Smoking and increased Alzheimer's disease risk: A review of potential mechanisms

Alzheimer's and Dementia

Volumn 10, Issue 3 SUPPL., 2014, Pages

  Durazzo, Timothy C ^a,b   Mattsson, Niklas ^a,b,c   Weiner, Michael W ^a,b,d  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF GOTHENBURG   (Sweden)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Alzheimer's disease; Amyloid; Cigarette smoking; Military; Oxidative stress; Risk; Tau; Tobacco; U.S. Armed Services

Indexed keywords

AMYLOID BETA PROTEIN; ANTIOXIDANT; CIGARETTE SMOKE; FLORBETAPIR F 18; NICOTINE; TAU PROTEIN; NICOTINIC AGENT;

ALCOHOL USE DISORDER; ALZHEIMER DISEASE; COHORT ANALYSIS; COMBUSTION; COMPARATIVE STUDY; HUMAN; IN VITRO STUDY; IN VIVO STUDY; NEUROBIOLOGY; NEUROPATHOLOGY; NONHUMAN; OXIDATIVE STRESS; PATHOPHYSIOLOGY; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REVIEW; RISK FACTOR; SMOKING; SYSTEMATIC REVIEW; TRAUMATIC BRAIN INJURY; ADVERSE EFFECTS; ANIMAL; BRAIN; DRUG EFFECTS; PHYSIOLOGY;

ALZHEIMER DISEASE; ANIMALS; BRAIN; HUMANS; NICOTINE; NICOTINIC AGONISTS; OXIDATIVE STRESS; RISK FACTORS; SMOKING;

EID: 84902484347     PISSN: 15525260     EISSN: 15525279     Source Type: Journal    
DOI: 10.1016/j.jalz.2014.04.009     Document Type: Article

References (259)

1. D.M. DeMarini Genotoxicity of tobacco smoke and tobacco smoke condensate: a review Mutat Res 567 2004 447 474
2. S.R. Dube, A. McClave, C. James, R. Caraballo, R. Kaumann, and T.F. Pechacek et al. Vital signs: current cigarette smoking among adults aged ≥ 18 years - United States, 2009 MMWR Morb Mortal Wkly Rep 59 2010 1135 1140
3. C.D. Delnevo, D.A. Gundersen, and B.T. Hagman Declining estimated prevalence of alcohol drinking and smoking among young adults nationally: artifacts of sample undercoverage? Am J Epidemiol 167 2008 15 19
4. Current cigarette smoking among adults - United States, 2011 MMWR Morb Mortal Wkly Rep 61 2012 889 894
5. P. Jha, R. Peto, W. Zatonski, J. Boreham, M.J. Jarvis, and A.D. Lopez Social inequalities in male mortality, and in male mortality from smoking: indirect estimation from national death rates in England and Wales, Poland, and North America Lancet 368 2006 367 370
6. P. Dome, J. Lazary, M.P. Kalapos, and Z. Rihmer Smoking, nicotine and neuropsychiatric disorders Neurosci Biobehav Rev 34 2010 295 342
7. H.R. Alpert, G.N. Connolly, and L. Biener A prospective cohort study challenging the effectiveness of population-based medical intervention for smoking cessation Tob Control 22 2013 32 37
8. Bondurant S, Wedge R. Combating tobacco use in military and veteran populations: Institute of Medicine of the National Academies; 2009. Available at: http://www.nap.edu/catalog/12632.html. Accessed May 12, 2014.
9. Bray RM, Pemberton MR, Hourani LL, Witt, M, Rae-Olmsted KL, Brown JM, et al. 2008 Department of Defense survey of health related behaviors among active duty military personnel. Research Triangle Park, North Carolina: Research Triangle Institute (RTI) International. Technical Report RTI/10940-FR, 2009. Available at: www.tricare.mil/tma/2008HealthBehaviors.pdf. Accessed May 12, 2014.
10. E.A. Smith, and R.E. Malone Military exceptionalism or tobacco exceptionalism: how civilian health leaders' beliefs may impede military tobacco control efforts Am J Public Health 103 2013 599 604
11. C.K. Haddock, S.A. Jahnke, W.S. Poston, and L.N. Williams Cigarette prices in military retail: a review and proposal for advancing military health policy Mil Med 178 2013 563 569
12. E.A. Smith, and R.E. Malone Why strong tobacco control measures "can't" be implemented in the U.S. Military: a qualitative analysis Mil Med 177 2012 1202 1207
13. Services US Dept of Health and Human Services The health consequences of smoking: a report of the surgeon general 2004 Centers for Disease Control and Prevention Available at: http://www.cdc.gov/tobacco/data-statistics/sgr/2004/. Accessed May 12, 2014
14. T.C. Durazzo, D.J. Meyerhoff, and S.J. Nixon Chronic cigarette smoking: implications for neurocognition and brain neurobiology Int J Environ Res Public Health 7 2010 3760 3791
15. A. Sharma, and A. Brody In vivo brain imaging of human exposure to nicotine and tobacco Nicotine psychopharmacology 2009 Springer-Verlag Berlin Heidelberg 145 171
16. A. Azizian, J. Monterosso, J. O'Neill, and E.D. London Magnetic resonance imaging studies of cigarette smoking Nicotine psychopharmacology 2009 Springer-Verlag Berlin Heidelberg 113 143
17. G.E. Swan, and C.N. Lessov-Schlaggar The effects of tobacco smoke and nicotine on cognition and the brain Neuropsychol Rev 17 2007 259 273
18. T. Durazzo, P.S. Insel, M.W. Weiner The Alzheimer's Disease Neuroimaging Initiative Greater regional brain atrophy rate in healthy elders with a history of cigarette smoking Alzheimers Dement 8 2012 513 519
19. T. Durazzo, D.J. Meyerhoff, and S.J. Nixon Interactive effects of chronic cigarette smoking and age on hippocampal volumes Drug Alcohol Depend 133 2013 704 711
20. O.P. Almeida, G.J. Garrido, H. Alfonso, G. Hulse, N.T. Lautenschlager, and G.J. Hankey et al. 24-month effect of smoking cessation on cognitive function and brain structure in later life Neuroimage 55 2011 1480 1489
21. O.P. Almeida, G.J. Garrido, N.T. Lautenschlager, G.K. Hulse, K. Jamrozik, and L. Flicker Smoking is associated with reduced cortical regional gray matter density in brain regions associated with incipient Alzheimer disease Am J Geriatr Psychiatry 16 2008 92 98
22. J.K. Cataldo, J.J. Prochaska, and S.A. Glantz Cigarette smoking is a risk factor for Alzheimer's disease: an analysis controlling for tobacco industry affiliation J Alzheimers Dis 19 2010 465 480
23. M. Rusanen, S. Rovio, T. Ngandu, A. Nissinen, J. Tuomilehto, and H. Soininen et al. Midlife smoking, apolipoprotein E and risk of dementia and Alzheimer's disease: a population-based cardiovascular risk factors, aging and dementia study Dement Geriatr Cogn Disord 30 2010 277 284
24. M. Rusanen, M. Kivipelto, C.P. Quesenberry Jr., J. Zhou, and R.A. Whitmer Heavy smoking in midlife and long-term risk of Alzheimer disease and vascular dementia Arch Intern Med 171 2011 333 339
