-
1
-
-
84934443868
-
Heat shock factor 1 as a coordinator of stress and developmental pathways
-
Anckar J, Sistonen L. 2007. Heat shock factor 1 as a coordinator of stress and developmental pathways. Adv ExpMed Biol 594: 78-88.
-
(2007)
Adv ExpMed Biol
, vol.594
, pp. 78-88
-
-
Anckar, J.1
Sistonen, L.2
-
2
-
-
33845972658
-
Induction of the heat shock pathway during hypoxia requires regulation of heat shock factor by hypoxia-inducible factor-1
-
BairdNA, TurnbullDW, Johnson EA. 2006. Induction of the heat shock pathway during hypoxia requires regulation of heat shock factor by hypoxia-inducible factor-1. J Biol Chem 281: 38675-38681.
-
(2006)
J Biol Chem
, vol.281
, pp. 38675-38681
-
-
Baird, N.A.1
Turnbull, D.W.2
Johnson, E.A.3
-
4
-
-
55849132493
-
Insulin and aging
-
Bartke A. 2008. Insulin and aging. Cell Cycle 7: 3338-3343.
-
(2008)
Cell Cycle
, vol.7
, pp. 3338-3343
-
-
Bartke, A.1
-
5
-
-
33748561495
-
Chaperonin TRiC promotes the assembly of polyQ expansion proteins into nontoxic oligomers
-
Behrends C, Langer CA, Boteva R, Bottcher UM, Stemp MJ, Schaffar G, Rao BV, Giese A, Kretzschmar H, Siegers K, et al. 2006. Chaperonin TRiC promotes the assembly of polyQ expansion proteins into nontoxic oligomers. Mol Cell 23: 887-897.
-
(2006)
Mol Cell
, vol.23
, pp. 887-897
-
-
Behrends, C.1
Langer, C.A.2
Boteva, R.3
Bottcher, U.M.4
Stemp, M.J.5
Schaffar, G.6
Rao, B.V.7
Giese, A.8
Kretzschmar, H.9
Siegers, K.10
-
6
-
-
70349266064
-
Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging
-
Ben-Zvi A, Miller EA, Morimoto RI. 2009. Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging. Proc Natl Acad Sci 106: 14914-14919.
-
(2009)
Proc Natl Acad Sci
, vol.106
, pp. 14914-14919
-
-
Ben-Zvi, A.1
Miller, E.A.2
Morimoto, R.I.3
-
7
-
-
0030841350
-
Protein oxidation in aging, disease, and oxidative stress
-
Berlett BS, Stadtman ER. 1997. Protein oxidation in aging, disease, and oxidative stress. J Biol Chem 272: 20313-20316.
-
(1997)
J Biol Chem
, vol.272
, pp. 20313-20316
-
-
Berlett, B.S.1
Stadtman, E.R.2
-
8
-
-
27144458505
-
ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth
-
Bi M, Naczki C, Koritzinsky M, Fels D, Blais J, Hu N, Harding H, Novoa I, Varia M, Raleigh J, et al. 2005. ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth. EMBO J 24: 3470-3481.
-
(2005)
EMBO J
, vol.24
, pp. 3470-3481
-
-
Bi, M.1
Naczki, C.2
Koritzinsky, M.3
Fels, D.4
Blais, J.5
Hu, N.6
Harding, H.7
Novoa, I.8
Varia, M.9
Raleigh, J.10
-
9
-
-
70350519391
-
A kinetic assessment of the C. elegans amyloid disaggregation activity enables uncoupling of disassembly and proteolysis
-
Bieschke J, Cohen E, Murray A, Dillin A, Kelly JW. 2009. A kinetic assessment of the C. elegans amyloid disaggregation activity enables uncoupling of disassembly and proteolysis. Protein Sci 18: 2231-2241.
-
(2009)
Protein Sci
, vol.18
, pp. 2231-2241
-
-
Bieschke, J.1
Cohen, E.2
Murray, A.3
Dillin, A.4
Kelly, J.W.5
-
10
-
-
34249891333
-
Two neurons mediate dietrestriction-induced longevity in C. elegans
-
Bishop NA, Guarente L. 2007. Two neurons mediate dietrestriction-induced longevity in C. elegans. Nature 447: 545-549.
-
(2007)
Nature
, vol.447
, pp. 545-549
-
-
Bishop, N.A.1
Guarente, L.2
-
11
-
-
0036710928
-
Lipofuscin: Mechanisms of age-related accumulation and influence on cell function
-
Brunk UT, Terman A. 2002. Lipofuscin: mechanisms of age-related accumulation and influence on cell function. Free Radic Biol Med 33: 611-619.
-
(2002)
Free Radic Biol Med
, vol.33
, pp. 611-619
-
-
Brunk, U.T.1
Terman, A.2
-
12
-
-
33646127577
-
Molecular chaperones and protein quality control
-
Bukau B, Weissman J, Horwich A. 2006. Molecular chaperones and protein quality control. Cell 125: 443-451.
-
(2006)
Cell
, vol.125
, pp. 443-451
-
-
Bukau, B.1
Weissman, J.2
Horwich, A.3
-
13
-
-
0035918148
-
Phosphatidylinositol 3-kinase signaling inhibits DAF-16 DNA binding and function via 14-3-3-dependent and 14-3-3-independent pathways
-
Cahill CM, Tzivion G, Nasrin N, Ogg S, Dore J, Ruvkun G, Alexander-Bridges M. 2001. Phosphatidylinositol 3-kinase signaling inhibits DAF-16 DNA binding and function via 14-3-3-dependent and 14-3-3-independent pathways. J Biol Chem 276: 13402-13410.
-
(2001)
J Biol Chem
, vol.276
, pp. 13402-13410
-
-
Cahill, C.M.1
Tzivion, G.2
Nasrin, N.3
Ogg, S.4
Dore, J.5
Ruvkun, G.6
Alexander-Bridges, M.7
-
14
-
-
67651004289
-
A conserved ubiquitination pathway determines longevity in response to diet restriction
-
Carrano AC, Liu Z, Dillin A, Hunter T. 2009. A conserved ubiquitination pathway determines longevity in response to diet restriction. Nature 460: 396-399.
-
(2009)
Nature
, vol.460
, pp. 396-399
-
-
Carrano, A.C.1
Liu, Z.2
Dillin, A.3
Hunter, T.4
-
16
-
-
0036917631
-
Serum insulin-like growth factor I regulates brain amyloid-β levels
-
Carro E, Trejo JL, Gomez-Isla T, LeRoith D, Torres-Aleman I. 2002. Serum insulin-like growth factor I regulates brain amyloid-β levels. Nat Med 8: 1390-1397.
-
(2002)
Nat Med
, vol.8
, pp. 1390-1397
-
-
Carro, E.1
Trejo, J.L.2
Gomez-Isla, T.3
LeRoith, D.4
Torres-Aleman, I.5
-
17
-
-
67149107430
-
HIF-1 modulates dietary restriction-mediated lifespan extension via IRE-1 in Caenorhabditis elegans
-
Chen D, Thomas EL, Kapahi P. 2009. HIF-1 modulates dietary restriction-mediated lifespan extension via IRE-1 in Caenorhabditis elegans. PLoS Genet 5: e1000486.
-
(2009)
PLoS Genet
, vol.5
-
-
Chen, D.1
Thomas, E.L.2
Kapahi, P.3
-
18
-
-
33847680031
-
Ribosomal proteins Rpl10 and Rps6 are potent regulators of yeast replicative life span
-
Chiocchetti A, Zhou J, Zhu H, Karl T, HaubenreisserO, Rinnerthaler M, Heeren G, Oender K, Bauer J, Hintner H, et al. 2007. Ribosomal proteins Rpl10 and Rps6 are potent regulators of yeast replicative life span. Exp Gerontol 42: 275-286.
