메뉴 건너뛰기




Volumn 7, Issue , 2015, Pages

Chicken or the egg: Warburg effect and mitochondrial dysfunction

Author keywords

[No Author keywords available]

Indexed keywords

PYRUVATE DEHYDROGENASE; PYRUVATE KINASE; PYRUVIC ACID;

EID: 84928007579     PISSN: 20517599     EISSN: 20517599     Source Type: Journal    
DOI: 10.12703/P7-41     Document Type: Review
Times cited : (66)

References (110)
  • 1
    • 0001740285 scopus 로고
    • The metabolism of carcinoma cells
    • Warburg O: The Metabolism of Carcinoma Cells. J Cancer Res 1925, 9:148-63.
    • (1925) J Cancer Res , vol.9 , pp. 148-163
    • Warburg, O.1
  • 2
    • 12444279265 scopus 로고
    • On the origin of cancer cells
    • Warburg O: On the origin of cancer cells. Science 1956, 123:309-14.
    • (1956) Science , vol.123 , pp. 309-314
    • Warburg, O.1
  • 3
    • 0017173150 scopus 로고
    • The Warburg hypothesis fifty years later
    • Weinhouse S: The Warburg hypothesis fifty years later. Cancer Res Clin Oncol 1976, 87:115-26.
    • (1976) Cancer Res Clin Oncol , vol.87 , pp. 115-126
    • Weinhouse, S.1
  • 4
    • 11444255268 scopus 로고
    • On respiratory impairment in cancer cells
    • Weinhouse S: On respiratory impairment in cancer cells. Science 1956, 124:267-9.
    • (1956) Science , vol.124 , pp. 267-269
    • Weinhouse, S.1
  • 5
    • 78651059309 scopus 로고
    • Metabolism of neoplastic tissue. I. The oxidation of carbohydrate and fatty acids in transplanted tumors
    • Weinhouse S, Millington RH, Wenner CE: Metabolism of neoplastic tissue. I. The oxidation of carbohydrate and fatty acids in transplanted tumors. Cancer Res 1951, 11:845-50.
    • (1951) Cancer Res , vol.11 , pp. 845-850
    • Weinhouse, S.1    Millington, R.H.2    Wenner, C.E.3
  • 6
    • 0019319464 scopus 로고
    • Regulation of cellular energy metabolism: The Crabtree effect
    • Sussman I, Erecinska M, Wilson DF: Regulation of cellular energy metabolism: the Crabtree effect. Biochim Biophys Acta 1980, 591:209-23.
    • (1980) Biochim Biophys Acta , vol.591 , pp. 209-223
    • Sussman, I.1    Erecinska, M.2    Wilson, D.F.3
  • 7
    • 0000089325 scopus 로고
    • Observations on the carbohydrate metabolism of tumours
    • Crabtree H.G: Observations on the carbohydrate metabolism of tumours. Biochem J 1929, 23:536-45.
    • (1929) Biochem J , vol.23 , pp. 536-545
    • Crabtree, H.G.1
  • 10
    • 68549136820 scopus 로고    scopus 로고
    • Association between 18F-fluoro-2-deoxy-D-glucose uptake values and tumor vitality: Prognostic value of positron emission tomography in earlystage non-small cell lung cancer
    • Dooms C, van Baardwijk A, Verbeken E, van Suylen RJ, Stroobants S, De Ruysscher D, Vansteenkiste J: Association between 18F-fluoro-2-deoxy-D-glucose uptake values and tumor vitality: prognostic value of positron emission tomography in earlystage non-small cell lung cancer. J Thorac Oncol 2009, 4:822-8.
    • (2009) J Thorac Oncol , vol.4 , pp. 822-828
    • Dooms, C.1    Van Baardwijk, A.2    Verbeken, E.3    Van Suylen, R.J.4    Stroobants, S.5    De Ruysscher, D.6    Vansteenkiste, J.7
  • 11
    • 0037065947 scopus 로고    scopus 로고
    • FDG-PET. A possible prognostic factor in head and neck cancer
    • Halfpenny W, et al.: FDG-PET. A possible prognostic factor in head and neck cancer. Br J Cancer 2002, 86:512-6.
