Estrogen-responsive genes for environmental studies

Environmental Technology and Innovation

Volumn 1-2, Issue C, 2014, Pages 16-28

  Kiyama, Ryoiti ^a   Zhu, Yun ^a,b   Kawaguchi, Kayoko ^a   Iitake, Nobuko ^a   Wada Kiyama, Yuko ^c   Dong, Sijun ^d  

^a NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

^b Scinet Company   (Japan)

^c NIPPON MEDICAL SCHOOL   (Japan)

^d INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

Author keywords

DNA microarray; Endocrine disruptor; Estrogen responsive gene; Gene expression proofing; Signal transduction; Toxicity pathway

Indexed keywords

EID: 84927731020     PISSN: None     EISSN: 23521864     Source Type: Journal    
DOI: 10.1016/j.eti.2014.09.001     Document Type: Article

References (226)

1. Ahmad-Annuar A., Ciani L., Simeonidis I., Herreros J., Fredj N.B., Rosso S.B., et al. Signaling across the synapse: a role for Wnt and Dishevelled in presynaptic assembly and neurotransmitter release. J Cell Biol 2006, 174:127-139.
2. Aimola P., Carmignani M., Volpe A.R., Di Benedetto A., Claudio L., Waalkes M.P., et al. Cadmium induces p53-dependent apoptosis in human prostate epithelial cells. PLoS One 2012, 7:e33647.
3. Almeida M., Han L., Martin-Millan M., Plotkin L.I., Stewart S.A., Roberson P.K., et al. Skeletal involution by age-associated oxidative stress and its acceleration by loss of sex steroids. J Biol Chem 2007, 282:27285-27297.
4. Ammann P., Rizzoli R., Bonjour J.P., Bourrin S., Meyer J.M., Vassalli P., et al. Transgenic mice expressing soluble tumor necrosis factor-receptor are protected against bone loss caused by estrogen deficiency. J Clin Invest 1997, 99:1699-1703.
5. Andreev D.E., Hirnet J., Terenin I.M., Dmitriev S.E., Niepmann M., Shatsky I.N. Glycyl-tRNA synthetase specifically binds to the poliovirus IRES to activate translation initiation. Nucleic Acids Res 2012, 40:5602-5614.
6. Arlt A., Schäfer H. Role of the immediate early response 3 (IER3) gene in cellular stress response, inflammation and tumorigenesis. Eur J Cell Biol 2011, 90:545-552.
7. Ayoub N., Jeyasekharan A.D., Bernal J.A., Venkitaraman A.R. HP1-beta mobilization promotes chromatin changes that initiate the DNA damage response. Nature 2008, 453:682-686.
8. Baba K., Okada K., Kinoshita T., Imaoka S. Bisphenol A disrupts Notch signaling by inhibiting gamma-secretase activity and causes eye dysplasia of Xenopus laevis. Toxicol Sci 2009, 108:344-355.
9. Balasubramanian S., Efimova T., Eckert R.L. Green tea polyphenol stimulates a Ras, MEKK1, MEK3, and p38 cascade to increase activator protein 1 factor-dependent involucrin gene expression in normal human keratinocytes. J Biol Chem 2002, 277:1828-1836.
10. Balasubramanian M.N., Shan J., Kilberg M.S. Dynamic changes in genomic histone association and modification during activation of the ASNS and ATF3 genes by amino acid limitation. Biochem J 2013, 449:219-229.
11. Balthazart J., Ball G.F. Is brain estradiol a hormone or a neurotransmitter?. Trends Neurosci 2006, 29:241-249.
12. Bareiss S., Kim K., Lu Q. Delta-catenin/NPRAP: A new member of the glycogen synthase kinase-3beta signaling complex that promotes beta-catenin turnover in neurons. J Neurosci Res 2010, 88:2350-2363.
13. Barros R.P., Gustafsson J.Å Estrogen receptors and the metabolic network. Cell Metab 2011, 14:289-299.
14. Bassermann F., Frescas D., Guardavaccaro D., Busino L., Peschiaroli A., Pagano M. The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint. Cell 2008, 134:256-267.
15. Beecher G.R. Overview of dietary flavonoids: nomenclature, occurrence and intake. J Nutr 2003, 133. 3248S-54S.
16. Bharathi S.P., Raj H.M., Jain S., Banerjee B.D., Ahmed T., Arora V.K. Role of pesticides in the induction of tumor angiogenesis. Anticancer Res 2013, 33:231-240.
17. Bigsby R., Chapin R.E., Daston G.P., Davis B.J., Gorski J., Gray L.E., et al. Evaluating the effects of endocrine disruptors on endocrine function during development. Environ Health Perspect 1999, 107(Suppl 4):613-618.
18. Bishop P.L., Manuppello J.R., Willett C.E., Sandler J.T. Animal use and lessons learned in the U.S. high production volume chemicals challenge program. Environ Health Perspect 2012, 120:1631-1639.
19. Blesson C.S., Sahlin L. Expression pattern and signalling pathways in neutrophil like HL-60 cells after treatment with estrogen receptor selective ligands. Mol Cell Endocrinol 2012, 361:179-190.
20. Boreddy S.R., Sahu R.P., Srivastava S.K. Benzyl isothiocyanate suppresses pancreatic tumor angiogenesis and invasion by inhibiting HIF-α/VEGF/Rho-GTPases: pivotal role of STAT-3. PLoS One 2011, 6:e25799.
21. Buckley N.E., Nic An tSaoir C.B., Blayney J.K., Oram L.C., Crawford N.T., D'Costa Z.C., et al. BRCA1 is a key regulator of breast differentiation through activation of Notch signalling with implications for anti-endocrine treatment of breast cancers. Nucleic Acids Res 2013, 41:8601-8614.
22. Carrillo-García C., Prochnow S., Simeonova I.K., Strelau J., Hölzl-Wenig G., Mandl C., et al. Growth/differentiation factor 15 promotes EGFR signalling, and regulates proliferation and migration in the hippocampus of neonatal and young adult mice. Development 2014, 141:773-783.
