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Volumn 49, Issue 3, 2013, Pages 388-398

Understanding Metabolic Regulation and Its Influence on Cell Physiology

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE PHOSPHATE; ADENOSINE TRIPHOSPHATE; ADENYLATE KINASE; STEROL REGULATORY ELEMENT BINDING PROTEIN 1;

EID: 84873459097     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2013.01.018     Document Type: Review
Times cited : (253)

References (99)
  • 1
    • 0025276048 scopus 로고
    • Cellular concentrations of enzymes and their substrates
    • Albe K.R., Butler M.H., Wright B.E. Cellular concentrations of enzymes and their substrates. J. Theor. Biol. 1990, 143:163-195.
    • (1990) J. Theor. Biol. , vol.143 , pp. 163-195
    • Albe, K.R.1    Butler, M.H.2    Wright, B.E.3
  • 4
    • 33745155105 scopus 로고    scopus 로고
    • Determination of confidence intervals of metabolic fluxes estimated from stable isotope measurements
    • Antoniewicz M.R., Kelleher J.K., Stephanopoulos G. Determination of confidence intervals of metabolic fluxes estimated from stable isotope measurements. Metab. Eng. 2006, 8:324-337.
    • (2006) Metab. Eng. , vol.8 , pp. 324-337
    • Antoniewicz, M.R.1    Kelleher, J.K.2    Stephanopoulos, G.3
  • 5
    • 77956534963 scopus 로고    scopus 로고
    • Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice
    • NIH Mouse Metabolic Phenotyping Center Consortium
    • Ayala J.E., Samuel V.T., Morton G.J., Obici S., Croniger C.M., Shulman G.I., Wasserman D.H., McGuinness O.P. Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice. Dis. Model. Mech. 2010, 3:525-534. NIH Mouse Metabolic Phenotyping Center Consortium.
    • (2010) Dis. Model. Mech. , vol.3 , pp. 525-534
    • Ayala, J.E.1    Samuel, V.T.2    Morton, G.J.3    Obici, S.4    Croniger, C.M.5    Shulman, G.I.6    Wasserman, D.H.7    McGuinness, O.P.8
  • 6
    • 0013968249 scopus 로고
    • Pentose cycle activity in muscle from fetal, neonatal and infant rhesus monkeys
    • Beatty C.H., Basinger G.M., Bocek R.M. Pentose cycle activity in muscle from fetal, neonatal and infant rhesus monkeys. Arch. Biochem. Biophys. 1966, 117:275-281.
    • (1966) Arch. Biochem. Biophys. , vol.117 , pp. 275-281
    • Beatty, C.H.1    Basinger, G.M.2    Bocek, R.M.3
  • 8
    • 0019471878 scopus 로고
    • Transport of energy in muscle: the phosphorylcreatine shuttle
    • Bessman S.P., Geiger P.J. Transport of energy in muscle: the phosphorylcreatine shuttle. Science 1981, 211:448-452.
    • (1981) Science , vol.211 , pp. 448-452
    • Bessman, S.P.1    Geiger, P.J.2
  • 9
    • 0029990892 scopus 로고    scopus 로고
    • Selective distribution of lactate dehydrogenase isoenzymes in neurons and astrocytes of human brain
    • Bittar P.G., Charnay Y., Pellerin L., Bouras C., Magistretti P.J. Selective distribution of lactate dehydrogenase isoenzymes in neurons and astrocytes of human brain. J. Cereb. Blood Flow Metab. 1996, 16:1079-1089.
    • (1996) J. Cereb. Blood Flow Metab. , vol.16 , pp. 1079-1089
    • Bittar, P.G.1    Charnay, Y.2    Pellerin, L.3    Bouras, C.4    Magistretti, P.J.5
  • 10
    • 0031974007 scopus 로고    scopus 로고
    • Nonoxidative pentose phosphate pathways and their direct role in ribose synthesis in tumors: is cancer a disease of cellular glucose metabolism?
    • Boros L.G., Lee P.W., Brandes J.L., Cascante M., Muscarella P., Schirmer W.J., Melvin W.S., Ellison E.C. Nonoxidative pentose phosphate pathways and their direct role in ribose synthesis in tumors: is cancer a disease of cellular glucose metabolism?. Med. Hypotheses 1998, 50:55-59.