    • (2002) Br J Cancer , vol.86 , pp. 512-516
    • Halfpenny, W.1
  • 13
    • 84872478184 scopus 로고    scopus 로고
    • Expression of glucose transporters in cancers
    • Szablewski L: Expression of glucose transporters in cancers. Biochim Biophys Acta 2013, 1835:164-9.
    • (2013) Biochim Biophys Acta , vol.1835 , pp. 164-169
    • Szablewski, L.1
  • 14
    • 0036077547 scopus 로고    scopus 로고
    • Glucose transporters: Expression, regulation and cancer
    • Medina RA, Owen GI: Glucose transporters: expression, regulation and cancer. Biol Res 2002, 35:9-26.
    • (2002) Biol Res , vol.35 , pp. 9-26
    • Medina, R.A.1    Owen, G.I.2
  • 15
    • 0035937715 scopus 로고    scopus 로고
    • Regulation of glut1 mRNA by hypoxia-inducible factor-1. Interaction between H-ras and hypoxia
    • Chen C, Pore N, Behrooz A, Ismail-Beigi F, Maity A: Regulation of glut1 mRNA by hypoxia-inducible factor-1. Interaction between H-ras and hypoxia. J Biol Chem 2001, 276:9519-25.
    • (2001) J Biol Chem , vol.276 , pp. 9519-9525
    • Chen, C.1    Pore, N.2    Behrooz, A.3    Ismail-Beigi, F.4    Maity, A.5
  • 16
    • 0026801196 scopus 로고
    • Identification of two enhancer elements in the gene encoding the type 1 glucose transporter from the mouse which are responsive to serum, growth factor, and oncogenes
    • Murakami T, Nishiyama T, Shirotani T, Shinohara Y, Kan M, Ishii K, Kanai F, Nakazuru S, Ebina Y: Identification of two enhancer elements in the gene encoding the type 1 glucose transporter from the mouse which are responsive to serum, growth factor, and oncogenes. J Biol Chem 1992, 26:9300-6.
    • (1992) J Biol Chem , vol.26 , pp. 9300-9306
    • Murakami, T.1    Nishiyama, T.2    Shirotani, T.3    Shinohara, Y.4    Kan, M.5    Ishii, K.6    Kanai, F.7    Nakazuru, S.8    Ebina, Y.9
  • 17
    • 0028805375 scopus 로고
    • Hypoxia and mitochondrial inhibitors regulate expression of glucose transporter-1 via distinct Cis-acting sequences
    • Ebert BL, Firth JD, Ratcliffe PJ: Hypoxia and mitochondrial inhibitors regulate expression of glucose transporter-1 via distinct Cis-acting sequences. J Biol Chem 1995, 270:29083-9.
    • (1995) J Biol Chem , vol.270 , pp. 29083-29089
    • Ebert, B.L.1    Firth, J.D.2    Ratcliffe, P.J.3
  • 18
    • 0028518842 scopus 로고
    • Subcellular localization and trafficking of the GLUT4 glucose transporter isoform in insulinresponsive cells
    • Holman GD, Cushman SW: Subcellular localization and trafficking of the GLUT4 glucose transporter isoform in insulinresponsive cells. Bioessays 1994, 16:753-9.
    • (1994) Bioessays , vol.16 , pp. 753-759
    • Holman, G.D.1    Cushman, S.W.2
  • 20
    • 84875153197 scopus 로고    scopus 로고
    • Glucose transport families SLC5 and SLC50
    • Wright EM: Glucose transport families SLC5 and SLC50. Mol Aspects Med 2013, 34:183-96.
    • (2013) Mol Aspects Med , vol.34 , pp. 183-196
    • Wright, E.M.1
  • 21
    • 84858782079 scopus 로고    scopus 로고
    • AMPK: A nutrient and energy sensor that maintains energy homeostasis
    • Hardie DG, Ross FA, Hawley SA: AMPK: a nutrient and energy sensor that maintains energy homeostasis. Nat Rev Mol Cell Biol 2012, 13:251-62.
    • (2012) Nat Rev Mol Cell Biol , vol.13 , pp. 251-262
    • Hardie, D.G.1    Ross, F.A.2    Hawley, S.A.3
  • 22
    • 33746924468 scopus 로고    scopus 로고
    • Hexokinase II: Cancer's double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria
    • Mathupala SP, Ko YH, Pedersen PL: Hexokinase II: cancer's double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria. Oncogene 2006, 25:4777-86.