-
(2007)
Exp Gerontol
, vol.42
, pp. 275-286
-
-
Chiocchetti, A.1
Zhou, J.2
Zhu, H.3
Karl, T.4
Haubenreisser, O.5
Rinnerthaler, M.6
Heeren, G.7
Oender, K.8
Bauer, J.9
Hintner, H.10
-
19
-
-
0042467550
-
Rationalization of the effects of mutations on peptide and protein aggregation rates
-
Chiti F, Stefani M, Taddei N, Ramponi G, Dobson CM. 2003. Rationalization of the effects of mutations on peptide and protein aggregation rates. Nature 424: 805-808.
-
(2003)
Nature
, vol.424
, pp. 805-808
-
-
Chiti, F.1
Stefani, M.2
Taddei, N.3
Ramponi, G.4
Dobson, C.M.5
-
20
-
-
11244309014
-
Proteolysis: From the lysosome to ubiquitin and the proteasome
-
Ciechanover A. 2005. Proteolysis: from the lysosome to ubiquitin and the proteasome. Nat Rev Mol Cell Biol 6: 79-87.
-
(2005)
Nat Rev Mol Cell Biol
, vol.6
, pp. 79-87
-
-
Ciechanover, A.1
-
21
-
-
52449086907
-
The insulin paradox: Aging, proteotoxicity and neurodegeneration
-
Cohen E, Dillin A. 2008. The insulin paradox: aging, proteotoxicity and neurodegeneration. Nat Rev Neurosci 9: 759-767.
-
(2008)
Nat Rev Neurosci
, vol.9
, pp. 759-767
-
-
Cohen, E.1
Dillin, A.2
-
22
-
-
33748792821
-
Opposing activities protect against age-onset proteotoxicity
-
Cohen E, Bieschke J, Perciavalle RM, Kelly JW, Dillin A. 2006. Opposing activities protect against age-onset proteotoxicity. Science 313: 1604-1610.
-
(2006)
Science
, vol.313
, pp. 1604-1610
-
-
Cohen, E.1
Bieschke, J.2
Perciavalle, R.M.3
Kelly, J.W.4
Dillin, A.5
-
23
-
-
71449108913
-
Reduced IGF-1 signaling delays ageassociated proteotoxicity in mice
-
Cohen E, Paulsson JF, Blinder P, Burstyn-Cohen T, Du D, Estepa G, Adame A, Pham HM, Holzenberger M, Kelly JW, et al. 2009. Reduced IGF-1 signaling delays ageassociated proteotoxicity in mice. Cell 139: 1157-1169.
-
(2009)
Cell
, vol.139
, pp. 1157-1169
-
-
Cohen, E.1
Paulsson, J.F.2
Blinder, P.3
Burstyn-Cohen, T.4
Du, D.5
Estepa, G.6
Adame, A.7
Pham, H.M.8
Holzenberger, M.9
Kelly, J.W.10
-
24
-
-
70349782312
-
Extension of Drosophila life span by RNAi of the mitochondrial respiratory chain
-
Copeland JM, Cho J, Lo TJr, Hur JH, Bahadorani S, Arabyan T, Rabie J, Soh J, Walker DW. 2009. Extension of Drosophila life span by RNAi of the mitochondrial respiratory chain. Curr Biol 19: 1591-1598.
-
(2009)
Curr Biol
, vol.19
, pp. 1591-1598
-
-
Copeland, J.M.1
Cho, J.2
Lo Jr., T.3
Hur, J.H.4
Bahadorani, S.5
Arabyan, T.6
Rabie, J.7
Soh, J.8
Walker, D.W.9
-
25
-
-
56349168452
-
Autophagy and aging: Keeping that old broom working
-
Cuervo AM. 2008. Autophagy and aging: keeping that old broom working. Trends Genet 24: 604-612.
-
(2008)
Trends Genet
, vol.24
, pp. 604-612
-
-
Cuervo, A.M.1
-
26
-
-
0034613294
-
Age-related decline in chaperonemediated autophagy
-
Cuervo AM, Dice JF. 2000. Age-related decline in chaperonemediated autophagy. J Biol Chem 275: 31505-31513.
-
(2000)
J Biol Chem
, vol.275
, pp. 31505-31513
-
-
Cuervo, A.M.1
Dice, J.F.2
-
27
-
-
34548658230
-
Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis
-
Dai C, Whitesell L, Rogers AB, Lindquist S. 2007. Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis. Cell 130: 1005-1018.
-
(2007)
Cell
, vol.130
, pp. 1005-1018
-
-
Dai, C.1
Whitesell, L.2
Rogers, A.B.3
Lindquist, S.4
-
28
-
-
0037174629
-
Timing requirements for insulin/IGF-1 signaling in C. elegans
-
Dillin A, Crawford DK, Kenyon C. 2002a. Timing requirements for insulin/IGF-1 signaling in C. elegans. Science 298: 830-834.
-
(2002)
Science
, vol.298
, pp. 830-834
-
-
Dillin, A.1
Crawford, D.K.2
Kenyon, C.3
-
29
-
-
0037147103
-
Rates of behavior and aging specified by mitochondrial function during development
-
Dillin A, Hsu AL, Arantes-Oliveira N, Lehrer-Graiwer J, Hsin H, Fraser AG, Kamath RS, Ahringer J, Kenyon C. 2002b. Rates of behavior and aging specified by mitochondrial function during development. Science 298: 2398-2401.
-
(2002)
Science
, vol.298
, pp. 2398-2401
-
-
Dillin, A.1
Hsu, A.L.2
Arantes-Oliveira, N.3
Lehrer-Graiwer, J.4
Hsin, H.5
Fraser, A.G.6
Kamath, R.S.7
Ahringer, J.8
Kenyon, C.9
-
30
-
-
9744223523
-
Proteasome inhibition increases DNA and RNA oxidation in astrocyte and neuron cultures
-
Ding Q, Dimayuga E, Markesbery WR, Keller JN. 2004. Proteasome inhibition increases DNA and RNA oxidation in astrocyte and neuron cultures. J Neurochem 91: 1211-1218.
-
(2004)
J Neurochem
, vol.91
, pp. 1211-1218
-
-
Ding, Q.1
Dimayuga, E.2
Markesbery, W.R.3
Keller, J.N.4
-
31
-
-
0034954561
-
Age-related changes in the regulation of autophagic proteolysis in rat isolated hepatocytes
-
Donati A, Cavallini G, Paradiso C, Vittorini S, Pollera M, Gori Z, Bergamini E. 2001. Age-related changes in the regulation of autophagic proteolysis in rat isolated hepatocytes. J Gerontol A Biol Sci Med Sci 56: B288-B293.
-
(2001)
J Gerontol A Biol Sci Med Sci
, vol.56
-
-
Donati, A.1
Cavallini, G.2
Paradiso, C.3
Vittorini, S.4
Pollera, M.5
Gori, Z.6
Bergamini, E.7
-
32
-
-
50949086260
-
Effect of aging and anti-aging caloric restriction on the endocrine regulation of rat liver autophagy
-
Donati A, Recchia G, Cavallini G, Bergamini E. 2008. Effect of aging and anti-aging caloric restriction on the endocrine regulation of rat liver autophagy. J Gerontol A Biol Sci Med Sci 63: 550-555.
-
(2008)
J Gerontol A Biol Sci Med Sci
, vol.63
, pp. 550-555
-
-
Donati, A.1
Recchia, G.2
Cavallini, G.3
Bergamini, E.4
-
33
-
-
34547810054
-
Quantitative mass spectrometry identifies insulin signaling targets in C. elegans
-
Dong MQ, Venable JD, Au N, Xu T, Park SK, Cociorva D, Johnson JR, Dillin A, Yates JR 3rd. 2007. Quantitative mass spectrometry identifies insulin signaling targets in C. elegans. Science 317: 660-663.
-
(2007)
Science
, vol.317
, pp. 660-663
-
-
Dong, M.Q.1
Venable, J.D.2
Au, N.3
Xu, T.4
Park, S.K.5
Cociorva, D.6
Johnson, J.R.7
Dillin, A.8
Yates III, J.R.9
-
34
-
-
47549097539
-
Mistranslation-induced protein misfolding as a dominant constraint on codingsequence evolution
-
Drummond DA, Wilke CO. 2008. Mistranslation-induced protein misfolding as a dominant constraint on codingsequence evolution. Cell 134: 341-352.