    • (1998) Med. Hypotheses , vol.50 , pp. 55-59
    • Boros, L.G.1    Lee, P.W.2    Brandes, J.L.3    Cascante, M.4    Muscarella, P.5    Schirmer, W.J.6    Melvin, W.S.7    Ellison, E.C.8
  • 13
    • 0035834409 scopus 로고    scopus 로고
    • A conserved family of prolyl-4-hydroxylases that modify HIF
    • Bruick R.K., McKnight S.L. A conserved family of prolyl-4-hydroxylases that modify HIF. Science 2001, 294:1337-1340.
    • (2001) Science , vol.294 , pp. 1337-1340
    • Bruick, R.K.1    McKnight, S.L.2
  • 15
    • 37049236727 scopus 로고
    • Nature and Development of Lactic Dehydrogenases: The two major types of this enzyme form molecular hybrids which change in makeup during development
    • Cahn R.D., Zwilling E., Kaplan N.O., Levine L. Nature and Development of Lactic Dehydrogenases: The two major types of this enzyme form molecular hybrids which change in makeup during development. Science 1962, 136:962-969.
    • (1962) Science , vol.136 , pp. 962-969
    • Cahn, R.D.1    Zwilling, E.2    Kaplan, N.O.3    Levine, L.4
  • 19
    • 77952562382 scopus 로고    scopus 로고
    • Glucose addiction of TSC null cells is caused by failed mTORC1-dependent balancing of metabolic demand with supply
    • Choo A.Y., Kim S.G., Vander Heiden M.G., Mahoney S.J., Vu H., Yoon S.O., Cantley L.C., Blenis J. Glucose addiction of TSC null cells is caused by failed mTORC1-dependent balancing of metabolic demand with supply. Mol. Cell 2010, 38:487-499.
    • (2010) Mol. Cell , vol.38 , pp. 487-499
    • Choo, A.Y.1    Kim, S.G.2    Vander Heiden, M.G.3    Mahoney, S.J.4    Vu, H.5    Yoon, S.O.6    Cantley, L.C.7    Blenis, J.8
  • 21
    • 0023605591 scopus 로고
    • Determination of Krebs cycle metabolic carbon exchange in vivo and its use to estimate the individual contributions of gluconeogenesis and glycogenolysis to overall glucose output in man
    • Consoli A., Kennedy F., Miles J., Gerich J. Determination of Krebs cycle metabolic carbon exchange in vivo and its use to estimate the individual contributions of gluconeogenesis and glycogenolysis to overall glucose output in man. J. Clin. Invest. 1987, 80:1303-1310.
    • (1987) J. Clin. Invest. , vol.80 , pp. 1303-1310
    • Consoli, A.1    Kennedy, F.2    Miles, J.3    Gerich, J.4
  • 23
    • 84858414020 scopus 로고    scopus 로고
    • Cellular metabolism and disease: what do metabolic outliers teach us?
    • DeBerardinis R.J., Thompson C.B. Cellular metabolism and disease: what do metabolic outliers teach us?. Cell 2012, 148:1132-1144.
    • (2012) Cell , vol.148 , pp. 1132-1144
    • DeBerardinis, R.J.1    Thompson, C.B.2
  • 24
    • 0031680034 scopus 로고    scopus 로고
    • Adenylate kinase: kinetic behavior in intact cells indicates it is integral to multiple cellular processes
    • Dzeja P.P., Zeleznikar R.J., Goldberg N.D. Adenylate kinase: kinetic behavior in intact cells indicates it is integral to multiple cellular processes. Mol. Cell. Biochem. 1998, 184:169-182.
    • (1998) Mol. Cell. Biochem. , vol.184 , pp. 169-182
    • Dzeja, P.P.1    Zeleznikar, R.J.2    Goldberg, N.D.3
  • 27
    • 68549085318 scopus 로고    scopus 로고
    • Altered regulation of metabolic pathways in human lung cancer discerned by (13)C stable isotope-resolved metabolomics (SIRM)
    • Fan T.W., Lane A.N., Higashi R.M., Farag M.A., Gao H., Bousamra M., Miller D.M. Altered regulation of metabolic pathways in human lung cancer discerned by (13)C stable isotope-resolved metabolomics (SIRM). Mol. Cancer 2009, 8:41.
