-
1
-
-
0025276048
-
Cellular concentrations of enzymes and their substrates
-
Albe K.R., Butler M.H., Wright B.E. Cellular concentrations of enzymes and their substrates. J. Theor. Biol. 1990, 143:163-195.
-
(1990)
J. Theor. Biol.
, vol.143
, pp. 163-195
-
-
Albe, K.R.1
Butler, M.H.2
Wright, B.E.3
-
2
-
-
82755166890
-
Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses
-
Anastasiou D., Poulogiannis G., Asara J.M., Boxer M.B., Jiang J.K., Shen M., Bellinger G., Sasaki A.T., Locasale J.W., Auld D.S., et al. Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses. Science 2011, 334:1278-1283.
-
(2011)
Science
, vol.334
, pp. 1278-1283
-
-
Anastasiou, D.1
Poulogiannis, G.2
Asara, J.M.3
Boxer, M.B.4
Jiang, J.K.5
Shen, M.6
Bellinger, G.7
Sasaki, A.T.8
Locasale, J.W.9
Auld, D.S.10
-
3
-
-
84866842363
-
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis
-
Anastasiou D., Yu Y., Israelsen W.J., Jiang J.K., Boxer M.B., Hong B.S., Tempel W., Dimov S., Shen M., Jha A., et al. Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis. Nat. Chem. Biol. 2012, 8:839-847.
-
(2012)
Nat. Chem. Biol.
, vol.8
, pp. 839-847
-
-
Anastasiou, D.1
Yu, Y.2
Israelsen, W.J.3
Jiang, J.K.4
Boxer, M.B.5
Hong, B.S.6
Tempel, W.7
Dimov, S.8
Shen, M.9
Jha, A.10
-
4
-
-
33745155105
-
Determination of confidence intervals of metabolic fluxes estimated from stable isotope measurements
-
Antoniewicz M.R., Kelleher J.K., Stephanopoulos G. Determination of confidence intervals of metabolic fluxes estimated from stable isotope measurements. Metab. Eng. 2006, 8:324-337.
-
(2006)
Metab. Eng.
, vol.8
, pp. 324-337
-
-
Antoniewicz, M.R.1
Kelleher, J.K.2
Stephanopoulos, G.3
-
5
-
-
77956534963
-
Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice
-
NIH Mouse Metabolic Phenotyping Center Consortium
-
Ayala J.E., Samuel V.T., Morton G.J., Obici S., Croniger C.M., Shulman G.I., Wasserman D.H., McGuinness O.P. Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice. Dis. Model. Mech. 2010, 3:525-534. NIH Mouse Metabolic Phenotyping Center Consortium.
-
(2010)
Dis. Model. Mech.
, vol.3
, pp. 525-534
-
-
Ayala, J.E.1
Samuel, V.T.2
Morton, G.J.3
Obici, S.4
Croniger, C.M.5
Shulman, G.I.6
Wasserman, D.H.7
McGuinness, O.P.8
-
6
-
-
0013968249
-
Pentose cycle activity in muscle from fetal, neonatal and infant rhesus monkeys
-
Beatty C.H., Basinger G.M., Bocek R.M. Pentose cycle activity in muscle from fetal, neonatal and infant rhesus monkeys. Arch. Biochem. Biophys. 1966, 117:275-281.
-
(1966)
Arch. Biochem. Biophys.
, vol.117
, pp. 275-281
-
-
Beatty, C.H.1
Basinger, G.M.2
Bocek, R.M.3
-
7
-
-
33745918951
-
TIGAR, a p53-inducible regulator of glycolysis and apoptosis
-
Bensaad K., Tsuruta A., Selak M.A., Vidal M.N., Nakano K., Bartrons R., Gottlieb E., Vousden K.H. TIGAR, a p53-inducible regulator of glycolysis and apoptosis. Cell 2006, 126:107-120.
-
(2006)
Cell
, vol.126
, pp. 107-120
-
-
Bensaad, K.1
Tsuruta, A.2
Selak, M.A.3
Vidal, M.N.4
Nakano, K.5
Bartrons, R.6
Gottlieb, E.7
Vousden, K.H.8
-
8
-
-
0019471878
-
Transport of energy in muscle: the phosphorylcreatine shuttle
-
Bessman S.P., Geiger P.J. Transport of energy in muscle: the phosphorylcreatine shuttle. Science 1981, 211:448-452.
-
(1981)
Science
, vol.211
, pp. 448-452
-
-
Bessman, S.P.1
Geiger, P.J.2
-
9
-
-
0029990892
-
Selective distribution of lactate dehydrogenase isoenzymes in neurons and astrocytes of human brain
-
Bittar P.G., Charnay Y., Pellerin L., Bouras C., Magistretti P.J. Selective distribution of lactate dehydrogenase isoenzymes in neurons and astrocytes of human brain. J. Cereb. Blood Flow Metab. 1996, 16:1079-1089.
-
(1996)
J. Cereb. Blood Flow Metab.
, vol.16
, pp. 1079-1089
-
-
Bittar, P.G.1
Charnay, Y.2
Pellerin, L.3
Bouras, C.4
Magistretti, P.J.5
-
10
-
-
0031974007
-
Nonoxidative pentose phosphate pathways and their direct role in ribose synthesis in tumors: is cancer a disease of cellular glucose metabolism?
-
Boros L.G., Lee P.W., Brandes J.L., Cascante M., Muscarella P., Schirmer W.J., Melvin W.S., Ellison E.C. Nonoxidative pentose phosphate pathways and their direct role in ribose synthesis in tumors: is cancer a disease of cellular glucose metabolism?. Med. Hypotheses 1998, 50:55-59.
-
(1998)
Med. Hypotheses
, vol.50
, pp. 55-59
-
-
Boros, L.G.1
Lee, P.W.2
Brandes, J.L.3
Cascante, M.4
Muscarella, P.5
Schirmer, W.J.6
Melvin, W.S.7
Ellison, E.C.8
-
11
-
-
84863552418
-
A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans
-
Bricker D.K., Taylor E.B., Schell J.C., Orsak T., Boutron A., Chen Y.C., Cox J.E., Cardon C.M., Van Vranken J.G., Dephoure N., et al. A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans. Science 2012, 337:96-100.
-
(2012)
Science
, vol.337
, pp. 96-100
-
-
Bricker, D.K.1
Taylor, E.B.2
Schell, J.C.3
Orsak, T.4
Boutron, A.5
Chen, Y.C.6
Cox, J.E.7
Cardon, C.M.8
Van Vranken, J.G.9
Dephoure, N.10
-
12
-
-
79960585263
-
Tumor imaging using hyperpolarized 13C magnetic resonance spectroscopy
-
Brindle K.M., Bohndiek S.E., Gallagher F.A., Kettunen M.I. Tumor imaging using hyperpolarized 13C magnetic resonance spectroscopy. Magn. Reson. Med. 2011, 66:505-519.
-
(2011)
Magn. Reson. Med.