    • (2006) Oncogene , vol.25 , pp. 4777-4786
    • Mathupala, S.P.1    Ko, Y.H.2    Pedersen, P.L.3
  • 23
    • 35649014840 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1
    • Kim JW, Gao P, Liu YC, Semenza GL, Dang CV: Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1. Mol Cell Biol 2007, 27:7381-93.
    • (2007) Mol Cell Biol , vol.27 , pp. 7381-7393
    • Kim, J.W.1    Gao, P.2    Liu, Y.C.3    Semenza, G.L.4    Dang, C.V.5
  • 24
    • 0942290437 scopus 로고    scopus 로고
    • In self-defence: Hexokinase promotes voltage-dependent anion channel closure and prevents mitochondria-mediated apoptotic cell death
    • Azoulay-Zohar H, Israelson A, Abu-Hamad S, Shoshan-Barmatz V: In self-defence: hexokinase promotes voltage-dependent anion channel closure and prevents mitochondria-mediated apoptotic cell death. Biochem J 2004, 377:347-55.
    • (2004) Biochem J , vol.377 , pp. 347-355
    • Azoulay-Zohar, H.1    Israelson, A.2    Abu-Hamad, S.3    Shoshan-Barmatz, V.4
  • 25
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D, Weinberg RA: The hallmarks of cancer. Cell 2000, 100:57-70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 26
    • 0042575733 scopus 로고
    • High aerobic glycolysis of rat hepatoma cells in culture: Role of mitochondrial hexokinase
    • Bustamante E, Pedersen PL: High aerobic glycolysis of rat hepatoma cells in culture: role of mitochondrial hexokinase. Proc Natl Acad Sci U S A 1977, 74:3735-9.
    • (1977) Proc Natl Acad Sci u S a , vol.74 , pp. 3735-3739
    • Bustamante, E.1    Pedersen, P.L.2
  • 27
    • 0037056002 scopus 로고    scopus 로고
    • Mitochondrial bound type II hexokinase: A key player in the growth and survival of many cancers and an ideal prospect for therapeutic intervention
    • Pedersen PL, Mathupala S, Rempel A, Geschwind JF, Ko YH: Mitochondrial bound type II hexokinase: a key player in the growth and survival of many cancers and an ideal prospect for therapeutic intervention. Biochim Biophys Acta 2002, 1555:14-20.
    • (2002) Biochim Biophys Acta , vol.1555 , pp. 14-20
    • Pedersen, P.L.1    Mathupala, S.2    Rempel, A.3    Geschwind, J.F.4    Ko, Y.H.5
  • 28
    • 24644488689 scopus 로고    scopus 로고
    • Regulation of phosphoglucose isomerase/autocrine motility factor expression by hypoxia
    • Funasaka T, Yanagawa T, Hogan V, Raz A: Regulation of phosphoglucose isomerase/autocrine motility factor expression by hypoxia. FASEB J 2005, 19:1422-30.
    • (2005) FASEB J , vol.19 , pp. 1422-1430
    • Funasaka, T.1    Yanagawa, T.2    Hogan, V.3    Raz, A.4
  • 29
    • 0026321067 scopus 로고
    • Serum phosphohexose isomerase activities in patients with colorectal cancer
    • Filella X, Molina R, Jo J, Mas E, Ballesta AM: Serum phosphohexose isomerase activities in patients with colorectal cancer. Tumour Biol 1991, 1:360-7.
    • (1991) Tumour Biol , vol.1 , pp. 360-367
    • Filella, X.1    Molina, R.2    Jo, J.3    Mas, E.4    Ballesta, A.M.5
  • 30
    • 0025000748 scopus 로고
    • The diagnostic validity of the serum tumor marker phosphohexose isomerase (PHI) in patients with gastrointestinal, kidney, and breast cancer
    • Baumann M, Kappl A, Lang T, Brand K, Siegfried W, Paterok E: The diagnostic validity of the serum tumor marker phosphohexose isomerase (PHI) in patients with gastrointestinal, kidney, and breast cancer. Cancer Invest 1990, 8:351-6.