-
(2008)
Cell
, vol.134
, pp. 341-352
-
-
Drummond, D.A.1
Wilke, C.O.2
-
35
-
-
70449529855
-
Induction of autophagy by spermidine promotes longevity
-
Eisenberg T, Knauer H, Schauer A, Buttner S, Ruckenstuhl C, Carmona-Gutierrez D, Ring J, Schroeder S, Magnes C, Antonacci L, et al. 2009. Induction of autophagy by spermidine promotes longevity. Nat Cell Biol 11: 1305-1314.
-
(2009)
Nat Cell Biol
, vol.11
, pp. 1305-1314
-
-
Eisenberg, T.1
Knauer, H.2
Schauer, A.3
Buttner, S.4
Ruckenstuhl, C.5
Carmona-Gutierrez, D.6
Ring, J.7
Schroeder, S.8
Magnes, C.9
Antonacci, L.10
-
36
-
-
0035515923
-
Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans
-
Feng J, Bussiere F, Hekimi S. 2001. Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans. Dev Cell 1: 633-644.
-
(2001)
Dev Cell
, vol.1
, pp. 633-644
-
-
Feng, J.1
Bussiere, F.2
Hekimi, S.3
-
37
-
-
16344363800
-
Altered proteasome structure, function, and oxidation in aged muscle
-
Ferrington DA, Husom AD, Thompson LV. 2005. Altered proteasome structure, function, and oxidation in aged muscle. FASEB J 19: 644-646.
-
(2005)
FASEB J
, vol.19
, pp. 644-646
-
-
Ferrington, D.A.1
Husom, A.D.2
Thompson, L.V.3
-
38
-
-
35848955910
-
Decreased insulin-receptor signaling promotes the autophagic degradation of β-amyloid peptide in C. elegans
-
Florez-McClure ML, Hohsfield LA, Fonte G, Bealor MT, Link CD. 2007. Decreased insulin-receptor signaling promotes the autophagic degradation of β-amyloid peptide in C. elegans. Autophagy 3: 569-580.
-
(2007)
Autophagy
, vol.3
, pp. 569-580
-
-
Florez-McClure, M.L.1
Hohsfield, L.A.2
Fonte, G.3
Bealor, M.T.4
Link, C.D.5
-
39
-
-
5044229348
-
Molecular mechanisms of translational control
-
Gebauer F, Hentze MW. 2004. Molecular mechanisms of translational control. Nat Rev Mol Cell Biol 5: 827-835.
-
(2004)
Nat Rev Mol Cell Biol
, vol.5
, pp. 827-835
-
-
Gebauer, F.1
Hentze, M.W.2
-
40
-
-
33644850056
-
Progressive disruption of cellular protein folding in models of polyglutamine diseases
-
Gidalevitz T, Ben-Zvi A, Ho KH, Brignull HR, Morimoto RI. 2006. Progressive disruption of cellular protein folding in models of polyglutamine diseases. Science 311: 1471-1474.
-
(2006)
Science
, vol.311
, pp. 1471-1474
-
-
Gidalevitz, T.1
Ben-Zvi, A.2
Ho, K.H.3
Brignull, H.R.4
Morimoto, R.I.5
-
41
-
-
62149129690
-
Destabilizing protein polymorphisms in the genetic background direct phenotypic expression of mutant SOD1 toxicity
-
Gidalevitz T, Krupinski T, Garcia S, Morimoto RI. 2009. Destabilizing protein polymorphisms in the genetic background direct phenotypic expression of mutant SOD1 toxicity. PLoS Genet 5: e1000399.
-
(2009)
PLoS Genet
, vol.5
-
-
Gidalevitz, T.1
Krupinski, T.2
Garcia, S.3
Morimoto, R.I.4
-
42
-
-
72949117234
-
Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila
-
Grandison RC, Piper MD, Partridge L. 2009. Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila. Nature 462: 1061-1064.
-
(2009)
Nature
, vol.462
, pp. 1061-1064
-
-
Grandison, R.C.1
Piper, M.D.2
Partridge, L.3
-
43
-
-
21144460742
-
Analysis of long-lived C. elegans daf-2 mutants using serial analysis of gene expression
-
Halaschek-Wiener J, Khattra JS, McKay S, Pouzyrev A, Stott JM, Yang GS, Holt RA, Jones SJ, Marra MA, Brooks-Wilson AR, et al. 2005. Analysis of long-lived C. elegans daf-2 mutants using serial analysis of gene expression. Genome Res 15: 603-615.
-
(2005)
Genome Res
, vol.15
, pp. 603-615
-
-
Halaschek-Wiener, J.1
Khattra, J.S.2
McKay, S.3
Pouzyrev, A.4
Stott, J.M.5
Yang, G.S.6
Holt, R.A.7
Jones, S.J.8
Marra, M.A.9
Brooks-Wilson, A.R.10
-
44
-
-
41949097891
-
C elegans model identifies genetic modifiers of α-synuclein inclusion formation during aging
-
van Ham TJ, Thijssen KL, Breitling R, Hofstra RM, Plasterk RH, Nollen EA. 2008. C elegans model identifies genetic modifiers of α-synuclein inclusion formation during aging. PLoS Genet 4: e1000027.
-
(2008)
PLoS Genet
, vol.4
-
-
van Ham, T.J.1
Thijssen, K.L.2
Breitling, R.3
Hofstra, R.M.4
Plasterk, R.H.5
Nollen, E.A.6
-
45
-
-
38649084391
-
Hypothesis-based RNAi screening identifies neuroprotective genes in a Parkinson's disease model
-
Hamamichi S, Rivas RN, Knight AL, Cao S, Caldwell KA, Caldwell GA. 2008. Hypothesis-based RNAi screening identifies neuroprotective genes in a Parkinson's disease model. Proc Natl Acad Sci 105: 728-733.
-
(2008)
Proc Natl Acad Sci
, vol.105
, pp. 728-733
-
-
Hamamichi, S.1
Rivas, R.N.2
Knight, A.L.3
Cao, S.4
Caldwell, K.A.5
Caldwell, G.A.6
-
46
-
-
77953020414
-
A photoconvertible reporter of the ubiquitin-proteasome system in vivo
-
Hamer G, Matilainen O, Holmberg CI. 2010. A photoconvertible reporter of the ubiquitin-proteasome system in vivo. Nat Methods 7: 473-478.
-
(2010)
Nat Methods
, vol.7
, pp. 473-478
-
-
Hamer, G.1
Matilainen, O.2
Holmberg, C.I.3
-
47
-
-
40149105890
-
A role for autophagy in the extension of lifespan by dietary restriction in C. elegans
-
Hansen M, Chandra A, Mitic LL, Onken B, Driscoll M, Kenyon C. 2008. A role for autophagy in the extension of lifespan by dietary restriction in C. elegans. PLoS Genet 4: e24.
-
(2008)
PLoS Genet
, vol.4
-
-
Hansen, M.1
Chandra, A.2
Mitic, L.L.3
Onken, B.4
Driscoll, M.5
Kenyon, C.6
-
48
-
-
33846423520
-
Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans
-
Hansen M, Taubert S, Crawford D, Libina N, Lee SJ, Kenyon C. 2007. Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans. Aging Cell 6: 95-110.
-
(2007)
Aging Cell
, vol.6
, pp. 95-110
-
-
Hansen, M.1
Taubert, S.2
Crawford, D.3
Libina, N.4
Lee, S.J.5
Kenyon, C.6
-
49
-
-
67650944993
-
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
-
Harrison DE, Strong R, Sharp ZD, Nelson JF, Astle CM, Flurkey K, Nadon NL, Wilkinson JE, Frenkel K, Carter CS, et al. 2009. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 460: 392-395.
-
(2009)
Nature
, vol.460
, pp. 392-395
-
-
Harrison, D.E.1
Strong, R.2
Sharp, Z.D.3
Nelson, J.F.4
Astle, C.M.5
Flurkey, K.6
Nadon, N.L.7
Wilkinson, J.E.8
Frenkel, K.9
Carter, C.S.10
-
50
-
-
0037470539
-
Genetics and the specificity of the aging process
-
Hekimi S, Guarente L. 2003. Genetics and the specificity of the aging process. Science 299: 1351-1354.