23. Casati L., Sendra R., Poletti A., Negri-Cesi P., Celotti F. Androgen receptor activation by polychlorinated biphenyls: epigenetic effects mediated by the histone demethylase Jarid1b. Epigenetics 2013, 8:1061-1068.
24. Caserta D., Maranghi L., Mantovani A., Marci R., Maranghi F., Moscarini M. Impact of endocrine disruptor chemicals in gynaecology. Hum Reprod Update 2008, 14:59-72.
25. Casimiro M.C., Wang C., Li Z., Di Sante G., Willmart N.E., Addya S., et al. Cyclin D1 determines estrogen signaling in the mammary gland in vivo. Mol Endocrinol 2013, 27:1415-1428.
26. Castets P., Rüegg M.A. MTORC1 determines autophagy through ULK1 regulation in skeletal muscle. Autophagy 2013, 9:1435-1437.
27. Cenci S., Weitzmann M.N., Gentile M.A., Aisa M.C., Pacifici R. M-CSF neutralization and egr-1 deficiency prevent ovariectomy-induced bone loss. J Clin Invest 2000, 105:1279-1287.
28. Chang J., Wang Z., Tang E., Fan Z., McCauley L., Franceschi R., et al. Inhibition of osteoblastic bone formation by nuclear factor-kappaB. Nat Med 2009, 15:682-689.
29. Charatcharoenwitthaya N., Khosla S., Atkinson E.J., McCready L.K., Riggs B.L. Effect of blockade of TNF-alpha and interleukin-1 action on bone resorption in early postmenopausal women. J Bone Miner Res 2007, 22:724-729.
30. Charles G.D. In vitro models in endocrine disruptor screening. ILAR J 2004, 45:494-501.
31. Chen X., Qin Q., Zhang W., Zhang Y., Zheng H., Liu C., et al. Activation of the PI3K-AKT-mTOR signaling pathway promotes DEHP-induced Hep3B cell proliferation. Food Chem Toxicol 2013, 59:325-333.
32. Chen L., Xu B., Liu L., Luo Y., Zhou H., Chen W., et al. Cadmium induction of reactive oxygen species activates the mTOR pathway, leading to neuronal cell death. Free Radic Biol Med 2011, 50:624-632.
33. Chepelev N.L., Enikanolaiye M.I., Chepelev L.L., Almohaisen A., Chen Q., Scoggan K.A., et al. Bisphenol A activates the Nrf1/2-antioxidant response element pathway in HEK 293 cells. Chem Res Toxicol 2013, 26:498-506.
34. Choe B.I., Lee G.H. Searching and review on the three Rs information in Korea: time for quality assessment and continued education. BMB Rep 2013, 46:335-337.
35. Cocci P., Mosconi G., Palermo F.A. Effects of 4-nonylphenol on hepatic gene expression of peroxisome proliferator -activated receptors and cytochrome P450 isoforms (CYP1A1 and CYP3A4) in juvenile sole (Solea solea). Chemosphere 2013, 93:1176-1181.
36. Conneely O.M., Sullivan W.P., Toft D.O., Birnbaumer M., Cook R.G., Maxwell B.L., et al. Molecular cloning of the chicken progesterone receptor. Science 1986, 233:767-770.
37. Cordero-Herrera I., Martín M.A., Bravo L., Goya L., Ramos S. Epicatechin gallate induces cell death via p53 activation and stimulation of p38 and JNK in human colon cancer SW480 cells. Nutr Cancer 2013, 65:718-728.
38. Coughlan N., Thillainadesan G., Andrews J., Isovic M., Torchia J. β-Estradiol-dependent activation of the JAK/STAT pathway requires p/CIP and CARM1. Biochim Biophys Acta 2013, 1833:1463-1475.
39. Crews D., McLachlan J.A. Epigenetics, evolution, endocrine disruption, health, and disease. Endocrinology 2006, 147:S4-S10.
40. de Bot S.T., Vermeer S., Buijsman W., Heister A., Voorendt M., Verrips A., et al. Pure adult-onset spastic paraplegia caused by a novel mutation in the KIAA0196 (SPG8) gene. J Neurol 2013, 260:1765-1769.
41. Diersch S., Wenzel P., Szameitat M., Eser P., Paul M.C., Seidler B., et al. Efemp1 and p27(Kip1) modulate responsiveness of pancreatic cancer cells towards a dual PI3K/mTOR inhibitor in preclinical models. Oncotarget 2013, 4:277-288.
42. Dong S., Terasaka S., Kiyama R. Bisphenol A induces a rapid activation of Erk1/2 through GPR30 in human breast cancer cells. Environ Pollut 2011, 159:212-218.
43. Fang C., Wu X., Huang Q., Liao Y., Liu L., Qiu L., et al. PFOS elicits transcriptional responses of the ER, AHR and PPAR pathways in Oryzias melastigma in a stage-specific manner. Aquat Toxicol 2012, 106-107:9-19.
44. Fauth E., Scherthan H., Zankl H. Chromosome painting reveals specific patterns of chromosome occurrence in mitomycin C- and diethylstilboestrol-induced micronuclei. Mutagenesis 2000, 15:459-467.
45. Fernandez S.V., Huang Y., Snider K.E., Zhou Y., Pogash T.J., Russo J. Expression and DNA methylation changes in human breast epithelial cells after bisphenol a exposure. Int J Oncol 2012, 41:369-377.
46. Forough R., Lindner L., Partridge C., Jones B., Guy G., Clark G. Elevated 80K-H protein in breast cancer: a role for FGF-1 stimulation of 80K-H. Int J Biol Markers 2003, 18:89-98.
47. Frontini M., Soutoglou E., Argentini M., Bole-Feysot C., Jost B., Scheer E., et al. TAF9b (formerly TAF9L) is a bona fide TAF that has unique and overlapping roles with TAF9. Mol Cell Biol 2005, 25:4638-4649.