    • (1990) Cancer Invest , vol.8 , pp. 351-356
    • Baumann, M.1    Kappl, A.2    Lang, T.3    Brand, K.4    Siegfried, W.5    Paterok, E.6
  • 31
    • 0025740495 scopus 로고
    • Purification of human tumor cell autocrine motility factor and molecular cloning of its receptor
    • Watanabe H, Carmi P, Hogan V, Raz T, Silletti S, Nabi IR, Raz A: Purification of human tumor cell autocrine motility factor and molecular cloning of its receptor. J Biol Chem 1991, 266:13442-8.
    • (1991) J Biol Chem , vol.266 , pp. 13442-13448
    • Watanabe, H.1    Carmi, P.2    Hogan, V.3    Raz, T.4    Silletti, S.5    Nabi, I.R.6    Raz, A.7
  • 32
    • 0042858146 scopus 로고    scopus 로고
    • Regulation of cell proliferation by autocrine motility factor/phosphoglucose isomerase signaling
    • Tsutsumi S, Yanagawa T, Shimura T, Fukumori T, Hogan V, Kuwano H, Raz A: Regulation of cell proliferation by autocrine motility factor/phosphoglucose isomerase signaling. J Biol Chem 2003, 278:32165-72.
    • (2003) J Biol Chem , vol.278 , pp. 32165-32172
    • Tsutsumi, S.1    Yanagawa, T.2    Shimura, T.3    Fukumori, T.4    Hogan, V.5    Kuwano, H.6    Raz, A.7
  • 33
    • 79953149305 scopus 로고    scopus 로고
    • The crystal complex of phosphofructokinase-2 of Escherichia coli with fructose-6-phosphate: Kinetic and structural analysis of the allosteric ATP inhibition
    • Cabrera R, Baez M, Pereira HM, Caniuguir A, Garratt RC, Babul J: The crystal complex of phosphofructokinase-2 of Escherichia coli with fructose-6-phosphate: kinetic and structural analysis of the allosteric ATP inhibition. J Biol Chem 2011, 286:5774-83.
    • (2011) J Biol Chem , vol.286 , pp. 5774-5783
    • Cabrera, R.1    Baez, M.2    Pereira, H.M.3    Caniuguir, A.4    Garratt, R.C.5    Babul, J.6
  • 34
    • 0019585720 scopus 로고
    • Regulatory properties of phosphofructokinase 2 from Escherichia coli
    • Kotlarz D, Buc H: Regulatory properties of phosphofructokinase 2 from Escherichia coli. Eur J Biochem 1981, 117:569-74.
    • (1981) Eur J Biochem , vol.117 , pp. 569-574
    • Kotlarz, D.1    Buc, H.2
  • 35
    • 77954457039 scopus 로고
    • Kinetics of Regulatory Enzymes. Escherichia Coli Phosphofructokinase
    • Atkinson DE, Walton GM: Kinetics of Regulatory Enzymes. Escherichia Coli Phosphofructokinase. J Biol Chem 1965, 240:757-63.
    • (1965) J Biol Chem , vol.240 , pp. 757-763
    • Atkinson, D.E.1    Walton, G.M.2
  • 36
    • 67349131613 scopus 로고    scopus 로고
    • Regulation of glucose metabolism by 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases in cancer
    • Yalcin A, Telang S, Clem B, Chesney J: Regulation of glucose metabolism by 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases in cancer. Exp Mol Pathol 2009, 86: 174-9.
    • (2009) Exp Mol Pathol , vol.86 , pp. 174-179
    • Yalcin, A.1    Telang, S.2    Clem, B.3    Chesney, J.4
  • 37
    • 33748060829 scopus 로고    scopus 로고
    • Roles for fructose-2,6-bisphosphate in the control of fuel metabolism: Beyond its allosteric effects on glycolytic and gluconeogenic enzymes
    • Wu C, Khan SA, Peng LJ, Lange AJ: Roles for fructose-2,6-bisphosphate in the control of fuel metabolism: beyond its allosteric effects on glycolytic and gluconeogenic enzymes. Adv Enzyme Regul 2006, 46:72-88.
