-
1
-
-
0001740285
-
The metabolism of carcinoma cells
-
Warburg O: The Metabolism of Carcinoma Cells. J Cancer Res 1925, 9:148-63.
-
(1925)
J Cancer Res
, vol.9
, pp. 148-163
-
-
Warburg, O.1
-
2
-
-
12444279265
-
On the origin of cancer cells
-
Warburg O: On the origin of cancer cells. Science 1956, 123:309-14.
-
(1956)
Science
, vol.123
, pp. 309-314
-
-
Warburg, O.1
-
3
-
-
0017173150
-
The Warburg hypothesis fifty years later
-
Weinhouse S: The Warburg hypothesis fifty years later. Cancer Res Clin Oncol 1976, 87:115-26.
-
(1976)
Cancer Res Clin Oncol
, vol.87
, pp. 115-126
-
-
Weinhouse, S.1
-
4
-
-
11444255268
-
On respiratory impairment in cancer cells
-
Weinhouse S: On respiratory impairment in cancer cells. Science 1956, 124:267-9.
-
(1956)
Science
, vol.124
, pp. 267-269
-
-
Weinhouse, S.1
-
5
-
-
78651059309
-
Metabolism of neoplastic tissue. I. The oxidation of carbohydrate and fatty acids in transplanted tumors
-
Weinhouse S, Millington RH, Wenner CE: Metabolism of neoplastic tissue. I. The oxidation of carbohydrate and fatty acids in transplanted tumors. Cancer Res 1951, 11:845-50.
-
(1951)
Cancer Res
, vol.11
, pp. 845-850
-
-
Weinhouse, S.1
Millington, R.H.2
Wenner, C.E.3
-
6
-
-
0019319464
-
Regulation of cellular energy metabolism: The Crabtree effect
-
Sussman I, Erecinska M, Wilson DF: Regulation of cellular energy metabolism: the Crabtree effect. Biochim Biophys Acta 1980, 591:209-23.
-
(1980)
Biochim Biophys Acta
, vol.591
, pp. 209-223
-
-
Sussman, I.1
Erecinska, M.2
Wilson, D.F.3
-
7
-
-
0000089325
-
Observations on the carbohydrate metabolism of tumours
-
Crabtree H.G: Observations on the carbohydrate metabolism of tumours. Biochem J 1929, 23:536-45.
-
(1929)
Biochem J
, vol.23
, pp. 536-545
-
-
Crabtree, H.G.1
-
8
-
-
33748120494
-
PET and PET/CT using 18F-FDG in the diagnosis and management of cancer patients
-
Endo K, Oriuchi N, Higuchi T, Iida Y, Hanaoka H, Miyakubo M, Ishikita T, Koyama K: PET and PET/CT using 18F-FDG in the diagnosis and management of cancer patients. Int J Clin Oncol 2006, 11:286-96.
-
(2006)
Int J Clin Oncol
, vol.11
, pp. 286-296
-
-
Endo, K.1
Oriuchi, N.2
Higuchi, T.3
Iida, Y.4
Hanaoka, H.5
Miyakubo, M.6
Ishikita, T.7
Koyama, K.8
-
9
-
-
84901255240
-
Prognostic value of FDG PET imaging in patients with laryngeal cancer
-
Kitajima K, Suenaga Y, Kanda T, Miyawaki D, Yoshida K, Ejima Y, Sasaki R, Komatsu H, Saito M, Otsuki N, Nibu K, Kiyota N, Minamikawa T, Sugimura K: Prognostic value of FDG PET imaging in patients with laryngeal cancer. PLoS One 2014, 9: e96999.
-
(2014)
PLoS One
, vol.9
, pp. e96999
-
-
Kitajima, K.1
Suenaga, Y.2
Kanda, T.3
Miyawaki, D.4
Yoshida, K.5
Ejima, Y.6
Sasaki, R.7
Komatsu, H.8
Saito, M.9
Otsuki, N.10
Nibu, K.11
Kiyota, N.12
Minamikawa, T.13
Sugimura, K.14
-
10
-
-
68549136820
-
Association between 18F-fluoro-2-deoxy-D-glucose uptake values and tumor vitality: Prognostic value of positron emission tomography in earlystage non-small cell lung cancer
-
Dooms C, van Baardwijk A, Verbeken E, van Suylen RJ, Stroobants S, De Ruysscher D, Vansteenkiste J: Association between 18F-fluoro-2-deoxy-D-glucose uptake values and tumor vitality: prognostic value of positron emission tomography in earlystage non-small cell lung cancer. J Thorac Oncol 2009, 4:822-8.
-
(2009)
J Thorac Oncol
, vol.4
, pp. 822-828
-
-
Dooms, C.1
Van Baardwijk, A.2
Verbeken, E.3
Van Suylen, R.J.4
Stroobants, S.5
De Ruysscher, D.6
Vansteenkiste, J.7
-
11
-
-
0037065947
-
FDG-PET. A possible prognostic factor in head and neck cancer
-
Halfpenny W, et al.: FDG-PET. A possible prognostic factor in head and neck cancer. Br J Cancer 2002, 86:512-6.
-
(2002)
Br J Cancer
, vol.86
, pp. 512-516
-
-
Halfpenny, W.1
-
12
-
-
0016374648
-
Transport of sugars in tumor cell membranes
-
Hatanaka M, Hain SF, Biassoni L, Maisey MN, Sherman JA, McGurk M: Transport of sugars in tumor cell membranes. Biochim Biophys Acta, 1974, 355(1): p. 77-104.
-
(1974)
Biochim Biophys Acta
, vol.355
, Issue.1
, pp. 77-104
-
-
Hatanaka, M.1
Hain, S.F.2
Biassoni, L.3
Maisey, M.N.4
Sherman, J.A.5
McGurk, M.6
-
13
-
-
84872478184
-
Expression of glucose transporters in cancers
-
Szablewski L: Expression of glucose transporters in cancers. Biochim Biophys Acta 2013, 1835:164-9.
-
(2013)
Biochim Biophys Acta
, vol.1835
, pp. 164-169
-
-
Szablewski, L.1
-
14
-
-
0036077547
-
Glucose transporters: Expression, regulation and cancer
-
Medina RA, Owen GI: Glucose transporters: expression, regulation and cancer. Biol Res 2002, 35:9-26.
-
(2002)
Biol Res
, vol.35
, pp. 9-26
-
-
Medina, R.A.1
Owen, G.I.2
-
15
-
-
0035937715
-
Regulation of glut1 mRNA by hypoxia-inducible factor-1. Interaction between H-ras and hypoxia
-
Chen C, Pore N, Behrooz A, Ismail-Beigi F, Maity A: Regulation of glut1 mRNA by hypoxia-inducible factor-1. Interaction between H-ras and hypoxia. J Biol Chem 2001, 276:9519-25.
-
(2001)
J Biol Chem
, vol.276
, pp. 9519-9525
-
-
Chen, C.1
Pore, N.2
Behrooz, A.3
Ismail-Beigi, F.4
Maity, A.5
-
16
-
-
0026801196
-
Identification of two enhancer elements in the gene encoding the type 1 glucose transporter from the mouse which are responsive to serum, growth factor, and oncogenes
-
Murakami T, Nishiyama T, Shirotani T, Shinohara Y, Kan M, Ishii K, Kanai F, Nakazuru S, Ebina Y: Identification of two enhancer elements in the gene encoding the type 1 glucose transporter from the mouse which are responsive to serum, growth factor, and oncogenes. J Biol Chem 1992, 26:9300-6.
-
(1992)
J Biol Chem
, vol.26
, pp. 9300-9306
-
-
Murakami, T.1
Nishiyama, T.2
Shirotani, T.3
Shinohara, Y.4
Kan, M.5
Ishii, K.6
Kanai, F.7
Nakazuru, S.8
Ebina, Y.9
-
17
-
-
0028805375
-
Hypoxia and mitochondrial inhibitors regulate expression of glucose transporter-1 via distinct Cis-acting sequences
-
Ebert BL, Firth JD, Ratcliffe PJ: Hypoxia and mitochondrial inhibitors regulate expression of glucose transporter-1 via distinct Cis-acting sequences. J Biol Chem 1995, 270:29083-9.
-
(1995)
J Biol Chem
, vol.270
, pp. 29083-29089
-
-
Ebert, B.L.1
Firth, J.D.2
Ratcliffe, P.J.3
-
18
-
-
0028518842
-
Subcellular localization and trafficking of the GLUT4 glucose transporter isoform in insulinresponsive cells
-
Holman GD, Cushman SW: Subcellular localization and trafficking of the GLUT4 glucose transporter isoform in insulinresponsive cells. Bioessays 1994, 16:753-9.
