Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease

Nature Medicine

Volumn 20, Issue 11, 2014, Pages 1254-1262

  Zhang, Zhentao ^a,b   Song, Mingke ^a   Liu, Xia ^a   Kang, Seong Su ^a   Kwon, Il Sun ^a   Duong, Duc M ^a   Seyfried, Nicholas T ^a   Hu, William T ^a   Liu, Zhixue ^c   Wang, Jian Zhi ^d   Cheng, Liming ^e   Sun, Yi E ^e   Yu, Shan Ping ^a   Levey, Allan I ^a   Ye, Keqiang ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b RENMIN HOSPITAL OF WUHAN UNIVERSITY   (China)

^c Shanghai Jiao Tong University Affiliated Sixth People s Hospital   (China)

^d HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^e TONGJI UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARAGINE; PROTEINASE; TAU PROTEIN; CALPAIN; CASPASE; CYSTEINE PROTEINASE; LEGUMAIN; NEUROTOXIN;

AGING; ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; IN VITRO STUDY; MICROTUBULE ASSEMBLY; MOUSE; NERVE DEGENERATION; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; SYNAPSE; UPREGULATION; AGED; AMINO ACID SEQUENCE; ANIMAL; BRAIN; CHEMISTRY; COGNITION; COMPLICATION; ENZYMOLOGY; GENE INACTIVATION; HEK293 CELL LINE; MEMORY DISORDER; METABOLISM; MOLECULAR GENETICS; NEUROFIBRILLARY TANGLE; PATHOLOGY; PATHOPHYSIOLOGY; PHOSPHORYLATION; PROTEIN TERTIARY STRUCTURE; SOLUBILITY; TRANSGENIC MOUSE;

AGED; AGING; ALZHEIMER DISEASE; AMINO ACID SEQUENCE; ANIMALS; ASPARAGINE; BRAIN; CALPAIN; CASPASES; COGNITION; CYSTEINE ENDOPEPTIDASES; GENE KNOCKOUT TECHNIQUES; HEK293 CELLS; HUMANS; MEMORY DISORDERS; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; NEUROFIBRILLARY TANGLES; NEUROTOXINS; PHOSPHORYLATION; PROTEIN STRUCTURE, TERTIARY; SOLUBILITY; SYNAPSES; TAU PROTEINS; UP-REGULATION;

EID: 84910669129     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.3700     Document Type: Article

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