    • (2006) Adv Enzyme Regul , vol.46 , pp. 72-88
    • Wu, C.1    Khan, S.A.2    Peng, L.J.3    Lange, A.J.4
  • 38
    • 38049077430 scopus 로고    scopus 로고
    • 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB3) is up-regulated in high-grade astrocytomas
    • Kessler R, Bleichert F, Warnke JP, Eschrich K: 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB3) is up-regulated in high-grade astrocytomas. J Neurooncol 2008, 86:257-64.
    • (2008) J Neurooncol , vol.86 , pp. 257-264
    • Kessler, R.1    Bleichert, F.2    Warnke, J.P.3    Eschrich, K.4
  • 41
    • 0242710750 scopus 로고    scopus 로고
    • Hypoxic regulation of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene family (PFKFB-1-4) expression in vivo
    • Minchenko OI, Opentanova I, Caro J: Hypoxic regulation of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene family (PFKFB-1-4) expression in vivo. FEBS Lett 2003, 554:264-70.
    • (2003) FEBS Lett , vol.554 , pp. 264-270
    • Minchenko, O.I.1    Opentanova, I.2    Caro, J.3
  • 43
    • 84864767268 scopus 로고    scopus 로고
    • Functional metabolic screen identifies 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 as an important regulator of prostate cancer cell survival
    • Ros S, Santos CR, Moco S, Baenke F, Kelly G, Howell M, Zamboni N, Schulze A: Functional metabolic screen identifies 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 as an important regulator of prostate cancer cell survival. Cancer Discov 2012, 2:328-43.
    • (2012) Cancer Discov , vol.2 , pp. 328-343
    • Ros, S.1    Santos, C.R.2    Moco, S.3    Baenke, F.4    Kelly, G.5    Howell, M.6    Zamboni, N.7    Schulze, A.8
  • 46
    • 77950919036 scopus 로고    scopus 로고
    • Quantitative proteomics identification of phosphoglycerate mutase 1 as a novel therapeutic target in hepatocellular carcinoma
    • Ren F, Wu H, Lei Y, Zhang H, Liu R, Zhao Y, Chen X, Zeng D, Tong A, Chen L, Wei Y, Huang C: Quantitative proteomics identification of phosphoglycerate mutase 1 as a novel therapeutic target in hepatocellular carcinoma. Mol Cancer 2010, 9:81.
    • (2010) Mol Cancer , vol.9 , pp. 81
    • Ren, F.1    Wu, H.2    Lei, Y.3    Zhang, H.4    Liu, R.5    Zhao, Y.6    Chen, X.7    Zeng, D.8    Tong, A.9    Chen, L.10    Wei, Y.11    Huang, C.12
  • 51
    • 84863486244 scopus 로고    scopus 로고
    • The pentose phosphate pathway: An antioxidant defense and a crossroad in tumor cell fate
    • Riganti C, Gazzano E, Polimeni M, Aldieri E, Ghigo D: The pentose phosphate pathway: an antioxidant defense and a crossroad in tumor cell fate. Free Radic Biol Med 2012, 53:421-36.
    • (2012) Free Radic Biol Med , vol.53 , pp. 421-436
    • Riganti, C.1    Gazzano, E.2    Polimeni, M.3    Aldieri, E.4    Ghigo, D.5
  • 52
    • 0024432603 scopus 로고
    • Regulation of cellular glutathione
    • Deneke SM, Fanburg BL: Regulation of cellular glutathione. Am J Physiol 1989, 257:163-73.
    • (1989) Am J Physiol , vol.257 , pp. 163-173
    • Deneke, S.M.1    Fanburg, B.L.2
  • 56
    • 0034006016 scopus 로고    scopus 로고
    • HIF-1: Mediator of physiological and pathophysiological responses to hypoxia
    • Semenza GL: HIF-1: mediator of physiological and pathophysiological responses to hypoxia. J Appl Physiol (1985) 2000, 88:1474-80.
    • (2000) J Appl Physiol , vol.88 , pp. 1474-1480
    • Semenza, G.L.1
  • 60
    • 33744783432 scopus 로고    scopus 로고
    • Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance
    • Fantin VR, St-Pierre J, Leder P: Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance. Cancer Cell 2006, 9(6):425-34.