, vol.66
, pp. 505-519
-
-
Brindle, K.M.1
Bohndiek, S.E.2
Gallagher, F.A.3
Kettunen, M.I.4
-
13
-
-
0035834409
-
A conserved family of prolyl-4-hydroxylases that modify HIF
-
Bruick R.K., McKnight S.L. A conserved family of prolyl-4-hydroxylases that modify HIF. Science 2001, 294:1337-1340.
-
(2001)
Science
, vol.294
, pp. 1337-1340
-
-
Bruick, R.K.1
McKnight, S.L.2
-
14
-
-
0015404261
-
Insulin and muscle amino acid balance
-
Cahill G.F., Aoki T.T., Brennan M.F., Müller W.A. Insulin and muscle amino acid balance. Proc. Nutr. Soc. 1972, 31:233-238.
-
(1972)
Proc. Nutr. Soc.
, vol.31
, pp. 233-238
-
-
Cahill, G.F.1
Aoki, T.T.2
Brennan, M.F.3
Müller, W.A.4
-
15
-
-
37049236727
-
Nature and Development of Lactic Dehydrogenases: The two major types of this enzyme form molecular hybrids which change in makeup during development
-
Cahn R.D., Zwilling E., Kaplan N.O., Levine L. Nature and Development of Lactic Dehydrogenases: The two major types of this enzyme form molecular hybrids which change in makeup during development. Science 1962, 136:962-969.
-
(1962)
Science
, vol.136
, pp. 962-969
-
-
Cahn, R.D.1
Zwilling, E.2
Kaplan, N.O.3
Levine, L.4
-
17
-
-
0015218982
-
Allosteric properties of skeletal muscle pyruvate kinase
-
Carminatti H., Jiménez de Asúa L., Leiderman B., Rozengurt E. Allosteric properties of skeletal muscle pyruvate kinase. J. Biol. Chem. 1971, 246:7284-7288.
-
(1971)
J. Biol. Chem.
, vol.246
, pp. 7284-7288
-
-
Carminatti, H.1
Jiménez de Asúa, L.2
Leiderman, B.3
Rozengurt, E.4
-
18
-
-
0032578458
-
Mitochondrial reactive oxygen species trigger hypoxia-induced transcription
-
Chandel N.S., Maltepe E., Goldwasser E., Mathieu C.E., Simon M.C., Schumacker P.T. Mitochondrial reactive oxygen species trigger hypoxia-induced transcription. Proc. Natl. Acad. Sci. USA 1998, 95:11715-11720.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 11715-11720
-
-
Chandel, N.S.1
Maltepe, E.2
Goldwasser, E.3
Mathieu, C.E.4
Simon, M.C.5
Schumacker, P.T.6
-
19
-
-
77952562382
-
Glucose addiction of TSC null cells is caused by failed mTORC1-dependent balancing of metabolic demand with supply
-
Choo A.Y., Kim S.G., Vander Heiden M.G., Mahoney S.J., Vu H., Yoon S.O., Cantley L.C., Blenis J. Glucose addiction of TSC null cells is caused by failed mTORC1-dependent balancing of metabolic demand with supply. Mol. Cell 2010, 38:487-499.
-
(2010)
Mol. Cell
, vol.38
, pp. 487-499
-
-
Choo, A.Y.1
Kim, S.G.2
Vander Heiden, M.G.3
Mahoney, S.J.4
Vu, H.5
Yoon, S.O.6
Cantley, L.C.7
Blenis, J.8
-
20
-
-
79955547561
-
The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases
-
Chowdhury R., Yeoh K.K., Tian Y.M., Hillringhaus L., Bagg E.A., Rose N.R., Leung I.K., Li X.S., Woon E.C., Yang M., et al. The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases. EMBO Rep. 2011, 12:463-469.
-
(2011)
EMBO Rep.
, vol.12
, pp. 463-469
-
-
Chowdhury, R.1
Yeoh, K.K.2
Tian, Y.M.3
Hillringhaus, L.4
Bagg, E.A.5
Rose, N.R.6
Leung, I.K.7
Li, X.S.8
Woon, E.C.9
Yang, M.10
-
21
-
-
0023605591
-
Determination of Krebs cycle metabolic carbon exchange in vivo and its use to estimate the individual contributions of gluconeogenesis and glycogenolysis to overall glucose output in man
-
Consoli A., Kennedy F., Miles J., Gerich J. Determination of Krebs cycle metabolic carbon exchange in vivo and its use to estimate the individual contributions of gluconeogenesis and glycogenolysis to overall glucose output in man. J. Clin. Invest. 1987, 80:1303-1310.
-
(1987)
J. Clin. Invest.
, vol.80
, pp. 1303-1310
-
-
Consoli, A.1
Kennedy, F.2
Miles, J.3
Gerich, J.4
-
22
-
-
72049125350
-
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
-
Dang L., White D.W., Gross S., Bennett B.D., Bittinger M.A., Driggers E.M., Fantin V.R., Jang H.G., Jin S., Keenan M.C., et al. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature 2009, 462:739-744.
-
(2009)
Nature
, vol.462
, pp. 739-744
-
-
Dang, L.1
White, D.W.2
Gross, S.3
Bennett, B.D.4
Bittinger, M.A.5
Driggers, E.M.6
Fantin, V.R.7
Jang, H.G.8
Jin, S.9
Keenan, M.C.10
-
23
-
-
84858414020
-
Cellular metabolism and disease: what do metabolic outliers teach us?
-
DeBerardinis R.J., Thompson C.B. Cellular metabolism and disease: what do metabolic outliers teach us?. Cell 2012, 148:1132-1144.
-
(2012)
Cell
, vol.148
, pp. 1132-1144
-
-
DeBerardinis, R.J.1
Thompson, C.B.2
-
24
-
-
0031680034
-
Adenylate kinase: kinetic behavior in intact cells indicates it is integral to multiple cellular processes
-
Dzeja P.P., Zeleznikar R.J., Goldberg N.D. Adenylate kinase: kinetic behavior in intact cells indicates it is integral to multiple cellular processes. Mol. Cell. Biochem. 1998, 184:169-182.
-
(1998)
Mol. Cell. Biochem.
, vol.184
, pp. 169-182
-
-
Dzeja, P.P.1
Zeleznikar, R.J.2
Goldberg, N.D.3
-
25
-
-
79251587803
-
Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy
-
Egan D.F., Shackelford D.B., Mihaylova M.M., Gelino S., Kohnz R.A., Mair W., Vasquez D.S., Joshi A., Gwinn D.M., Taylor R., et al. Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy. Science 2011, 331:456-461.
-
(2011)
Science
, vol.331
, pp. 456-461
-
-
Egan, D.F.1
Shackelford, D.B.2
Mihaylova, M.M.3
Gelino, S.4
Kohnz, R.A.5
Mair, W.6
Vasquez, D.S.7
Joshi, A.8
Gwinn, D.M.9
Taylor, R.10
-
26
-
-
17944375360
-
C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
-
Epstein A.C., Gleadle J.M., McNeill L.A., Hewitson K.S., O'Rourke J., Mole D.R., Mukherji M., Metzen E., Wilson M.I., Dhanda A., et al. C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell 2001, 107:43-54.
