signaling pathway
    • Yamamoto A, Cremona ML, Rothman JE. 2006. Autophagymediated clearance of huntingtin aggregates triggered by the insulin-signaling pathway. J Cell Biol 172: 719-731.
    • (2006) J Cell Biol , vol.172 , pp. 719-731
    • Yamamoto, A.1    Cremona, M.L.2    Rothman, J.E.3
  • 132
  • 133
    • 51349095898 scopus 로고    scopus 로고
    • Restoration of chaperonemediated autophagy in aging liver improves cellular maintenance and hepatic function
    • Zhang C, Cuervo AM. 2008. Restoration of chaperonemediated autophagy in aging liver improves cellular maintenance and hepatic function. Nat Med 14: 959-965.
    • (2008) Nat Med , vol.14 , pp. 959-965
    • Zhang, C.1    Cuervo, A.M.2
  • 134
    • 68149149835 scopus 로고    scopus 로고
    • The HIF-1 Hypoxia-Inducible Factor Modulates Lifespan in C. elegans
    • Zhang Y, Shao Z, Zhai Z, Shen C, Powell-Coffman JA. 2009. The HIF-1 Hypoxia-Inducible Factor Modulates Lifespan in C. elegans. PLoS ONE 4: e6348.
    • (2009) PLoS ONE , vol.4
    • Zhang, Y.1    Shao, Z.2    Zhai, Z.3    Shen, C.4    Powell-Coffman, J.A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.