48. Funabashi T., Kawaguchi M., Furuta M., Fukushima A., Kimura F. Exposure to bisphenol A during gestation and lactation causes loss of sex difference in corticotropin-releasing hormone-immunoreactive neurons in the bed nucleus of the stria terminalis of rats. Psychoneuroendocrinology 2004, 29:475-485.
49. Golub M.S., Hogrefe C.E., Germann S.L., Lasley B.L., Natarajan K., Tarantal A.F. Effects of exogenous estrogenic agents on pubertal growth and reproductive system maturation in female rhesus monkeys. Toxicol Sci 2003, 74:103-113.
50. Gong Y., Somwar R., Politi K., Balak M., Chmielecki J., Jiang X., et al. Induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas. PLoS Med 2007, 4:e294.
51. Gossner G., Choi M., Tan L., Fogoros S., Griffith K.A., Kuenker M., Liu J.R. Genistein-induced apoptosis and autophagocytosis in ovarian cancer cells. Gynecol Oncol 2007, 105:23-30.
52. Guichard C., Amaddeo G., Imbeaud S., Ladeiro Y., Pelletier L., Maad I.B., et al. Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma. Nat Genet 2012, 44:694-698.
53. Hahn S.S., Tang Q., Zheng F., Zhao S., Wu J., Chen J. Repression of integrin-linked kinase by antidiabetes drugs through cross-talk of PPARγ- and AMPKα-dependent signaling: role of AP-2α and Sp1. Cell Signal 2014, 26:639-647.
54. Han E.H., Kim J.Y., Kim H.K., Hwang Y.P., Jeong H.G. o, p'-DDT induces cyclooxygenase-2 gene expression in murine macrophages: Role of AP-1 and CRE promoter elements and PI3-kinase/Akt/MAPK signaling pathways. Toxicol Appl Pharmacol 2008, 233:333-342.
55. Hanson M.L., Brundage K.M., Schafer R., Tou J.C., Barnett J.B. Prenatal cadmium exposure dysregulates sonic hedgehog and Wnt/beta-catenin signaling in the thymus resulting in altered thymocyte development. Toxicol Appl Pharmacol 2010, 242:136-145.
56. He T., Stepulak A., Holmström T.H., Omary M.B., Eriksson J.E. The intermediate filament protein keratin 8 is a novel cytoplasmic substrate for c-Jun N-terminal kinase. J Biol Chem 2002, 277:10767-10774.
57. Heining E., Bhushan R., Paarmann P., Henis Y.I., Knaus P. Spatial segregation of BMP/Smad signaling affects osteoblast differentiation in C2C12 cells. PLoS One 2011, 6:e25163.
58. Hennigar S.R., Myers J.L., Tagliaferro A.R. Exposure of alveolar macrophages to polybrominated diphenyl ethers suppresses the release of pro-inflammatory products in vitro. Exp Biol Med 2012, 237:429-434.
59. Hinkelbein J., Feldmann R.E., Kalenka A. Time-dependent alterations of cerebral proteins following short-term normobaric hyperoxia. Mol Cell Biochem 2010, 339:9-21.
60. Hou Y.J., Zhu C.C., Xu Y.X., Cui X.S., Kim N.H., Sun S.C. Zearalenone exposure affects mouse oocyte meiotic maturation and granulosa cell proliferation. Environ Toxicol 2014, [in press].
61. Hu W.Y., Shi G.B., Hu D.P., Nelles J.L., Prins G.S. Actions of estrogens and endocrine disrupting chemicals on human prostate stem/progenitor cells and prostate cancer risk. Mol Cell Endocrinol 2012, 354:63-73.
62. Huang Y., Sook-Kim M., Ratovitski E. Midkine promotes tetraspanin-integrin interaction and induces FAK-Stat1alpha pathway contributing to migration/invasiveness of human head and neck squamous cell carcinoma cells. Biochem Biophys Res Commun 2008, 377:474-478.
63. Huan J., Wang L., Xing L., Qin X., Feng L., Pan X., et al. Insights into significant pathways and gene interaction networks underlying breast cancer cell line MCF-7 treated with 17β-estradiol (E2). Gene 2014, 533:346-355.
64. Hutchinson T.H., Brown R., Brugger K.E., Campbell P.M., Holt M., Länge R., et al. Ecological risk assessment of endocrine disruptors. Environ Health Perspect 2000, 108:1007-1014.
65. Huynh L.N., Thangavel M., Chen T., Cottrell R., Mitchell J.M., Praetorius-Ibba M. Linking tRNA localization with activation of nutritional stress responses. Cell Cycle 2010, 9:3112-3118.
66. Igarashi A., Ohtsu S., Muroi M., Tanamoto K. Effects of possible endocrine disrupting chemicals on bacterial component-induced activation of NF-κB. Biol Pharm Bull 2006, 29:2120-2122.
67. Iguchi T., Watanabe H., Katsu Y. Application of ecotoxicogenomics for studying endocrine disruption in vertebrates and invertebrates. Environ Health Perspect 2006, 114:101-105.
68. Inomata S. Safety assurance of cosmetic in Japan: current situation and future prospects. J Oleo Sci 2014, 63:1-6.
69. Inoue A., Omoto Y., Yamaguchi Y., Kiyama R., Hayashi S.I. Transcription factor EGR3 is involved in the estrogen-signaling pathway in breast cancer cells. J Mol Endocrinol 2004, 32:649-661.
70. Inoue A., Yoshida N., Omoto Y., Oguchi S., Yamori T., Kiyama R., et al. Development of cDNA microarray for expression profiling of estrogen-responsive genes. J Mol Endocrinol 2002, 29:175-192.
71. Ise R., Han D., Takahashi Y., Terasaka S., Inoue A., Tanji M., et al. Expression profiling of the estrogen responsive genes in response to phytoestrogens using a customized DNA microarray. FEBS Lett 2005, 579:1732-1740.