-
(2001)
Cell
, vol.107
, pp. 43-54
-
-
Epstein, A.C.1
Gleadle, J.M.2
McNeill, L.A.3
Hewitson, K.S.4
O'Rourke, J.5
Mole, D.R.6
Mukherji, M.7
Metzen, E.8
Wilson, M.I.9
Dhanda, A.10
-
27
-
-
68549085318
-
Altered regulation of metabolic pathways in human lung cancer discerned by (13)C stable isotope-resolved metabolomics (SIRM)
-
Fan T.W., Lane A.N., Higashi R.M., Farag M.A., Gao H., Bousamra M., Miller D.M. Altered regulation of metabolic pathways in human lung cancer discerned by (13)C stable isotope-resolved metabolomics (SIRM). Mol. Cancer 2009, 8:41.
-
(2009)
Mol. Cancer
, vol.8
, pp. 41
-
-
Fan, T.W.1
Lane, A.N.2
Higashi, R.M.3
Farag, M.A.4
Gao, H.5
Bousamra, M.6
Miller, D.M.7
-
28
-
-
78650019179
-
Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation
-
Figueroa M.E., Abdel-Wahab O., Lu C., Ward P.S., Patel J., Shih A., Li Y., Bhagwat N., Vasanthakumar A., Fernandez H.F., et al. Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation. Cancer Cell 2010, 18:553-567.
-
(2010)
Cancer Cell
, vol.18
, pp. 553-567
-
-
Figueroa, M.E.1
Abdel-Wahab, O.2
Lu, C.3
Ward, P.S.4
Patel, J.5
Shih, A.6
Li, Y.7
Bhagwat, N.8
Vasanthakumar, A.9
Fernandez, H.F.10
-
29
-
-
77149134353
-
Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations
-
Gross S., Cairns R.A., Minden M.D., Driggers E.M., Bittinger M.A., Jang H.G., Sasaki M., Jin S., Schenkein D.P., Su S.M., et al. Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations. J. Exp. Med. 2010, 207:339-344.
-
(2010)
J. Exp. Med.
, vol.207
, pp. 339-344
-
-
Gross, S.1
Cairns, R.A.2
Minden, M.D.3
Driggers, E.M.4
Bittinger, M.A.5
Jang, H.G.6
Sasaki, M.7
Jin, S.8
Schenkein, D.P.9
Su, S.M.10
-
30
-
-
80053035284
-
AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function
-
Hardie D.G. AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function. Genes Dev. 2011, 25:1895-1908.
-
(2011)
Genes Dev.
, vol.25
, pp. 1895-1908
-
-
Hardie, D.G.1
-
31
-
-
0742323124
-
New stable isotope-mass spectrometric techniques for measuring fluxes through intact metabolic pathways in mammalian systems: introduction of moving pictures into functional genomics and biochemical phenotyping
-
Hellerstein M.K. New stable isotope-mass spectrometric techniques for measuring fluxes through intact metabolic pathways in mammalian systems: introduction of moving pictures into functional genomics and biochemical phenotyping. Metab. Eng. 2004, 6:85-100.
-
(2004)
Metab. Eng.
, vol.6
, pp. 85-100
-
-
Hellerstein, M.K.1
-
32
-
-
84863553135
-
Identification and functional expression of the mitochondrial pyruvate carrier
-
Herzig S., Raemy E., Montessuit S., Veuthey J.L., Zamboni N., Westermann B., Kunji E.R.S., Martinou J.C. Identification and functional expression of the mitochondrial pyruvate carrier. Science 2012, 337:93-96.
-
(2012)
Science
, vol.337
, pp. 93-96
-
-
Herzig, S.1
Raemy, E.2
Montessuit, S.3
Veuthey, J.L.4
Zamboni, N.5
Westermann, B.6
Kunji, E.R.S.7
Martinou, J.C.8
-
33
-
-
0029591465
-
Glutamine metabolism in AS-30D hepatoma cells. Evidence for its conversion into lipids via reductive carboxylation
-
Holleran A.L., Briscoe D.A., Fiskum G., Kelleher J.K. Glutamine metabolism in AS-30D hepatoma cells. Evidence for its conversion into lipids via reductive carboxylation. Mol. Cell. Biochem. 1995, 152:95-101.
-
(1995)
Mol. Cell. Biochem.
, vol.152
, pp. 95-101
-
-
Holleran, A.L.1
Briscoe, D.A.2
Fiskum, G.3
Kelleher, J.K.4
-
34
-
-
0017285585
-
Regulation of pentose phosphate pathway dehydrogenases by NADP+/NADPH ratios
-
Holten D., Procsal D., Chang H.L. Regulation of pentose phosphate pathway dehydrogenases by NADP+/NADPH ratios. Biochem. Biophys. Res. Commun. 1976, 68:436-441.
-
(1976)
Biochem. Biophys. Res. Commun.
, vol.68
, pp. 436-441
-
-
Holten, D.1
Procsal, D.2
Chang, H.L.3
-
35
-
-
80053902441
-
Imaging cytosolic NADH-NAD(+) redox state with a genetically encoded fluorescent biosensor
-
Hung Y.P., Albeck J.G., Tantama M., Yellen G. Imaging cytosolic NADH-NAD(+) redox state with a genetically encoded fluorescent biosensor. Cell Metab. 2011, 14:545-554.
-
(2011)
Cell Metab.
, vol.14
, pp. 545-554
-
-
Hung, Y.P.1
Albeck, J.G.2
Tantama, M.3
Yellen, G.4
-
36
-
-
0345167800
-
TSC2 mediates cellular energy response to control cell growth and survival
-
Inoki K., Zhu T., Guan K.L. TSC2 mediates cellular energy response to control cell growth and survival. Cell 2003, 115:577-590.
-
(2003)
Cell
, vol.115
, pp. 577-590
-
-
Inoki, K.1
Zhu, T.2
Guan, K.L.3
-
37
-
-
0035917313
-
HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing
-
Ivan M., Kondo K., Yang H., Kim W., Valiando J., Ohh M., Salic A., Asara J.M., Lane W.S., Kaelin W.G. HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science 2001, 292:464-468.
-
(2001)
Science
, vol.292
, pp. 464-468
-
-
Ivan, M.1
Kondo, K.2
Yang, H.3
Kim, W.4
Valiando, J.5
Ohh, M.6
Salic, A.7
Asara, J.M.8
Lane, W.S.9
Kaelin, W.G.10
-
38
-
-
0035917808
-
Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation
-
Jaakkola P., Mole D.R., Tian Y.M., Wilson M.I., Gielbert J., Gaskell S.J., von Kriegsheim A., Hebestreit H.F., Mukherji M., Schofield C.J., et al. Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 2001, 292:468-472.
