A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans

Science

Volumn 336, Issue 6090, 2012, Pages 96-100

  Bricker, Daniel K ^a   Taylor, Eric B ^a   Schell, John C ^a   Orsak, Thomas ^a   Boutron, Audrey ^b   Chen, Yu Chan ^a   Cox, James E ^a   Cardon, Caleb M ^a   Van Vranken, Jonathan G ^a   Dephoure, Noah ^c   Redin, Claire ^d   Boudina, Sihem ^a   Gygi, Steven P ^c   Brivet, Michèle ^b   Thummel, Carl S ^a   Rutter, Jared ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b BICÊTRE HOSPITAL   (France)

^c HARVARD MEDICAL SCHOOL   (United States)

^d INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

MONOCARBOXYLATE TRANSPORTER 1; MONOCARBOXYLATE TRANSPORTER 2; PYRUVIC ACID; AMINO ACID; ANION TRANSPORT PROTEIN; CARRIER PROTEIN; DROSOPHILA PROTEIN; MITOCHONDRIAL PROTEIN; MPC1 PROTEIN, DROSOPHILA; MPC1 PROTEIN, HUMAN; MPC1 PYRUVATE CARRIER PROTEIN, S CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEIN;

AMINO ACID; CARBON; CARBOXYLIC ACID; CELL ORGANELLE; ENZYME ACTIVITY; EUKARYOTE; FLY; MEMBRANE; METABOLISM; MITOCHONDRION; OXIDATION; PROTEIN; YEAST;

ARTICLE; CITRIC ACID CYCLE; CONTROLLED STUDY; DEPLETION; DROSOPHILA; GENE EXPRESSION; GENE LOCUS; GENE SILENCING; HUMAN; HUMAN CELL; LACTIC ACIDOSIS; MAMMAL CELL; MITOCHONDRIAL MEMBRANE; MUTANT; NONHUMAN; OXIDATION; POINT MUTATION; PRIORITY JOURNAL; YEAST; AMINO ACID SEQUENCE; ANIMAL; CARBOHYDRATE METABOLISM; CHEMISTRY; DROSOPHILA MELANOGASTER; GENETICS; METABOLISM; METABOLOMICS; MITOCHONDRION; MOLECULAR GENETICS; OXIDATION REDUCTION REACTION; SACCHAROMYCES CEREVISIAE; TRANSPORT AT THE CELLULAR LEVEL;

EUKARYOTA; MAMMALIA;

AMINO ACID SEQUENCE; AMINO ACIDS; ANIMALS; ANION TRANSPORT PROTEINS; BIOLOGICAL TRANSPORT; CARBOHYDRATE METABOLISM; CITRIC ACID CYCLE; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; HUMANS; METABOLOMICS; MITOCHONDRIA; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; MITOCHONDRIAL MEMBRANES; MITOCHONDRIAL PROTEINS; MOLECULAR SEQUENCE DATA; OXIDATION-REDUCTION; POINT MUTATION; PYRUVIC ACID; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

EID: 84863552418     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1218099     Document Type: Article

References (20)

1. D. Hanahan, R. A. Weinberg, Cell 144, 646 (2011).
2. S. E. Kahn, R. L. Hull, K. M. Utzschneider, Nature 444, 840 (2006).
3. A. P. Halestrap, R. M. Denton, Biochem. J. 138, 313 (1974).
4. A. P. Halestrap, Biochem. J. 172, 377 (1978).
5. A. P. Halestrap, Biochem. J. 148, 85 (1975).
6. S. Todisco, G. Agrimi, A. Castegna, F. Palmieri, J. Biol. Chem. 281, 1524 (2006).
7. J. C. Hildyard, A. P. Halestrap, Biochem. J. 374, 607 (2003).
8. M. Jiang et al., Mol. Biol. Rep. 36, 215 (2009).
9. D. J. Pagliarini et al., Cell 134, 112 (2008).
10. A. Sickmann et al., Proc. Natl. Acad. Sci. U.S.A. 100, 13207 (2003).
11. H. Y. Steensma, L. Holterman, I. Dekker, C. A. van Sluis, T. J. Wenzel, Eur. J. Biochem. 191, 769 (1990).
12. E. Boles, P. de Jong-Gubbels, J. T. Pronk, J. Bacteriol. 180, 2875 (1998).
13. S. Papa, G. Paradies, Eur. J. Biochem. 49, 265 (1974).
14. M. Brivet et al., Mol. Genet. Metab. 78, 186 (2003).
15. A. P. Thomas, A. P. Halestrap, Biochem. J. 196, 471 (1981).
16. S. Herzig et al., Science 337, 93 (2012).
17. R. A. Harris, M. M. Bowker-Kinley, B. Huang, P. Wu, Adv. Enzyme Regul. 42, 249 (2002).
18. F. M. Zwiebel, U. Schwabe, M. S. Olson, R. Scholz, Biochemistry 21, 346 (1982).
19. R. Rognstad, Int. J. Biochem. 15, 1417 (1983).
20. Materials and methods are available as supplementary materials on Science Online.