-
(1994)
Bioessays
, vol.16
, pp. 753-759
-
-
Holman, G.D.1
Cushman, S.W.2
-
19
-
-
0033575290
-
Regulation of GLUT1 gene transcription by the serine/ threonine kinase Akt1
-
Barthel A, Okino ST, Liao J, Nakatani K, Li J, Whitlock JP Jr, Roth RA: Regulation of GLUT1 gene transcription by the serine/ threonine kinase Akt1. J Biol Chem 1999, 274:20281-6.
-
(1999)
J Biol Chem
, vol.274
, pp. 20281-20286
-
-
Barthel, A.1
Okino, S.T.2
Liao, J.3
Nakatani, K.4
Li, J.5
Whitlock, J.P.6
Roth, R.A.7
-
20
-
-
84875153197
-
Glucose transport families SLC5 and SLC50
-
Wright EM: Glucose transport families SLC5 and SLC50. Mol Aspects Med 2013, 34:183-96.
-
(2013)
Mol Aspects Med
, vol.34
, pp. 183-196
-
-
Wright, E.M.1
-
21
-
-
84858782079
-
AMPK: A nutrient and energy sensor that maintains energy homeostasis
-
Hardie DG, Ross FA, Hawley SA: AMPK: a nutrient and energy sensor that maintains energy homeostasis. Nat Rev Mol Cell Biol 2012, 13:251-62.
-
(2012)
Nat Rev Mol Cell Biol
, vol.13
, pp. 251-262
-
-
Hardie, D.G.1
Ross, F.A.2
Hawley, S.A.3
-
22
-
-
33746924468
-
Hexokinase II: Cancer's double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria
-
Mathupala SP, Ko YH, Pedersen PL: Hexokinase II: cancer's double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria. Oncogene 2006, 25:4777-86.
-
(2006)
Oncogene
, vol.25
, pp. 4777-4786
-
-
Mathupala, S.P.1
Ko, Y.H.2
Pedersen, P.L.3
-
23
-
-
35649014840
-
Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1
-
Kim JW, Gao P, Liu YC, Semenza GL, Dang CV: Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1. Mol Cell Biol 2007, 27:7381-93.
-
(2007)
Mol Cell Biol
, vol.27
, pp. 7381-7393
-
-
Kim, J.W.1
Gao, P.2
Liu, Y.C.3
Semenza, G.L.4
Dang, C.V.5
-
24
-
-
0942290437
-
In self-defence: Hexokinase promotes voltage-dependent anion channel closure and prevents mitochondria-mediated apoptotic cell death
-
Azoulay-Zohar H, Israelson A, Abu-Hamad S, Shoshan-Barmatz V: In self-defence: hexokinase promotes voltage-dependent anion channel closure and prevents mitochondria-mediated apoptotic cell death. Biochem J 2004, 377:347-55.
-
(2004)
Biochem J
, vol.377
, pp. 347-355
-
-
Azoulay-Zohar, H.1
Israelson, A.2
Abu-Hamad, S.3
Shoshan-Barmatz, V.4
-
25
-
-
0034614637
-
The hallmarks of cancer
-
Hanahan D, Weinberg RA: The hallmarks of cancer. Cell 2000, 100:57-70.
-
(2000)
Cell
, vol.100
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
26
-
-
0042575733
-
High aerobic glycolysis of rat hepatoma cells in culture: Role of mitochondrial hexokinase
-
Bustamante E, Pedersen PL: High aerobic glycolysis of rat hepatoma cells in culture: role of mitochondrial hexokinase. Proc Natl Acad Sci U S A 1977, 74:3735-9.
-
(1977)
Proc Natl Acad Sci u S a
, vol.74
, pp. 3735-3739
-
-
Bustamante, E.1
Pedersen, P.L.2
-
27
-
-
0037056002
-
Mitochondrial bound type II hexokinase: A key player in the growth and survival of many cancers and an ideal prospect for therapeutic intervention
-
Pedersen PL, Mathupala S, Rempel A, Geschwind JF, Ko YH: Mitochondrial bound type II hexokinase: a key player in the growth and survival of many cancers and an ideal prospect for therapeutic intervention. Biochim Biophys Acta 2002, 1555:14-20.
-
(2002)
Biochim Biophys Acta
, vol.1555
, pp. 14-20
-
-
Pedersen, P.L.1
Mathupala, S.2
Rempel, A.3
Geschwind, J.F.4
Ko, Y.H.5
-
28
-
-
24644488689
-
Regulation of phosphoglucose isomerase/autocrine motility factor expression by hypoxia
-
Funasaka T, Yanagawa T, Hogan V, Raz A: Regulation of phosphoglucose isomerase/autocrine motility factor expression by hypoxia. FASEB J 2005, 19:1422-30.
-
(2005)
FASEB J
, vol.19
, pp. 1422-1430
-
-
Funasaka, T.1
Yanagawa, T.2
Hogan, V.3
Raz, A.4
-
29
-
-
0026321067
-
Serum phosphohexose isomerase activities in patients with colorectal cancer
-
Filella X, Molina R, Jo J, Mas E, Ballesta AM: Serum phosphohexose isomerase activities in patients with colorectal cancer. Tumour Biol 1991, 1:360-7.
-
(1991)
Tumour Biol
, vol.1
, pp. 360-367
-
-
Filella, X.1
Molina, R.2
Jo, J.3
Mas, E.4
Ballesta, A.M.5
-
30
-
-
0025000748
-
The diagnostic validity of the serum tumor marker phosphohexose isomerase (PHI) in patients with gastrointestinal, kidney, and breast cancer
-
Baumann M, Kappl A, Lang T, Brand K, Siegfried W, Paterok E: The diagnostic validity of the serum tumor marker phosphohexose isomerase (PHI) in patients with gastrointestinal, kidney, and breast cancer. Cancer Invest 1990, 8:351-6.
-
(1990)
Cancer Invest
, vol.8
, pp. 351-356
-
-
Baumann, M.1
Kappl, A.2
Lang, T.3
Brand, K.4
Siegfried, W.5
Paterok, E.6
-
31
-
-
0025740495
-
Purification of human tumor cell autocrine motility factor and molecular cloning of its receptor
-
Watanabe H, Carmi P, Hogan V, Raz T, Silletti S, Nabi IR, Raz A: Purification of human tumor cell autocrine motility factor and molecular cloning of its receptor. J Biol Chem 1991, 266:13442-8.
-
(1991)
J Biol Chem
, vol.266
, pp. 13442-13448
-
-
Watanabe, H.1
Carmi, P.2
Hogan, V.3
Raz, T.4
Silletti, S.5
Nabi, I.R.6
Raz, A.7
-
32
-
-
0042858146
-
Regulation of cell proliferation by autocrine motility factor/phosphoglucose isomerase signaling
-
Tsutsumi S, Yanagawa T, Shimura T, Fukumori T, Hogan V, Kuwano H, Raz A: Regulation of cell proliferation by autocrine motility factor/phosphoglucose isomerase signaling. J Biol Chem 2003, 278:32165-72.
-
(2003)
J Biol Chem
, vol.278
, pp. 32165-32172
-
-
Tsutsumi, S.1
Yanagawa, T.2
Shimura, T.3
Fukumori, T.4
Hogan, V.5
Kuwano, H.6
Raz, A.7
-
33
-
-
79953149305
-
The crystal complex of phosphofructokinase-2 of Escherichia coli with fructose-6-phosphate: Kinetic and structural analysis of the allosteric ATP inhibition
-
Cabrera R, Baez M, Pereira HM, Caniuguir A, Garratt RC, Babul J: The crystal complex of phosphofructokinase-2 of Escherichia coli with fructose-6-phosphate: kinetic and structural analysis of the allosteric ATP inhibition. J Biol Chem 2011, 286:5774-83.
-
(2011)
J Biol Chem
, vol.286
, pp. 5774-5783
-
-
Cabrera, R.1
Baez, M.2
Pereira, H.M.3
Caniuguir, A.4
Garratt, R.C.5
Babul, J.6
-
34
-
-
0019585720
-
Regulatory properties of phosphofructokinase 2 from Escherichia coli
-
Kotlarz D, Buc H: Regulatory properties of phosphofructokinase 2 from Escherichia coli. Eur J Biochem 1981, 117:569-74.