-
(2003)
Science
, vol.299
, pp. 1351-1354
-
-
Hekimi, S.1
Guarente, L.2
-
51
-
-
0035846604
-
daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans
-
Henderson ST, Johnson TE. 2001. daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans. Curr Biol 11: 1975-1980.
-
(2001)
Curr Biol
, vol.11
, pp. 1975-1980
-
-
Henderson, S.T.1
Johnson, T.E.2
-
52
-
-
77953091249
-
Insulin/IGF-1 signaling mutants reprogram ER stress response regulators to promote longevity
-
Henis-Korenblit S, Zhang P, Hansen M, McCormick M, See SJ, Cary M, Kenyon C. 2010. Insulin/IGF-1 signaling mutants reprogram ER stress response regulators to promote longevity. Proc Natl Acad Sci 107: 9730-9735.
-
(2010)
Proc Natl Acad Sci
, vol.107
, pp. 9730-9735
-
-
Henis-Korenblit, S.1
Zhang, P.2
Hansen, M.3
McCormick, M.4
See, S.J.5
Cary, M.6
Kenyon, C.7
-
53
-
-
0038826959
-
Lifespan extension of Drosophila melanogaster through hormesis by repeated mild heat stress
-
Hercus MJ, Loeschcke V, Rattan SI. 2003. Lifespan extension of Drosophila melanogaster through hormesis by repeated mild heat stress. Biogerontology 4: 149-156.
-
(2003)
Biogerontology
, vol.4
, pp. 149-156
-
-
Hercus, M.J.1
Loeschcke, V.2
Rattan, S.I.3
-
54
-
-
11144355021
-
Celegans SGK-1 is the critical component in the Akt/PKB kinase complex to control stress response and life span
-
Hertweck M, Gobel C, Baumeister R. 2004. Celegans SGK-1 is the critical component in the Akt/PKB kinase complex to control stress response and life span. Dev Cell 6: 577-588.
-
(2004)
Dev Cell
, vol.6
, pp. 577-588
-
-
Hertweck, M.1
Gobel, C.2
Baumeister, R.3
-
55
-
-
8344265219
-
Akt/PKB and pp38 MAPK signaling, translational initiation and longevity in Snell dwarf mouse livers
-
Hsieh CC, Papaconstantinou J. 2004. Akt/PKB and pp38 MAPK signaling, translational initiation and longevity in Snell dwarf mouse livers. Mech Ageing Dev 125: 785-798.
-
(2004)
Mech Ageing Dev
, vol.125
, pp. 785-798
-
-
Hsieh, C.C.1
Papaconstantinou, J.2
-
56
-
-
0038701745
-
Regulation of aging and age-related disease byDAF-16 and heat-shock factor
-
Hsu AL, Murphy CT, Kenyon C. 2003. Regulation of aging and age-related disease byDAF-16 and heat-shock factor. Science 300: 1142-1145.
-
(2003)
Science
, vol.300
, pp. 1142-1145
-
-
Hsu, A.L.1
Murphy, C.T.2
Kenyon, C.3
-
57
-
-
35848937781
-
Autophagy is required for dietary restriction-mediated life span extension in C. elegans
-
Jia K, Levine B. 2007. Autophagy is required for dietary restriction-mediated life span extension in C. elegans. Autophagy 3: 597-599.
-
(2007)
Autophagy
, vol.3
, pp. 597-599
-
-
Jia, K.1
Levine, B.2
-
58
-
-
4544311861
-
The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span
-
Jia K, Chen D, Riddle DL. 2004. The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span. Development 131: 3897-3906.
-
(2004)
Development
, vol.131
, pp. 3897-3906
-
-
Jia, K.1
Chen, D.2
Riddle, D.L.3
-
59
-
-
33846210657
-
Autophagy genes protect against disease caused by polyglutamine expansion proteins in Caenorhabditis elegans
-
Jia K, Hart AC, Levine B. 2007. Autophagy genes protect against disease caused by polyglutamine expansion proteins in Caenorhabditis elegans. Autophagy 3: 21-25.
-
(2007)
Autophagy
, vol.3
, pp. 21-25
-
-
Jia, K.1
Hart, A.C.2
Levine, B.3
-
60
-
-
77955292017
-
Role of autophagy in diabetes and mitochondria
-
Jung HS, Lee MS. 2010. Role of autophagy in diabetes and mitochondria. Ann N Y Acad Sci 1201: 79-83.
-
(2010)
Ann N Y Acad Sci
, vol.1201
, pp. 79-83
-
-
Jung, H.S.1
Lee, M.S.2
-
61
-
-
27744511769
-
Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients
-
Kaeberlein M, Powers RW3rd, Steffen KK, Westman EA, Hu D, Dang N, Kerr EO, Kirkland KT, Fields S, Kennedy BK. 2005. Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients. Science 310: 1193-1196.
-
(2005)
Science
, vol.310
, pp. 1193-1196
-
-
Kaeberlein, M.1
Powers III, R.W.2
Steffen, K.K.3
Westman, E.A.4
Hu, D.5
Dang, N.6
Kerr, E.O.7
Kirkland, K.T.8
Fields, S.9
Kennedy, B.K.10
-
62
-
-
20844451123
-
AMPactivated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism
-
Kahn BB, Alquier T, Carling D, Hardie DG. 2005. AMPactivated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab 1: 15-25.
-
(2005)
Cell Metab
, vol.1
, pp. 15-25
-
-
Kahn, B.B.1
Alquier, T.2
Carling, D.3
Hardie, D.G.4
-
63
-
-
16644365353
-
TOR pathway: Linking nutrient sensing to life span
-
Kapahi P, Zid B. 2004. TOR pathway: linking nutrient sensing to life span. Sci Aging Knowledge Environ 2004: PE34.
-
(2004)
Sci Aging Knowledge Environ
, vol.2004
-
-
Kapahi, P.1
Zid, B.2
-
64
-
-
3042648746
-
Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway
-
Kapahi P, Zid BM, Harper T, Koslover D, Sapin V, Benzer S. 2004. Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway. Curr Biol 14: 885-890.
-
(2004)
Curr Biol
, vol.14
, pp. 885-890
-
-
Kapahi, P.1
Zid, B.M.2
Harper, T.3
Koslover, D.4
Sapin, V.5
Benzer, S.6
-
65
-
-
4344618623
-
Autophagy, proteasomes, lipofuscin, and oxidative stress in the aging brain
-
Keller JN, Dimayuga E, Chen Q, Thorpe J, Gee J, Ding Q. 2004. Autophagy, proteasomes, lipofuscin, and oxidative stress in the aging brain. Int J Biochem Cell Biol 36: 2376-2391.
-
(2004)
Int J Biochem Cell Biol
, vol.36
, pp. 2376-2391
-
-
Keller, J.N.1
Dimayuga, E.2
Chen, Q.3
Thorpe, J.4
Gee, J.5
Ding, Q.6
-
66
-
-
79952911953
-
Dietary restriction delays aging, but not neuronal dysfunction, in Drosophila models of Alzheimer's disease
-
Kerr F, Augustin H, Piper MD, Gandy C, Allen MJ, Lovestone S, Partridge L. 2009. Dietary restriction delays aging, but not neuronal dysfunction, in Drosophila models of Alzheimer's disease. Neurobiol Aging 4: T225.
-
(2009)
Neurobiol Aging
, vol.4
-
-
Kerr, F.1
Augustin, H.2
Piper, M.D.3
Gandy, C.4
Allen, M.J.5
Lovestone, S.6
Partridge, L.7
-
67
-
-
33847690636
-
Altered dynamics of the lysosomal receptor for chaperone-mediated autophagy with age
-
Kiffin R, Kaushik S, Zeng M, Bandyopadhyay U, Zhang C, Massey AC, Martinez-Vicente M, Cuervo AM. 2007. Altered dynamics of the lysosomal receptor for chaperone-mediated autophagy with age. J Cell Sci 120: 782-791.