    • (2009) Mol. Cancer , vol.8 , pp. 41
    • Fan, T.W.1    Lane, A.N.2    Higashi, R.M.3    Farag, M.A.4    Gao, H.5    Bousamra, M.6    Miller, D.M.7
  • 30
    • 80053035284 scopus 로고    scopus 로고
    • AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function
    • Hardie D.G. AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function. Genes Dev. 2011, 25:1895-1908.
    • (2011) Genes Dev. , vol.25 , pp. 1895-1908
    • Hardie, D.G.1
  • 31
    • 0742323124 scopus 로고    scopus 로고
    • New stable isotope-mass spectrometric techniques for measuring fluxes through intact metabolic pathways in mammalian systems: introduction of moving pictures into functional genomics and biochemical phenotyping
    • Hellerstein M.K. New stable isotope-mass spectrometric techniques for measuring fluxes through intact metabolic pathways in mammalian systems: introduction of moving pictures into functional genomics and biochemical phenotyping. Metab. Eng. 2004, 6:85-100.
    • (2004) Metab. Eng. , vol.6 , pp. 85-100
    • Hellerstein, M.K.1
  • 33
    • 0029591465 scopus 로고
    • Glutamine metabolism in AS-30D hepatoma cells. Evidence for its conversion into lipids via reductive carboxylation
    • Holleran A.L., Briscoe D.A., Fiskum G., Kelleher J.K. Glutamine metabolism in AS-30D hepatoma cells. Evidence for its conversion into lipids via reductive carboxylation. Mol. Cell. Biochem. 1995, 152:95-101.
    • (1995) Mol. Cell. Biochem. , vol.152 , pp. 95-101
    • Holleran, A.L.1    Briscoe, D.A.2    Fiskum, G.3    Kelleher, J.K.4
  • 34
    • 0017285585 scopus 로고
    • Regulation of pentose phosphate pathway dehydrogenases by NADP+/NADPH ratios
    • Holten D., Procsal D., Chang H.L. Regulation of pentose phosphate pathway dehydrogenases by NADP+/NADPH ratios. Biochem. Biophys. Res. Commun. 1976, 68:436-441.
    • (1976) Biochem. Biophys. Res. Commun. , vol.68 , pp. 436-441
    • Holten, D.1    Procsal, D.2    Chang, H.L.3
  • 35
    • 80053902441 scopus 로고    scopus 로고
    • Imaging cytosolic NADH-NAD(+) redox state with a genetically encoded fluorescent biosensor
    • Hung Y.P., Albeck J.G., Tantama M., Yellen G. Imaging cytosolic NADH-NAD(+) redox state with a genetically encoded fluorescent biosensor. Cell Metab. 2011, 14:545-554.
    • (2011) Cell Metab. , vol.14 , pp. 545-554
    • Hung, Y.P.1    Albeck, J.G.2    Tantama, M.3    Yellen, G.4
  • 36
    • 0345167800 scopus 로고    scopus 로고
    • TSC2 mediates cellular energy response to control cell growth and survival
    • Inoki K., Zhu T., Guan K.L. TSC2 mediates cellular energy response to control cell growth and survival. Cell 2003, 115:577-590.
    • (2003) Cell , vol.115 , pp. 577-590
    • Inoki, K.1    Zhu, T.2    Guan, K.L.3
  • 39
    • 0021894478 scopus 로고
    • Respiratory control and the integration of heart high-energy phosphate metabolism by mitochondrial creatine kinase
    • Jacobus W.E. Respiratory control and the integration of heart high-energy phosphate metabolism by mitochondrial creatine kinase. Annu. Rev. Physiol. 1985, 47:707-725.
    • (1985) Annu. Rev. Physiol. , vol.47 , pp. 707-725
    • Jacobus, W.E.1
  • 40
    • 34547545892 scopus 로고    scopus 로고
    • AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha
    • Jäger S., Handschin C., St-Pierre J., Spiegelman B.M. AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha. Proc. Natl. Acad. Sci. USA 2007, 104:12017-12022.
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 12017-12022
    • Jäger, S.1    Handschin, C.2    St-Pierre, J.3    Spiegelman, B.M.4
  • 41
    • 79952280229 scopus 로고    scopus 로고
    • P53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase
    • Jiang P., Du W., Wang X., Mancuso A., Gao X., Wu M., Yang X. p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase. Nat. Cell Biol. 2011, 13:310-316.