25. 2012 Alzheimer's disease facts and figures Alzheimers Dement 8 2012 131 168
26. M. Prince, R. Bryce, E. Albanese, A. Wimo, W. Ribeiro, and C.P. Ferri The global prevalence of dementia: a systematic review and metaanalysis Alzheimers Dement 9 2013 63 75 e2
27. R.A. Sperling, P.S. Aisen, L.A. Beckett, D.A. Bennett, S. Craft, and A.M. Fagan et al. Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease Alzheimers Dement 7 2011 280 292
28. R.C. Petersen, R.O. Roberts, D.S. Knopman, B.F. Boeve, Y.E. Geda, and R.J. Ivnik et al. Mild cognitive impairment: ten years later Arch Neurol 66 2009 1447 1455
29. V. Drago, C. Babiloni, D. Bartres-Faz, A. Caroli, B. Bosch, and T. Hensch et al. Disease tracking markers for Alzheimer's disease at the prodromal (MCI) stage J Alzheimers Dis 26 Suppl 3 2011 159 199
30. C.R. Jack Jr., D.S. Knopman, W.J. Jagust, R.C. Petersen, M.W. Weiner, and P.S. Aisen et al. Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers Lancet neurology 12 2013 207 216
31. L.S. Schneider, P.S. Insel, and M.W. Weiner Treatment with cholinesterase inhibitors and memantine of patients in the Alzheimer's Disease Neuroimaging Initiative Arch Neurol 68 2011 58 66
32. P.T. Nelson, I. Alafuzoff, E.H. Bigio, C. Bouras, H. Braak, and N.J. Cairns et al. Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature J Neuropathol Exp Neurol 71 2012 362 381
33. A. de Calignon, M. Polydoro, M. Suarez-Calvet, C. William, D.H. Adamowicz, and K.J. Kopeikina et al. Propagation of tau pathology in a model of early Alzheimer's disease Neuron 73 2012 685 697
34. H. Braak, H. Zetterberg, K. Del Tredici, and K. Blennow Intraneuronal tau aggregation precedes diffuse plaque deposition, but amyloid-beta changes occur before increases of tau in cerebrospinal fluid Acta Neuropathol 126 2013 631 641
35. P. Vemuri, H.J. Wiste, S.D. Weigand, D.S. Knopman, L.M. Shaw, and J.Q. Trojanowski et al. Effect of apolipoprotein E on biomarkers of amyloid load and neuronal pathology in Alzheimer disease Ann Neurol 67 2010 308 316
36. H. Braak, D.R. Thal, E. Ghebremedhin, and K. Del Tredici Stages of the pathologic process in Alzheimer disease: age categories from 1 to 100 years J Neuropathol Exp Neurol 70 2011 960 969
37. S.L. Risacher, S. Kim, L. Shen, K. Nho, T. Foroud, and R.C. Green et al. The role of apolipoprotein E (APOE) genotype in early mild cognitive impairment (E-MCI) Front Aging Neurosci 5 2013 1 12 article 11
38. J.C. Morris, C.M. Roe, C. Xiong, A.M. Fagan, A.M. Goate, and D.M. Holtzman et al. APOE predicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging Ann Neurol 67 2010 122 131
39. H. Braak, and K. Del Tredici The pathological process underlying Alzheimer's disease in individuals under thirty Acta Neuropathol 121 2011 171 181
40. B.T. Hyman Amyloid-dependent and amyloid-independent stages of Alzheimer disease Arch Neurol 68 2011 1062 1064
41. C. Reitz Alzheimer's disease and the amyloid cascade hypothesis: a critical review Int J Alzheimers Dis 2012 10.1155/2012/369808 article ID 369808
42. S. Mondragon-Rodriguez, G. Basurto-Islas, H.G. Lee, G. Perry, X. Zhu, and R.J. Castellani et al. Causes versus effects: the increasing complexities of Alzheimer's disease pathogenesis Expert Rev Neurother 10 2010 683 691
43. K. Herrup Reimagining Alzheimer's disease - an age-based hypothesis J Neurosci 30 2010 16755 16762
44. S.W. Pimplikar, R.A. Nixon, N.K. Robakis, J. Shen, and L.H. Tsai Amyloid-independent mechanisms in Alzheimer's disease pathogenesis J Neurosci 30 2010 14946 14954
45. J. Hardy, and D.J. Selkoe The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics Science 297 2002 353 356
46. R.J. Bateman, C. Xiong, T.L. Benzinger, A.M. Fagan, A. Goate, and N.C. Fox et al. Clinical and biomarker changes in dominantly inherited Alzheimer's disease N Engl J Med 367 2012 795 804
47. J.C. Masdeu, J.L. Zubieta, and J. Arbizu Neuroimaging as a marker of the onset and progression of Alzheimer's disease J Neurol Sci 236 2005 55 64
48. J.L. Price, and J.C. Morris Tangles and plaques in nondemented aging and "preclinical" Alzheimer's disease Ann Neurol 45 1999 358 368
49. C.R. Jack Jr., D.S. Knopman, S.D. Weigand, H.J. Wiste, P. Vemuri, and V. Lowe et al. An operational approach to National Institute on Aging-Alzheimer's Association criteria for preclinical Alzheimer disease Ann Neurol 71 2012 765 775
50. R.J. Castellani, M.A. Smith, G. Perry, and R.P. Friedland Cerebral amyloid angiopathy: major contributor or decorative response to Alzheimer's disease pathogenesis Neurobiol Aging 25 2004 599 602 discussion 3-4
51. D.R. Thal, E. Ghebremedhin, M. Orantes, and O.D. Wiestler Vascular pathology in Alzheimer disease: correlation of cerebral amyloid angiopathy and arteriosclerosis/lipohyalinosis with cognitive decline J Neuropathol Exp Neurol 62 2003 1287 1301
52. N. Allen, A.C. Robinson, J. Snowden, Y.S. Davidson, and D.M. Mann Patterns of cerebral amyloid angiopathy define histopathological phenotypes in Alzheimer's disease Neuropathol Appl Neurobiol 40 2014 136 148
53. T. Iwatsubo, A. Odaka, N. Suzuki, H. Mizusawa, N. Nukina, and Y. Ihara Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43) Neuron 13 1994 45 53
54. J. Attems, K. Jellinger, D.R. Thal, and W. Van Nostrand Review: sporadic cerebral amyloid angiopathy Neuropathol Appl Neurobiol 37 2011 75 93
55. D.A. Butterfield, A.M. Swomley, and R. Sultana Amyloid beta-peptide (1-42)-induced oxidative stress in Alzheimer disease: importance in disease pathogenesis and progression Antioxid Redox Signal 19 2013 823 835
56. D.J. Selkoe, and D. Schenk Alzheimer's disease: molecular understanding predicts amyloid-based therapeutics Annu Rev Pharmacol Toxicol 43 2003 545 584
57. T.J. Revett, G.B. Baker, J. Jhamandas, and S. Kar Glutamate system, amyloid β peptides and tau protein: functional interrelationships and relevance to Alzheimer disease pathology J Psychiatry Neurosci 38 2013 6 23