-
(2007)
J Cell Sci
, vol.120
, pp. 782-791
-
-
Kiffin, R.1
Kaushik, S.2
Zeng, M.3
Bandyopadhyay, U.4
Zhang, C.5
Massey, A.C.6
Martinez-Vicente, M.7
Cuervo, A.M.8
-
68
-
-
13944262937
-
Understanding the odd science of aging
-
Kirkwood TB. 2005. Understanding the odd science of aging. Cell 120: 437-447.
-
(2005)
Cell
, vol.120
, pp. 437-447
-
-
Kirkwood, T.B.1
-
69
-
-
0032573178
-
The genetics of caloric restriction in Caenorhabditis elegans
-
Lakowski B, Hekimi S. 1998. The genetics of caloric restriction in Caenorhabditis elegans. Proc Natl Acad Sci 95: 13091-13096.
-
(1998)
Proc Natl Acad Sci
, vol.95
, pp. 13091-13096
-
-
Lakowski, B.1
Hekimi, S.2
-
70
-
-
0035846601
-
Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway
-
Lee RY, Hench J, Ruvkun G. 2001. Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway. Curr Biol 11: 1950-1957.
-
(2001)
Curr Biol
, vol.11
, pp. 1950-1957
-
-
Lee, R.Y.1
Hench, J.2
Ruvkun, G.3
-
71
-
-
33748432548
-
Editing-defective tRNA synthetase causes protein misfolding and neurodegeneration
-
Lee JW, Beebe K, Nangle LA, Jang J, Longo-Guess CM, Cook SA, Davisson MT, Sundberg JP, Schimmel P, Ackerman SL. 2006. Editing-defective tRNA synthetase causes protein misfolding and neurodegeneration. Nature 443: 50-55.
-
(2006)
Nature
, vol.443
, pp. 50-55
-
-
Lee, J.W.1
Beebe, K.2
Nangle, L.A.3
Jang, J.4
Longo-Guess, C.M.5
Cook, S.A.6
Davisson, M.T.7
Sundberg, J.P.8
Schimmel, P.9
Ackerman, S.L.10
-
72
-
-
0037228016
-
A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity
-
Lee SS, Lee RY, Fraser AG, Kamath RS, Ahringer J, Ruvkun G. 2003. A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity. Nat Genet 33: 40-48.
-
(2003)
Nat Genet
, vol.33
, pp. 40-48
-
-
Lee, S.S.1
Lee, R.Y.2
Fraser, A.G.3
Kamath, R.S.4
Ahringer, J.5
Ruvkun, G.6
-
73
-
-
33846596646
-
RLE-1, an E3 ubiquitin ligase, regulates C. elegans aging by catalyzing DAF-16 polyubiquitination
-
LiW, Gao B, Lee SM, Bennett K, FangD. 2007. RLE-1, an E3 ubiquitin ligase, regulates C. elegans aging by catalyzing DAF-16 polyubiquitination. Dev Cell 12: 235-246.
-
(2007)
Dev Cell
, vol.12
, pp. 235-246
-
-
Li, W.1
Gao, B.2
Lee, S.M.3
Bennett, K.4
Fang, D.5
-
74
-
-
0030657540
-
daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans
-
Lin K, Dorman JB, Rodan A, Kenyon C. 1997. daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans. Science 278: 1319-1322.
-
(1997)
Science
, vol.278
, pp. 1319-1322
-
-
Lin, K.1
Dorman, J.B.2
Rodan, A.3
Kenyon, C.4
-
75
-
-
0034967720
-
Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling
-
Lin K, Hsin H, Libina N, Kenyon C. 2001. Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling. Nat Genet 28: 139-145.
-
(2001)
Nat Genet
, vol.28
, pp. 139-145
-
-
Lin, K.1
Hsin, H.2
Libina, N.3
Kenyon, C.4
-
76
-
-
0028981288
-
Expression of human β-amyloid peptide in transgenic Caenorhabditis elegans
-
Link CD. 1995. Expression of human β-amyloid peptide in transgenic Caenorhabditis elegans. Proc Natl Acad Sci 92: 9368-9372.
-
(1995)
Proc Natl Acad Sci
, vol.92
, pp. 9368-9372
-
-
Link, C.D.1
-
77
-
-
0029123058
-
Thermotolerance and extended life-span conferred by singlegene mutations and induced by thermal stress
-
Lithgow GJ, White TM, Melov S, Johnson TE. 1995. Thermotolerance and extended life-span conferred by singlegene mutations and induced by thermal stress. Proc Natl Acad Sci 92: 7540-7544.
-
(1995)
Proc Natl Acad Sci
, vol.92
, pp. 7540-7544
-
-
Lithgow, G.J.1
White, T.M.2
Melov, S.3
Johnson, T.E.4
-
78
-
-
26944501617
-
Evolutionary conservation of the clk-1-dependent mechanism of longevity: Loss of mclk1 increases cellular fitness and lifespan in mice
-
Liu X, Jiang N, Hughes B, Bigras E, Shoubridge E, Hekimi S. 2005. Evolutionary conservation of the clk-1-dependent mechanism of longevity: loss of mclk1 increases cellular fitness and lifespan in mice. Genes Dev 19: 2424-2434.
-
(2005)
Genes Dev
, vol.19
, pp. 2424-2434
-
-
Liu, X.1
Jiang, N.2
Hughes, B.3
Bigras, E.4
Shoubridge, E.5
Hekimi, S.6
-
79
-
-
50649099122
-
Aging and survival: The genetics of life span extension by dietary restriction
-
Mair W, Dillin A. 2008. Aging and survival: the genetics of life span extension by dietary restriction. Annu Rev Biochem 77: 727-754.
-
(2008)
Annu Rev Biochem
, vol.77
, pp. 727-754
-
-
Mair, W.1
Dillin, A.2
-
80
-
-
0141766912
-
Demography of dietary restriction and death in Drosophila
-
MairW, Goymer P, Pletcher SD, Partridge L. 2003. Demography of dietary restriction and death in Drosophila. Science 301: 1731-1733.
-
(2003)
Science
, vol.301
, pp. 1731-1733
-
-
Mair, W.1
Goymer, P.2
Pletcher, S.D.3
Partridge, L.4
-
81
-
-
8444224619
-
Balancing Akt with S6K: Implications for both metabolic diseases and tumorigenesis
-
Manning BD. 2004. Balancing Akt with S6K: implications for both metabolic diseases and tumorigenesis. J Cell Biol 167: 399-403.
-
(2004)
J Cell Biol
, vol.167
, pp. 399-403
-
-
Manning, B.D.1
-
82
-
-
77956334156
-
Insulin-like signaling determines survival during stress via posttranscriptional mechanisms in C. elegans
-
McColl G, Rogers AN, Alavez S, Hubbard AE, Melov S, Link CD, Bush AI, Kapahi P, LithgowGJ. 2010. Insulin-like signaling determines survival during stress via posttranscriptional mechanisms in C. elegans. Cell Metab 12: 260-272.
-
(2010)
Cell Metab
, vol.12
, pp. 260-272
-
-
McColl, G.1
Rogers, A.N.2
Alavez, S.3
Hubbard, A.E.4
Melov, S.5
Link, C.D.6
Bush, A.I.7
Kapahi, P.8
Lithgow, G.J.9
-
83
-
-
0042631524
-
Transcriptional outputs of the Caenorhabditis elegans forkhead protein DAF-16
-
McElwee J, Bubb K, Thomas JH. 2003. Transcriptional outputs of the Caenorhabditis elegans forkhead protein DAF-16. Aging Cell 2: 111-121.
-
(2003)
Aging Cell
, vol.2
, pp. 111-121
-
-
McElwee, J.1
Bubb, K.2
Thomas, J.H.3
-
84
-
-
0032571397
-
Targeted disruption of heat shock transcription factor 1 abolishes thermotolerance and protection against heatinducible apoptosis
-
McMillan DR, Xiao X, Shao L, Graves K, Benjamin IJ. 1998. Targeted disruption of heat shock transcription factor 1 abolishes thermotolerance and protection against heatinducible apoptosis. J Biol Chem 273: 7523-7528.