    • (2011) Nat. Cell Biol. , vol.13 , pp. 310-316
    • Jiang, P.1    Du, W.2    Wang, X.3    Mancuso, A.4    Gao, X.5    Wu, M.6    Yang, X.7
  • 42
    • 43649093915 scopus 로고    scopus 로고
    • Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway
    • Kaelin W.G., Ratcliffe P.J. Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. Mol. Cell 2008, 30:393-402.
    • (2008) Mol. Cell , vol.30 , pp. 393-402
    • Kaelin, W.G.1    Ratcliffe, P.J.2
  • 43
    • 0027438281 scopus 로고
    • Isotopomer studies of gluconeogenesis and the Krebs cycle with 13C-labeled lactate
    • Katz J., Wals P., Lee W.N. Isotopomer studies of gluconeogenesis and the Krebs cycle with 13C-labeled lactate. J. Biol. Chem. 1993, 268:25509-25521.
    • (1993) J. Biol. Chem. , vol.268 , pp. 25509-25521
    • Katz, J.1    Wals, P.2    Lee, W.N.3
  • 44
    • 1642306943 scopus 로고    scopus 로고
    • Profiling substrate fluxes in the isolated working mouse heart using 13C-labeled substrates: focusing on the origin and fate of pyruvate and citrate carbons
    • Khairallah M., Labarthe F., Bouchard B., Danialou G., Petrof B.J., Des Rosiers C. Profiling substrate fluxes in the isolated working mouse heart using 13C-labeled substrates: focusing on the origin and fate of pyruvate and citrate carbons. Am. J. Physiol. Heart Circ. Physiol. 2004, 286:H1461-H1470.
    • (2004) Am. J. Physiol. Heart Circ. Physiol. , vol.286
    • Khairallah, M.1    Labarthe, F.2    Bouchard, B.3    Danialou, G.4    Petrof, B.J.5    Des Rosiers, C.6
  • 45
    • 33644614520 scopus 로고    scopus 로고
    • HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia
    • Kim J.W., Tchernyshyov I., Semenza G.L., Dang C.V. HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. Cell Metab. 2006, 3:177-185.
    • (2006) Cell Metab. , vol.3 , pp. 177-185
    • Kim, J.W.1    Tchernyshyov, I.2    Semenza, G.L.3    Dang, C.V.4
  • 47
    • 0013998644 scopus 로고
    • The regulation of the release of ketone bodies by the liver
    • Krebs H.A. The regulation of the release of ketone bodies by the liver. Adv. Enzyme Regul. 1966, 4:339-354.
    • (1966) Adv. Enzyme Regul. , vol.4 , pp. 339-354
    • Krebs, H.A.1
  • 48
    • 80052338863 scopus 로고    scopus 로고
    • Glutamine synthetase is a genetic determinant of cell type-specific glutamine independence in breast epithelia
    • Kung H.N., Marks J.R., Chi J.T. Glutamine synthetase is a genetic determinant of cell type-specific glutamine independence in breast epithelia. PLoS Genet. 2011, 7:e1002229.
    • (2011) PLoS Genet. , vol.7
    • Kung, H.N.1    Marks, J.R.2    Chi, J.T.3
  • 51
    • 0031804597 scopus 로고    scopus 로고
    • Mass isotopomer study of the nonoxidative pathways of the pentose cycle with [1,2-13C2]glucose
    • Lee W.N., Boros L.G., Puigjaner J., Bassilian S., Lim S., Cascante M. Mass isotopomer study of the nonoxidative pathways of the pentose cycle with [1,2-13C2]glucose. Am. J. Physiol. 1998, 274:E843-E851.
    • (1998) Am. J. Physiol. , vol.274
    • Lee, W.N.1    Boros, L.G.2    Puigjaner, J.3    Bassilian, S.4    Lim, S.5    Cascante, M.6
  • 52
    • 79953755370 scopus 로고    scopus 로고
    • AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice
    • Li Y., Xu S., Mihaylova M.M., Zheng B., Hou X., Jiang B., Park O., Luo Z., Lefai E., Shyy J.Y., et al. AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice. Cell Metab. 2011, 13:376-388.