-
(1981)
Eur J Biochem
, vol.117
, pp. 569-574
-
-
Kotlarz, D.1
Buc, H.2
-
35
-
-
77954457039
-
Kinetics of Regulatory Enzymes. Escherichia Coli Phosphofructokinase
-
Atkinson DE, Walton GM: Kinetics of Regulatory Enzymes. Escherichia Coli Phosphofructokinase. J Biol Chem 1965, 240:757-63.
-
(1965)
J Biol Chem
, vol.240
, pp. 757-763
-
-
Atkinson, D.E.1
Walton, G.M.2
-
36
-
-
67349131613
-
Regulation of glucose metabolism by 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases in cancer
-
Yalcin A, Telang S, Clem B, Chesney J: Regulation of glucose metabolism by 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases in cancer. Exp Mol Pathol 2009, 86: 174-9.
-
(2009)
Exp Mol Pathol
, vol.86
, pp. 174-179
-
-
Yalcin, A.1
Telang, S.2
Clem, B.3
Chesney, J.4
-
37
-
-
33748060829
-
Roles for fructose-2,6-bisphosphate in the control of fuel metabolism: Beyond its allosteric effects on glycolytic and gluconeogenic enzymes
-
Wu C, Khan SA, Peng LJ, Lange AJ: Roles for fructose-2,6-bisphosphate in the control of fuel metabolism: beyond its allosteric effects on glycolytic and gluconeogenic enzymes. Adv Enzyme Regul 2006, 46:72-88.
-
(2006)
Adv Enzyme Regul
, vol.46
, pp. 72-88
-
-
Wu, C.1
Khan, S.A.2
Peng, L.J.3
Lange, A.J.4
-
38
-
-
38049077430
-
6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB3) is up-regulated in high-grade astrocytomas
-
Kessler R, Bleichert F, Warnke JP, Eschrich K: 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB3) is up-regulated in high-grade astrocytomas. J Neurooncol 2008, 86:257-64.
-
(2008)
J Neurooncol
, vol.86
, pp. 257-264
-
-
Kessler, R.1
Bleichert, F.2
Warnke, J.P.3
Eschrich, K.4
-
39
-
-
25444464113
-
Overexpression of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-4 in the human breast and colon malignant tumors
-
Minchenko OH, Ochiai A, Opentanova IL, Ogura T, Minchenko DO, Caro J, Komisarenko SV, Esumi H: Overexpression of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-4 in the human breast and colon malignant tumors. Biochimie 2005, 87:1005-10.
-
(2005)
Biochimie
, vol.87
, pp. 1005-1010
-
-
Minchenko, O.H.1
Ochiai, A.2
Opentanova, I.L.3
Ogura, T.4
Minchenko, D.O.5
Caro, J.6
Komisarenko, S.V.7
Esumi, H.8
-
40
-
-
84896509301
-
Reduced methylation of PFKFB3 in cancer cells shunts glucose towards the pentose phosphate pathway
-
Yamamoto T, Takano N, Ishiwata K, Ohmura M, Nagahata Y, Matsuura T, Kamata A, Sakamoto K, Nakanishi T, Kubo A, Hishiki T, Suematsu M: Reduced methylation of PFKFB3 in cancer cells shunts glucose towards the pentose phosphate pathway. Nat Commun 2014, 5:3480.
-
(2014)
Nat Commun
, vol.5
, pp. 3480
-
-
Yamamoto, T.1
Takano, N.2
Ishiwata, K.3
Ohmura, M.4
Nagahata, Y.5
Matsuura, T.6
Kamata, A.7
Sakamoto, K.8
Nakanishi, T.9
Kubo, A.10
Hishiki, T.11
Suematsu, M.12
-
41
-
-
0242710750
-
Hypoxic regulation of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene family (PFKFB-1-4) expression in vivo
-
Minchenko OI, Opentanova I, Caro J: Hypoxic regulation of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene family (PFKFB-1-4) expression in vivo. FEBS Lett 2003, 554:264-70.
-
(2003)
FEBS Lett
, vol.554
, pp. 264-270
-
-
Minchenko, O.I.1
Opentanova, I.2
Caro, J.3
-
42
-
-
84863721201
-
RNAi screening in glioma stem-like cells identifies PFKFB4 as a key molecule important for cancer cell survival
-
Goidts V, Bageritz J, Puccio L, Nakata S, Zapatka M, Barbus S, Toedt G, Campos B, Korshunov A, Momma S, Van Schaftingen E, Reifenberger G, Herold-Mende C, Lichter P, Radlwimmer B: RNAi screening in glioma stem-like cells identifies PFKFB4 as a key molecule important for cancer cell survival. Oncogene 2012, 31:3235-43.
-
(2012)
Oncogene
, vol.31
, pp. 3235-3243
-
-
Goidts, V.1
Bageritz, J.2
Puccio, L.3
Nakata, S.4
Zapatka, M.5
Barbus, S.6
Toedt, G.7
Campos, B.8
Korshunov, A.9
Momma, S.10
Van Schaftingen, E.11
Reifenberger, G.12
Herold-Mende, C.13
Lichter, P.14
Radlwimmer, B.15
-
43
-
-
84864767268
-
Functional metabolic screen identifies 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 as an important regulator of prostate cancer cell survival
-
Ros S, Santos CR, Moco S, Baenke F, Kelly G, Howell M, Zamboni N, Schulze A: Functional metabolic screen identifies 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 as an important regulator of prostate cancer cell survival. Cancer Discov 2012, 2:328-43.
-
(2012)
Cancer Discov
, vol.2
, pp. 328-343
-
-
Ros, S.1
Santos, C.R.2
Moco, S.3
Baenke, F.4
Kelly, G.5
Howell, M.6
Zamboni, N.7
Schulze, A.8
-
44
-
-
33745918951
-
TIGAR, a p53-inducible regulator of glycolysis and apoptosis
-
Bensaad K, Tsuruta A, Selak MA, Vidal MN, Nakano K, Bartrons R, Gottlieb E, Vousden KH: TIGAR, a p53-inducible regulator of glycolysis and apoptosis. Cell, 2006. 126(1): p. 107-20.
-
(2006)
Cell
, vol.126
, Issue.1
, pp. 107-120
-
-
Bensaad, K.1
Tsuruta, A.2
Selak, M.A.3
Vidal, M.N.4
Nakano, K.5
Bartrons, R.6
Gottlieb, E.7
Vousden, K.H.8
-
45
-
-
84887430076
-
Metabolic regulation by p53 family members
-
Berkers CR, Maddocks OD, Cheung EC, Mor I, Vousden KH: Metabolic regulation by p53 family members. Cell Metab 2013, 18:617-33.
-
(2013)
Cell Metab
, vol.18
, pp. 617-633
-
-
Berkers, C.R.1
Maddocks, O.D.2
Cheung, E.C.3
Mor, I.4
Vousden, K.H.5
-
46
-
-
77950919036
-
Quantitative proteomics identification of phosphoglycerate mutase 1 as a novel therapeutic target in hepatocellular carcinoma
-
Ren F, Wu H, Lei Y, Zhang H, Liu R, Zhao Y, Chen X, Zeng D, Tong A, Chen L, Wei Y, Huang C: Quantitative proteomics identification of phosphoglycerate mutase 1 as a novel therapeutic target in hepatocellular carcinoma. Mol Cancer 2010, 9:81.
-
(2010)
Mol Cancer
, vol.9
, pp. 81
-
-
Ren, F.1
Wu, H.2
Lei, Y.3
Zhang, H.4
Liu, R.5
Zhao, Y.6
Chen, X.7
Zeng, D.8
Tong, A.9
Chen, L.10
Wei, Y.11
Huang, C.12
-
47
-
-
11244347171
-
Glycolytic enzymes can modulate cellular life span
-
Kondoh H, Lleonart ME, Gil J, Wang J, Degan P, Peters G, Martinez D, Carnero A, Beach D: Glycolytic enzymes can modulate cellular life span. Cancer Res 2005, 65:177-85.
-
(2005)
Cancer Res
, vol.65
, pp. 177-185
-
-
Kondoh, H.1
Lleonart, M.E.2
Gil, J.3
Wang, J.4
Degan, P.5
Peters, G.6
Martinez, D.7
Carnero, A.8
Beach, D.9
-
48
-
-
84869077946
-
Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth
-
Hitosugi T, Zhou L, Elf S, Fan J, Kang HB, Seo JH, Shan C, Dai Q, Zhang L, Xie J, Gu TL, Jin P, Aleèkoviæ M, LeRoy G, Kang Y, Sudderth JA, DeBerardinis RJ, Luan CH, Chen GZ, Muller S, Shin DM, Owonikoko TK, Lonial S, Arellano ML, Khoury HJ, Khuri FR, Lee BH, Ye K, Boggon TJ, Kang S, He C, Chen J: Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth. Cancer Cell 2012, 22:585-600.