-
(1998)
J Biol Chem
, vol.273
, pp. 7523-7528
-
-
McMillan, D.R.1
Xiao, X.2
Shao, L.3
Graves, K.4
Benjamin, I.J.5
-
85
-
-
66349098677
-
Proteasomal regulation of the hypoxic response modulates aging in C. elegans
-
Mehta R, Steinkraus KA, Sutphin GL, Ramos FJ, Shamieh LS, Huh A, Davis C, Chandler-Brown D, Kaeberlein M. 2009. Proteasomal regulation of the hypoxic response modulates aging in C. elegans. Science 324: 1196-1198.
-
(2009)
Science
, vol.324
, pp. 1196-1198
-
-
Mehta, R.1
Steinkraus, K.A.2
Sutphin, G.L.3
Ramos, F.J.4
Shamieh, L.S.5
Huh, A.6
Davis, C.7
Chandler-Brown, D.8
Kaeberlein, M.9
-
86
-
-
0042691506
-
Autophagy genes are essential for dauer development and life-span extension in C. elegans
-
Melendez A, Talloczy Z, Seaman M, Eskelinen EL, Hall DH, Levine B. 2003. Autophagy genes are essential for dauer development and life-span extension in C. elegans. Science 301: 1387-1391.
-
(2003)
Science
, vol.301
, pp. 1387-1391
-
-
Melendez, A.1
Talloczy, Z.2
Seaman, M.3
Eskelinen, E.L.4
Hall, D.H.5
Levine, B.6
-
87
-
-
44849094781
-
Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging
-
Morimoto RI. 2008. Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging. Genes Dev 22: 1427-1438.
-
(2008)
Genes Dev
, vol.22
, pp. 1427-1438
-
-
Morimoto, R.I.1
-
88
-
-
0742323000
-
Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones
-
Morley JF, Morimoto RI. 2004. Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones. Mol Biol Cell 15: 657-664.
-
(2004)
Mol Biol Cell
, vol.15
, pp. 657-664
-
-
Morley, J.F.1
Morimoto, R.I.2
-
89
-
-
0036678146
-
The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans
-
Morley JF, Brignull HR, Weyers JJ, Morimoto RI. 2002. The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans. Proc Natl Acad Sci 99: 10417-10422.
-
(2002)
Proc Natl Acad Sci
, vol.99
, pp. 10417-10422
-
-
Morley, J.F.1
Brignull, H.R.2
Weyers, J.J.3
Morimoto, R.I.4
-
90
-
-
0029768753
-
A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans
-
Morris JZ, Tissenbaum HA, Ruvkun G. 1996. A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans. Nature 382: 536-539.
-
(1996)
Nature
, vol.382
, pp. 536-539
-
-
Morris, J.Z.1
Tissenbaum, H.A.2
Ruvkun, G.3
-
91
-
-
2442649342
-
Overexpression of the small mitochondrial Hsp22 extends Drosophila life span and increases resistance to oxidative stress
-
Morrow G, Samson M, Michaud S, Tanguay RM. 2004. Overexpression of the small mitochondrial Hsp22 extends Drosophila life span and increases resistance to oxidative stress. FASEB J 18: 598-599.
-
(2004)
FASEB J
, vol.18
, pp. 598-599
-
-
Morrow, G.1
Samson, M.2
Michaud, S.3
Tanguay, R.M.4
-
92
-
-
0037274713
-
Positive selection of Caenorhabditis elegans mutants with increased stress resistance and longevity
-
Muñoz MJ, Riddle DL. 2003. Positive selection of Caenorhabditis elegans mutants with increased stress resistance and longevity. Genetics 163: 171-180.
-
(2003)
Genetics
, vol.163
, pp. 171-180
-
-
Muñoz, M.J.1
Riddle, D.L.2
-
93
-
-
0042092531
-
Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans
-
Murphy CT, McCarroll SA, Bargmann CI, Fraser A, Kamath RS, Ahringer J, Li H, Kenyon C. 2003. Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Nature 424: 277-283.
-
(2003)
Nature
, vol.424
, pp. 277-283
-
-
Murphy, C.T.1
McCarroll, S.A.2
Bargmann, C.I.3
Fraser, A.4
Kamath, R.S.5
Ahringer, J.6
Li, H.7
Kenyon, C.8
-
94
-
-
2342652188
-
Genome-wide RNA interference screen identifies previously undescribed regulators of polyglutamine aggregation
-
Nollen EA, Garcia SM, van Haaften G, Kim S, Chavez A, Morimoto RI, Plasterk RH. 2004. Genome-wide RNA interference screen identifies previously undescribed regulators of polyglutamine aggregation. Proc Natl Acad Sci 101: 6403-6408.
-
(2004)
Proc Natl Acad Sci
, vol.101
, pp. 6403-6408
-
-
Nollen, E.A.1
Garcia, S.M.2
van Haaften, G.3
Kim, S.4
Chavez, A.5
Morimoto, R.I.6
Plasterk, R.H.7
-
95
-
-
0032238299
-
The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway
-
Ogg S, Ruvkun G. 1998. The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway. Mol Cell 2: 887-893.
-
(1998)
Mol Cell
, vol.2
, pp. 887-893
-
-
Ogg, S.1
Ruvkun, G.2
-
96
-
-
0030659557
-
The Fork head transcription factorDAF-16 transduces insulin-like metabolic and longevity signals in C. elegans
-
Ogg S, Paradis S, Gottlieb S, Patterson GI, Lee L, Tissenbaum HA, Ruvkun G. 1997. The Fork head transcription factorDAF-16 transduces insulin-like metabolic and longevity signals in C. elegans. Nature 389: 994-999.
-
(1997)
Nature
, vol.389
, pp. 994-999
-
-
Ogg, S.1
Paradis, S.2
Gottlieb, S.3
Patterson, G.I.4
Lee, L.5
Tissenbaum, H.A.6
Ruvkun, G.7
-
97
-
-
31744438846
-
Identification of direct DAF-16 targets controlling longevity, metabolism and diapause by chromatin immunoprecipitation
-
Oh SW, Mukhopadhyay A, Dixit BL, Raha T, Green MR, Tissenbaum HA. 2006. Identification of direct DAF-16 targets controlling longevity, metabolism and diapause by chromatin immunoprecipitation. Nat Genet 38: 251-257.
-
(2006)
Nat Genet
, vol.38
, pp. 251-257
-
-
Oh, S.W.1
Mukhopadhyay, A.2
Dixit, B.L.3
Raha, T.4
Green, M.R.5
Tissenbaum, H.A.6
-
98
-
-
5644231992
-
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes
-
Ozcan U, Cao Q, Yilmaz E, Lee AH, Iwakoshi NN, Ozdelen E, Tuncman G, Görgün C, Glimcher LH, Hotamisligil GS. 2004. Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 306: 457-461.
-
(2004)
Science
, vol.306
, pp. 457-461
-
-
Ozcan, U.1
Cao, Q.2
Yilmaz, E.3
Lee, A.H.4
Iwakoshi, N.N.5
Ozdelen, E.6
Tuncman, G.7
Görgün, C.8
Glimcher, L.H.9
Hotamisligil, G.S.10
-
99
-
-
33846418352
-
Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans
-
Pan KZ, Palter JE, Rogers AN, Olsen A, ChenD, Lithgow GJ, Kapahi P. 2007. Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans. Aging Cell 6: 111-119.
-
(2007)
Aging Cell
, vol.6
, pp. 111-119
-
-
Pan, K.Z.1
Palter, J.E.2
Rogers, A.N.3
Olsen, A.4
Chen, D.5
Lithgow, G.J.6
Kapahi, P.7
-
100
-
-
68149169938
-
Signals of youth: Endocrine regulation of aging in Caenorhabditis elegans
-
Panowski SH, Dillin A. 2009. Signals of youth: Endocrine regulation of aging in Caenorhabditis elegans. Trends Endocrinol Metab 20: 259-264.