58. S.E. Lesne, M.A. Sherman, M. Grant, M. Kuskowski, J.A. Schneider, and D.A. Bennett et al. Brain amyloid-beta oligomers in ageing and Alzheimer's disease Brain 136 2013 1383 1398
59. B. Bulic, J. Ness, S. Hahn, A. Rennhack, T. Jumpertz, and S. Weggen Chemical biology, molecular mechanism and clinical perspective of gamma-secretase modulators in Alzheimer's disease Curr Neuropharmacol 9 2011 598 622
60. X. Wang, and E.K. Michaelis Selective neuronal vulnerability to oxidative stress in the brain Front Aging Neurosci 30 2010 12
61. L. Minghetti Role of inflammation in neurodegenerative diseases Curr Opin Neurol 18 2005 315 321
62. P.J. Khandelwal, A.M. Herman, and C.E. Moussa Inflammation in the early stages of neurodegenerative pathology J Neuroimmunol 238 2011 1 11
63. G.T. Sutherland, B. Chami, P. Youssef, and P.K. Witting Oxidative stress in Alzheimer's disease: primary villain or physiological by-product? Redox Rep 18 2013 134 141
64. S.M. Waseem, M.H. Mobarak, N. Islam, and Z. Ahmad Comparative study of pulmonary functions and oxidative stress in smokers and non-smokers Indian J Physiol Pharmacol 56 2012 345 352
65. D. Mungas, R. Tractenberg, J.A. Schneider, P.K. Crane, and D.A. Bennett A 2-process model for neuropathology of Alzheimer's disease Neurobiol Aging 35 2013 301 308
66. K. Luan, J.L. Rosales, and K.Y. Lee Viewpoint: crosstalks between neurofibrillary tangles and amyloid plaque formation Ageing Res Rev 12 2013 174 181
67. M.L. Daviglus, B.L. Plassman, A. Pirzada, C.C. Bell, P.E. Bowen, and J.R. Burke et al. Risk factors and preventive interventions for Alzheimer disease: state of the science Arch Neurol 68 2011 1185 1190
68. J. Raber, Y. Huang, and J.W. Ashford ApoE genotype accounts for the vast majority of AD risk and AD pathology Neurobiol Aging 25 2004 641 650
69. E.H. Corder, A.M. Saunders, W.J. Strittmatter, D.E. Schmechel, P.C. Gaskell, and G.W. Small et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families Science 261 1993 921 923
70. D.E. Barnes, and K. Yaffe The projected effect of risk factor reduction on Alzheimer's disease prevalence Lancet Neurol 10 2011 819 828
71. M. Kivipelto, S. Rovio, T. Ngandu, I. Kareholt, M. Eskelinen, and B. Winblad et al. Apolipoprotein E epsilon4 magnifies lifestyle risks for dementia: a population-based study J Cell Mol Med 12 2008 2762 2771
72. G. Jun, A.C. Naj, G.W. Beecham, L.S. Wang, J. Buros, and P.J. Gallins et al. Meta-analysis confirms CR1, CLU, and PICALM as Alzheimer disease risk loci and reveals interactions with APOE genotypes Arch Neurol 67 2010 1473 1484
73. A.G. van Norden, E.J. van Dijk, K.F. de Laat, P. Scheltens, M.G. Olderikkert, and F.E. de Leeuw Dementia: Alzheimer pathology and vascular factors: from mutually exclusive to interaction Biochim Biophys Acta 1822 2012 340 349
74. W. Jagust Apolipoprotein E, neurodegeneration, and Alzheimer disease JAMA Neurol 70 2013 299 300
75. K.D. Ersche, A. Barnes, P.S. Jones, S. Morein-Zamir, T.W. Robbins, and E.T. Bullmore Abnormal structure of frontostriatal brain systems is associated with aspects of impulsivity and compulsivity in cocaine dependence Brain 134 Pt 7 2011 2013 2024
76. T. Etgen, D. Sander, H. Bickel, and H. Forstl Mild cognitive impairment and dementia: the importance of modifiable risk factors Dtsch Arztebl Int 108 2011 743 750
77. K.J. Anstey, C. von Sanden, A. Salim, and R. O'Kearney Smoking as a risk factor for dementia and cognitive decline: a meta-analysis of prospective studies Am J Epidemiol 166 2007 367 378
78. N.T. Aggarwal, J.L. Bienias, D.A. Bennett, R.S. Wilson, M.C. Morris, and J.A. Schneider et al. The relation of cigarette smoking to incident Alzheimer's disease in a biracial urban community population Neuroepidemiology 26 2006 140 146
79. C. Reitz, T. den Heijer, C. van Duijn, A. Hofman, and M.M. Breteler Relation between smoking and risk of dementia and Alzheimer disease: the Rotterdam Study Neurology 69 2007 998 1005
80. A. Ott, A.J. Slooter, A. Hofman, F. van Harskamp, J.C. Witteman, and C. Van Broeckhoven et al. Smoking and risk of dementia and Alzheimer's disease in a population-based cohort study: the Rotterdam Study Lancet 351 1998 1840 1843
81. C. Merchant, M.X. Tang, S. Albert, J. Manly, Y. Stern, and R. Mayeux The influence of smoking on the risk of Alzheimer's disease Neurology 52 1999 1408 1412
82. C. Dufouil, C. Tzourio, C. Brayne, C. Berr, P. Amouyel, and A. Alperovitch Influence of apolipoprotein E genotype on the risk of cognitive deterioration in moderate drinkers and smokers Epidemiology 11 2000 280 284
83. C. Reitz, J. Luchsinger, M.X. Tang, and R. Mayeux Effect of smoking and time on cognitive function in the elderly without dementia Neurology 65 2005 870 875
84. S.L. Tyas, L.R. White, H. Petrovitch, G. Webster Ross, D.J. Foley, and H.K. Heimovitz et al. Mid-life smoking and late-life dementia: the Honolulu-Asia Aging Study Neurobiol Aging 24 2003 589 596
85. D. Juan, D.H. Zhou, J. Li, J.Y. Wang, C. Gao, and M. Chen A 2-year follow-up study of cigarette smoking and risk of dementia Eur J Neurol 11 2004 277 282
86. L.J. Launer, K. Andersen, M.E. Dewey, L. Letenneur, A. Ott, and L.A. Amaducci et al. Rates and risk factors for dementia and Alzheimer's disease: results from EURODEM pooled analyses. EURODEM Incidence Research Group and Work Groups. European Studies of Dementia Neurology 52 1999 78 84
87. M.N. Sabbagh, S.L. Tyas, S.C. Emery, L.A. Hansen, M.F. Alford, and R.T. Reid et al. Smoking affects the phenotype of Alzheimer disease Neurology 64 2005 1301 1303
88. J. Weuve, E.J. Tchetgen Tchetgen, M.M. Glymour, T.L. Beck, N.T. Aggarwal, and R.S. Wilson et al. Accounting for bias due to selective attrition: the example of smoking and cognitive decline Epidemiology 23 2012 119 128
89. S.M. Debanne, R.A. Bielefeld, V.K. Cheruvu, T. Fritsch, and D.Y. Rowland Alzheimer's disease and smoking: bias in cohort studies J Alzheimers Dis 11 2007 313 321
90. M.A. Hernan, A. Alonso, and G. Logroscino Cigarette smoking and dementia: potential selection bias in the elderly Epidemiology 19 2008 448 450
91. W.A. Kukull The association between smoking and Alzheimer's disease: effects of study design and bias Biol Psychiatry 49 2001 194 199