72. Ishido M., Yonemoto J., Morita M. Mesencephalic neurodegeneration in the orally administered bisphenol A-caused hyperactive rats. Toxicol Lett 2007, 173:66-72.
73. Ishitani T., Ishitani S., Matsumoto K., Itoh M. Nemo-like kinase is involved in NGF-induced neurite outgrowth via phosphorylating MAP1B and paxillin. J Neurochem 2009, 111:1104-1118.
74. Iwata M., Eshima Y., Kagechika H., Miyaura H. The endocrine disruptors nonylphenol and octylphenol exert direct effects on T cells to suppress Th1 development and enhance Th2 development. Immunol Lett 2004, 94:135-139.
75. Izrailit J., Berman H.K., Datti A., Wrana J.L., Reedijk M. High throughput kinase nhibitor screens reveal TRB3 and MAPK-ERK/TGFβ pathways as fundamental Notch regulators in breast cancer. Proc Natl Acad Sci USA 2013, 110:1714-1719.
76. Jayashree S., Indumathi D., Akilavalli N., Sathish S., Selvaraj J., Balasubramanian K. Effect of bisphenol-A on insulin signal transduction and glucose oxidation in liver of adult male albino rat. Environ Toxicol Pharmacol 2013, 35:300-310.
77. Jee S., Hwang D., Seo S., Kim Y., Kim C., Kim B., et al. Microarray analysis of insulin-regulated gene expression in the liver: the use of transgenic mice co-expressing insulin-siRNA and human IDE as an animal model. Int J Mol Med 2007, 20:829-835.
78. Jiang J., Mohan P., Maxwell C.A. The cytoskeletal protein RHAMM and ERK1/2 activity maintain the pluripotency of murine embryonic stem cells. PLoS One 2013, 8:e73548.
79. Jin M.H., Hong C.H., Lee H.Y., Kang H.J., Han S.W. Enhanced TGF-beta1 is involved in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induced oxidative stress in C57BL/6 mouse testis. Toxicol Lett 2008, 178:202-209.
80. Jones W.M., Chao A.T., Zavortink M., Saint R., Bejsovec A. Cytokinesis proteins Tum and Pav have a nuclear role in Wnt regulation. J Cell Sci 2010, 123:2179-2189.
81. Juang H.H. Nitroprusside stimulates mitochondrial aconitase gene expression through the cyclic adenosine 3', 5'-monosphosphate signal transduction pathway in human prostate carcinoma cells. Prostate 2004, 61:92-102.
82. Jung E.M., An B.S., Yang H., Choi K.C., Jeung E.B. Biomarker genes for detecting estrogenic activity of endocrine disruptors via estrogen receptors. Int J Environ Res Public Health 2012, 9:698-711.
83. Kanan Y., Wicker L.D., Al-Ubaidi M.R., Mandal N.A., Kasus-Jacobi A. Retinol dehydrogenases RDH11 and RDH12 in the mouse retina: expression levels during development and regulation by oxidative stress. Invest Ophthalmol Vis Sci 2008, 49:1071-1078.
84. Khosla S., Oursler M.J., Monroe D.G. Estrogen and the skeleton. Trends Endocrinol Metab 2012, 23:576-581.
85. Kimble R.B., Vannice J.L., Bloedow D.C., Thompson R.C., Hopfer W., Kung V.T., et al. Interleukin-1 receptor antagonist decreases bone loss and bone resorption in ovariectomized rats. J Clin Invest 1994, 93:1959-1967.
86. Kim H.J., Kim J.G., Moon M.Y., Park S.H., Park J.B. IκB kinase γ/nuclear factor-κB-essential modulator (IKKγ/NEMO) facilitates RhoA GTPase activation, which, in turn, activates Rho-associated KINASE (ROCK) to phosphorylate IKKβ in response to transforming growth factor (TGF)-β1. J Biol Chem 2014, 289:1429-1440.
87. Kiyama R., Zhu Y. DNA microarray-based gene expression profiling of estrogenic chemicals. Cell Mol Life Sci 2014, 71:2065-2082.
88. Knoll J.G., Wolf C.A., Tobet S.A. Estrogen modulates neuronal movements within the developing preoptic area/anterior hypothalamus. Eur J Neurosci 2007, 26:1091-1099.
89. Kobayashi S., Okamoto H., Iwamoto T., Toyama Y., Tomatsu T., Yamanaka H., et al. A role for the aryl hydrocarbon receptor and the dioxin TCDD in rheumatoid arthritis. Rheumatology 2008, 47:1317-1322.
90. Kojima H., Inoue T., Kunimoto H., Nakajima K. IL-6-STAT3 signaling and premature senescence. JAKSTAT 2013, 2:e25763.
91. Komoike Y., Matsuoka M. Exposure to tributyltin induces endoplasmic reticulum stress and the unfolded protein response in zebrafish. Aquat Toxicol 2013, 142-143:221-229.
92. Kousteni S., Bellido T., Plotkin L.I., O'Brien C.A., Bodenner D.L., Han L., et al. Nongenotropic, sex-nonspecific signaling through the estrogen or androgen receptors: dissociation from transcriptional activity. Cell 2001, 104:719-730.
93. Kudo C., Wada K., Masuda T., Yonemura T., Shibuya A., Fujimoto Y., et al. Nonylphenol induces the death of neural stem cells due to activation of the caspase cascade and regulation of the cell cycle. J Neurochem 2004, 88:1416-1423.
94. Kumeta M., Gilmore J.L., Umeshima H., Ishikawa M., Kitajiri S., Horigome T., et al. Caprice/MISP is a novel F-actin bundling protein critical for actin-based cytoskeletal reorganizations. Genes Cells 2014, 19:338-349.
95. Kuo C.H., Hsieh C.C., Kuo H.F., Huang M.Y., Yang S.N., Chen L.C., et al. Phthalates suppress type I interferon in human plasmacytoid dendritic cells via epigenetic regulation. Allergy 2013, 68:870-879.