-
(2001)
Science
, vol.292
, pp. 468-472
-
-
Jaakkola, P.1
Mole, D.R.2
Tian, Y.M.3
Wilson, M.I.4
Gielbert, J.5
Gaskell, S.J.6
von Kriegsheim, A.7
Hebestreit, H.F.8
Mukherji, M.9
Schofield, C.J.10
-
39
-
-
0021894478
-
Respiratory control and the integration of heart high-energy phosphate metabolism by mitochondrial creatine kinase
-
Jacobus W.E. Respiratory control and the integration of heart high-energy phosphate metabolism by mitochondrial creatine kinase. Annu. Rev. Physiol. 1985, 47:707-725.
-
(1985)
Annu. Rev. Physiol.
, vol.47
, pp. 707-725
-
-
Jacobus, W.E.1
-
40
-
-
34547545892
-
AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha
-
Jäger S., Handschin C., St-Pierre J., Spiegelman B.M. AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha. Proc. Natl. Acad. Sci. USA 2007, 104:12017-12022.
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 12017-12022
-
-
Jäger, S.1
Handschin, C.2
St-Pierre, J.3
Spiegelman, B.M.4
-
41
-
-
79952280229
-
P53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase
-
Jiang P., Du W., Wang X., Mancuso A., Gao X., Wu M., Yang X. p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase. Nat. Cell Biol. 2011, 13:310-316.
-
(2011)
Nat. Cell Biol.
, vol.13
, pp. 310-316
-
-
Jiang, P.1
Du, W.2
Wang, X.3
Mancuso, A.4
Gao, X.5
Wu, M.6
Yang, X.7
-
42
-
-
43649093915
-
Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway
-
Kaelin W.G., Ratcliffe P.J. Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. Mol. Cell 2008, 30:393-402.
-
(2008)
Mol. Cell
, vol.30
, pp. 393-402
-
-
Kaelin, W.G.1
Ratcliffe, P.J.2
-
43
-
-
0027438281
-
Isotopomer studies of gluconeogenesis and the Krebs cycle with 13C-labeled lactate
-
Katz J., Wals P., Lee W.N. Isotopomer studies of gluconeogenesis and the Krebs cycle with 13C-labeled lactate. J. Biol. Chem. 1993, 268:25509-25521.
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 25509-25521
-
-
Katz, J.1
Wals, P.2
Lee, W.N.3
-
44
-
-
1642306943
-
Profiling substrate fluxes in the isolated working mouse heart using 13C-labeled substrates: focusing on the origin and fate of pyruvate and citrate carbons
-
Khairallah M., Labarthe F., Bouchard B., Danialou G., Petrof B.J., Des Rosiers C. Profiling substrate fluxes in the isolated working mouse heart using 13C-labeled substrates: focusing on the origin and fate of pyruvate and citrate carbons. Am. J. Physiol. Heart Circ. Physiol. 2004, 286:H1461-H1470.
-
(2004)
Am. J. Physiol. Heart Circ. Physiol.
, vol.286
-
-
Khairallah, M.1
Labarthe, F.2
Bouchard, B.3
Danialou, G.4
Petrof, B.J.5
Des Rosiers, C.6
-
45
-
-
33644614520
-
HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia
-
Kim J.W., Tchernyshyov I., Semenza G.L., Dang C.V. HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. Cell Metab. 2006, 3:177-185.
-
(2006)
Cell Metab.
, vol.3
, pp. 177-185
-
-
Kim, J.W.1
Tchernyshyov, I.2
Semenza, G.L.3
Dang, C.V.4
-
46
-
-
84862776918
-
Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation
-
Koivunen P., Lee S., Duncan C.G., Lopez G., Lu G., Ramkissoon S., Losman J.A., Joensuu P., Bergmann U., Gross S., et al. Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation. Nature 2012, 483:484-488.
-
(2012)
Nature
, vol.483
, pp. 484-488
-
-
Koivunen, P.1
Lee, S.2
Duncan, C.G.3
Lopez, G.4
Lu, G.5
Ramkissoon, S.6
Losman, J.A.7
Joensuu, P.8
Bergmann, U.9
Gross, S.10
-
47
-
-
0013998644
-
The regulation of the release of ketone bodies by the liver
-
Krebs H.A. The regulation of the release of ketone bodies by the liver. Adv. Enzyme Regul. 1966, 4:339-354.
-
(1966)
Adv. Enzyme Regul.
, vol.4
, pp. 339-354
-
-
Krebs, H.A.1
-
48
-
-
80052338863
-
Glutamine synthetase is a genetic determinant of cell type-specific glutamine independence in breast epithelia
-
Kung H.N., Marks J.R., Chi J.T. Glutamine synthetase is a genetic determinant of cell type-specific glutamine independence in breast epithelia. PLoS Genet. 2011, 7:e1002229.
-
(2011)
PLoS Genet.
, vol.7
-
-
Kung, H.N.1
Marks, J.R.2
Chi, J.T.3
-
49
-
-
0028985271
-
Use of 2H2O for estimating rates of gluconeogenesis. Application to the fasted state
-
Landau B.R., Wahren J., Chandramouli V., Schumann W.C., Ekberg K., Kalhan S.C. Use of 2H2O for estimating rates of gluconeogenesis. Application to the fasted state. J. Clin. Invest. 1995, 95:172-178.
-
(1995)
J. Clin. Invest.
, vol.95
, pp. 172-178
-
-
Landau, B.R.1
Wahren, J.2
Chandramouli, V.3
Schumann, W.C.4
Ekberg, K.5
Kalhan, S.C.6
-
50
-
-
84855453655
-
Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells
-
Le A., Lane A.N., Hamaker M., Bose S., Gouw A., Barbi J., Tsukamoto T., Rojas C.J., Slusher B.S., Zhang H., et al. Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells. Cell Metab. 2012, 15:110-121.
-
(2012)
Cell Metab.
, vol.15
, pp. 110-121
-
-
Le, A.1
Lane, A.N.2
Hamaker, M.3
Bose, S.4
Gouw, A.5
Barbi, J.6
Tsukamoto, T.7
Rojas, C.J.8
Slusher, B.S.9
Zhang, H.10
-
51
-
-
0031804597
-
Mass isotopomer study of the nonoxidative pathways of the pentose cycle with [1,2-13C2]glucose
-
Lee W.N., Boros L.G., Puigjaner J., Bassilian S., Lim S., Cascante M. Mass isotopomer study of the nonoxidative pathways of the pentose cycle with [1,2-13C2]glucose. Am. J. Physiol. 1998, 274:E843-E851.
-
(1998)
Am. J. Physiol.
, vol.274
-
-
Lee, W.N.1
Boros, L.G.2
Puigjaner, J.3
Bassilian, S.4
Lim, S.5
Cascante, M.6
-
52
-
-
79953755370
-
AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice
-
Li Y., Xu S., Mihaylova M.M., Zheng B., Hou X., Jiang B., Park O., Luo Z., Lefai E., Shyy J.Y., et al. AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice. Cell Metab. 2011, 13:376-388.
-
(2011)
Cell Metab.