92. C.C. Chang, Y. Zhao, C.W. Lee, and M. Ganguli Smoking, death, and Alzheimer disease: a case of competing risks Alzheimer Dis Assoc Disord 26 2012 300 306
93. R. Peters, R. Poulter, J. Warner, N. Beckett, L. Burch, and C. Bulpitt Smoking, dementia and cognitive decline in the elderly, a systematic review BMC Geriatr 8 2008 36
94. J.A. Ambrose, and R.S. Barua The pathophysiology of cigarette smoking and cardiovascular disease: an update J Am Coll Cardiol 43 2004 1731 1737
95. E.D. Boudreaux, J.L. Francis, C.L. Carmack Taylor, I.C. Scarinci, and P.J. Brantley Changing multiple health behaviors: smoking and exercise Prev Med 36 2003 471 478
96. G.G. Casasola, J.L. Alvarez-Sala, J.A. Marques, J.M. Sanchez-Alarcos, D.P. Tashkin, and D. Espinos Cigarette smoking behavior and respiratory alterations during sleep in a healthy population Sleep Breath 6 2002 19 24
97. M. Bartal Health effects of tobacco use and exposure Monaldi Arch Chest Dis 56 2001 545 554
98. T.C. Durazzo, and D.J. Meyerhoff Neurobiological and neurocognitive effects of chronic cigarette smoking and alcoholism Front Biosci 12 2007 4079 4100
99. C. Davatzikos, P. Bhatt, L.M. Shaw, K.N. Batmanghelich, and J.Q. Trojanowski Prediction of MCI to AD conversion, via MRI, CSF biomarkers, and pattern classification Neurobiol Aging 32 2011 2322.e19 2322.e27
100. C. Misra, Y. Fan, and C. Davatzikos Baseline and longitudinal patterns of brain atrophy in MCI patients, and their use in prediction of short-term conversion to AD: results from ADNI Neuroimage 44 2009 1415 1422
101. C.A. de Jager, A.C. Schrijnemaekers, T.E. Honey, and M.M. Budge Detection of MCI in the clinic: evaluation of the sensitivity and specificity of a computerised test battery, the Hopkins Verbal Learning Test and the MMSE Age Ageing 38 2009 455 460
102. M. Wagner, S. Schulze-Rauschenbach, N. Petrovsky, J. Brinkmeyer, C. von der Goltz, and G. Grunder et al. Neurocognitive impairments in non-deprived smokers-results from a population-based multi-center study on smoking-related behavior Addict Biol 18 2012 752 761 10.1111/j.1369-1600.2011.00429.x
103. T.C. Durazzo, D.J. Meyerhoff, and S.J. Nixon A comprehensive assessment of neurocognition in middle-aged chronic cigarette smokers Drug Alcohol Depend 122 2012 105 111
104. S. Kuhn, F. Schubert, and J. Gallinat Reduced thickness of medial orbitofrontal cortex in smokers Biol Psychiatry 68 2010 1061 1065
105. T.C. Durazzo, A. Mon, D. Pennington, C. Abe, S. Gazdzinski, and D.J. Meyerhoff Interactive effects of chronic cigarette smoking and age on brain volumes in controls and alcohol-dependent individuals in early abstinence Addict Biol 19 2014 132 143 10.1111/j.1369-1600.2012.00492
106. A.L. Brody, M.A. Mandelkern, M.E. Jarvik, G.S. Lee, E.C. Smith, and J.C. Huang et al. Differences between smokers and nonsmokers in regional gray matter volumes and densities Biol Psychiatry 55 2004 77 84
107. J. Gallinat, E. Meisenzahl, L.K. Jacobsen, P. Kalus, J. Bierbrauer, and T. Kienast et al. Smoking and structural brain deficits: a volumetric MR investigation Eur J Neurosci 24 2006 1744 1750
108. S. Kuhn, A. Romanowski, C. Schilling, A. Mobascher, T. Warbrick, and G. Winterer et al. Brain grey matter deficits in smokers: focus on the cerebellum Brain Struct Funct 217 2012 517 522
109. J. Gallinat, and F. Schubert Regional cerebral glutamate concentrations and chronic tobacco consumption Pharmacopsychiatry 40 2007 64 67
110. J. Gallinat, U.E. Lang, L.K. Jacobsen, M. Bajbouj, P. Kalus, and D. von Haebler et al. Abnormal hippocampal neurochemistry in smokers: evidence from proton magnetic resonance spectroscopy at 3 T J Clin Psychopharmacol 27 2007 80 84
111. X. Zhang, B.J. Salmeron, T.J. Ross, X. Geng, Y. Yang, and E.A. Stein Factors underlying prefrontal and insula structural alterations in smokers Neuroimage 54 2011 42 48
112. T.C. Durazzo, A. Mon, S. Gazdzinski, and D.J. Meyerhoff Chronic cigarette smoking in alcohol dependence: associations with cortical thickness and N-acetylaspartate levels in the extended brain reward system Addict Biol 18 2011 379 391
113. J.B. Langbaum, K. Chen, W. Lee, C. Reschke, D. Bandy, and A.S. Fleisher et al. Categorical and correlational analyses of baseline fluorodeoxyglucose positron emission tomography images from the Alzheimer's Disease Neuroimaging Initiative (ADNI) Neuroimage 45 2009 1107 1116
114. S. De Santi, M.J. de Leon, H. Rusinek, A. Convit, C.Y. Tarshish, and A. Roche et al. Hippocampal formation glucose metabolism and volume losses in MCI and AD Neurobiol Aging 22 2001 529 539
115. T.C. Durazzo, S.L. Fryer, J.C. Rothlind, M. Vertinski, S. Gazdzinski, and A. Mon et al. Measures of learning, memory and processing speed accurately predict smoking status in short-term abstinent treatment-seeking alcohol-dependent individuals Alcohol Alcohol 45 2010 507 513
116. T.C. Durazzo, J.C. Rothlind, S. Gazdzinski, P. Banys, and D.J. Meyerhoff A comparison of neurocognitive function in nonsmoking and chronically smoking short-term abstinent alcoholics Alcohol 39 2006 1 11
117. T.C. Durazzo, S. Gazdzinski, P. Banys, and D.J. Meyerhoff Cigarette smoking exacerbates chronic alcohol-induced brain damage: a preliminary metabolite imaging study Alcohol Clin Exp Res 28 2004 1849 1860
118. S. Gazdzinski, T. Durazzo, G.H. Jahng, F. Ezekiel, P. Banys, and D. Meyerhoff Effects of chronic alcohol dependence and chronic cigarette smoking on cerebral perfusion: a preliminary magnetic resonance study Alcohol Clin Exp Res 30 2006 947 958
119. S. Gazdzinski, T.C. Durazzo, C. Studholme, E. Song, P. Banys, and D.J. Meyerhoff Quantitative brain MRI in alcohol dependence: preliminary evidence for effects of concurrent chronic cigarette smoking on regional brain volumes Alcohol Clin Exp Res 29 2005 1484 1495
120. Gazdzinski S, Durazzo TC, Ezekiel F, Jahng G-H, Meyerhoff DJ. Effects of chronic alcohol dependence and chronic cigarette smoking on cerebral perfusion. In: Proc Intl Soc Mag Reson Med; 2005 May 7-13, 2005; Miami Beach, FL; 2005. p. 1138.