-
(2012)
Cancer Cell
, vol.22
, pp. 585-600
-
-
Hitosugi, T.1
Zhou, L.2
Elf, S.3
Fan, J.4
Kang, H.B.5
Seo, J.H.6
Shan, C.7
Dai, Q.8
Zhang, L.9
Xie, J.10
Gu, T.L.11
Jin, P.12
Aleèkoviæ, M.13
LeRoy, G.14
Kang, Y.15
Sudderth, J.A.16
DeBerardinis, R.J.17
Luan, C.H.18
Chen, G.Z.19
Muller, S.20
Shin, D.M.21
Owonikoko, T.K.22
Lonial, S.23
Arellano, M.L.24
Khoury, H.J.25
Khuri, F.R.26
Lee, B.H.27
Ye, K.28
Boggon, T.J.29
Kang, S.30
He, C.31
Chen, J.32
more..
-
50
-
-
40749163248
-
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
-
Christofk HR, Vander Heiden MG, Harris MH, Ramanathan A, Gerszten RE, Wei R, Fleming MD, Schreiber SL, Cantley LC: The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature 2008, 452:230-3.
-
(2008)
Nature
, vol.452
, pp. 230-233
-
-
Christofk, H.R.1
Vander Heiden, M.G.2
Harris, M.H.3
Ramanathan, A.4
Gerszten, R.E.5
Wei, R.6
Fleming, M.D.7
Schreiber, S.L.8
Cantley, L.C.9
-
51
-
-
84863486244
-
The pentose phosphate pathway: An antioxidant defense and a crossroad in tumor cell fate
-
Riganti C, Gazzano E, Polimeni M, Aldieri E, Ghigo D: The pentose phosphate pathway: an antioxidant defense and a crossroad in tumor cell fate. Free Radic Biol Med 2012, 53:421-36.
-
(2012)
Free Radic Biol Med
, vol.53
, pp. 421-436
-
-
Riganti, C.1
Gazzano, E.2
Polimeni, M.3
Aldieri, E.4
Ghigo, D.5
-
52
-
-
0024432603
-
Regulation of cellular glutathione
-
Deneke SM, Fanburg BL: Regulation of cellular glutathione. Am J Physiol 1989, 257:163-73.
-
(1989)
Am J Physiol
, vol.257
, pp. 163-173
-
-
Deneke, S.M.1
Fanburg, B.L.2
-
53
-
-
40749099894
-
Pyruvate kinase M2 is a phosphotyrosine-binding protein
-
Christofk HR, Vander Heiden MG, Wu N, Asara JM, Cantley LC: Pyruvate kinase M2 is a phosphotyrosine-binding protein. Nature 2008, 452:181-6.
-
(2008)
Nature
, vol.452
, pp. 181-186
-
-
Christofk, H.R.1
Vander Heiden, M.G.2
Wu, N.3
Asara, J.M.4
Cantley, L.C.5
-
54
-
-
77956674635
-
Evidence for an alternative glycolytic pathway in rapidly proliferating cells
-
Vander Heiden MG, Locasale JW, Swanson KD, Sharfi H, Heffron GJ, Amador-Noguez D, Christofk HR, Wagner G, Rabinowitz JD, Asara JM, Cantley LC: Evidence for an alternative glycolytic pathway in rapidly proliferating cells. Science 2010, 329:1492-9.
-
(2010)
Science
, vol.329
, pp. 1492-1499
-
-
Vander Heiden, M.G.1
Locasale, J.W.2
Swanson, K.D.3
Sharfi, H.4
Heffron, G.J.5
Amador-Noguez, D.6
Christofk, H.R.7
Wagner, G.8
Rabinowitz, J.D.9
Asara, J.M.10
Cantley, L.C.11
-
55
-
-
84885589840
-
PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells
-
IsraelsenWJ, Dayton TL,Davidson SM, Fiske BP,HosiosAM, Bellinger G, Li J, Yu Y, Sasaki M, Horner JW, Burga LN, Xie J, JurczakMJ, DePinho RA, ClishCB, Jacks T, Kibbey RG,WulfGM,Di Vizio D, MillsGB,Cantley LC, Vander Heiden MG: PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells. Cell 2013, 155:397-409.
-
(2013)
Cell
, vol.155
, pp. 397-409
-
-
Israelsen, W.J.1
Dayton, T.L.2
Davidson, S.M.3
Fiske, B.P.4
Hosios, A.M.5
Bellinger, G.6
Li, J.7
Yu, Y.8
Sasaki, M.9
Horner, J.W.10
Burga, L.N.11
Xie, J.12
Jurczak, M.J.13
De Pinho, R.A.14
Clish, C.B.15
Jacks, T.16
Kibbey, R.G.17
Wulf, G.M.18
Di Vizio, D.19
Mills, G.B.20
Cantley, L.C.21
Vander Heiden, M.G.22
more..
-
56
-
-
0034006016
-
HIF-1: Mediator of physiological and pathophysiological responses to hypoxia
-
Semenza GL: HIF-1: mediator of physiological and pathophysiological responses to hypoxia. J Appl Physiol (1985) 2000, 88:1474-80.
-
(2000)
J Appl Physiol
, vol.88
, pp. 1474-1480
-
-
Semenza, G.L.1
-
57
-
-
0030921103
-
C-Myc transactivation of LDH-A: Implications for tumor metabolism and growth
-
Shim H, Dolde C, Lewis BC, Wu CS, Dang G, Jungmann RA, Dalla-Favera R, Dang CV: c-Myc transactivation of LDH-A: implications for tumor metabolism and growth. Proc Natl Acad Sci U S A 1997, 94:6658-63.
-
(1997)
Proc Natl Acad Sci u S a
, vol.94
, pp. 6658-6663
-
-
Shim, H.1
Dolde, C.2
Lewis, B.C.3
Wu, C.S.4
Dang, G.5
Jungmann, R.A.6
Dalla-Favera, R.7
Dang, C.V.8
-
58
-
-
83255171153
-
Tyrosine phosphorylation of lactate dehydrogenase A is important for NADH/NAD(+) redox homeostasis in cancer cells
-
Fan J, Hitosugi T, Chung TW, Xie J, Ge Q, Gu TL, Polakiewicz RD, Chen GZ, Boggon TJ, Lonial S, Khuri FR, Kang S, Chen J: Tyrosine phosphorylation of lactate dehydrogenase A is important for NADH/NAD(+) redox homeostasis in cancer cells. Mol Cell Biol 2011, 31:4938-50.
-
(2011)
Mol Cell Biol
, vol.31
, pp. 4938-4950
-
-
Fan, J.1
Hitosugi, T.2
Chung, T.W.3
Xie, J.4
Ge, Q.5
Gu, T.L.6
Polakiewicz, R.D.7
Chen, G.Z.8
Boggon, T.J.9
Lonial, S.10
Khuri, F.R.11
Kang, S.12
Chen, J.13
-
59
-
-
76649126249
-
Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression
-
Le A, Cooper CR, Gouw AM, Dinavahi R, Maitra A, Deck LM, Royer RE, Vander Jagt DL, Semenza GL, Dang CV: Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression. Proc Natl Acad Sci U S A 2010, 107:2037-42.
-
(2010)
Proc Natl Acad Sci u S a
, vol.107
, pp. 2037-2042
-
-
Le, A.1
Cooper, C.R.2
Gouw, A.M.3
Dinavahi, R.4
Maitra, A.5
Deck, L.M.6
Royer, R.E.7
Vander Jagt, D.L.8
Semenza, G.L.9
Dang, C.V.10
-
60
-
-
33744783432
-
Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance
-
Fantin VR, St-Pierre J, Leder P: Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance. Cancer Cell 2006, 9(6):425-34.
-
(2006)
Cancer Cell
, vol.9
, Issue.6
, pp. 425-434
-
-
Fantin, V.R.1
St-Pierre, J.2
Leder, P.3
-
61
-
-
33646917296
-
The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism
-
Ullah MS, Davies AJ, Halestrap AP: The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism. J Biol Chem 2006, 281:9030-7.
-
(2006)
J Biol Chem
, vol.281
, pp. 9030-9037
-
-
Ullah, M.S.1
Davies, A.J.2
Halestrap, A.P.3
-
62
-
-
80053640489
-
CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors
-
Le Floch R, Chiche J, Marchiq I, Naiken T, Ilc K, Murray CM, Critchlow SE, Roux D, Simon MP, Pouysségur J: CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors. Proc Natl Acad Sci U S A 2011, 108:16663-8.