    • (2006) Cancer Cell , vol.9 , Issue.6 , pp. 425-434
    • Fantin, V.R.1    St-Pierre, J.2    Leder, P.3
  • 61
    • 33646917296 scopus 로고    scopus 로고
    • The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism
    • Ullah MS, Davies AJ, Halestrap AP: The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism. J Biol Chem 2006, 281:9030-7.
    • (2006) J Biol Chem , vol.281 , pp. 9030-9037
    • Ullah, M.S.1    Davies, A.J.2    Halestrap, A.P.3
  • 63
    • 0016259467 scopus 로고
    • Inhibition of mitochondrial pyruvate transport by phenylpyruvate and alphaketoisocaproate
    • Halestrap AP, Brand MD, Denton RM: Inhibition of mitochondrial pyruvate transport by phenylpyruvate and alphaketoisocaproate. Biochim Biophys Acta 1974, 367:102-8.
    • (1974) Biochim Biophys Acta , vol.367 , pp. 102-108
    • Halestrap, A.P.1    Brand, M.D.2    Denton, R.M.3
  • 69
    • 0346158376 scopus 로고    scopus 로고
    • Regulation of pyruvate dehydrogenase complex activity by reversible phosphorylation
    • Holness MJ, Sugden MC: Regulation of pyruvate dehydrogenase complex activity by reversible phosphorylation. Biochem Soc Trans 2003, 31:1143-51.
    • (2003) Biochem Soc Trans , vol.31 , pp. 1143-1151
    • Holness, M.J.1    Sugden, M.C.2
  • 70
    • 0037404976 scopus 로고    scopus 로고
    • Recent advances in mechanisms regulating glucose oxidation at the level of the pyruvate dehydrogenase complex by PDKs
    • Sugden MC, Holness MJ: Recent advances in mechanisms regulating glucose oxidation at the level of the pyruvate dehydrogenase complex by PDKs. Am J Physiol Endocrinol Metab 2003, 284:E855-62.
    • (2003) Am J Physiol Endocrinol Metab , vol.284 , pp. E855-E862
    • Sugden, M.C.1    Holness, M.J.2
  • 71
    • 33644622570 scopus 로고    scopus 로고
    • HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption
    • Papandreou I, Cairns RA, Fontana L, Lim AL, Denko NC: HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption. Cell Metab 2006, 3:187-97.
    • (2006) Cell Metab , vol.3 , pp. 187-197
    • Papandreou, I.1    Cairns, R.A.2    Fontana, L.3    Lim, A.L.4    Denko, N.C.5
  • 72
    • 33644614520 scopus 로고    scopus 로고
    • HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
    • Kim JW, Tchernyshyov I, Semenza GL, Dang CV: HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. Cell Metab 2006, 3:177-85.
    • (2006) Cell Metab , vol.3 , pp. 177-185
    • Kim, J.W.1    Tchernyshyov, I.2    Semenza, G.L.3    Dang, C.V.4
  • 75
    • 0031972736 scopus 로고    scopus 로고
    • Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex
    • Bowker-Kinley MM, Davis WI, Wu P, Harris RA, Popov KM: Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex. Biochem J 1998, 329:191-6.
    • (1998) Biochem J , vol.329 , pp. 191-196
    • Bowker-Kinley, M.M.1    Davis, W.I.2    Wu, P.3    Harris, R.A.4    Popov, K.M.5
  • 77
    • 30744469862 scopus 로고    scopus 로고
    • Regulatory roles of the N-terminal domain based on crystal structures of human pyruvate dehydrogenase kinase 2 containing physiological and synthetic ligands
    • Knoechel TR, Tucker AD, Robinson CM, Phillips C, Taylor W, Bungay PJ, Kasten SA, Roche TE, Brown DG: Regulatory roles of the N-terminal domain based on crystal structures of human pyruvate dehydrogenase kinase 2 containing physiological and synthetic ligands. Biochemistry 2006, 45:402-15.
    • (2006) Biochemistry , vol.45 , pp. 402-415
    • Knoechel, T.R.1    Tucker, A.D.2    Robinson, C.M.3    Phillips, C.4    Taylor, W.5    Bungay, P.J.6    Kasten, S.A.7    Roche, T.E.8    Brown, D.G.9
  • 78
    • 0024452528 scopus 로고
    • The pharmacology of dichloroacetate
    • Stacpoole PW: The pharmacology of dichloroacetate. Metabolism 1989, 38:1124-44.