96. Lake D.F., Faigel D.O. The emerging role of QSOX1 in cancer. Antioxid Redox Signal 2014, 21:485-496.
97. Lazari M.F., Lucas T.F., Yasuhara F., Gomes G.R., Siu E.R., Royer C., et al. Estrogen receptors and function in the male reproductive system. Arq Bras Endocrinol Metabol 2009, 53:923-933.
98. Lee H.R., Hwang K.A., Nam K.H., Kim H.C., Choi K.C. Progression of breast cancer cells was enhanced by endocrine-disrupting chemicals, triclosan and octylphenol, via an estrogen receptor-dependent signaling pathway in cellular and mouse xenograft models. Chem Res Toxicol 2014, 27:834-842.
99. Lee M.H., Kim E., Kim T.S. Exposure to 4-tert-octylphenol, an environmentally persistent alkylphenol, enhances interleukin-4 production in T cells via NF-AT activation. Toxicol Appl Pharmacol 2004, 197:19-28.
100. Liao Y., Wang J., Huang Q.S., Fang C., Kiyama R., Shen H., et al. Evaluation of cellular response to perfluorooctane sulfonate in human umbilical vein endothelial cells. Toxicol In Vitro 2012, 26:421-428.
101. Li Y., Burns K.A., Arao Y., Luh C.J., Korach K.S. Differential estrogenic actions of endocrine-disrupting chemicals bisphenol A, bisphenol AF, and zearalenone through estrogen receptor α and β in vitro. Environ Health Perspect 2012, 120:1029-1035.
102. Li Z., Li J., Mo B., Hu C., Liu H., Qi H., et al. Genistein induces G2/M cell cycle arrest via stable activation of ERK1/2 pathway in MDA-MB-231 breast cancer cells. Cell Biol Toxicol 2008, 24:401-409.
103. Li L., Shen L., She H., Yue S., Feng D., Luo Z. Nitric oxide-induced activation of NF-κB-mediated NMDA-induced CTP: phosphocholine cytidylyltransferase alpha expression inhibition in A549 cells. Cell Biol Toxicol 2011, 27:41-47.
104. Liedtke C.M., Cole T.S. Activation of NKCC1 by hyperosmotic stress in human tracheal epithelial cells involves PKC-delta and ERK. Biochim Biophys Acta 2002, 1589:77-88.
105. Lin B.C., Suzawa M., Blind R.D., Tobias S.C., Bulun S.E., Scanlan T.S., et al. Stimulating the GPR30 estrogen receptor with a novel tamoxifen analogue activates SF-1 and promotes endometrial cell proliferation. Cancer Res 2009, 69:5415-5423.
106. Lin J.C., Wu Y.Y., Wu J.Y., Lin T.C., Wu C.T., Chang Y.L., et al. TROP2 is epigenetically inactivated and modulates IGF-1R signalling in lung adenocarcinoma. EMBO Mol Med 2012, 4:472-485.
107. Liu X.M., Xiong X.F., Song Y., Tang R.J., Liang X.Q., Cao E.H. Possible roles of a tumor suppressor gene PIG11 in hepatocarcinogenesis and As2O3-induced apoptosis in liver cancer cells. J Gastroenterol 2009, 44:460-469.
108. Liu Y., Zhou Z.G., Chen K.L., Zhou B., Yang L., Yan H., et al. The ER chaperone GRP78 is associated with the severity of cerulein-induced pancreatic inflammation via regulating apoptosis of pancreatic acinar cells. Hepatogastroenterology 2012, 59:1670-1676.
109. Lorenzetti S., Altieri I., Arabi S., Balduzzi D., Bechi N., Cordelli E., et al. Innovative non-animal testing strategies for reproductive toxicology: the contribution of Italian partners within the EU project ReProTect. Ann Ist Super Sanita 2011, 47:429-444.
110. Louis-Brennetot C., Coindre J.M., Ferreira C., Pérot G., Terrier P., Aurias A. The CDKN2A/CDKN2B/CDK4/CCND1 pathway is pivotal in well-differentiated and dedifferentiated liposarcoma oncogenesis: an analysis of 104 tumors. Genes Chromosom Cancer 2011, 50:896-907.
111. Lu J., Yu J.Y., Lim S.S., Son Y.O., Kim D.H., Lee S.A., et al. Cellular mechanisms of the cytotoxic effects of the zearalenone metabolites α-zearalenol and β-zearalenol on RAW264.7 macrophages. Toxicol In Vitro 2013, 27:1007-1017.
112. Lux A., Beil C., Majety M., Barron S., Gallione C.J., Kuhn H.M., et al. Human retroviral gag- and gag-pol-like proteins interact with the transforming growth factor-beta receptor activin receptor-like kinase 1. J Biol Chem 2005, 280:8482-8493.
113. Ma L., Tao Y., Duran A., Llado V., Galvez A., Barger J.F., et al. Control of nutrient stress-induced metabolic reprogramming by PKCζ in tumorigenesis. Cell 2013, 152:599-611.
114. Macias J.D., Gerkin R.D., Locke D., Macias M.P. Differential gene expression in cholesteatoma by DNA chip analysis. Laryngoscope 2013, 123:S1-S21.
115. Macon M.B., Fenton S.E. Endocrine disruptors and the breast: early life effects and later life disease. J Mammary Gland Biol Neoplasia 2013, 18:43-61.
116. Majid S.M., Liss A.S., You M., Bose H.R. The suppression of SH3BGRL is important for v-Rel-mediated transformation. Oncogene 2006, 25:756-768.
117. Mangala Priya V., Mayilvanan C., Akilavalli N., Rajesh P., Balasubramanian K. Lactational exposure of phthalate impairs insulin signaling in the cardiac muscle of F1 female albino rats. Cardiovasc Toxicol 2014, 14:10-20.
118. Marathe N., Rangaswami H., Zhuang S., Boss G.R., Pilz R.B. Pro-survival effects of 17β-estradiol on osteocytes are mediated by nitric oxide/cGMP via differential actions of cGMP-dependent protein kinases I and II. J Biol Chem 2012, 287:978-988.