-
(2011)
Proc Natl Acad Sci u S a
, vol.108
, pp. 16663-16668
-
-
Le Floch, R.1
Chiche, J.2
Marchiq, I.3
Naiken, T.4
Ilc, K.5
Murray, C.M.6
Critchlow, S.E.7
Roux, D.8
Simon, M.P.9
Pouysségur, J.10
-
63
-
-
0016259467
-
Inhibition of mitochondrial pyruvate transport by phenylpyruvate and alphaketoisocaproate
-
Halestrap AP, Brand MD, Denton RM: Inhibition of mitochondrial pyruvate transport by phenylpyruvate and alphaketoisocaproate. Biochim Biophys Acta 1974, 367:102-8.
-
(1974)
Biochim Biophys Acta
, vol.367
, pp. 102-108
-
-
Halestrap, A.P.1
Brand, M.D.2
Denton, R.M.3
-
64
-
-
84863552418
-
A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans
-
Bricker DK, Taylor EB, Schell JC, Orsak T, Boutron A, Chen YC, Cox JE, Cardon CM, Van Vranken JG, Dephoure N, Redin C, Boudina S, Gygi SP, Brivet M, Thummel CS, Rutter J: A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans. Science 2012, 337:96-100.
-
(2012)
Science
, vol.337
, pp. 96-100
-
-
Bricker, D.K.1
Taylor, E.B.2
Schell, J.C.3
Orsak, T.4
Boutron, A.5
Chen, Y.C.6
Cox, J.E.7
Cardon, C.M.8
Van Vranken, J.G.9
Dephoure, N.10
Redin, C.11
Boudina, S.12
Gygi, S.P.13
Brivet, M.14
Thummel, C.S.15
Rutter, J.16
-
65
-
-
84863553135
-
Identification and functional expression of the mitochondrial pyruvate carrier
-
Herzig S, Raemy E, Montessuit S, Veuthey JL, Zamboni N, Westermann B, Kunji ER, Martinou JC: Identification and functional expression of the mitochondrial pyruvate carrier. Science 2012, 337:93-6.
-
(2012)
Science
, vol.337
, pp. 93-96
-
-
Herzig, S.1
Raemy, E.2
Montessuit, S.3
Veuthey, J.L.4
Zamboni, N.5
Westermann, B.6
Kunji, E.R.7
Martinou, J.C.8
-
66
-
-
84922430730
-
Regulation of Substrate Utilization by the Mitochondrial Pyruvate Carrier
-
Vacanti NM, Divakaruni AS, Green CR, Parker SJ, Henry RR, Ciaraldi TP, Murphy AN, Metallo CM: Regulation of Substrate Utilization by the Mitochondrial Pyruvate Carrier. Mol Cell 2014, 56:425-35.
-
(2014)
Mol Cell
, vol.56
, pp. 425-435
-
-
Vacanti, N.M.1
Divakaruni, A.S.2
Green, C.R.3
Parker, S.J.4
Henry, R.R.5
Ciaraldi, T.P.6
Murphy, A.N.7
Metallo, C.M.8
-
67
-
-
84922468705
-
Glutamine oxidation maintains the TCA cycle and cell survival during impaired mitochondrial pyruvate transport
-
Yang C, Ko B, Hensley CT, Jiang L, Wasti AT, Kim J, Sudderth J, Calvaruso MA, Lumata L, Mitsche M, Rutter J, Merritt ME, DeBerardinis RJ: Glutamine Oxidation Maintains the TCA Cycle and Cell Survival during Impaired Mitochondrial Pyruvate Transport. Mol Cell 2014, 56:414-24.
-
(2014)
Mol Cell
, vol.56
, pp. 414-424
-
-
Yang, C.1
Ko, B.2
Hensley, C.T.3
Jiang, L.4
Wasti, A.T.5
Kim, J.6
Sudderth, J.7
Calvaruso, Ma.8
Lumata, L.9
Mitsche, M.10
Rutter, J.11
Merritt, M.E.12
De Berardinis, R.J.13
-
68
-
-
84922445353
-
A role for the mitochondrial pyruvate carrier as a repressor of the warburg effect and colon cancer cell growth
-
Schell JC, Olson KA, Jiang L, Hawkins AJ, Van Vranken JG, Xie J, Egnatchik RA, Earl EG, DeBerardinis RJ, Rutter J: A Role for the Mitochondrial Pyruvate Carrier as a Repressor of the Warburg Effect and Colon Cancer Cell Growth. Mol Cell 2014, 56:400-413.
-
(2014)
Mol Cell
, vol.56
, pp. 400-413
-
-
Schell, J.C.1
Olson, K.A.2
Jiang, L.3
Hawkins, A.J.4
Van Vranken, J.G.5
Xie, J.6
Egnatchik, R.A.7
Earl, E.G.8
DeBerardinis, R.J.9
Rutter, J.10
-
69
-
-
0346158376
-
Regulation of pyruvate dehydrogenase complex activity by reversible phosphorylation
-
Holness MJ, Sugden MC: Regulation of pyruvate dehydrogenase complex activity by reversible phosphorylation. Biochem Soc Trans 2003, 31:1143-51.
-
(2003)
Biochem Soc Trans
, vol.31
, pp. 1143-1151
-
-
Holness, M.J.1
Sugden, M.C.2
-
70
-
-
0037404976
-
Recent advances in mechanisms regulating glucose oxidation at the level of the pyruvate dehydrogenase complex by PDKs
-
Sugden MC, Holness MJ: Recent advances in mechanisms regulating glucose oxidation at the level of the pyruvate dehydrogenase complex by PDKs. Am J Physiol Endocrinol Metab 2003, 284:E855-62.
-
(2003)
Am J Physiol Endocrinol Metab
, vol.284
, pp. E855-E862
-
-
Sugden, M.C.1
Holness, M.J.2
-
71
-
-
33644622570
-
HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption
-
Papandreou I, Cairns RA, Fontana L, Lim AL, Denko NC: HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption. Cell Metab 2006, 3:187-97.
-
(2006)
Cell Metab
, vol.3
, pp. 187-197
-
-
Papandreou, I.1
Cairns, R.A.2
Fontana, L.3
Lim, A.L.4
Denko, N.C.5
-
72
-
-
33644614520
-
HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
-
Kim JW, Tchernyshyov I, Semenza GL, Dang CV: HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. Cell Metab 2006, 3:177-85.
-
(2006)
Cell Metab
, vol.3
, pp. 177-185
-
-
Kim, J.W.1
Tchernyshyov, I.2
Semenza, G.L.3
Dang, C.V.4
-
73
-
-
84255162057
-
Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism
-
Hitosugi T, Fan J, Chung TW, Lythgoe K, Wang X, Xie J, Ge Q, Gu TL, Polakiewicz RD, Roesel JL, Chen GZ, Boggon TJ, Lonial S, Fu H, Khuri FR, Kang S, Chen J: Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism. Mol Cell 2011, 44:864-77.
-
(2011)
Mol Cell
, vol.44
, pp. 864-877
-
-
Hitosugi, T.1
Fan, J.2
Chung, T.W.3
Lythgoe, K.4
Wang, X.5
Xie, J.6
Ge, Q.7
Gu, T.L.8
Polakiewicz, R.D.9
Roesel, J.L.10
Chen, G.Z.11
Boggon, T.J.12
Lonial, S.13
Fu, H.14
Khuri, F.R.15
Kang, S.16
Chen, J.17
-
74
-
-
84894263431
-
Tyr phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate the pyruvate dehydrogenase complex
-
Fan J, Shan C, Kang HB, Elf S, Xie J, Tucker M, Gu TL, Aguiar M, Lonning S, Chen H, Mohammadi M, Britton LM, Garcia BA, Alečković M, Kang Y, Kaluz S, Devi N, Van Meir EG, Hitosugi T, Seo JH, Lonial S, Gaddh M, Arellano M, Khoury HJ, Khuri FR, Boggon TJ, Kang S, Chen J: Tyr phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate the pyruvate dehydrogenase complex. Mol Cell 2014, 53:534-48.