, vol.13
, pp. 376-388
-
-
Li, Y.1
Xu, S.2
Mihaylova, M.M.3
Zheng, B.4
Hou, X.5
Jiang, B.6
Park, O.7
Luo, Z.8
Lefai, E.9
Shyy, J.Y.10
-
53
-
-
0030823179
-
Chronic effect of fatty acids on insulin release is not through the alteration of glucose metabolism in a pancreatic beta-cell line (beta HC9)
-
Liang Y., Buettger C., Berner D.K., Matschinsky F.M. Chronic effect of fatty acids on insulin release is not through the alteration of glucose metabolism in a pancreatic beta-cell line (beta HC9). Diabetologia 1997, 40:1018-1027.
-
(1997)
Diabetologia
, vol.40
, pp. 1018-1027
-
-
Liang, Y.1
Buettger, C.2
Berner, D.K.3
Matschinsky, F.M.4
-
54
-
-
84858796262
-
IDH mutation impairs histone demethylation and results in a block to cell differentiation
-
Lu C., Ward P.S., Kapoor G.S., Rohle D., Turcan S., Abdel-Wahab O., Edwards C.R., Khanin R., Figueroa M.E., Melnick A., et al. IDH mutation impairs histone demethylation and results in a block to cell differentiation. Nature 2012, 483:474-478.
-
(2012)
Nature
, vol.483
, pp. 474-478
-
-
Lu, C.1
Ward, P.S.2
Kapoor, G.S.3
Rohle, D.4
Turcan, S.5
Abdel-Wahab, O.6
Edwards, C.R.7
Khanin, R.8
Figueroa, M.E.9
Melnick, A.10
-
55
-
-
12944303650
-
Growth factor regulation of autophagy and cell survival in the absence of apoptosis
-
Lum J.J., Bauer D.E., Kong M., Harris M.H., Li C., Lindsten T., Thompson C.B. Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell 2005, 120:237-248.
-
(2005)
Cell
, vol.120
, pp. 237-248
-
-
Lum, J.J.1
Bauer, D.E.2
Kong, M.3
Harris, M.H.4
Li, C.5
Lindsten, T.6
Thompson, C.B.7
-
56
-
-
44449177159
-
Identification of metabolic fluxes in hepatic cells from transient 13C-labeling experiments: Part II. Flux estimation
-
Maier K., Hofmann U., Reuss M., Mauch K. Identification of metabolic fluxes in hepatic cells from transient 13C-labeling experiments: Part II. Flux estimation. Biotechnol. Bioeng. 2008, 100:355-370.
-
(2008)
Biotechnol. Bioeng.
, vol.100
, pp. 355-370
-
-
Maier, K.1
Hofmann, U.2
Reuss, M.3
Mauch, K.4
-
57
-
-
84862016091
-
Analysis of tumor metabolism reveals mitochondrial glucose oxidation in genetically diverse human glioblastomas in the mouse brain in vivo
-
Marin-Valencia I., Yang C., Mashimo T., Cho S., Baek H., Yang X.L., Rajagopalan K.N., Maddie M., Vemireddy V., Zhao Z., et al. Analysis of tumor metabolism reveals mitochondrial glucose oxidation in genetically diverse human glioblastomas in the mouse brain in vivo. Cell Metab. 2012, 15:827-837.
-
(2012)
Cell Metab.
, vol.15
, pp. 827-837
-
-
Marin-Valencia, I.1
Yang, C.2
Mashimo, T.3
Cho, S.4
Baek, H.5
Yang, X.L.6
Rajagopalan, K.N.7
Maddie, M.8
Vemireddy, V.9
Zhao, Z.10
-
58
-
-
82755168823
-
Flux through hepatic pyruvate carboxylase and phosphoenolpyruvate carboxykinase detected by hyperpolarized 13C magnetic resonance
-
Merritt M.E., Harrison C., Sherry A.D., Malloy C.R., Burgess S.C. Flux through hepatic pyruvate carboxylase and phosphoenolpyruvate carboxykinase detected by hyperpolarized 13C magnetic resonance. Proc. Natl. Acad. Sci. USA 2011, 108:19084-19089.
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 19084-19089
-
-
Merritt, M.E.1
Harrison, C.2
Sherry, A.D.3
Malloy, C.R.4
Burgess, S.C.5
-
59
-
-
70449519259
-
Evaluation of 13C isotopic tracers for metabolic flux analysis in mammalian cells
-
Metallo C.M., Walther J.L., Stephanopoulos G. Evaluation of 13C isotopic tracers for metabolic flux analysis in mammalian cells. J. Biotechnol. 2009, 144:167-174.
-
(2009)
J. Biotechnol.
, vol.144
, pp. 167-174
-
-
Metallo, C.M.1
Walther, J.L.2
Stephanopoulos, G.3
-
60
-
-
84856014884
-
Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia
-
Metallo C.M., Gameiro P.A., Bell E.L., Mattaini K.R., Yang J., Hiller K., Jewell C.M., Johnson Z.R., Irvine D.J., Guarente L., et al. Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia. Nature 2012, 481:380-384.
-
(2012)
Nature
, vol.481
, pp. 380-384
-
-
Metallo, C.M.1
Gameiro, P.A.2
Bell, E.L.3
Mattaini, K.R.4
Yang, J.5
Hiller, K.6
Jewell, C.M.7
Johnson, Z.R.8
Irvine, D.J.9
Guarente, L.10
-
61
-
-
84863764614
-
Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming
-
Mitsuishi Y., Taguchi K., Kawatani Y., Shibata T., Nukiwa T., Aburatani H., Yamamoto M., Motohashi H. Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming. Cancer Cell 2012, 22:66-79.
-
(2012)
Cancer Cell
, vol.22
, pp. 66-79
-
-
Mitsuishi, Y.1
Taguchi, K.2
Kawatani, Y.3
Shibata, T.4
Nukiwa, T.5
Aburatani, H.6
Yamamoto, M.7
Motohashi, H.8
-
62
-
-
84855987831
-
Reductive carboxylation supports growth in tumour cells with defective mitochondria
-
Mullen A.R., Wheaton W.W., Jin E.S., Chen P.H., Sullivan L.B., Cheng T., Yang Y., Linehan W.M., Chandel N.S., DeBerardinis R.J. Reductive carboxylation supports growth in tumour cells with defective mitochondria. Nature 2012, 481:385-388.
-
(2012)
Nature
, vol.481
, pp. 385-388
-
-
Mullen, A.R.1
Wheaton, W.W.2
Jin, E.S.3
Chen, P.H.4
Sullivan, L.B.5
Cheng, T.6
Yang, Y.7
Linehan, W.M.8
Chandel, N.S.9
DeBerardinis, R.J.10
-
63
-
-
53649110425
-
Systems-level metabolic flux profiling identifies fatty acid synthesis as a target for antiviral therapy
-
Munger J., Bennett B.D., Parikh A., Feng X.J., McArdle J., Rabitz H.A., Shenk T., Rabinowitz J.D. Systems-level metabolic flux profiling identifies fatty acid synthesis as a target for antiviral therapy. Nat. Biotechnol. 2008, 26:1179-1186.
-
(2008)
Nat. Biotechnol.
