Identification and functional expression of the mitochondrial pyruvate carrier

Science

Volumn 336, Issue 6090, 2012, Pages 93-96

  Herzig, Sébastien ^a   Raemy, Etienne ^a   Montessuit, Sylvie ^a   Veuthey, Jean Luc ^a   Zamboni, Nicola ^b   Westermann, Benedikt ^c   Kunji, Edmund R S ^d   Martinou, Jean Claude ^a  

^a UNIVERSITY OF GENEVA   (Switzerland)

^b Institute of Molecular Systems Biology   (Switzerland)

^c UNIVERSITY OF BAYREUTH   (Germany)

^d MEDICAL RESEARCH COUNCIL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

MONOCARBOXYLATE TRANSPORTER 1; MONOCARBOXYLATE TRANSPORTER 2; ANION TRANSPORT PROTEIN; CARRIER PROTEIN; LEUCINE; MPC1 PYRUVATE CARRIER PROTEIN, S CEREVISIAE; MPC2 PROTEIN, S CEREVISIAE; MPC3 PROTEIN, S CEREVISIAE; PYRUVIC ACID; RECOMBINANT PROTEIN; SACCHAROMYCES CEREVISIAE PROTEIN; THIOCTIC ACID; VALINE;

BACTERIUM; ENZYME ACTIVITY; GENE EXPRESSION; IDENTIFICATION METHOD; MEMBRANE; MITOCHONDRION; PROTEIN;

ARTICLE; CONTROLLED STUDY; LACTOCOCCUS LACTIS; MAMMAL; MITOCHONDRION; MOUSE; MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN INTAKE; PROTON TRANSPORT; YEAST; AMINO ACID SEQUENCE; ANIMAL; BIOSYNTHESIS; CHEMISTRY; CULTURE MEDIUM; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; MITOCHONDRIAL MEMBRANE; MOLECULAR GENETICS; SACCHAROMYCES CEREVISIAE; TRANSPORT AT THE CELLULAR LEVEL;

LACTOCOCCUS LACTIS; MAMMALIA;

AMINO ACID SEQUENCE; ANIMALS; ANION TRANSPORT PROTEINS; BIOLOGICAL TRANSPORT; BIOSYNTHETIC PATHWAYS; CULTURE MEDIA; LACTOCOCCUS LACTIS; LEUCINE; MICE; MITOCHONDRIA; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; MITOCHONDRIAL MEMBRANES; MOLECULAR SEQUENCE DATA; PYRUVIC ACID; RECOMBINANT PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; THIOCTIC ACID; VALINE;

EID: 84863553135     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1218530     Document Type: Article

References (17)

1. J. K. Hiltunen, Z. Chen, A. M. Haapalainen, R. K. Wierenga, A. J. Kastaniotis, Prog. Lipid Res. 49, 27 (2010).
2. L. J. Reed, J. Biol. Chem. 276, 38329 (2001).
3. A. P. Halestrap, Biochem. J. 148, 85 (1975).
4. S. Da Cruz et al., J. Biol. Chem. 278, 41566 (2003).
5. D. K. Bricker et al., Science 337, 96 (2012).
6. J. R. Dickinson, I. W. Dawes, J. Gen. Microbiol. 138, 2029 (1992).
7. J. R. Dickinson, D. J. Roy, I. W. Dawes, Mol. Gen. Genet. 204, 103 (1986).
8. R. A. Harris, M. Joshi, N. H. Jeoung, M. Obayashi, J. Nutr. 135 (suppl.), 1527S (2005).
9. M. S. Schonauer, A. J. Kastaniotis, V. A. Kursu, J. K. Hiltunen, C. L. Dieckmann, J. Biol. Chem. 284, 23234 (2009).
10. J. E. Lawson, R. H. Behal, L. J. Reed, Biochemistry 30, 2834 (1991).
11. K. M. Humphries, L. I. Szweda, Biochemistry 37, 15835 (1998).
12. H. Wada, D. Shintani, J. Ohlrogge, Proc. Natl. Acad. Sci. U.S.A. 94, 1591 (1997).
13. U. Hoja et al., J. Biol. Chem. 279, 21779 (2004).
14. A. P. Halestrap, R. M. Denton, Biochem. J. 148, 97 (1975).
15. K. D. MacIsaac et al., BMC Bioinformatics 7, 113 (2006).
16. E. R. Kunji, D. J. Slotboom, B. Poolman, Biochim. Biophys. Acta 1610, 97 (2003).
17. E. R. Kunji, E. J. Smid, R. Plapp, B. Poolman, W. N. Konings, J. Bacteriol. 175, 2052 (1993).