    • (2011) Cell Metab. , vol.13 , pp. 376-388
    • Li, Y.1    Xu, S.2    Mihaylova, M.M.3    Zheng, B.4    Hou, X.5    Jiang, B.6    Park, O.7    Luo, Z.8    Lefai, E.9    Shyy, J.Y.10
  • 53
    • 0030823179 scopus 로고    scopus 로고
    • Chronic effect of fatty acids on insulin release is not through the alteration of glucose metabolism in a pancreatic beta-cell line (beta HC9)
    • Liang Y., Buettger C., Berner D.K., Matschinsky F.M. Chronic effect of fatty acids on insulin release is not through the alteration of glucose metabolism in a pancreatic beta-cell line (beta HC9). Diabetologia 1997, 40:1018-1027.
    • (1997) Diabetologia , vol.40 , pp. 1018-1027
    • Liang, Y.1    Buettger, C.2    Berner, D.K.3    Matschinsky, F.M.4
  • 55
    • 12944303650 scopus 로고    scopus 로고
    • Growth factor regulation of autophagy and cell survival in the absence of apoptosis
    • Lum J.J., Bauer D.E., Kong M., Harris M.H., Li C., Lindsten T., Thompson C.B. Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell 2005, 120:237-248.
    • (2005) Cell , vol.120 , pp. 237-248
    • Lum, J.J.1    Bauer, D.E.2    Kong, M.3    Harris, M.H.4    Li, C.5    Lindsten, T.6    Thompson, C.B.7
  • 56
    • 44449177159 scopus 로고    scopus 로고
    • Identification of metabolic fluxes in hepatic cells from transient 13C-labeling experiments: Part II. Flux estimation
    • Maier K., Hofmann U., Reuss M., Mauch K. Identification of metabolic fluxes in hepatic cells from transient 13C-labeling experiments: Part II. Flux estimation. Biotechnol. Bioeng. 2008, 100:355-370.
    • (2008) Biotechnol. Bioeng. , vol.100 , pp. 355-370
    • Maier, K.1    Hofmann, U.2    Reuss, M.3    Mauch, K.4
  • 57
    • 84862016091 scopus 로고    scopus 로고
    • Analysis of tumor metabolism reveals mitochondrial glucose oxidation in genetically diverse human glioblastomas in the mouse brain in vivo
    • Marin-Valencia I., Yang C., Mashimo T., Cho S., Baek H., Yang X.L., Rajagopalan K.N., Maddie M., Vemireddy V., Zhao Z., et al. Analysis of tumor metabolism reveals mitochondrial glucose oxidation in genetically diverse human glioblastomas in the mouse brain in vivo. Cell Metab. 2012, 15:827-837.
    • (2012) Cell Metab. , vol.15 , pp. 827-837
    • Marin-Valencia, I.1    Yang, C.2    Mashimo, T.3    Cho, S.4    Baek, H.5    Yang, X.L.6    Rajagopalan, K.N.7    Maddie, M.8    Vemireddy, V.9    Zhao, Z.10
  • 58
    • 82755168823 scopus 로고    scopus 로고
    • Flux through hepatic pyruvate carboxylase and phosphoenolpyruvate carboxykinase detected by hyperpolarized 13C magnetic resonance
    • Merritt M.E., Harrison C., Sherry A.D., Malloy C.R., Burgess S.C. Flux through hepatic pyruvate carboxylase and phosphoenolpyruvate carboxykinase detected by hyperpolarized 13C magnetic resonance. Proc. Natl. Acad. Sci. USA 2011, 108:19084-19089.
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 19084-19089
    • Merritt, M.E.1    Harrison, C.2    Sherry, A.D.3    Malloy, C.R.4    Burgess, S.C.5
  • 59
    • 70449519259 scopus 로고    scopus 로고
    • Evaluation of 13C isotopic tracers for metabolic flux analysis in mammalian cells
    • Metallo C.M., Walther J.L., Stephanopoulos G. Evaluation of 13C isotopic tracers for metabolic flux analysis in mammalian cells. J. Biotechnol. 2009, 144:167-174.