, vol.26
, pp. 1179-1186
-
-
Munger, J.1
Bennett, B.D.2
Parikh, A.3
Feng, X.J.4
McArdle, J.5
Rabitz, H.A.6
Shenk, T.7
Rabinowitz, J.D.8
-
64
-
-
84872376676
-
Isotopically nonstationary (13)C flux analysis of Myc-induced metabolic reprogramming in B-cells
-
Murphy T.A., Dang C.V., Young J.D. Isotopically nonstationary (13)C flux analysis of Myc-induced metabolic reprogramming in B-cells. Metab. Eng. 2013, 15:206-217.
-
(2013)
Metab. Eng.
, vol.15
, pp. 206-217
-
-
Murphy, T.A.1
Dang, C.V.2
Young, J.D.3
-
65
-
-
0018691116
-
Theoretical principles in the approaches to control of metabolic pathways and their application to glycolysis in muscle
-
Newsholme E.A., Crabtree B. Theoretical principles in the approaches to control of metabolic pathways and their application to glycolysis in muscle. J. Mol. Cell. Cardiol. 1979, 11:839-856.
-
(1979)
J. Mol. Cell. Cardiol.
, vol.11
, pp. 839-856
-
-
Newsholme, E.A.1
Crabtree, B.2
-
66
-
-
79959338922
-
AMPK is a direct adenylate charge-regulated protein kinase
-
Oakhill J.S., Steel R., Chen Z.P., Scott J.W., Ling N., Tam S., Kemp B.E. AMPK is a direct adenylate charge-regulated protein kinase. Science 2011, 332:1433-1435.
-
(2011)
Science
, vol.332
, pp. 1433-1435
-
-
Oakhill, J.S.1
Steel, R.2
Chen, Z.P.3
Scott, J.W.4
Ling, N.5
Tam, S.6
Kemp, B.E.7
-
67
-
-
33644622570
-
HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption
-
Papandreou I., Cairns R.A., Fontana L., Lim A.L., Denko N.C. HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption. Cell Metab. 2006, 3:187-197.
-
(2006)
Cell Metab.
, vol.3
, pp. 187-197
-
-
Papandreou, I.1
Cairns, R.A.2
Fontana, L.3
Lim, A.L.4
Denko, N.C.5
-
68
-
-
50049117073
-
A 13C isotope labeling strategy reveals the influence of insulin signaling on lipogenesis in C. elegans
-
Perez C.L., Van Gilst M.R. A 13C isotope labeling strategy reveals the influence of insulin signaling on lipogenesis in C. elegans. Cell Metab. 2008, 8:266-274.
-
(2008)
Cell Metab.
, vol.8
, pp. 266-274
-
-
Perez, C.L.1
Van Gilst, M.R.2
-
69
-
-
0029043852
-
6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase: a metabolic signaling enzyme
-
Pilkis S.J., Claus T.H., Kurland I.J., Lange A.J. 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase: a metabolic signaling enzyme. Annu. Rev. Biochem. 1995, 64:799-835.
-
(1995)
Annu. Rev. Biochem.
, vol.64
, pp. 799-835
-
-
Pilkis, S.J.1
Claus, T.H.2
Kurland, I.J.3
Lange, A.J.4
-
70
-
-
0033392917
-
Zonation of acetate labeling across the liver: implications for studies of lipogenesis by MIDA
-
Puchowicz M.A., Bederman I.R., Comte B., Yang D., David F., Stone E., Jabbour K., Wasserman D.H., Brunengraber H. Zonation of acetate labeling across the liver: implications for studies of lipogenesis by MIDA. Am. J. Physiol. 1999, 277:E1022-E1027.
-
(1999)
Am. J. Physiol.
, vol.277
-
-
Puchowicz, M.A.1
Bederman, I.R.2
Comte, B.3
Yang, D.4
David, F.5
Stone, E.6
Jabbour, K.7
Wasserman, D.H.8
Brunengraber, H.9
-
71
-
-
76749123832
-
Metabolic flux analysis in mammalian cell culture
-
Quek L.E., Dietmair S., Krömer J.O., Nielsen L.K. Metabolic flux analysis in mammalian cell culture. Metab. Eng. 2010, 12:161-171.
-
(2010)
Metab. Eng.
, vol.12
, pp. 161-171
-
-
Quek, L.E.1
Dietmair, S.2
Krömer, J.O.3
Nielsen, L.K.4
-
72
-
-
9244228937
-
Endocrine control of metabolism
-
Randle P.J. Endocrine control of metabolism. Annu. Rev. Physiol. 1963, 25:291-324.
-
(1963)
Annu. Rev. Physiol.
, vol.25
, pp. 291-324
-
-
Randle, P.J.1
-
73
-
-
34247131735
-
Pyruvate dehydrogenase kinase regulatory mechanisms and inhibition in treating diabetes, heart ischemia, and cancer
-
Roche T.E., Hiromasa Y. Pyruvate dehydrogenase kinase regulatory mechanisms and inhibition in treating diabetes, heart ischemia, and cancer. Cell. Mol. Life Sci. 2007, 64:830-849.
-
(2007)
Cell. Mol. Life Sci.
, vol.64
, pp. 830-849
-
-
Roche, T.E.1
Hiromasa, Y.2
-
74
-
-
80052592013
-
Mesenchymal stem cells induce resistance to chemotherapy through the release of platinum-induced fatty acids
-
Roodhart J.M., Daenen L.G., Stigter E.C., Prins H.J., Gerrits J., Houthuijzen J.M., Gerritsen M.G., Schipper H.S., Backer M.J., van Amersfoort M., et al. Mesenchymal stem cells induce resistance to chemotherapy through the release of platinum-induced fatty acids. Cancer Cell 2011, 20:370-383.
-
(2011)
Cancer Cell
, vol.20
, pp. 370-383
-
-
Roodhart, J.M.1
Daenen, L.G.2
Stigter, E.C.3
Prins, H.J.4
Gerrits, J.5
Houthuijzen, J.M.6
Gerritsen, M.G.7
Schipper, H.S.8
Backer, M.J.9
van Amersfoort, M.10
-
75
-
-
84864767268
-
Functional metabolic screen identifies 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 as an important regulator of prostate cancer cell survival
-
Ros S., Santos C.R., Moco S., Baenke F., Kelly G., Howell M., Zamboni N., Schulze A. Functional metabolic screen identifies 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 as an important regulator of prostate cancer cell survival. Cancer Discov. 2012, 2:328-343.
-
(2012)
Cancer Discov.
, vol.2
, pp. 328-343
-
-
Ros, S.1
Santos, C.R.2
Moco, S.3
Baenke, F.4
Kelly, G.5
Howell, M.6
Zamboni, N.7
Schulze, A.8
-
76
-
-
0016410664
-
Muscle amino acid metabolism and gluconeogenesis
-
Ruderman N.B. Muscle amino acid metabolism and gluconeogenesis. Annu. Rev. Med. 1975, 26:245-258.
-
(1975)
Annu. Rev. Med.