121. S. Gazdzinski, T.C. Durazzo, A. Mon, P.H. Yeh, and D.J. Meyerhoff Cerebral white matter recovery in abstinent alcoholics - a multimodality magnetic resonance study Brain 133 2010 1043 1053
122. A. Mon, T.C. Durazzo, S. Gazdzinski, and D.J. Meyerhoff The impact of chronic cigarette smoking on recovery from cortical gray matter perfusion deficits in alcohol dependence: longitudinal arterial spin labeling MRI Alcohol Clin Exp Res 33 2009 1314 1321
123. S. Gazdzinski, T.C. Durazzo, P.H. Yeh, D. Hardin, P. Banys, and D.J. Meyerhoff Chronic cigarette smoking modulates injury and short-term recovery of the medial temporal lobe in alcoholics Psychiatry Res 162 2008 133 145
124. D.L. Pennington, T.C. Durazzo, T. Schmidt, A. Mon, C. Abe, and D.J. Meyerhoff The effects of chronic cigarette smoking on cognitive recovery during early abstinence from alcohol Alcohol Clin Exp Res 37 2013 1220 1227
125. T.C. Durazzo, J.C. Rothlind, S. Gazdzinski, P. Banys, and D.J. Meyerhoff Chronic smoking is associated with differential neurocognitive recovery in abstinent alcoholic patients: a preliminary investigation Alcohol Clin Exp Res 31 2007 1114 1127
126. T.C. Durazzo, D. Tosun, S. Buckley, S. Gazdzinski, A. Mon, and S.L. Fryer et al. Cortical thickness, surface area, and volume of the brain reward system in alcohol dependence: relationships to relapse and extended abstinence Alcohol Clin Exp Res 35 2011 1187 1200
127. T.C. Durazzo, D.L. Pennington, T.P. Schmidt, A. Mon, C. Abe, and D.J. Meyerhoff Neurocognition in 1-month-abstinent treatment-seeking alcohol-dependent individuals: interactive effects of age and chronic cigarette smoking Alcohol Clin Exp Res 37 2013 1794 1803
128. T.C. Durazzo, J.C. Rothlind, S. Gazdzinski, and D.J. Meyerhoff The relationships of sociodemographic factors, medical, psychiatric, and substance-misuse co-morbidities to neurocognition in short-term abstinent alcohol-dependent individuals Alcohol 42 2008 439 449
129. T.C. Durazzo, L. Abadjian, A. Kincaid, T. Bilovsky-Muniz, L. Boreta, and G.E. Gauger The influence of chronic cigarette smoking on neurocognitive recovery after mild traumatic brain injury J Neurotrauma 30 2013 1013 1022
130. A.L. Petraglia, J.C. Maroon, and J.E. Bailes From the field of play to the field of combat: a review of the pharmacological management of concussion Neurosurgery 70 2012 1520 1533 discussion 33
131. J.E. Wilk, P.D. Bliese, P.Y. Kim, J.L. Thomas, D. McGurk, and C.W. Hoge Relationship of combat experiences to alcohol misuse among U.S. soldiers returning from the Iraq war Drug Alcohol Depend 108 2010 115 121
132. R.C. Seet, C.Y. Lee, W.M. Loke, S.H. Huang, H. Huang, and W.F. Looi et al. Biomarkers of oxidative damage in cigarette smokers: which biomarkers might reflect acute versus chronic oxidative stress? Free Radic Biol Med 50 2011 1787 1793
133. A. Valavanidis, T. Vlachogianni, and K. Fiotakis Tobacco smoke: involvement of reactive oxygen species and stable free radicals in mechanisms of oxidative damage, carcinogenesis and synergistic effects with other respirable particles Int J Environ Res Public Health 6 2009 445 462
134. J.B. Schulz, J. Lindenau, J. Seyfried, and J. Dichgans Glutathione, oxidative stress and neurodegeneration Eur J Biochem 267 2000 4904 4911
135. S.E. Moriarty, J.H. Shah, M. Lynn, S. Jiang, K. Openo, and D.P. Jones et al. Oxidation of glutathione and cysteine in human plasma associated with smoking Free Radic Biol Med 35 2003 1582 1588
136. J. Fowles, M. Bates, and D. Noiton The chemical constituents in cigarettes and cigarette smoke: priorities for harm reduction 2000 Epidemiology and Toxicology Group, Institute of Environmental Science and Research Ltd Porirua, New Zealand Available at: http://legacy.library.ucsf.edu/documentStore/ s/v/h/svh93a00/Ssvh93a00.pdf. Accessed May 12, 2014.
137. B. Gonthier, N. Signorini-Allibe, A. Soubeyran, H. Eysseric, F. Lamarche, and L. Barret Ethanol can modify the effects of certain free radical-generating systems on astrocytes Alcohol Clin Exp Res 28 2004 526 534
138. D. Wu, and A.I. Cederbaum Alcohol, oxidative stress, and free radical damage Alcohol Res Health 27 2003 277 284
139. M. Vallett, T. Tabatabaie, R.J. Briscoe, T.J. Baird, W.W. Beatty, and R.A. Floyd et al. Free radical production during ethanol intoxication, dependence, and withdrawal Alcohol Clin Exp Res 21 1997 275 285
140. P.J. Brooks Brain atrophy and neuronal loss in alcoholism: a role for DNA damage? Neurochem Int 37 2000 403 412
141. D. Pratico Prostanoid and isoprostanoid pathways in atherogenesis Atherosclerosis 201 2008 8 16
142. F.T. Crews, R. Bechara, L.A. Brown, D.M. Guidot, P. Mandrekar, and S. Oak et al. Cytokines and alcohol Alcohol Clin Exp Res 30 2006 720 730
143. L.A. Voloboueva, and R.G. Giffard Inflammation, mitochondria, and the inhibition of adult neurogenesis J Neurosci Res 89 2011 1989 1996
144. C. Guerri, and M. Pascual Mechanisms involved in the neurotoxic, cognitive, and neurobehavioral effects of alcohol consumption during adolescence Alcohol 44 2010 15 26
145. C. Perricone, C. De Carolis, and R. Perricone Glutathione: a key player in autoimmunity Autoimmun Rev 8 2009 697 701
146. F.T. Crews, and K. Nixon Mechanisms of neurodegeneration and regeneration in alcoholism Alcohol Alcohol 44 2009 115 127
147. A. Khanna, M. Guo, M. Mehra, and W. Royal 3rd Inflammation and oxidative stress induced by cigarette smoke in Lewis rat brains J Neuroimmunol 254 2013 69 75
148. R. Gill, A. Tsung, and T. Billiar Linking oxidative stress to inflammation: toll-like receptors Free Radic Biol Med 48 2010 1121 1132
149. A.M. Enciu, M. Gherghiceanu, and B.O. Popescu Triggers and effectors of oxidative stress at blood-brain barrier level: relevance for brain ageing and neurodegeneration Oxid Med Cell Longev 2013 2013 297512
150. P. Kovacic Unifying mechanism for addiction and toxicity of abused drugs with application to dopamine and glutamate mediators: electron transfer and reactive oxygen species Med Hypotheses 65 2005 90 96
151. K. Anbarasi, G. Vani, K. Balakrishna, and C.S. Devi Effect of bacoside A on brain antioxidant status in cigarette smoke exposed rats Life Sci 78 2006 1378 1384
152. J.A. Chalela, R.L. Wolf, J.A. Maldjian, and S.E. Kasner MRI identification of early white matter injury in anoxic-ischemic encephalopathy Neurology 56 2001 481 485
153. S.G. Mueller, A.H. Trabesinger, P. Boesiger, and H.G. Wieser Brain glutathione levels in patients with epilepsy measured by in vivo (1)H-MRS Neurology 57 2001 1422 1427
154. D. Pratico The neurobiology of isoprostanes and Alzheimer's disease Biochim Biophys Acta 1801 2010 930 933