-
(2009)
Trends Endocrinol Metab
, vol.20
, pp. 259-264
-
-
Panowski, S.H.1
Dillin, A.2
-
101
-
-
34249888736
-
PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans
-
Panowski SH, Wolff S, Aguilaniu H, Durieux J, Dillin A. 2007. PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans. Nature 447: 550-555.
-
(2007)
Nature
, vol.447
, pp. 550-555
-
-
Panowski, S.H.1
Wolff, S.2
Aguilaniu, H.3
Durieux, J.4
Dillin, A.5
-
102
-
-
0032529189
-
Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor
-
Paradis S, Ruvkun G. 1998. Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor. Genes Dev 12: 2488-2498.
-
(1998)
Genes Dev
, vol.12
, pp. 2488-2498
-
-
Paradis, S.1
Ruvkun, G.2
-
103
-
-
13944282128
-
Sex and death:What is the connection?
-
Partridge L, GemsD, Withers DJ. 2005. Sex and death:What is the connection? Cell 120: 461-472.
-
(2005)
Cell
, vol.120
, pp. 461-472
-
-
Partridge, L.1
Gems, D.2
Withers, D.J.3
-
104
-
-
17744372861
-
Roles of the heat shock transcription factors in regulation of the heat shock response and beyond
-
Pirkkala L, Nykanen P, Sistonen L. 2001. Roles of the heat shock transcription factors in regulation of the heat shock response and beyond. FASEB J 15: 1118-1131.
-
(2001)
FASEB J
, vol.15
, pp. 1118-1131
-
-
Pirkkala, L.1
Nykanen, P.2
Sistonen, L.3
-
105
-
-
0042161896
-
Control of cell number by Drosophila FOXO: Downstream and feedback regulation of the insulin receptor pathway
-
Puig O, Marr MT, Ruhf ML, Tjian R. 2003. Control of cell number by Drosophila FOXO: Downstream and feedback regulation of the insulin receptor pathway. Genes Dev 17: 2006-2020.
-
(2003)
Genes Dev
, vol.17
, pp. 2006-2020
-
-
Puig, O.1
Marr, M.T.2
Ruhf, M.L.3
Tjian, R.4
-
106
-
-
13444259647
-
Regulation of cap-dependent translation by eIF4E inhibitory proteins
-
Richter JD, Sonenberg N. 2005. Regulation of cap-dependent translation by eIF4E inhibitory proteins. Nature 433: 477-480.
-
(2005)
Nature
, vol.433
, pp. 477-480
-
-
Richter, J.D.1
Sonenberg, N.2
-
107
-
-
75649129374
-
Cancer linked to Alzheimer disease but not vascular dementia
-
Roe CM, Fitzpatrick AL, Xiong C, SiehW, Kuller L, Miller JP, Williams MM, Kopan R, Behrens MI, Morris JC. 2010. Cancer linked to Alzheimer disease but not vascular dementia. Neurology 74: 106-112.
-
(2010)
Neurology
, vol.74
, pp. 106-112
-
-
Roe, C.M.1
Fitzpatrick, A.L.2
Xiong, C.3
Sieh, W.4
Kuller, L.5
Miller, J.P.6
Williams, M.M.7
Kopan, R.8
Behrens, M.I.9
Morris, J.C.10
-
108
-
-
36248964713
-
Gene activities that mediate increased life span of C. elegans insulin-like signaling mutants
-
Samuelson AV, Carr CE, Ruvkun G. 2007. Gene activities that mediate increased life span of C. elegans insulin-like signaling mutants. Genes Dev 21: 2976-2994.
-
(2007)
Genes Dev
, vol.21
, pp. 2976-2994
-
-
Samuelson, A.V.1
Carr, C.E.2
Ruvkun, G.3
-
109
-
-
22244446505
-
The mammalian unfolded protein response
-
Schroder M, Kaufman RJ. 2005. The mammalian unfolded protein response. Annu Rev Biochem 74: 739-789.
-
(2005)
Annu Rev Biochem
, vol.74
, pp. 739-789
-
-
Schroder, M.1
Kaufman, R.J.2
-
110
-
-
70349669095
-
Ribosomal protein S6 kinase 1 signaling regulates mammalian life span
-
Selman C, Tullet JM, WieserD, Irvine E, Lingard SJ, Choudhury AI, Claret M, Al-Qassab H, Carmignac D, Ramadani F, et al. 2009. Ribosomal protein S6 kinase 1 signaling regulates mammalian life span. Science 326: 140-144.
-
(2009)
Science
, vol.326
, pp. 140-144
-
-
Selman, C.1
Tullet, J.M.2
Wieser, D.3
Irvine, E.4
Lingard, S.J.5
Choudhury, A.I.6
Claret, M.7
Al-Qassab, H.8
Carmignac, D.9
Ramadani, F.10
-
111
-
-
18244379033
-
Evidence for down-regulation of phosphoinositide 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR)-dependent translation regulatory signaling pathways in Ames dwarf mice
-
Sharp ZD, Bartke A. 2005. Evidence for down-regulation of phosphoinositide 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR)-dependent translation regulatory signaling pathways in Ames dwarf mice. J Gerontol A Biol Sci Med Sci 60: 293-300.
-
(2005)
J Gerontol A Biol Sci Med Sci
, vol.60
, pp. 293-300
-
-
Sharp, Z.D.1
Bartke, A.2
-
112
-
-
2942722444
-
Hsp104 catalyzes formation and elimination of self-replicating Sup35 prion conformers
-
Shorter J, Lindquist S. 2004. Hsp104 catalyzes formation and elimination of self-replicating Sup35 prion conformers. Science 304: 1793-1797.
-
(2004)
Science
, vol.304
, pp. 1793-1797
-
-
Shorter, J.1
Lindquist, S.2
-
113
-
-
38949099761
-
Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila
-
Simonsen A, Cumming RC, Brech A, Isakson P, Schubert DR, Finley KD. 2008. Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila. Autophagy 4: 176-184.
-
(2008)
Autophagy
, vol.4
, pp. 176-184
-
-
Simonsen, A.1
Cumming, R.C.2
Brech, A.3
Isakson, P.4
Schubert, D.R.5
Finley, K.D.6
-
114
-
-
40649129442
-
Nonenzymatic posttranslational protein modifications in ageing
-
Soskic V, Groebe K, Schrattenholz A. 2008. Nonenzymatic posttranslational protein modifications in ageing. Exp Gerontol 43: 247-257.
-
(2008)
Exp Gerontol
, vol.43
, pp. 247-257
-
-
Soskic, V.1
Groebe, K.2
Schrattenholz, A.3
-
115
-
-
0344944630
-
Protein aggregation and aggregate toxicity: New insights into protein folding, misfolding diseases and biological evolution
-
Stefani M, Dobson CM. 2003. Protein aggregation and aggregate toxicity: New insights into protein folding, misfolding diseases and biological evolution. J Mol Med 81: 678-699.
-
(2003)
J Mol Med
, vol.81
, pp. 678-699
-
-
Stefani, M.1
Dobson, C.M.2
-
116
-
-
41949089130
-
Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4
-
Steffen KK, MacKay VL, Kerr EO, Tsuchiya M, Hu D, Fox LA, Dang N, Johnston ED, Oakes JA, Tchao BN, et al. 2008. Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4. Cell 133: 292-302.
-
(2008)
Cell
, vol.133
, pp. 292-302
-
-
Steffen, K.K.1
McKay, V.L.2
Kerr, E.O.3
Tsuchiya, M.4
Hu, D.5
Fox, L.A.6
Dang, N.7
Johnston, E.D.8
Oakes, J.A.9
Tchao, B.N.10
-
117
-
-
43449138491
-
Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf-1-dependent mechanism in Caenorhabditis elegans
-
Steinkraus KA, Smith ED, Davis C, CarrD, Pendergrass WR, Sutphin GL, Kennedy BK, Kaeberlein M. 2008. Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf-1-dependent mechanism in Caenorhabditis elegans. Aging Cell 7: 394-404.