    • (1989) Metabolism , vol.38 , pp. 1124-1144
    • Stacpoole, P.W.1
  • 79
    • 84873459097 scopus 로고    scopus 로고
    • Understanding metabolic regulation and its influence on cell physiology
    • Metallo CM, Vander Heiden MG: Understanding metabolic regulation and its influence on cell physiology. Mol Cell 2013, 49:388-98.
    • (2013) Mol Cell , vol.49 , pp. 388-398
    • Metallo, C.M.1    Vander Heiden, M.G.2
  • 80
    • 75149148563 scopus 로고    scopus 로고
    • Q's next: The diverse functions of glutamine in metabolism, cell biology and cancer
    • DeBerardinis RJ, Cheng T: Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer. Oncogene 2010, 29:313-24.
    • (2010) Oncogene , vol.29 , pp. 313-324
    • DeBerardinis, R.J.1    Cheng, T.2
  • 81
    • 84883497454 scopus 로고    scopus 로고
    • Glutamine and cancer: Cell biology, physiology, and clinical opportunities
    • Hensley CT, Wasti AT, DeBerardinis RJ: Glutamine and cancer: cell biology, physiology, and clinical opportunities. J Clin Invest 2013, 123:3678-84.
    • (2013) J Clin Invest , vol.123 , pp. 3678-3684
    • Hensley, C.T.1    Wasti, A.T.2    DeBerardinis, R.J.3
  • 83
    • 37449034854 scopus 로고    scopus 로고
    • Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
    • DeBerardinis RJ, Mancuso A, Daikhin E, Nissim I, Yudkoff M, Wehrli S, Thompson CB: Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis. Proc Natl Acad Sci U S A 2007, 104:19345-50.
    • (2007) Proc Natl Acad Sci u S a , vol.104 , pp. 19345-19350
    • DeBerardinis, R.J.1    Mancuso, A.2    Daikhin, E.3    Nissim, I.4    Yudkoff, M.5    Wehrli, S.6    Thompson, C.B.7
  • 89
    • 84877109282 scopus 로고    scopus 로고
    • Cofactor balance by nicotinamide nucleotide transhydrogenase (NNT) coordinates reductive carboxylation and glucose catabolism in the tricarboxylic acid (TCA) cycle
    • Gameiro PA, Laviolette LA, Kelleher JK, Iliopoulos O, Stephanopoulos G: Cofactor balance by nicotinamide nucleotide transhydrogenase (NNT) coordinates reductive carboxylation and glucose catabolism in the tricarboxylic acid (TCA) cycle. J Biol Chem 2013, 288:12967-77.
    • (2013) J Biol Chem , vol.288 , pp. 12967-12977
    • Gameiro, P.A.1    Laviolette, L.A.2    Kelleher, J.K.3    Iliopoulos, O.4    Stephanopoulos, G.5
  • 91
    • 84860378609 scopus 로고    scopus 로고
    • Cancerassociated isocitrate dehydrogenase mutations inactivate NADPH-dependent reductive carboxylation
    • Leonardi R, Subramanian C, Jackowski S, Rock CO: Cancerassociated isocitrate dehydrogenase mutations inactivate NADPH-dependent reductive carboxylation. J Biol Chem 2012, 287:14615-20.
    • (2012) J Biol Chem , vol.287 , pp. 14615-14620
    • Leonardi, R.1    Subramanian, C.2    Jackowski, S.3    Rock, C.O.4
  • 92
    • 65549096661 scopus 로고    scopus 로고
    • De novo fatty-acid synthesis and related pathways as molecular targets for cancer therapy
    • Mashima T, Seimiya H, Tsuruo T: De novo fatty-acid synthesis and related pathways as molecular targets for cancer therapy. Br J Cancer 2009, 100:1369-72.
    • (2009) Br J Cancer , vol.100 , pp. 1369-1372
    • Mashima, T.1    Seimiya, H.2    Tsuruo, T.3
  • 93
    • 0036385719 scopus 로고    scopus 로고
    • Activation of fatty acid synthesis during neoplastic transformation: Role of mitogen-activated protein kinase and phosphatidylinositol 3-kinase
    • Yang YA, Han WF, Morin PJ, Chrest FJ, Pizer ES: Activation of fatty acid synthesis during neoplastic transformation: role of mitogen-activated protein kinase and phosphatidylinositol 3-kinase. Exp Cell Res 2002, 279:80-90.