155. P. Kochunov, P.M. Thompson, J.L. Lancaster, G. Bartzokis, S. Smith, and T. Coyle et al. Relationship between white matter fractional anisotropy and other indices of cerebral health in normal aging: tract-based spatial statistics study of aging Neuroimage 35 2007 478 487
156. G. Bartzokis Quadratic trajectories of brain myelin content: unifying construct for neuropsychiatric disorders Neurobiol Aging 25 2004 49 62
157. M.L. Circu, and T.Y. Aw Reactive oxygen species, cellular redox systems, and apoptosis Free Radic Biol Med 48 2010 749 762
158. B. Halliwell Oxidative stress and neurodegeneration: where are we now? J Neurochem 97 2006 1634 1658
159. S. Tsiara, M. Elisaf, and D.P. Mikhailidis Influence of smoking on predictors of vascular disease Angiology 54 2003 507 530
160. P.G. Shields Tobacco smoking, harm reduction, and biomarkers J Natl Cancer Inst 94 2002 1435 1444
161. T. Kurth, C.S. Kase, K. Berger, E.S. Schaeffner, J.E. Buring, and J.M. Gaziano Smoking and the risk of hemorrhagic stroke in men Stroke 34 2003 1151 1155
162. J.H. Ryu, T.V. Colby, T.E. Hartman, and R. Vassallo Smoking-related interstitial lung diseases: a concise review Eur Respir J 17 2001 122 132
163. W.G. Kuschner, A. D'Alessandro, H. Wong, and P.D. Blanc Dose-dependent cigarette smoking-related inflammatory responses in healthy adults Eur Respir J 9 1996 1989 1994
164. R. Talhout, T. Schulz, E. Florek, J. van Benthem, P. Wester, and A. Opperhuizen Hazardous compounds in tobacco smoke Int J Environ Res Public Health 8 2011 613 628
165. S. Deveci, F. Deveci, Y. Acik, and A. Ozan The measurement of exhaled carbon monoxide in healthy smokers and non-smokers Respir Med 98 2004 551 556
166. J.R. Alonso, F. Cardellach, J. Casademont, and O. Miro Reversible inhibition of mitochondrial complex IV activity in PBMC following acute smoking Eur Respir J 23 2004 214 218
167. P. Mazzone, W. Tierney, M. Hossain, V. Puvenna, D. Janigro, and L. Cucullo Pathophysiological impact of cigarette smoke exposure on the cerebrovascular system with a focus on the blood-brain barrier: expanding the awareness of smoking toxicity in an underappreciated area Int J Environ Res Public Health 7 2010 4111 4126
168. B. Giunta, J. Deng, J. Jin, E. Sadic, S. Rum, and H. Zhou et al. Evaluation of how cigarette smoke is a direct risk factor for Alzheimer's disease Technol Innov 14 2012 39 48
169. J. Barr, C.S. Sharma, S. Sarkar, K. Wise, L. Dong, and A. Periyakaruppan et al. Nicotine induces oxidative stress and activates nuclear transcription factor kappa B in rat mesencephalic cells Mol Cell Biochem 297 2007 93 99
170. K. Anbarasi, G. Vani, K. Balakrishna, and C.S. Devi Effect of bacoside A on membrane-bound ATPases in the brain of rats exposed to cigarette smoke J Biochem Mol Toxicol 19 2005 59 65
171. K. Anbarasi, G. Vani, K. Balakrishna, and C.S. Devi Creatine kinase isoenzyme patterns upon chronic exposure to cigarette smoke: protective effect of bacoside A Vascul Pharmacol 42 2005 57 61
172. K. Anbarasi, G. Kathirvel, G. Vani, G. Jayaraman, and C.S. Shyamala Devi Cigarette smoking induces heat shock protein 70 kDa expression and apoptosis in rat brain: modulation by bacoside A Neuroscience 138 2006 1127 1135
173. K. Anbarasi, G. Vani, and C.S. Devi Protective effect of bacoside A on cigarette smoking-induced brain mitochondrial dysfunction in rats J Environ Pathol Toxicol Oncol 24 2005 225 234
174. C.R. Rueff-Barroso, E.T. Trajano, J.N. Alves, R.O. Paiva, M. Lanzetti, and K.M. Pires et al. Organ-related cigarette smoke-induced oxidative stress is strain-dependent Med Sci Monit 16 2010 BR218 BR226
175. Y.S. Ho, X. Yang, S.C. Yeung, K. Chiu, C.F. Lau, and A.W. Tsang et al. Cigarette smoking accelerated brain aging and induced pre-Alzheimer-like neuropathology in rats PLoS One 7 2012 e36752
176. S. Das, N. Gautam, S.K. Dey, T. Maiti, and S. Roy Oxidative stress in the brain of nicotine-induced toxicity: protective role of Andrographis paniculata Nees and vitamin E Appl Physiol Nutr Metab 34 2009 124 135
177. J.A. Sonnen, E.B. Larson, S.L. Gray, A. Wilson, S.G. Kohama, and P.K. Crane et al. Free radical damage to cerebral cortex in Alzheimer's disease, microvascular brain injury, and smoking Ann Neurol 65 2009 226 229
178. S.H. Kim, J.S. Kim, H.S. Shin, and C.L. Keen Influence of smoking on markers of oxidative stress and serum mineral concentrations in teenage girls in Korea Nutrition 19 2003 240 243
179. S.H. Kim, J.L. Ensunsa, Q.Y. Zhu, J.S. Kim, H.S. Shin, and C.L. Keen An 18-month follow-up study on the influence of smoking on blood antioxidant status of teenage girls in comparison with adult male smokers in Korea Nutrition 20 2004 437 444
180. V. Reichert, X. Xue, D. Bartscherer, D. Jacobsen, C. Fardellone, and P. Zolan et al. A pilot study to examine the effects of smoking cessation on serum markers of inflammation in women at risk for cardiovascular disease Chest 136 2009 212 219
181. R.J. Bloomer Decreased blood antioxidant capacity and increased lipid peroxidation in young cigarette smokers compared to nonsmokers: impact of dietary intake Nutr J 6 2007 39
182. H.C. Box, R.J. O'Connor, H.B. Patrzyc, H. Iijima, J.B. Dawidzik, and H.G. Freund et al. Reduction in oxidatively generated DNA damage following smoking cessation Tob Induc Dis 9 2011 5
183. M. Reilly, N. Delanty, J.A. Lawson, and G.A. FitzGerald Modulation of oxidant stress in vivo in chronic cigarette smokers Circulation 94 1996 19 25
184. G.L. Milne, E.S. Musiek, and J.D. Morrow F2-isoprostanes as markers of oxidative stress in vivo: an overview Biomarkers 10 Suppl 1 2005 S10 S23
185. J.E. Slemmer, J.J. Shacka, M.I. Sweeney, and J.T. Weber Antioxidants and free radical scavengers for the treatment of stroke, traumatic brain injury and aging Curr Med Chem 15 2008 404 414
186. J.W. Gawryluk, J.F. Wang, A.C. Andreazza, L. Shao, and L.T. Young Decreased levels of glutathione, the major brain antioxidant, in post-mortem prefrontal cortex from patients with psychiatric disorders Int J Neuropsychopharmacol 14 2011 123 130
187. D.M. Townsend, K.D. Tew, and H. Tapiero The importance of glutathione in human disease Biomed Pharmacother 57 2003 145 155
188. R. Srinivasan, H. Ratiney, K.E. Hammond-Rosenbluth, D. Pelletier, and S.J. Nelson MR spectroscopic imaging of glutathione in the white and gray matter at 7 T with an application to multiple sclerosis Magn Reson Imaging 28 2010 163 170
189. L.G. Kaiser, M. Marjanska, G.B. Matson, I. Iltis, S.D. Bush, and B.J. Soher et al. (1)H MRS detection of glycine residue of reduced glutathione in vivo J Magn Reson 202 2010 259 266
190. S.J. Wood, G.E. Berger, R.M. Wellard, T.M. Proffitt, M. McConchie, and M. Berk et al. Medial temporal lobe glutathione concentration in first episode psychosis: a 1H-MRS investigation Neurobiol Dis 33 2009 354 357