-
(2014)
Mol Cell
, vol.53
, pp. 534-548
-
-
Fan, J.1
Shan, C.2
Kang, H.B.3
Elf, S.4
Xie, J.5
Tucker, M.6
Gu, T.L.7
Aguiar, M.8
Lonning, S.9
Chen, H.10
Mohammadi, M.11
Britton, L.M.12
Garcia, B.A.13
Alečković, M.14
Kang, Y.15
Kaluz, S.16
Devi, N.17
Van Meir, E.G.18
Hitosugi, T.19
Seo, J.H.20
Lonial, S.21
Gaddh, M.22
Arellano, M.23
Khoury, H.J.24
Khuri, F.R.25
Boggon, T.J.26
Kang, S.27
Chen, J.28
more..
-
75
-
-
0031972736
-
Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex
-
Bowker-Kinley MM, Davis WI, Wu P, Harris RA, Popov KM: Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex. Biochem J 1998, 329:191-6.
-
(1998)
Biochem J
, vol.329
, pp. 191-196
-
-
Bowker-Kinley, M.M.1
Davis, W.I.2
Wu, P.3
Harris, R.A.4
Popov, K.M.5
-
76
-
-
33846002728
-
A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth
-
Bonnet S, Archer SL, Allalunis-Turner J, Haromy A, Beaulieu C, Thompson R, Lee CT, Lopaschuk GD, Puttagunta L, Bonnet S, Harry G, Hashimoto K, Porter CJ, Andrade MA, Thebaud B, Michelakis ED: A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth. Cancer Cell 2007, 11:37-51.
-
(2007)
Cancer Cell
, vol.11
, pp. 37-51
-
-
Bonnet, S.1
Archer, S.L.2
Allalunis-Turner, J.3
Haromy, A.4
Beaulieu, C.5
Thompson, R.6
Lee, C.T.7
Lopaschuk, G.D.8
Puttagunta, L.9
Bonnet, S.10
Harry, G.11
Hashimoto, K.12
Porter, C.J.13
Andrade, M.A.14
Thebaud, B.15
Michelakis, E.D.16
-
77
-
-
30744469862
-
Regulatory roles of the N-terminal domain based on crystal structures of human pyruvate dehydrogenase kinase 2 containing physiological and synthetic ligands
-
Knoechel TR, Tucker AD, Robinson CM, Phillips C, Taylor W, Bungay PJ, Kasten SA, Roche TE, Brown DG: Regulatory roles of the N-terminal domain based on crystal structures of human pyruvate dehydrogenase kinase 2 containing physiological and synthetic ligands. Biochemistry 2006, 45:402-15.
-
(2006)
Biochemistry
, vol.45
, pp. 402-415
-
-
Knoechel, T.R.1
Tucker, A.D.2
Robinson, C.M.3
Phillips, C.4
Taylor, W.5
Bungay, P.J.6
Kasten, S.A.7
Roche, T.E.8
Brown, D.G.9
-
78
-
-
0024452528
-
The pharmacology of dichloroacetate
-
Stacpoole PW: The pharmacology of dichloroacetate. Metabolism 1989, 38:1124-44.
-
(1989)
Metabolism
, vol.38
, pp. 1124-1144
-
-
Stacpoole, P.W.1
-
79
-
-
84873459097
-
Understanding metabolic regulation and its influence on cell physiology
-
Metallo CM, Vander Heiden MG: Understanding metabolic regulation and its influence on cell physiology. Mol Cell 2013, 49:388-98.
-
(2013)
Mol Cell
, vol.49
, pp. 388-398
-
-
Metallo, C.M.1
Vander Heiden, M.G.2
-
80
-
-
75149148563
-
Q's next: The diverse functions of glutamine in metabolism, cell biology and cancer
-
DeBerardinis RJ, Cheng T: Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer. Oncogene 2010, 29:313-24.
-
(2010)
Oncogene
, vol.29
, pp. 313-324
-
-
DeBerardinis, R.J.1
Cheng, T.2
-
81
-
-
84883497454
-
Glutamine and cancer: Cell biology, physiology, and clinical opportunities
-
Hensley CT, Wasti AT, DeBerardinis RJ: Glutamine and cancer: cell biology, physiology, and clinical opportunities. J Clin Invest 2013, 123:3678-84.
-
(2013)
J Clin Invest
, vol.123
, pp. 3678-3684
-
-
Hensley, C.T.1
Wasti, A.T.2
DeBerardinis, R.J.3
-
82
-
-
57749088701
-
Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction
-
Wise DR, DeBerardinis RJ, Mancuso A, Sayed N, Zhang XY, Pfeiffer HK, Nissim I, Daikhin E, Yudkoff M, McMahon SB, Thompson CB: Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction. Proc Natl Acad Sci U S A 2008, 105:18782-7.
-
(2008)
Proc Natl Acad Sci u S a
, vol.105
, pp. 18782-18787
-
-
Wise, D.R.1
DeBerardinis, R.J.2
Mancuso, A.3
Sayed, N.4
Zhang, X.Y.5
Pfeiffer, H.K.6
Nissim, I.7
Daikhin, E.8
Yudkoff, M.9
McMahon, S.B.10
Thompson, C.B.11
-
83
-
-
37449034854
-
Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
-
DeBerardinis RJ, Mancuso A, Daikhin E, Nissim I, Yudkoff M, Wehrli S, Thompson CB: Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis. Proc Natl Acad Sci U S A 2007, 104:19345-50.
-
(2007)
Proc Natl Acad Sci u S a
, vol.104
, pp. 19345-19350
-
-
DeBerardinis, R.J.1
Mancuso, A.2
Daikhin, E.3
Nissim, I.4
Yudkoff, M.5
Wehrli, S.6
Thompson, C.B.7
-
84
-
-
84902332213
-
Quantitative flux analysis reveals folate-dependent NADPH production
-
Fan J, Ye J, Kamphorst JJ, Shlomi T, Thompson CB, Rabinowitz JD: Quantitative flux analysis reveals folate-dependent NADPH production. Nature 2014, 510:298-302.
-
(2014)
Nature
, vol.510
, pp. 298-302
-
-
Fan, J.1
Ye, J.2
Kamphorst, J.J.3
Shlomi, T.4
Thompson, C.B.5
Rabinowitz, J.D.6
-
85
-
-
84855987831
-
Reductive carboxylation supports growth in tumour cells with defective mitochondria
-
Mullen AR, Wheaton WW, Jin ES, Chen PH, Sullivan LB, Cheng T, Yang Y, Linehan WM, Chandel NS, DeBerardinis RJ: Reductive carboxylation supports growth in tumour cells with defective mitochondria. Nature 2012, 481:385-8.
-
(2012)
Nature
, vol.481
, pp. 385-388
-
-
Mullen, A.R.1
Wheaton, W.W.2
Jin, E.S.3
Chen, P.H.4
Sullivan, L.B.5
Cheng, T.6
Yang, Y.7
Linehan, W.M.8
Chandel, N.S.9
DeBerardinis, R.J.10
-
86
-
-
83755178091
-
Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of alpha-ketoglutarate to citrate to support cell growth and viability
-
Wise DR, Ward PS, Shay JE, Cross JR, Gruber JJ, Sachdeva UM, Platt JM, DeMatteo RG, Simon MC, Thompson CB: Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of alpha-ketoglutarate to citrate to support cell growth and viability. Proc Natl Acad Sci U S A 2011, 108:19611-6.
-
(2011)
Proc Natl Acad Sci u S a
, vol.108
, pp. 19611-19616
-
-
Wise, D.R.1
Ward, P.S.2
Shay, J.E.3
Cross, J.R.4
Gruber, J.J.5
Sachdeva, U.M.6
Platt, J.M.7
DeMatteo, R.G.8
Simon, M.C.9
Thompson, C.B.10
-
87
-
-
84856014884
-
Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia
-
Metallo CM, Gameiro PA, Bell EL, Mattaini KR, Yang J, Hiller K, Jewell CM, Johnson ZR, Irvine DJ, Guarente L, Kelleher JK, Vander Heiden MG, Iliopoulos O, Stephanopoulos G: Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia. Nature 2012, 481:380-4.
-
(2012)
Nature
, vol.481
, pp. 380-384
-
-
Metallo, C.M.1
Gameiro, P.A.2
Bell, E.L.3
Mattaini, K.R.4
Yang, J.5
Hiller, K.6
Jewell, C.M.7
Johnson, Z.R.8
Irvine, D.J.9
Guarente, L.10
Kelleher, J.K.11
Vander Heiden, M.G.12
Iliopoulos, O.13
Stephanopoulos, G.14
-
88
-
-
84902343371
-
Oxidation of alpha-ketoglutarate is required for reductive carboxylation in cancer cells with mitochondrial defects
-
Mullen AR, Hu Z, Shi X, Jiang L, Boroughs LK, Kovacs Z, Boriack R, Rakheja D, Sullivan LB, Linehan WM, Chandel NS, DeBerardinis RJ: Oxidation of alpha-ketoglutarate is required for reductive carboxylation in cancer cells with mitochondrial defects. Cell Rep 2014, 7:1679-90.