-
(2008)
Aging Cell
, vol.7
, pp. 394-404
-
-
Steinkraus, K.A.1
Smith, E.D.2
Davis, C.3
Carr, D.4
Pendergrass, W.R.5
Sutphin, G.L.6
Kennedy, B.K.7
Kaeberlein, M.8
-
118
-
-
33847199335
-
eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans
-
Syntichaki P, Troulinaki K, Tavernarakis N. 2007. eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans. Nature 445: 922-926.
-
(2007)
Nature
, vol.445
, pp. 922-926
-
-
Syntichaki, P.1
Troulinaki, K.2
Tavernarakis, N.3
-
119
-
-
0029560552
-
The effect of age on formation and elimination of autophagic vacuoles in mouse hepatocytes
-
Terman A. 1995. The effect of age on formation and elimination of autophagic vacuoles in mouse hepatocytes. Gerontology 41 Suppl 2: 319-326.
-
(1995)
Gerontology
, vol.41
, Issue.SUPPL. 2
, pp. 319-326
-
-
Terman, A.1
-
120
-
-
0035826271
-
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
-
Tissenbaum HA, Guarente L. 2001. Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature 410: 227-230.
-
(2001)
Nature
, vol.410
, pp. 227-230
-
-
Tissenbaum, H.A.1
Guarente, L.2
-
121
-
-
40849118472
-
Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans
-
Tullet JM, Hertweck M, An JH, Baker J, Hwang JY, Liu S, Oliveira RP, Baumeister R, Blackwell TK. 2008. Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans. Cell 132: 1025-1038.
-
(2008)
Cell
, vol.132
, pp. 1025-1038
-
-
Tullet, J.M.1
Hertweck, M.2
An, J.H.3
Baker, J.4
Hwang, J.Y.5
Liu, S.6
Oliveira, R.P.7
Baumeister, R.8
Blackwell, T.K.9
-
122
-
-
0642367846
-
Genetics: Influence of TOR kinase on lifespan in C. elegans
-
Vellai T, Takacs-Vellai K, Zhang Y, Kovacs AL, Orosz L, Muller F. 2003. Genetics: influence of TOR kinase on lifespan in C. elegans. Nature 426: 620.
-
(2003)
Nature
, vol.426
, pp. 620
-
-
Vellai, T.1
Takacs-Vellai, K.2
Zhang, Y.3
Kovacs, A.L.4
Orosz, L.5
Muller, F.6
-
123
-
-
0032860808
-
The age-related accumulation of protein carbonyl in rat liver correlates with the age-related decline in liver proteolytic activities
-
Vittorini S, Paradiso C, Donati A, Cavallini G, Masini M, Gori Z, Pollera M, Bergamini E. 1999. The age-related accumulation of protein carbonyl in rat liver correlates with the age-related decline in liver proteolytic activities. J Gerontol A Biol Sci Med Sci 54: B318-B323.
-
(1999)
J Gerontol A Biol Sci Med Sci
, vol.54
-
-
Vittorini, S.1
Paradiso, C.2
Donati, A.3
Cavallini, G.4
Masini, M.5
Gori, Z.6
Pollera, M.7
Bergamini, E.8
-
124
-
-
0041507039
-
Lifespan extension in C. elegans by a molecular chaperone dependent upon insulinlike signals
-
Walker GA, Lithgow GJ. 2003. Lifespan extension in C. elegans by a molecular chaperone dependent upon insulinlike signals. Aging Cell 2: 131-139.
-
(2003)
Aging Cell
, vol.2
, pp. 131-139
-
-
Walker, G.A.1
Lithgow, G.J.2
-
125
-
-
0035881470
-
Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase
-
Wang X, LiW, Williams M, Terada N, Alessi DR, Proud CG. 2001. Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase. EMBO J 20: 4370-4379.
-
(2001)
EMBO J
, vol.20
, pp. 4370-4379
-
-
Wang, X.1
Li, W.2
Williams, M.3
Terada, N.4
Alessi, D.R.5
Proud, C.G.6
-
126
-
-
60749101582
-
Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1
-
Westerheide SD, Anckar J, Stevens SM Jr, Sistonen L, Morimoto RI. 2009. Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1. Science 323: 1063-1066.
-
(2009)
Science
, vol.323
, pp. 1063-1066
-
-
Westerheide, S.D.1
Anckar, J.2
Stevens Jr., S.M.3
Sistonen, L.4
Morimoto, R.I.5
-
127
-
-
33751431218
-
The trifecta of aging in Caenorhabditis elegans
-
Wolff S, Dillin A. 2006. The trifecta of aging in Caenorhabditis elegans. Exp Gerontol 41: 894-903.
-
(2006)
Exp Gerontol
, vol.41
, pp. 894-903
-
-
Wolff, S.1
Dillin, A.2
-
128
-
-
33644750381
-
SMK-1, an essential regulator of DAF-16-mediated longevity
-
Wolff S, Ma H, Burch D, Maciel GA, Hunter T, Dillin A. 2006. SMK-1, an essential regulator of DAF-16-mediated longevity. Cell 124: 1039-1053.
-
(2006)
Cell
, vol.124
, pp. 1039-1053
-
-
Wolff, S.1
Ma, H.2
Burch, D.3
Maciel, G.A.4
Hunter, T.5
Dillin, A.6
-
129
-
-
0346668317
-
Insulin receptor substrate and pp55 orthologous adaptor proteins function in the Caenorhabditis elegans daf-2/insulin-like signaling pathway
-
Wolkow CA, Munoz MJ, Riddle DL, Ruvkun G. 2002. Insulin receptor substrate and pp55 orthologous adaptor proteins function in the Caenorhabditis elegans daf-2/insulin-like signaling pathway. J Biol Chem 277: 49591-49597.
-
(2002)
J Biol Chem
, vol.277
, pp. 49591-49597
-
-
Wolkow, C.A.1
Munoz, M.J.2
Riddle, D.L.3
Ruvkun, G.4
-
130
-
-
32044465506
-
TORsignaling in growth and metabolism
-
Wullschleger S, Loewith R, Hall MN. 2006. TORsignaling in growth and metabolism. Cell 124: 471-484.
-
(2006)
Cell
, vol.124
, pp. 471-484
-
-
Wullschleger, S.1
Loewith, R.2
Hall, M.N.3
-
131
-
-
33644540193
-
Autophagymediated clearance of huntingtin aggregates triggered by the insulin-signaling pathway
-
Yamamoto A, Cremona ML, Rothman JE. 2006. Autophagymediated clearance of huntingtin aggregates triggered by the insulin-signaling pathway. J Cell Biol 172: 719-731.
-
(2006)
J Cell Biol
, vol.172
, pp. 719-731
-
-
Yamamoto, A.1
Cremona, M.L.2
Rothman, J.E.3
-
133
-
-
51349095898
-
Restoration of chaperonemediated autophagy in aging liver improves cellular maintenance and hepatic function
-
Zhang C, Cuervo AM. 2008. Restoration of chaperonemediated autophagy in aging liver improves cellular maintenance and hepatic function. Nat Med 14: 959-965.
-
(2008)
Nat Med
, vol.14
, pp. 959-965
-
-
Zhang, C.1
Cuervo, A.M.2
-
134
-
-
68149149835
-
The HIF-1 Hypoxia-Inducible Factor Modulates Lifespan in C. elegans
-
Zhang Y, Shao Z, Zhai Z, Shen C, Powell-Coffman JA. 2009. The HIF-1 Hypoxia-Inducible Factor Modulates Lifespan in C. elegans. PLoS ONE 4: e6348.
-
(2009)
PLoS ONE
, vol.4
-
-
Zhang, Y.1
Shao, Z.2
Zhai, Z.3
Shen, C.4
Powell-Coffman, J.A.5
-
135
-
-
70349438679
-
4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila
-
Zid BM, Rogers AN, Katewa SD, Vargas MA, Kolipinski MC, Lu TA, Benzer S, Kapahi P. 2009. 4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila. Cell 139: 149-160.
-
(2009)
Cell
, vol.139
, pp. 149-160
-
-
Zid, B.M.1
Rogers, A.N.2
Katewa, S.D.3
Vargas, M.A.4
Kolipinski, M.C.5
Lu, T.A.6
Benzer, S.7
Kapahi, P.8
|