119. Marino M., Pellegrini M., La Rosa P., Acconcia F. Susceptibility of estrogen receptor rapid responses to xenoestrogens: Physiological outcomes. Steroids 2012, 77:910-917.
120. Maruyama N.O., Lucas T.F., Porto C.S., Abdalla F.M. Estrogen receptor ESR1 regulates the phospholipase C-inositol phosphate signaling in the hippocampus from rats in proestrous and estrous phases. Steroids 2013, 78:8-14.
121. Masuyama H., Hiramatsu Y. Involvement of suppressor for Gal 1 in the ubiquitin/proteasome-mediated degradation of estrogen receptors. J Biol Chem 2004, 279:12020-12026.
122. McCarthy M.M. Estradiol and the developing brain. Physiol Rev 2008, 88:91-124.
123. McLachlan J.A., Simpson E., Martin M. Endocrine disrupters and female reproductive health. Best Pract Res Clin Endocrinol Metab 2006, 20:63-75.
124. Menghi G., Sabbieti M.G., Marchetti L., Menghi M., Materazzi S., Hurley M.M. Phthalate esters influence FGF-2 translocation in Py1a rat osteoblasts. Eur J Morphol 2001, 39:155-162.
125. Michałowicz J. Bisphenol A-sources, toxicity and biotransformation. Environ Toxicol Pharmacol 2014, 37:738-758.
126. Mitsui T., Ishida M., Izawa M., Kagami Y., Arita J. Inhibition of Bcl3 gene expression mediates the anti-proliferative action of estrogen in pituitary lactotrophs in primary culture. Mol Cell Endocrinol 2011, 345:68-78.
127. Moggs J.G. Molecular responses to xenoestrogens: mechanistic insights from toxicogenomics. Toxicology 2005, 213:177-193.
128. Morales S.A., Telander D., Notterpek L., Wadehra M., Braun J., Gordon L.K. Rewiring integrin-mediated signaling and cellular response with the peripheral myelinprotein 22 and epithelial membrane protein 2 components of the tetraspan web. Invest Ophthalmol Vis Sci 2011, 52:5465-5472.
129. Moran D.M., Trusk P.B., Pry K., Paz K., Sidransky D., Bacus S.S. KRAS mutation status is associated with enhanced dependency on folate metabolism pathways in non small cell lung cancer cells. Mol Cancer Ther 2014, 13:1611-1624.
130. Morinaga H., Yanase T., Nomura M., Okabe T., Goto K., Harada N., et al. A benzimidazole fungicide, benomyl, and its metabolite, carbendazim, induce aromatase activity in a human ovarian granulose-like tumor cell line (KGN). Endocrinology 2004, 145:1860-1869.
131. Motaghed M., Al-Hassan F.M., Hamid S.S. Thymoquinone regulates gene expression levels in the estrogen metabolic and interferon pathways in MCF7 breast cancer cells. Int J Mol Med 2014, 33:8-16.
132. Naganawa T., Xiao L., Abogunde E., Sobue T., Kalajzic I., Sabbieti M., et al. In vivo and in vitro comparison of the effects of FGF-2 null and haplo-insufficiency on bone formation in mice. Biochem Biophys Res Commun 2006, 339:490-498.
133. Nakamura Y., Hinoi E., Iezaki T., Takada S., Hashizume S., Takahata Y., et al. Repression of adipogenesis through promotion of Wnt/β-catenin signaling by TIS7 up-regulated in adipocytes under hypoxia. Biochim Biophys Acta 2013, 1832:1117-1128.
134. Nakatsu Y., Kotake Y., Hino A., Ohta S. Activation of AMP-activated protein kinase by tributyltin induces neuronal cell death. Toxicol Appl Pharmacol 2008, 230:358-363.
135. National Research Council Toxicity Testing in the 21st Century: A vision and a strategy 2007, National Academies Press, Washington.
136. Nelson H.D. Menopause. Lancet 2008, 371:760-770.
137. O'Farrell F., Rusten T.E., Stenmark H. Phosphoinositide 3-kinases as accelerators and brakes of autophagy. FEBS J 2013, 280:6322-6337.
138. Olesen C., Nyeng P., Kalisz M., Jensen T.H., Møller M., Tommerup N., et al. Global gene expression analysis in fetal mouse ovaries with and without meiosis and comparison of selected genes with meiosis in the testis. Cell Tissue Res 2007, 328:207-221.
139. Onodera Y., Nam J.M., Hashimoto A., Norman J.C., Shirato H., Hashimoto S., et al. Rab5c promotes AMAP1-PRKD2 complex formation to enhance β1 integrin recycling in EGF-induced cancer invasion. J Cell Biol 2012, 197:983-996.
140. Paria B.C., Das S.K., Andrews G.K., Dey S.K. Expression of the epidermal growth factor receptor gene is regulated in mouse blastocysts during delayed implantation. Proc Natl Acad Sci USA 1993, 90:55-59.
141. Parsyan A., Shahbazian D., Martineau Y., Petroulakis E., Alain T., Larsson O., et al. The helicase protein DHX29 promotes translation initiation, cell proliferation, and tumorigenesis. Proc Natl Acad Sci USA 2009, 106:22217-22222.
142. Parveen M., Zhu Y., Kiyama R. Expression profiling of the genes responding to zearalenone and its analogues using estrogen-responsive genes. FEBS Lett 2009, 583:2377-2384.
143. Poth J.M., Brodsky K., Ehrentraut H., Grenz A., Eltzschig H.K. Transcriptional control of adenosine signaling by hypoxia-inducible transcription factors during ischemic or inflammatory disease. J Mol Med 2013, 91:183-193.
144. Pulikkan J.A., Madera D., Xue L., Bradley P., Landrette S.F., Kuo Y.H., et al. Thrombopoietin/MPL participates in initiating and maintaining RUNX1-ETO acute myeloid leukemia via PI3K/AKT signaling. Blood 2012, 120:868-879.