-
(2014)
Cell Rep
, vol.7
, pp. 1679-1690
-
-
Mullen, A.R.1
Hu, Z.2
Shi, X.3
Jiang, L.4
Boroughs, L.K.5
Kovacs, Z.6
Boriack, R.7
Rakheja, D.8
Sullivan, L.B.9
Linehan, W.M.10
Chandel, N.S.11
DeBerardinis, R.J.12
-
89
-
-
84877109282
-
Cofactor balance by nicotinamide nucleotide transhydrogenase (NNT) coordinates reductive carboxylation and glucose catabolism in the tricarboxylic acid (TCA) cycle
-
Gameiro PA, Laviolette LA, Kelleher JK, Iliopoulos O, Stephanopoulos G: Cofactor balance by nicotinamide nucleotide transhydrogenase (NNT) coordinates reductive carboxylation and glucose catabolism in the tricarboxylic acid (TCA) cycle. J Biol Chem 2013, 288:12967-77.
-
(2013)
J Biol Chem
, vol.288
, pp. 12967-12977
-
-
Gameiro, P.A.1
Laviolette, L.A.2
Kelleher, J.K.3
Iliopoulos, O.4
Stephanopoulos, G.5
-
90
-
-
84875354450
-
In vivo HIF-mediated reductive carboxylation is regulated by citrate levels and sensitizes VHL-deficient cells to glutamine deprivation
-
Gameiro PA, Yang J, Metelo AM, Pérez-Carro R, Baker R, Wang Z, Arreola A, Rathmell WK, Olumi A, López-Larrubia P, Stephanopoulos G, Iliopoulos O: In vivo HIF-mediated reductive carboxylation is regulated by citrate levels and sensitizes VHL-deficient cells to glutamine deprivation. Cell Metab 2013, 17:372-85.
-
(2013)
Cell Metab
, vol.17
, pp. 372-385
-
-
Gameiro, P.A.1
Yang, J.2
Metelo, A.M.3
Pérez-Carro, R.4
Baker, R.5
Wang, Z.6
Arreola, A.7
Rathmell, W.K.8
Olumi, A.9
López-Larrubia, P.10
Stephanopoulos, G.11
Iliopoulos, O.12
-
91
-
-
84860378609
-
Cancerassociated isocitrate dehydrogenase mutations inactivate NADPH-dependent reductive carboxylation
-
Leonardi R, Subramanian C, Jackowski S, Rock CO: Cancerassociated isocitrate dehydrogenase mutations inactivate NADPH-dependent reductive carboxylation. J Biol Chem 2012, 287:14615-20.
-
(2012)
J Biol Chem
, vol.287
, pp. 14615-14620
-
-
Leonardi, R.1
Subramanian, C.2
Jackowski, S.3
Rock, C.O.4
-
92
-
-
65549096661
-
De novo fatty-acid synthesis and related pathways as molecular targets for cancer therapy
-
Mashima T, Seimiya H, Tsuruo T: De novo fatty-acid synthesis and related pathways as molecular targets for cancer therapy. Br J Cancer 2009, 100:1369-72.
-
(2009)
Br J Cancer
, vol.100
, pp. 1369-1372
-
-
Mashima, T.1
Seimiya, H.2
Tsuruo, T.3
-
93
-
-
0036385719
-
Activation of fatty acid synthesis during neoplastic transformation: Role of mitogen-activated protein kinase and phosphatidylinositol 3-kinase
-
Yang YA, Han WF, Morin PJ, Chrest FJ, Pizer ES: Activation of fatty acid synthesis during neoplastic transformation: role of mitogen-activated protein kinase and phosphatidylinositol 3-kinase. Exp Cell Res 2002, 279:80-90.
-
(2002)
Exp Cell Res
, vol.279
, pp. 80-90
-
-
Yang, Y.A.1
Han, W.F.2
Morin, P.J.3
Chrest, F.J.4
Pizer, E.S.5
-
94
-
-
30544433533
-
ATP citrate lyase is an important component of cell growth and transformation
-
Bauer DE, Hatzivassiliou G, Zhao F, Andreadis C, Thompson CB: ATP citrate lyase is an important component of cell growth and transformation. Oncogene 2005, 24:6314-22.
-
(2005)
Oncogene
, vol.24
, pp. 6314-6322
-
-
Bauer, D.E.1
Hatzivassiliou, G.2
Zhao, F.3
Andreadis, C.4
Thompson, C.B.5
-
95
-
-
77649305610
-
The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate
-
Ward PS, Patel J, Wise DR, Abdel-Wahab O, Bennett BD, Coller HA, Cross JR, Fantin VR, Hedvat CV, Perl AE, Rabinowitz JD, Carroll M, Su SM, Sharp KA, Levine RL, Thompson CB: The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate. Cancer Cell 2010, 17:225-34.
-
(2010)
Cancer Cell
, vol.17
, pp. 225-234
-
-
Ward, P.S.1
Patel, J.2
Wise, D.R.3
Abdel-Wahab, O.4
Bennett, B.D.5
Coller, H.A.6
Cross, J.R.7
Fantin, V.R.8
Hedvat, C.V.9
Perl, A.E.10
Rabinowitz, J.D.11
Carroll, M.12
Su, S.M.13
Sharp, K.A.14
Levine, R.L.15
Thompson, C.B.16
-
96
-
-
72049125350
-
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
-
Dang L, White DW, Gross S, Bennett BD, Bittinger MA, Driggers EM, Fantin VR, Jang HG, Jin S, Keenan MC, Marks KM, Prins RM, Ward PS, Yen KE, Liau LM, Rabinowitz JD, Cantley LC, Thompson CB, Vander Heiden MG, Su SM: Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature 2009, 462:739-44.
-
(2009)
Nature
, vol.462
, pp. 739-744
-
-
Dang, L.1
White, D.W.2
Gross, S.3
Bennett, B.D.4
Bittinger, M.A.5
Driggers, E.M.6
Fantin, V.R.7
Jang, H.G.8
Jin, S.9
Keenan, M.C.10
Marks, K.M.11
Prins, R.M.12
Ward, P.S.13
Yen, K.E.14
Liau, L.M.15
Rabinowitz, J.D.16
Cantley, L.C.17
Thompson, C.B.18
Vander Heiden, M.G.19
Su, S.M.20
more..
-
97
-
-
84863456251
-
The mechanisms of IDH mutations in tumorigenesis
-
Ye D, Xiong Y, Guan KL: The mechanisms of IDH mutations in tumorigenesis. Cell Res 2012, 22:1102-4.
-
(2012)
Cell Res
, vol.22
, pp. 1102-1104
-
-
Ye, D.1
Xiong, Y.2
Guan, K.L.3
-
98
-
-
78651463452
-
Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of alpha-ketoglutarate-dependent dioxygenases
-
Xu W, Yang H, Liu Y, Yang Y, Wang P, Kim SH, Ito S, Yang C, Wang P, Xiao MT, Liu LX, JiangWQ, Liu J, Zhang JY, Wang B, Frye S, Zhang Y, Xu YH, Lei QY, Guan KL, Zhao SM, Xiong Y: Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of alpha-ketoglutarate-dependent dioxygenases. Cancer Cell 2011, 19: 17-30.
-
(2011)
Cancer Cell
, vol.19
, pp. 17-30
-
-
Xu, W.1
Yang, H.2
Liu, Y.3
Yang, Y.4
Wang, P.5
Kim, S.H.6
Ito, S.7
Yang, C.8
Wang, P.9
Xiao, M.T.10
Liu, L.X.11
Jiang, W.Q.12
Liu, J.13
Zhang, J.Y.14
Wang, B.15
Frye, S.16
Zhang, Y.17
Xu, Y.H.18
Lei, Q.Y.19
Guan, K.L.20
Zhao, S.M.21
Xiong, Y.22
more..
-
99
-
-
78650019179
-
Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation
-
Figueroa ME, Abdel-Wahab O, Lu C, Ward PS, Patel J, Shih A, Li Y, Bhagwat N, Vasanthakumar A, Fernandez HF, Tallman MS, Sun Z, Wolniak K, Peeters JK, Liu W, Choe SE, Fantin VR, Paietta E, Löwenberg B, Licht JD, Godley LA, Delwel R, Valk PJ, Thompson CB, Levine RL, Melnick A: Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation. Cancer Cell 2010, 18:553-67.