, vol.26
, pp. 245-258
-
-
Ruderman, N.B.1
-
77
-
-
0035856949
-
Insulin signalling and the regulation of glucose and lipid metabolism
-
Saltiel A.R., Kahn C.R. Insulin signalling and the regulation of glucose and lipid metabolism. Nature 2001, 414:799-806.
-
(2001)
Nature
, vol.414
, pp. 799-806
-
-
Saltiel, A.R.1
Kahn, C.R.2
-
78
-
-
84866480031
-
D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function
-
Sasaki M., Knobbe C.B., Itsumi M., Elia A.J., Harris I.S., Chio I.I., Cairns R.A., McCracken S., Wakeham A., Haight J., et al. D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function. Genes Dev. 2012, 26:2038-2049.
-
(2012)
Genes Dev.
, vol.26
, pp. 2038-2049
-
-
Sasaki, M.1
Knobbe, C.B.2
Itsumi, M.3
Elia, A.J.4
Harris, I.S.5
Chio, I.I.6
Cairns, R.A.7
McCracken, S.8
Wakeham, A.9
Haight, J.10
-
79
-
-
84865520089
-
IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics
-
Sasaki M., Knobbe C.B., Munger J.C., Lind E.F., Brenner D., Brüstle A., Harris I.S., Holmes R., Wakeham A., Haight J., et al. IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics. Nature 2012, 488:656-659.
-
(2012)
Nature
, vol.488
, pp. 656-659
-
-
Sasaki, M.1
Knobbe, C.B.2
Munger, J.C.3
Lind, E.F.4
Brenner, D.5
Brüstle, A.6
Harris, I.S.7
Holmes, R.8
Wakeham, A.9
Haight, J.10
-
80
-
-
33846061120
-
Metabolic networks in motion: 13C-based flux analysis
-
Sauer U. Metabolic networks in motion: 13C-based flux analysis. Mol. Syst. Biol. 2006, 2:62.
-
(2006)
Mol. Syst. Biol.
, vol.2
, pp. 62
-
-
Sauer, U.1
-
81
-
-
82755183511
-
Comparative metabolic flux profiling of melanoma cell lines: beyond the Warburg effect
-
Scott D.A., Richardson A.D., Filipp F.V., Knutzen C.A., Chiang G.G., Ronai Z.A., Osterman A.L., Smith J.W. Comparative metabolic flux profiling of melanoma cell lines: beyond the Warburg effect. J. Biol. Chem. 2011, 286:42626-42634.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 42626-42634
-
-
Scott, D.A.1
Richardson, A.D.2
Filipp, F.V.3
Knutzen, C.A.4
Chiang, G.G.5
Ronai, Z.A.6
Osterman, A.L.7
Smith, J.W.8
-
82
-
-
80054737427
-
Itaconic acid is a mammalian metabolite induced during macrophage activation
-
Strelko C.L., Lu W., Dufort F.J., Seyfried T.N., Chiles T.C., Rabinowitz J.D., Roberts M.F. Itaconic acid is a mammalian metabolite induced during macrophage activation. J. Am. Chem. Soc. 2011, 133:16386-16389.
-
(2011)
J. Am. Chem. Soc.
, vol.133
, pp. 16386-16389
-
-
Strelko, C.L.1
Lu, W.2
Dufort, F.J.3
Seyfried, T.N.4
Chiles, T.C.5
Rabinowitz, J.D.6
Roberts, M.F.7
-
83
-
-
82955239838
-
Excessive hepatic mitochondrial TCA cycle and gluconeogenesis in humans with nonalcoholic fatty liver disease
-
Sunny N.E., Parks E.J., Browning J.D., Burgess S.C. Excessive hepatic mitochondrial TCA cycle and gluconeogenesis in humans with nonalcoholic fatty liver disease. Cell Metab. 2011, 14:804-810.
-
(2011)
Cell Metab.
, vol.14
, pp. 804-810
-
-
Sunny, N.E.1
Parks, E.J.2
Browning, J.D.3
Burgess, S.C.4
-
84
-
-
66149146320
-
Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1
-
Tahiliani M., Koh K.P., Shen Y., Pastor W.A., Bandukwala H., Brudno Y., Agarwal S., Iyer L.M., Liu D.R., Aravind L., Rao A. Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science 2009, 324:930-935.
-
(2009)
Science
, vol.324
, pp. 930-935
-
-
Tahiliani, M.1
Koh, K.P.2
Shen, Y.3
Pastor, W.A.4
Bandukwala, H.5
Brudno, Y.6
Agarwal, S.7
Iyer, L.M.8
Liu, D.R.9
Aravind, L.10
Rao, A.11
-
85
-
-
70449624093
-
Reactivating HIF prolyl hydroxylases under hypoxia results in metabolic catastrophe and cell death
-
Tennant D.A., Frezza C., MacKenzie E.D., Nguyen Q.D., Zheng L., Selak M.A., Roberts D.L., Dive C., Watson D.G., Aboagye E.O., Gottlieb E. Reactivating HIF prolyl hydroxylases under hypoxia results in metabolic catastrophe and cell death. Oncogene 2009, 28:4009-4021.
-
(2009)
Oncogene
, vol.28
, pp. 4009-4021
-
-
Tennant, D.A.1
Frezza, C.2
MacKenzie, E.D.3
Nguyen, Q.D.4
Zheng, L.5
Selak, M.A.6
Roberts, D.L.7
Dive, C.8
Watson, D.G.9
Aboagye, E.O.10
Gottlieb, E.11
-
86
-
-
32844454603
-
Histone demethylation by a family of JmjC domain-containing proteins
-
Tsukada Y., Fang J., Erdjument-Bromage H., Warren M.E., Borchers C.H., Tempst P., Zhang Y. Histone demethylation by a family of JmjC domain-containing proteins. Nature 2006, 439:811-816.
-
(2006)
Nature
, vol.439
, pp. 811-816
-
-
Tsukada, Y.1
Fang, J.2
Erdjument-Bromage, H.3
Warren, M.E.4
Borchers, C.H.5
Tempst, P.6
Zhang, Y.7
-
87
-
-
66249108601
-
Understanding the Warburg effect: the metabolic requirements of cell proliferation
-
Vander Heiden M.G., Cantley L.C., Thompson C.B. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 2009, 324:1029-1033.
-
(2009)
Science
, vol.324
, pp. 1029-1033
-
-
Vander Heiden, M.G.1
Cantley, L.C.2
Thompson, C.B.3
-
88
-
-
77956674635
-
Evidence for an alternative glycolytic pathway in rapidly proliferating cells
-
Vander Heiden M.G., Locasale J.W., Swanson K.D., Sharfi H., Heffron G.J., Amador-Noguez D., Christofk H.R., Wagner G., Rabinowitz J.D., Asara J.M., Cantley L.C. Evidence for an alternative glycolytic pathway in rapidly proliferating cells. Science 2010, 329:1492-1499.