    • (2002) Exp Cell Res , vol.279 , pp. 80-90
    • Yang, Y.A.1    Han, W.F.2    Morin, P.J.3    Chrest, F.J.4    Pizer, E.S.5
  • 94
    • 30544433533 scopus 로고    scopus 로고
    • ATP citrate lyase is an important component of cell growth and transformation
    • Bauer DE, Hatzivassiliou G, Zhao F, Andreadis C, Thompson CB: ATP citrate lyase is an important component of cell growth and transformation. Oncogene 2005, 24:6314-22.
    • (2005) Oncogene , vol.24 , pp. 6314-6322
    • Bauer, D.E.1    Hatzivassiliou, G.2    Zhao, F.3    Andreadis, C.4    Thompson, C.B.5
  • 97
    • 84863456251 scopus 로고    scopus 로고
    • The mechanisms of IDH mutations in tumorigenesis
    • Ye D, Xiong Y, Guan KL: The mechanisms of IDH mutations in tumorigenesis. Cell Res 2012, 22:1102-4.
    • (2012) Cell Res , vol.22 , pp. 1102-1104
    • Ye, D.1    Xiong, Y.2    Guan, K.L.3
  • 100
    • 0344305801 scopus 로고    scopus 로고
    • On the association of succinate dehydrogenase mutations with hereditary paraganglioma
    • Baysal BE: On the association of succinate dehydrogenase mutations with hereditary paraganglioma. Trends Endocrinol Metab 2003, 14:453-9.
    • (2003) Trends Endocrinol Metab , vol.14 , pp. 453-459
    • Baysal, B.E.1
  • 103
    • 43649093915 scopus 로고    scopus 로고
    • Oxygen sensing by metazoans: The central role of the HIF hydroxylase pathway
    • Kaelin WG Jr., Ratcliffe PJ: Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. Mol Cell 2008, 30:393-402.
    • (2008) Mol Cell , vol.30 , pp. 393-402
    • Kaelin, W.G.1    Ratcliffe, P.J.2
  • 104
    • 0035812772 scopus 로고    scopus 로고
    • HIF-1, O(2), and the 3 PHDs: How animal cells signal hypoxia to the nucleus
    • Semenza GL: HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus. Cell 2001, 107:1-3.
    • (2001) Cell , vol.107 , pp. 1-3
    • Semenza, G.L.1
  • 105
    • 0032760945 scopus 로고    scopus 로고
    • Structural and mechanistic studies on 2-oxoglutarate-dependent oxygenases and related enzymes
    • Schofield CJ, Zhang Z: Structural and mechanistic studies on 2-oxoglutarate-dependent oxygenases and related enzymes. Curr Opin Struct Biol 1999, 9:722-31.
    • (1999) Curr Opin Struct Biol , vol.9 , pp. 722-731
    • Schofield, C.J.1    Zhang, Z.2
  • 106
    • 36249005491 scopus 로고    scopus 로고
    • Succinate inhibition of alpha-ketoglutarate-dependent enzymes in a yeast model of paraganglioma
    • Smith EH, Janknecht R, Maher LJ 3rd: Succinate inhibition of alpha-ketoglutarate-dependent enzymes in a yeast model of paraganglioma. Hum Mol Genet 2007, 16:3136-48.
    • (2007) Hum Mol Genet , vol.16 , pp. 3136-3148
    • Smith, E.H.1    Janknecht, R.2    Maher, L.J.3
  • 109
    • 84909951484 scopus 로고    scopus 로고
    • Oncometa-bolites-driven tumorigenesis: From genetics to targeted therapy
    • Morin A, Letouzé E, Gimenez-Roqueplo AP, Favier J: Oncometa-bolites-driven tumorigenesis: From genetics to targeted therapy. Int J Cancer 2014, 135:2237-48.
    • (2014) Int J Cancer , vol.135 , pp. 2237-2248
    • Morin, A.1    Letouzé, E.2    Gimenez-Roqueplo, A.P.3    Favier, J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.