145. Qiu F., Chen Y.R., Liu X., Chu C.Y., Shen L.J., Xu J., et al. Arginine starvation impairs mitochondrial respiratory function in ASS1-deficient breast cancer cells. Sci Signal 2014, 7:ra31.
146. Qin L., Chen X., Wu Y., Feng Z., He T., Wang L., et al. Steroid receptor coactivator-1 upregulates integrin α5 expression to promote breast cancer cell adhesion and migration. Cancer Res 2011, 71:1742-1751.
147. Rajesh P., Balasubramanian K. Di(2-ethylhexyl)phthalate exposure impairs insulin receptor and glucose transporter 4 gene expression in L6 myotubes. Hum Exp Toxicol 2013, 33:685-700.
148. Rajini B., Graham C., Wistow G., Sharma Y. Stability, homodimerization, and calcium-binding properties of a single, variant betagamma-crystallin domain of the protein absent in melanoma 1 (AIM1). Biochemistry 2003, 42:4552-4559.
149. Rataj F., Möller F.J., Jähne M., Zierau O., Diel P., Vollmer G., et al. Regulation of uterine AHR battery gene expression by 17β-Estradiol is predominantly mediated by estrogen receptor α. Arch Toxicol 2012, 86:1603-1612.
150. Redies C., Hertel N., Hübner C.A. Cadherins and neuropsychiatric disorders. Brain Res 2012, 1470:130-144.
151. Rho J.Y., Wada-Kiyama Y., Onishi Y., Kiyama R., Sakuma Y. Expressional regulation of neuronal and cancer-related genes by estrogen in adult female rats. Endocr Res 2004, 30:257-267.
152. Rios-Esteves J., Resh M.D. Stearoyl CoA desaturase is required to produce active, lipid-modified Wnt proteins. Cell Rep 2013, 4:1072-1081.
153. Roche D.D., Liu K.J., Harland R.M., Monsoro-Burq A.H. Dazap2 is required for FGF-mediated posterior neural patterning, independent of Wnt and Cdx function. Dev Biol 2009, 333:26-36.
154. Rodriguez-Mozaz S., Marco M.P., Lopez de Alda M.J., Barceló D. Biosensors for environmental monitoring of endocrine disruptors: a review article. Anal Bioanal Chem 2004, 378:588-598.
155. Roggen E.L. In vitro toxicity testing in the twenty-first century. Front Pharmacol 2011, 2:3.
156. Rusyn I., Corton J.C. Mechanistic considerations for human relevance of cancer hazard of di(2-ethylhexyl) phthalate. Mutat Res 2012, 750:141-158.
157. Ryu S.Y., Hong G.U., Kim D.Y., Ro J.Y. Enolase 1 and calreticulin regulate the differentiation and function f mouse mast cells. Cell Signal 2012, 24:60-70.
158. Safe S.H. Endocrine disruptors and human health-is there a problem? An update. Environ Health Perspect 2000, 108:487-493.
159. Saito N., Munemasa S., Nakamura Y., Shimoishi Y., Mori I.C., Murata Y. Roles of RCN1, regulatory A subunit of protein phosphatase 2A, in methyl jasmonate signaling and signal crosstalk between methyl jasmonate and abscisic acid. Plant Cell Physiol 2008, 49:1396-1401.
160. Salian S., Doshi T., Vanage G. Neonatal exposure of male rats to bisphenol A impairs fertility and expression of sertoli cell junctional proteins in the testis. Toxicology 2009, 265:56-67.
161. Seth P., Krop I., Porter D., Polyak K. Novel estrogen and tamoxifen induced genes identified by SAGE (Serial Analysis of Gene Expression). Oncogene 2002, 21:836-843.
162. Shanle E.K., Xu W. Endocrine disrupting chemicals targeting estrogen receptor signaling: identification and mechanisms of action. Chem Res Toxicol 2011, 24:6-19.
163. Sharan S., Nikhil K., Roy P. Effects of low dose treatment of tributyltin on the regulation of estrogen receptor functions in MCF-7 cells. Toxicol Appl Pharmacol 2013, 269:176-186.
164. Shi Y., Fan X., Meng W., Deng H., Zhang N., An Z. Engagement of immune effector cells by trastuzumab induces HER2/ERBB2 downregulation in cancer cells through STAT1 activation. Breast Cancer Res 2014, 16:R33.
165. Shi Y., Song Y., Wang Y., Wang Y., Liang X., Hu Y., et al. β-Benzene hexachloride induces apoptosis of rat Sertoli cells through generation of reactive oxygen species and activation of JNKs and FasL. Environ Toxicol 2011, 26:124-135.
166. Shi X., Zhou B. The role of Nrf2 and MAPK pathways in PFOS-induced oxidative stress in zebrafish embryos. Toxicol Sci 2010, 115:391-400.
167. Sikka S.C., Wang R. Endocrine disruptors and estrogenic effects on male reproductive axis. Asian J Androl 2008, 10:134-145.
168. Song J., Markley J.L. Three-dimensional structure determined for a subunit of human tRNA splicing endonuclease (Sen15) reveals a novel dimeric fold. J Mol Biol 2007, 366:155-164.
169. Srivastava S., Toraldo G., Weitzmann M.N., Cenci S., Ross F.P., Pacifici R. Estrogen decreases osteoclast formation by down-regulating receptor activator of NF-κB ligand (RANKL)-induced JNK activation. J Biol Chem 2001, 276:8836-8840.
170. Stansfield B.K., Bessler W.K., Mali R., Mund J.A., Downing B.D., Kapur R., et al. Ras-Mek-Erk signaling regulates Nf1 heterozygous neointima formation. Am J Pathol 2014, 184:79-85.
171. Stokes W.S. Selecting appropriate animal models and experimental designs for endocrine disruptor research and testing studies. ILAR J 2004, 45:387-393.