-
(2010)
Science
, vol.329
, pp. 1492-1499
-
-
Vander Heiden, M.G.1
Locasale, J.W.2
Swanson, K.D.3
Sharfi, H.4
Heffron, G.J.5
Amador-Noguez, D.6
Christofk, H.R.7
Wagner, G.8
Rabinowitz, J.D.9
Asara, J.M.10
Cantley, L.C.11
-
89
-
-
63849301000
-
AMPK: Lessons from transgenic and knockout animals
-
Viollet B., Athea Y., Mounier R., Guigas B., Zarrinpashneh E., Horman S., Lantier L., Hebrard S., Devin-Leclerc J., Beauloye C., et al. AMPK: Lessons from transgenic and knockout animals. Front. Biosci. 2009, 14:19-44.
-
(2009)
Front. Biosci.
, vol.14
, pp. 19-44
-
-
Viollet, B.1
Athea, Y.2
Mounier, R.3
Guigas, B.4
Zarrinpashneh, E.5
Horman, S.6
Lantier, L.7
Hebrard, S.8
Devin-Leclerc, J.9
Beauloye, C.10
-
90
-
-
84255199079
-
The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation
-
Wang R., Dillon C.P., Shi L.Z., Milasta S., Carter R., Finkelstein D., McCormick L.L., Fitzgerald P., Chi H., Munger J., Green D.R. The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation. Immunity 2011, 35:871-882.
-
(2011)
Immunity
, vol.35
, pp. 871-882
-
-
Wang, R.1
Dillon, C.P.2
Shi, L.Z.3
Milasta, S.4
Carter, R.5
Finkelstein, D.6
McCormick, L.L.7
Fitzgerald, P.8
Chi, H.9
Munger, J.10
Green, D.R.11
-
91
-
-
77649305610
-
The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate
-
Ward P.S., Patel J., Wise D.R., Abdel-Wahab O., Bennett B.D., Coller H.A., Cross J.R., Fantin V.R., Hedvat C.V., Perl A.E., et al. The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate. Cancer Cell 2010, 17:225-234.
-
(2010)
Cancer Cell
, vol.17
, pp. 225-234
-
-
Ward, P.S.1
Patel, J.2
Wise, D.R.3
Abdel-Wahab, O.4
Bennett, B.D.5
Coller, H.A.6
Cross, J.R.7
Fantin, V.R.8
Hedvat, C.V.9
Perl, A.E.10
-
92
-
-
83755178091
-
Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability
-
Wise D.R., Ward P.S., Shay J.E., Cross J.R., Gruber J.J., Sachdeva U.M., Platt J.M., DeMatteo R.G., Simon M.C., Thompson C.B. Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability. Proc. Natl. Acad. Sci. USA 2011, 108:19611-19616.
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 19611-19616
-
-
Wise, D.R.1
Ward, P.S.2
Shay, J.E.3
Cross, J.R.4
Gruber, J.J.5
Sachdeva, U.M.6
Platt, J.M.7
DeMatteo, R.G.8
Simon, M.C.9
Thompson, C.B.10
-
93
-
-
84862632865
-
Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors
-
Xiao M., Yang H., Xu W., Ma S., Lin H., Zhu H., Liu L., Liu Y., Yang C., Xu Y., et al. Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors. Genes Dev. 2012, 26:1326-1338.
-
(2012)
Genes Dev.
, vol.26
, pp. 1326-1338
-
-
Xiao, M.1
Yang, H.2
Xu, W.3
Ma, S.4
Lin, H.5
Zhu, H.6
Liu, L.7
Liu, Y.8
Yang, C.9
Xu, Y.10
-
94
-
-
78651463452
-
Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases
-
Xu W., Yang H., Liu Y., Yang Y., Wang P., Kim S.H., Ito S., Yang C., Wang P., Xiao M.T., et al. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. Cancer Cell 2011, 19:17-30.
-
(2011)
Cancer Cell
, vol.19
, pp. 17-30
-
-
Xu, W.1
Yang, H.2
Liu, Y.3
Yang, Y.4
Wang, P.5
Kim, S.H.6
Ito, S.7
Yang, C.8
Wang, P.9
Xiao, M.T.10
-
95
-
-
84865300414
-
Phosphofructokinase 1 glycosylation regulates cell growth and metabolism
-
Yi W., Clark P.M., Mason D.E., Keenan M.C., Hill C., Goddard W.A., Peters E.C., Driggers E.M., Hsieh-Wilson L.C. Phosphofructokinase 1 glycosylation regulates cell growth and metabolism. Science 2012, 337:975-980.
-
(2012)
Science
, vol.337
, pp. 975-980
-
-
Yi, W.1
Clark, P.M.2
Mason, D.E.3
Keenan, M.C.4
Hill, C.5
Goddard, W.A.6
Peters, E.C.7
Driggers, E.M.8
Hsieh-Wilson, L.C.9
-
96
-
-
84860321700
-
Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism
-
Ying H., Kimmelman A.C., Lyssiotis C.A., Hua S., Chu G.C., Fletcher-Sananikone E., Locasale J.W., Son J., Zhang H., Coloff J.L., et al. Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism. Cell 2012, 149:656-670.
-
(2012)
Cell
, vol.149
, pp. 656-670
-
-
Ying, H.1
Kimmelman, A.C.2
Lyssiotis, C.A.3
Hua, S.4
Chu, G.C.5
Fletcher-Sananikone, E.6
Locasale, J.W.7
Son, J.8
Zhang, H.9
Coloff, J.L.10
-
97
-
-
79551508527
-
13C metabolic flux analysis in complex systems
-
Zamboni N. 13C metabolic flux analysis in complex systems. Curr. Opin. Biotechnol. 2011, 22:103-108.
-
(2011)
Curr. Opin. Biotechnol.
, vol.22
, pp. 103-108
-
-
Zamboni, N.1
-
98
-
-
84862777168
-
Stromal control of cystine metabolism promotes cancer cell survival in chronic lymphocytic leukaemia
-
Zhang W., Trachootham D., Liu J., Chen G., Pelicano H., Garcia-Prieto C., Lu W., Burger J.A., Croce C.M., Plunkett W., et al. Stromal control of cystine metabolism promotes cancer cell survival in chronic lymphocytic leukaemia. Nat. Cell Biol. 2012, 14:276-286.
-
(2012)
Nat. Cell Biol.
, vol.14
, pp. 276-286
-
-
Zhang, W.1
Trachootham, D.2
Liu, J.3
Chen, G.4
Pelicano, H.5
Garcia-Prieto, C.6
Lu, W.7
Burger, J.A.8
Croce, C.M.9
Plunkett, W.10
-
99
-
-
77149148756
-
Regulation of cellular metabolism by protein lysine acetylation
-
Zhao S., Xu W., Jiang W., Yu W., Lin Y., Zhang T., Yao J., Zhou L., Zeng Y., Li H., et al. Regulation of cellular metabolism by protein lysine acetylation. Science 2010, 327:1000-1004.
-
(2010)
Science
, vol.327
, pp. 1000-1004
-
-
Zhao, S.1
Xu, W.2
Jiang, W.3
Yu, W.4
Lin, Y.5
Zhang, T.6
Yao, J.7
Zhou, L.8
Zeng, Y.9
Li, H.10
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