191. S.C. Lu Regulation of glutathione synthesis Mol Aspects Med 30 2009 42 59
192. R. Dringen, and J. Hirrlinger Glutathione pathways in the brain Biol Chem 384 2003 505 516
193. R. Cruz, W. Almaguer Melian, and J.A. Bergado Rosado Glutathione in cognitive function and neurodegeneration Rev Neurol 36 2003 877 886
194. K.L. Reichelt, and F. Fonnum Subcellular localization of N-acetyl-aspartyl-glutamate, N-acetyl-glutamate and glutathione in brain JNeurochem 16 1969 1409 1416
195. A. Meister, and M.E. Anderson Glutathione Annu Rev Biochem 52 1983 711 760
196. E. Mendez-Alvarez, R. Soto-Otero, I. Sanchez-Sellero, and M. Lopez-Rivadulla Lamas In vitro inhibition of catalase activity by cigarette smoke: relevance for oxidative stress J Appl Toxicol 18 1998 443 448
197. K. Panda, R. Chattopadhyay, D.J. Chattopadhyay, and I.B. Chatterjee Vitamin C prevents cigarette smoke-induced oxidative damage in vivo Free Radic Biol Med 29 2000 115 124
198. C.A. Northrop-Clewes, and D.I. Thurnham Monitoring micronutrients in cigarette smokers Clin Chim Acta 377 2007 14 38
199. O.F. Abdul-Rasheed, and W.T. Al-Rubayee Effects of cigarette smoking on lipid peroxidation and antioxidant status in Iraqi men at Baghdad city International Journal of Basic and Applied Sciences 2 2012 47 50
200. I. Almansa, A. Fernandez, C. Garcia-Ruiz, M. Muriach, J.M. Barcia, and M. Miranda et al. Brain mitochondrial alterations after chronic alcohol consumption J Physiol Biochem 65 2009 305 312
201. D. Pratico, C.M. Clark, F. Liun, J. Rokach, V.Y. Lee, and J.Q. Trojanowski Increase of brain oxidative stress in mild cognitive impairment: a possible predictor of Alzheimer disease Arch Neurol 59 2002 972 976
202. R.H. Swerdlow Alzheimer's disease pathologic cascades: who comes first, what drives what Neurotox Res 22 2012 182 194
203. S. Mondragon-Rodriguez, G. Perry, X. Zhu, P.I. Moreira, M.C. Acevedo-Aquino, and S. Williams Phosphorylation of tau protein as the link between oxidative stress, mitochondrial dysfunction, and connectivity failure: implications for Alzheimer's disease Oxid Med Cell Longev 2013 2013 940603
204. E. Tamagno, M. Guglielmotto, M. Aragno, R. Borghi, R. Autelli, and L. Giliberto et al. Oxidative stress activates a positive feedback between the gamma- and beta-secretase cleavages of the beta-amyloid precursor protein J Neurochem 104 2008 683 695
205. J.L. Tan, Q.X. Li, G.D. Ciccotosto, P.J. Crouch, J.G. Culvenor, and A.R. White et al. Mild oxidative stress induces redistribution of BACE1 in non-apoptotic conditions and promotes the amyloidogenic processing of Alzheimer's disease amyloid precursor protein PLoS One 8 2013 e61246
206. J.K. Cataldo, and S.A. Glantz Smoking cessation and Alzheimer's disease: facts, fallacies and promise Expert Rev Neurother 10 2010 629 631
207. I. Moreno-Gonzalez, L.D. Estrada, E. Sanchez-Mejias, and C. Soto Smoking exacerbates amyloid pathology in a mouse model of Alzheimer's disease Nat Commun 4 2013 1495
208. N.L. Benowitz, J. Hukkanen, and P. Jacob 3rd Nicotine chemistry, metabolism, kinetics and biomarkers Handb Exp Pharmacol 192 2009 29 60
209. E. Hellstrom-Lindahl, M. Mousavi, R. Ravid, and A. Nordberg Reduced levels of Abeta 40 and Abeta 42 in brains of smoking controls and Alzheimer's patients Neurobiol Dis 15 2004 351 360
210. A. Nordberg, E. Hellstrom-Lindahl, M. Lee, M. Johnson, M. Mousavi, and R. Hall et al. Chronic nicotine treatment reduces beta-amyloidosis in the brain of a mouse model of Alzheimer's disease (APPsw) J Neurochem 81 2002 655 658
211. H.D. Mansvelder, and D.S. McGehee Cellular and synaptic mechanisms of nicotine addiction J Neurobiol 53 2002 606 617
212. G. Mudo, N. Belluardo, and K. Fuxe Nicotinic receptor agonists as neuroprotective/neurotrophic drugs. Progress in molecular mechanisms J Neural Transm 114 2007 135 147
213. J.L. Yakel Cholinergic receptors: functional role of nicotinic ACh receptors in brain circuits and disease Pflugers Arch 465 2013 441 450
214. S.D. Buckingham, A.K. Jones, L.A. Brown, and D.B. Sattelle Nicotinic acetylcholine receptor signalling: roles in Alzheimer's disease and amyloid neuroprotection Pharmacol Rev 61 2009 39 61
215. J. Ulrich, G. Johannson-Locher, W.O. Seiler, and H.B. Stahelin Does smoking protect from Alzheimer's disease? Alzheimer-type changes in 301 unselected brains from patients with known smoking history Acta Neuropathol 94 1997 450 454
216. E. Perry, C. Martin-Ruiz, M. Lee, M. Griffiths, M. Johnson, and M. Piggott et al. Nicotinic receptor subtypes in human brain ageing, Alzheimer and Lewy body diseases Eur J Pharmacol 393 2000 215 222
217. J.A. Court, M. Johnson, D. Religa, J. Keverne, R. Kalaria, and E. Jaros et al. Attenuation of Abeta deposition in the entorhinal cortex of normal elderly individuals associated with tobacco smoking Neuropathol Appl Neurobiol 31 2005 522 535
218. E. Hellstrom-Lindahl, H. Moore, and A. Nordberg Increased levels of tau protein in SH-SY5Y cells after treatment with cholinesterase inhibitors and nicotinic agonists J Neurochem 74 2000 777 784
219. T. Utsuki, M. Shoaib, H.W. Holloway, D.K. Ingram, W.C. Wallace, and V. Haroutunian et al. Nicotine lowers the secretion of the Alzheimer's amyloid beta-protein precursor that contains amyloid beta-peptide in rat J Alzheimers Dis 4 2002 405 415
220. D.K. Lahiri, T. Utsuki, D. Chen, M.R. Farlow, M. Shoaib, and D.K. Ingram et al. Nicotine reduces the secretion of Alzheimer's beta-amyloid precursor protein containing beta-amyloid peptide in the rat without altering synaptic proteins Ann N Y Acad Sci 965 2002 364 372
221. M. Srivareerat, T.T. Tran, S. Salim, A.M. Aleisa, and K.A. Alkadhi Chronic nicotine restores normal Abeta levels and prevents short-term memory and E-LTP impairment in Abeta rat model of Alzheimer's disease Neurobiol Aging 32 2011 834 844
222. V. Echeverria, R. Zeitlin, S. Burgess, S. Patel, A. Barman, and G. Thakur et al. Cotinine reduces amyloid-beta aggregation and improves memory in Alzheimer's disease mice J Alzheimers Dis 24 2011 817 835
223. S. Oddo, A. Caccamo, K.N. Green, K. Liang, L. Tran, and Y. Chen et al. Chronic nicotine administration exacerbates tau pathology in a transgenic model of Alzheimer's disease Proc Natl Acad Sci U S A 102 2005 3046 3051
224. Y.M. Yang, and G.T. Liu Injury of mouse brain mitochondria induced by cigarette smoke extract and effect of vitamin C on it in vitro Biomed Environ Sci 16 2003 256 266
225. W.E. Klunk, H. Engler, A. Nordberg, Y. Wang, G. Blomqvist, and D.P. Holt et al. Imaging brain amyloid in Alzheimer's disease with Pittsburgh compound-B Ann Neurol 55 2004 306 319