    • (2009) J. Biotechnol. , vol.144 , pp. 167-174
    • Metallo, C.M.1    Walther, J.L.2    Stephanopoulos, G.3
  • 64
    • 84872376676 scopus 로고    scopus 로고
    • Isotopically nonstationary (13)C flux analysis of Myc-induced metabolic reprogramming in B-cells
    • Murphy T.A., Dang C.V., Young J.D. Isotopically nonstationary (13)C flux analysis of Myc-induced metabolic reprogramming in B-cells. Metab. Eng. 2013, 15:206-217.
    • (2013) Metab. Eng. , vol.15 , pp. 206-217
    • Murphy, T.A.1    Dang, C.V.2    Young, J.D.3
  • 65
    • 0018691116 scopus 로고
    • Theoretical principles in the approaches to control of metabolic pathways and their application to glycolysis in muscle
    • Newsholme E.A., Crabtree B. Theoretical principles in the approaches to control of metabolic pathways and their application to glycolysis in muscle. J. Mol. Cell. Cardiol. 1979, 11:839-856.
    • (1979) J. Mol. Cell. Cardiol. , vol.11 , pp. 839-856
    • Newsholme, E.A.1    Crabtree, B.2
  • 67
    • 33644622570 scopus 로고    scopus 로고
    • HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption
    • Papandreou I., Cairns R.A., Fontana L., Lim A.L., Denko N.C. HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption. Cell Metab. 2006, 3:187-197.
    • (2006) Cell Metab. , vol.3 , pp. 187-197
    • Papandreou, I.1    Cairns, R.A.2    Fontana, L.3    Lim, A.L.4    Denko, N.C.5
  • 68
    • 50049117073 scopus 로고    scopus 로고
    • A 13C isotope labeling strategy reveals the influence of insulin signaling on lipogenesis in C. elegans
    • Perez C.L., Van Gilst M.R. A 13C isotope labeling strategy reveals the influence of insulin signaling on lipogenesis in C. elegans. Cell Metab. 2008, 8:266-274.
    • (2008) Cell Metab. , vol.8 , pp. 266-274
    • Perez, C.L.1    Van Gilst, M.R.2
  • 69
    • 0029043852 scopus 로고
    • 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase: a metabolic signaling enzyme
    • Pilkis S.J., Claus T.H., Kurland I.J., Lange A.J. 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase: a metabolic signaling enzyme. Annu. Rev. Biochem. 1995, 64:799-835.
    • (1995) Annu. Rev. Biochem. , vol.64 , pp. 799-835
    • Pilkis, S.J.1    Claus, T.H.2    Kurland, I.J.3    Lange, A.J.4
  • 72
    • 9244228937 scopus 로고
    • Endocrine control of metabolism
    • Randle P.J. Endocrine control of metabolism. Annu. Rev. Physiol. 1963, 25:291-324.
    • (1963) Annu. Rev. Physiol. , vol.25 , pp. 291-324
    • Randle, P.J.1
  • 73
    • 34247131735 scopus 로고    scopus 로고
    • Pyruvate dehydrogenase kinase regulatory mechanisms and inhibition in treating diabetes, heart ischemia, and cancer
    • Roche T.E., Hiromasa Y. Pyruvate dehydrogenase kinase regulatory mechanisms and inhibition in treating diabetes, heart ischemia, and cancer. Cell. Mol. Life Sci. 2007, 64:830-849.
    • (2007) Cell. Mol. Life Sci. , vol.64 , pp. 830-849
    • Roche, T.E.1    Hiromasa, Y.2
  • 75
    • 84864767268 scopus 로고    scopus 로고
    • Functional metabolic screen identifies 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 as an important regulator of prostate cancer cell survival
    • Ros S., Santos C.R., Moco S., Baenke F., Kelly G., Howell M., Zamboni N., Schulze A. Functional metabolic screen identifies 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 as an important regulator of prostate cancer cell survival. Cancer Discov. 2012, 2:328-343.
    • (2012) Cancer Discov. , vol.2 , pp. 328-343
    • Ros, S.1    Santos, C.R.2    Moco, S.3    Baenke, F.4    Kelly, G.5    Howell, M.6    Zamboni, N.7    Schulze, A.8
  • 76
    • 0016410664 scopus 로고
    • Muscle amino acid metabolism and gluconeogenesis
    • Ruderman N.B. Muscle amino acid metabolism and gluconeogenesis. Annu. Rev. Med. 1975, 26:245-258.