-
(2010)
Cancer Cell
, vol.18
, pp. 553-567
-
-
Figueroa, M.E.1
Abdel-Wahab, O.2
Lu, C.3
Ward, P.S.4
Patel, J.5
Shih, A.6
Li, Y.7
Bhagwat, N.8
Vasanthakumar, A.9
Fernandez, H.F.10
Tallman, M.S.11
Sun, Z.12
Wolniak, K.13
Peeters, J.K.14
Liu, W.15
Choe, S.E.16
Fantin, V.R.17
Paietta, E.18
Löwenberg, B.19
Licht, J.D.20
Godley, L.A.21
Delwel, R.22
Valk, P.J.23
Thompson, C.B.24
Levine, R.L.25
Melnick, A.26
more..
-
100
-
-
0344305801
-
On the association of succinate dehydrogenase mutations with hereditary paraganglioma
-
Baysal BE: On the association of succinate dehydrogenase mutations with hereditary paraganglioma. Trends Endocrinol Metab 2003, 14:453-9.
-
(2003)
Trends Endocrinol Metab
, vol.14
, pp. 453-459
-
-
Baysal, B.E.1
-
101
-
-
0034602950
-
Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma
-
Baysal BE, Ferrell RE, Willett-Brozick JE, Lawrence EC, Myssiorek D, Bosch A, van der Mey A, Taschner PE, Rubinstein WS, Myers EN, Richard CW 3rd, Cornelisse CJ, Devilee P, Devlin B: Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma. Science 2000, 287:848-51.
-
(2000)
Science
, vol.287
, pp. 848-851
-
-
Baysal, B.E.1
Ferrell, R.E.2
Willett-Brozick, J.E.3
Lawrence, E.C.4
Myssiorek, D.5
Bosch, A.6
Van Der Mey, A.7
Taschner, P.E.8
Rubinstein, W.S.9
Myers, E.N.10
Richard, C.W.11
Cornelisse, C.J.12
Devilee, P.13
Devlin, B.14
-
102
-
-
18544365990
-
Multiple Leiomyoma Consortium: Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer
-
Tomlinson IP, AlamNA, Rowan AJ, Barclay E, Jaeger EE, KelsellD, Leigh I, Gorman P, Lamlum H, Rahman S, Roylance RR, Olpin S, Bevan S, Barker K, HearleN, Houlston RS, KiuruM, Lehtonen R, Karhu A, Vilkki S, Laiho P, Eklund C, Vierimaa O, Aittomäki K, Hietala M, Sistonen P, Paetau A, Salovaara R, Herva R, Launonen V, Aaltonen LA; Multiple Leiomyoma Consortium: Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer. Nat Genet 2002, 30:406-10.
-
(2002)
Nat Genet
, vol.30
, pp. 406-410
-
-
Tomlinson, I.P.1
Alam, N.A.2
Rowan, A.J.3
Barclay, E.4
Jaeger, E.E.5
Kelsell, D.6
Leigh, I.7
Gorman, P.8
Lamlum, H.9
Rahman, S.10
Roylance, R.R.11
Olpin, S.12
Bevan, S.13
Barker, K.14
Hearle, N.15
Houlston, R.S.16
Kiuru, M.17
Lehtonen, R.18
Karhu, A.19
Vilkki, S.20
Laiho, P.21
Eklund, C.22
Vierimaa, O.23
Aittomäki, K.24
Hietala, M.25
Sistonen, P.26
Paetau, A.27
Salovaara, R.28
Herva, R.29
Launonen, V.30
Aaltonen, L.A.31
more..
-
103
-
-
43649093915
-
Oxygen sensing by metazoans: The central role of the HIF hydroxylase pathway
-
Kaelin WG Jr., Ratcliffe PJ: Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. Mol Cell 2008, 30:393-402.
-
(2008)
Mol Cell
, vol.30
, pp. 393-402
-
-
Kaelin, W.G.1
Ratcliffe, P.J.2
-
104
-
-
0035812772
-
HIF-1, O(2), and the 3 PHDs: How animal cells signal hypoxia to the nucleus
-
Semenza GL: HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus. Cell 2001, 107:1-3.
-
(2001)
Cell
, vol.107
, pp. 1-3
-
-
Semenza, G.L.1
-
105
-
-
0032760945
-
Structural and mechanistic studies on 2-oxoglutarate-dependent oxygenases and related enzymes
-
Schofield CJ, Zhang Z: Structural and mechanistic studies on 2-oxoglutarate-dependent oxygenases and related enzymes. Curr Opin Struct Biol 1999, 9:722-31.
-
(1999)
Curr Opin Struct Biol
, vol.9
, pp. 722-731
-
-
Schofield, C.J.1
Zhang, Z.2
-
106
-
-
36249005491
-
Succinate inhibition of alpha-ketoglutarate-dependent enzymes in a yeast model of paraganglioma
-
Smith EH, Janknecht R, Maher LJ 3rd: Succinate inhibition of alpha-ketoglutarate-dependent enzymes in a yeast model of paraganglioma. Hum Mol Genet 2007, 16:3136-48.
-
(2007)
Hum Mol Genet
, vol.16
, pp. 3136-3148
-
-
Smith, E.H.1
Janknecht, R.2
Maher, L.J.3
-
107
-
-
19944433653
-
Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase
-
Selak MA, Armour SM, MacKenzie ED, Boulahbel H, Watson DG, Mansfield KD, Pan Y, Simon MC, Thompson CB, Gottlieb E: Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase. Cancer Cell 2005, 7:77-85.
-
(2005)
Cancer Cell
, vol.7
, pp. 77-85
-
-
Selak, M.A.1
Armour, S.M.2
MacKenzie, E.D.3
Boulahbel, H.4
Watson, D.G.5
Mansfield, K.D.6
Pan, Y.7
Simon, M.C.8
Thompson, C.B.9
Gottlieb, E.10
-
108
-
-
26444570010
-
Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations
-
Pollard PJ, Brière JJ, Alam NA, Barwell J, Barclay E, Wortham NC, Hunt T, Mitchell M, Olpin S, Moat SJ, Hargreaves IP, Heales SJ, Chung YL, Griffiths JR, Dalgleish A, McGrath JA, Gleeson MJ, Hodgson SV, Poulsom R, Rustin P, Tomlinson IP: Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations. Hum Mol Genet 2005, 14:2231-9.
-
(2005)
Hum Mol Genet
, vol.14
, pp. 2231-2239
-
-
Pollard, P.J.1
Brière, J.J.2
Alam, N.A.3
Barwell, J.4
Barclay, E.5
Wortham, N.C.6
Hunt, T.7
Mitchell, M.8
Olpin, S.9
Moat, S.J.10
Hargreaves, I.P.11
Heales, S.J.12
Chung, Y.L.13
Griffiths, J.R.14
Dalgleish, A.15
McGrath, J.A.16
Gleeson, M.J.17
Hodgson, S.V.18
Poulsom, R.19
Rustin, P.20
Tomlinson, I.P.21
more..
-
109
-
-
84909951484
-
Oncometa-bolites-driven tumorigenesis: From genetics to targeted therapy
-
Morin A, Letouzé E, Gimenez-Roqueplo AP, Favier J: Oncometa-bolites-driven tumorigenesis: From genetics to targeted therapy. Int J Cancer 2014, 135:2237-48.
-
(2014)
Int J Cancer
, vol.135
, pp. 2237-2248
-
-
Morin, A.1
Letouzé, E.2
Gimenez-Roqueplo, A.P.3
Favier, J.4
-
110
-
-
84900361541
-
Mitochondrial metabolism directs stemness and differentiation in P19 embryonal carcinoma stem cells
-
Vega-Naredo I, Loureiro R, Mesquita KA, Barbosa IA, Tavares LC, Branco AF, Erickson JR, Holy J, Perkins EL, Carvalho RA, Oliveira PJ: Mitochondrial metabolism directs stemness and differentiation in P19 embryonal carcinoma stem cells. Cell Death Differ 2014, 21:1560-74.
-
(2014)
Cell Death Differ
, vol.21
, pp. 1560-1574
-
-
Vega-Naredo, I.1
Loureiro, R.2
Mesquita, K.A.3
Barbosa, I.A.4
Tavares, L.C.5
Branco, A.F.6
Erickson, J.R.7
Holy, J.8
Perkins, E.L.9
Carvalho, R.A.10
Oliveira, P.J.11
|