226. R. Ni, A. Marutle, and A. Nordberg Modulation of alpha7 nicotinic acetylcholine receptor and fibrillar amyloid-beta interactions in Alzheimer's disease brain J Alzheimers Dis 33 2013 841 851
227. Y. Abreu-Villaca, F.J. Seidler, C.A. Tate, and T.A. Slotkin Nicotine is a neurotoxin in the adolescent brain: critical periods, patterns of exposure, regional selectivity, and dose thresholds for macromolecular alterations Brain Res 979 2003 114 128
228. T.A. Slotkin Nicotine and the adolescent brain: insights from an animal model Neurotoxicol Teratol 24 2002 369 384
229. M. Oz, D.E. Lorke, K.H. Yang, and G. Petroianu On the interaction of beta-amyloid peptides and alpha7-nicotinic acetylcholine receptors in Alzheimer's disease Curr Alzheimer Res 10 2013 618 630
230. C.M. Clark, J.A. Schneider, B.J. Bedell, T.G. Beach, W.B. Bilker, and M.A. Mintun et al. Use of florbetapir-PET for imaging beta-amyloid pathology JAMA 305 2011 275 283
231. S.M. Landau, C. Breault, A.D. Joshi, M. Pontecorvo, C.A. Mathis, and W.J. Jagust et al. Amyloid-beta imaging with Pittsburgh compound B and florbetapir: comparing radiotracers and quantification methods J Nucl Med 54 2013 70 77
232. D. Tosun, N. Schuff, D. Truran-Sacrey, L.M. Shaw, J.Q. Trojanowski, and P. Aisen et al. Relations between brain tissue loss, CSF biomarkers, and the ApoE genetic profile: a longitudinal MRI study Neurobiol Aging 31 2010 1340 1354
233. D.A. Bennett, J.A. Schneider, Z. Arvanitakis, J.F. Kelly, N.T. Aggarwal, and R.C. Shah et al. Neuropathology of older persons without cognitive impairment from two community-based studies Neurology 66 2006 1837 1844
234. G.W. Small, P. Siddarth, V. Kepe, L.M. Ercoli, A.C. Burggren, and S.Y. Bookheimer et al. Prediction of cognitive decline by positron emission tomography of brain amyloid and tau ArchNeurol 69 2012 215 222
235. V.L. Villemagne, K.E. Pike, G. Chetelat, K.A. Ellis, R.S. Mulligan, and P. Bourgeat et al. Longitudinal assessment of Abeta and cognition in aging and Alzheimer disease Ann Neurol 69 2011 181 192
236. M.M. Corrada, R. Brookmeyer, A. Paganini-Hill, D. Berlau, and C.H. Kawas Dementia incidence continues to increase with age in the oldest old: the 90+ study Ann Neurol 67 2010 114 121
237. P. Jha, C. Ramasundarahettige, V. Landsman, B. Rostron, M. Thun, and R.N. Anderson et al. 21st-century hazards of smoking and benefits of cessation in the United States N Engl J Med 368 2013 341 350
238. Y. Stern Cognitive reserve in ageing and Alzheimer's disease Lancet Neurol 11 2012 1006 1012
239. K.B. Filion, and R.V. Luepker Cigarette smoking and cardiovascular disease: lessons from Framingham Global Heart 8 2013 35 41
240. L. Gootjes, S.J. Teipel, Y. Zebuhr, R. Schwarz, G. Leinsinger, and P. Scheltens et al. Regional distribution of white matter hyperintensities in vascular dementia, Alzheimer's disease and healthy aging Dement Geriatr Cogn Disord 18 2004 180 188
241. D. Bhargava, M.F. Weiner, L.S. Hynan, R. Diaz-Arrastia, and A.M. Lipton Vascular disease and risk factors, rate of progression, and survival in Alzheimer's disease J Geriatr Psychiatry Neurol 19 2006 78 82
242. S.A. Jahnke, K.M. Hoffman, C.K. Haddock, M.A. Long, L.N. Williams, and H.A. Lando et al. Military tobacco policies: the good, the bad, and the ugly Mil Med 176 2011 1382 1387
243. M.W. Weiner, K.E. Friedl, A. Pacifico, J.C. Chapman, M.S. Jaffee, and D.M. Little et al. Military risk factors for Alzheimer's disease Alzheimers Dement 9 2013 445 451
244. S. Moylan, F.N. Jacka, J.A. Pasco, and M. Berk How cigarette smoking may increase the risk of anxiety symptoms and anxiety disorders: a critical review of biological pathways Brain Behav 3 2013 302 326
245. C. DeCarli, B.L. Miller, G.E. Swan, T. Reed, P.A. Wolf, and D. Carmelli Cerebrovascular and brain morphologic correlates of mild cognitive impairment in the National Heart, Lung, and Blood Institute Twin Study Arch Neurol 58 2001 643 647
246. G. Ravaglia, P. Forti, and F. Maioli et al. Conversion of mild cognitive impairment to dementia: predictive role of mild cognitive impairment subtypes and vascular risk factors Dement Geriatr Cogn Disord 21 2006 51 58
247. R.C. Petersen Early diagnosis of Alzheimer's disease: is MCI too late? Curr Alzheimer Res 6 2009 324 330
248. C.F. Xia, J. Arteaga, G. Chen, U. Gangadharmath, L.F. Gomez, and D. Kasi [(18)F]T807, a novel tau positron emission tomography imaging agent for Alzheimer's disease Alzheimers Dement 9 2013 666 676
249. L.G. Kaiser, N. Schuff, N. Cashdollar, and M.W. Weiner Age-related glutamate and glutamine concentration changes in normal human brain: 1H MR spectroscopy study at 4 T Neurobiol Aging 26 2005 665 672
250. D. Pratico, C.M. Clark, V.M. Lee, J.Q. Trojanowski, J. Rokach, and G.A. FitzGerald Increased 8,12-iso-iPF2alpha-VI in Alzheimer's disease: correlation of a noninvasive index of lipid peroxidation with disease severity Ann Neurol 48 2000 809 812
251. M. Handoko, M. Grant, M. Kuskowski, K.R. Zahs, A. Wallin, and K. Blennow et al. Correlation of specific amyloid-beta oligomers with tau in cerebrospinal fluid from cognitively normal older adults JAMA Neurol 70 2013 594 599
252. L.S. Honig, M.X. Tang, S. Albert, R. Costa, J. Luchsinger, and J. Manly et al. Stroke and the risk of Alzheimer disease Arch Neurol 60 2003 1707 1712
253. T. Erkinjuntti, G. Roman, S. Gauthier, H. Feldman, and K. Rockwood Emerging therapies for vascular dementia and vascular cognitive impairment Stroke 35 2004 1010 1017
254. S. Konno, J.S. Meyer, Y. Terayama, G.M. Margishvili, and K.F. Mortel Classification, diagnosis and treatment of vascular dementia Drugs Aging 11 1997 361 373
255. H.C. Yeh, B.B. Duncan, M.I. Schmidt, N.Y. Wang, and F.L. Brancati Smoking, smoking cessation, and risk for type 2 diabetes mellitus: a cohort study Ann Intern Med 152 2010 10 17
256. S.L. Bernstein, S. Yu, L.A. Post, J. Dziura, and N.A. Rigotti Undertreatment of tobacco use relative to other chronic conditions Am J Public Health 103 2013 e59 e65
257. M.J. Eisenberg, K.B. Filion, D. Yavin, P. Belisle, S. Mottillo, and L. Joseph et al. Pharmacotherapies for smoking cessation: a meta-analysis of randomized controlled trials CMAJ 179 2008 135 144
258. S.J. Vos, C. Xiong, P.J. Visser, M.S. Jasielec, J. Hassenstab, and E.A. Grant et al. Preclinical Alzheimer's disease and its outcome: a longitudinal cohort study Lancet Neurol 12 2013 957 965
259. C. Chrysohoou, D.B. Panagiotakos, C. Pitsavos, A. Zeimbekis, A. Zampelas, and L. Papademetriou et al. The associations between smoking, physical activity, dietary habits and plasma homocysteine levels in cardiovascular disease-free people: the 'ATTICA' study Vasc Med 9 2004 117 123