    • (1975) Annu. Rev. Med. , vol.26 , pp. 245-258
    • Ruderman, N.B.1
  • 77
    • 0035856949 scopus 로고    scopus 로고
    • Insulin signalling and the regulation of glucose and lipid metabolism
    • Saltiel A.R., Kahn C.R. Insulin signalling and the regulation of glucose and lipid metabolism. Nature 2001, 414:799-806.
    • (2001) Nature , vol.414 , pp. 799-806
    • Saltiel, A.R.1    Kahn, C.R.2
  • 80
    • 33846061120 scopus 로고    scopus 로고
    • Metabolic networks in motion: 13C-based flux analysis
    • Sauer U. Metabolic networks in motion: 13C-based flux analysis. Mol. Syst. Biol. 2006, 2:62.
    • (2006) Mol. Syst. Biol. , vol.2 , pp. 62
    • Sauer, U.1
  • 83
    • 82955239838 scopus 로고    scopus 로고
    • Excessive hepatic mitochondrial TCA cycle and gluconeogenesis in humans with nonalcoholic fatty liver disease
    • Sunny N.E., Parks E.J., Browning J.D., Burgess S.C. Excessive hepatic mitochondrial TCA cycle and gluconeogenesis in humans with nonalcoholic fatty liver disease. Cell Metab. 2011, 14:804-810.
    • (2011) Cell Metab. , vol.14 , pp. 804-810
    • Sunny, N.E.1    Parks, E.J.2    Browning, J.D.3    Burgess, S.C.4
  • 87
    • 66249108601 scopus 로고    scopus 로고
    • Understanding the Warburg effect: the metabolic requirements of cell proliferation
    • Vander Heiden M.G., Cantley L.C., Thompson C.B. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 2009, 324:1029-1033.
    • (2009) Science , vol.324 , pp. 1029-1033
    • Vander Heiden, M.G.1    Cantley, L.C.2    Thompson, C.B.3
  • 91
    • 77649305610 scopus 로고    scopus 로고
    • The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate
    • Ward P.S., Patel J., Wise D.R., Abdel-Wahab O., Bennett B.D., Coller H.A., Cross J.R., Fantin V.R., Hedvat C.V., Perl A.E., et al. The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate. Cancer Cell 2010, 17:225-234.
    • (2010) Cancer Cell , vol.17 , pp. 225-234
    • Ward, P.S.1    Patel, J.2    Wise, D.R.3    Abdel-Wahab, O.4    Bennett, B.D.5    Coller, H.A.6    Cross, J.R.7    Fantin, V.R.8    Hedvat, C.V.9    Perl, A.E.10
  • 93
    • 84862632865 scopus 로고    scopus 로고
    • Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors
    • Xiao M., Yang H., Xu W., Ma S., Lin H., Zhu H., Liu L., Liu Y., Yang C., Xu Y., et al. Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors. Genes Dev. 2012, 26:1326-1338.
    • (2012) Genes Dev. , vol.26 , pp. 1326-1338
    • Xiao, M.1    Yang, H.2    Xu, W.3    Ma, S.4    Lin, H.5    Zhu, H.6    Liu, L.7    Liu, Y.8    Yang, C.9    Xu, Y.10
  • 94
    • 78651463452 scopus 로고    scopus 로고
    • Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases
    • Xu W., Yang H., Liu Y., Yang Y., Wang P., Kim S.H., Ito S., Yang C., Wang P., Xiao M.T., et al. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. Cancer Cell 2011, 19:17-30.
    • (2011) Cancer Cell , vol.19 , pp. 17-30
    • Xu, W.1    Yang, H.2    Liu, Y.3    Yang, Y.4    Wang, P.5    Kim, S.H.6    Ito, S.7    Yang, C.8    Wang, P.9    Xiao, M.T.10
  • 97
    • 79551508527 scopus 로고    scopus 로고
    • 13C metabolic flux analysis in complex systems
    • Zamboni N. 13C metabolic flux analysis in complex systems. Curr. Opin. Biotechnol. 2011, 22:103-108.
    • (2011) Curr. Opin. Biotechnol. , vol.22 , pp. 103-108
    • Zamboni, N.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.