172. Storkebaum E., Leitão-Gonçalves R., Godenschwege T., Nangle L., Mejia M., Bosmans I., et al. Dominant mutations in the tyrosyl-tRNA synthetase gene recapitulate in Drosophila features of human Charcot-Marie-Tooth neuropathy. Proc Natl Acad Sci USA 2009, 106:11782-11787.
173. Stute P., Sielker S., Wood C.E., Register T.C., Lees C.J., Dewi F.N., et al. Life stage differences in mammary gland gene expression profile in non-human primates. Breast Cancer Res Treat 2012, 133:617-634.
174. Suh K.S., Malik M., Shukla A., Ryscavage A., Wright L., Jividen K., et al. CLIC4 is a tumor suppressor for cutaneous squamous cell cancer. Carcinogenesis 2012, 33:986-995.
175. Sun H., Xia Y., Wang L., Wang Y., Chang X. PSORS1C1 may be involved in rheumatoid arthritis. Immunol Lett 2013, 153:9-14.
176. Szabó Z., Hämäläinen J., Loikkanen I., Moilanen A.M., Hirvikoski P., Väisänen T., et al. Sorbitol dehydrogenase expression is regulated by androgens in the human prostate. Oncol Rep 2010, 23:1233-1239.
177. Takeo C., Ikeda K., Horie-Inoue K., Inoue S. Identification of Igf2, Igfbp2 and Enpp2 as estrogen-responsive genes in rat hippocampus. Endocr J 2009, 56:113-120.
178. Taniguchi N., Korekane H. Branched N-glycans and their implications for cell adhesion, signaling and clinical applications for cancer biomarkers and in therapeutics. BMB Rep 2011, 44:772-781.
179. Tanji M., Kiyama R. Expression profiling of estrogen responsive genes using genomic and proteomic techniques for the evaluation of endocrine disruptors. Current Pharmacogenomics 2004, 2:255-266.
180. Tatti M., Motta M., Di Bartolomeo S., Cianfanelli V., Salvioli R. Cathepsin-mediated regulation of autophagy in saposin C deficiency. Autophagy 2013, 9:241-243.
181. Taylor S.E., Martin-Hirsch P.L., Martin F.L. Oestrogen receptor splice variants in the pathogenesis of disease. Cancer Lett 2010, 288:133-148.
182. Taylor J.A., Richter C.A., Ruhlen R.L., vom Saal F.S. Estrogenic environmental chemicals and drugs: mechanisms for effects on the developing male urogenital system. J Steroid Biochem Mol Biol 2011, 127:83-95.
183. Terasaka S., Aita Y., Inoue A., Hayashi S., Nishigaki M., Aoyagi K., et al. Using a customized DNA microarray for expression profiling of the estrogen-responsive genes to evaluate estrogen activity among natural estrogens and industrial chemicals. Environ Health Perspect 2004, 112:773-781.
184. Tessier D.M., Matsumura F. Increased ErbB-2 tyrosine kinase activity, MAPK phosphorylation, and cell proliferation in the prostate cancer cell line LNCaP following treatment by select pesticides. Toxicol Sci 2001, 60(1):38-43.
185. Thakur P.C., Davison J.M., Stuckenholz C., Lu L., Bahary N. Dysregulated phosphatidylinositol signaling promotes endoplasmic-reticulum-stress-mediated intestinal mucosal injury and inflammation in zebrafish. Dis Model Mech 2014, 7:93-106.
186. Tilghman S.L., Nierth-Simpson E.N., Wallace R., Burow M.E., McLachlan J.A. Environmental hormones: Multiple pathways for response may lead to multiple disease outcomes. Steroids 2010, 75:520-523.
187. Tong Z.T., Wei J.H., Zhang J.X., Liang C.Z., Liao B., Lu J., et al. AIB1 predicts bladder cancer outcome and promotes bladder cancer cell proliferation through AKT and E2F1. Br J Cancer 2013, 108:1470-1479.
188. Trudeau V.L., Chiu S., Kennedy S.W., Brooks R.J. Octylphenol (OP) alters the expression of members of the amyloid protein family in the hypothalamus of the snapping turtle, Chelydra serpentina serpentine. Environ Health Perspect 2002, 110:269-275.
189. Turner E.C., Mulvaney E.P., Reid H.M., Kinsella B.T. Interaction of the human prostacyclin receptor with the PDZ adapter protein PDZK1: role in endothelial cell migration and angiogenesis. Mol Biol Cell 2011, 22:2664-2679.
190. Urruticoechea A., Aguilar H., Solé X., Capellà G., Martin L.A., Dowsett M., et al. Pre-clinical validation of early molecular markers of sensitivity to aromatase inhibitors in a mouse model of post-menopausal hormone-sensitive breast cancer. Breast Cancer Res Treat. 2008, 109:463-470.
191. Wada-Kiyama Y., Suzuki C., Hamada T., Rai D., Kiyama R., Kaneda M., et al. Estrogen-induced cell signaling in the sexually dimorphic nucleus of the rat preoptic area: potential involvement of cofilin in actin dynamics for cell migration. Biochem Biophys Res Commun 2013, 434:287-292.
192. Wan H.T., Zhao Y.G., Wong M.H., Lee K.F., Yeung W.S., Giesy J.P., et al. Testicular signaling is the potential target of perfluorooctanesulfonate-mediated subfertility in male mice. Biol Reprod 2011, 84:1016-1023.
193. Wang L., Cheng X., Li H., Qiu F., Yang N., Wang B., et al. Quercetin reduces oxidative stress and inhibits activation of c Jun N terminal kinase/activator protein 1 signaling in an experimental mouse model of abdominal aortic aneurysm. Mol Med Rep. 2014, 9:435-442.
194. Wang T., Ge Y., Xiao M., Lopez-Coral A., Li L., Roesch A., et al. SECTM1 produced by tumor cells attracts human monocytes via CD7-mediated activation of the PI3K pathway. J Invest Dermatol. 2014, 134:1108-1118.
195. Wang C., Li N., Liu X., Zheng Y., Cao X. A novel endogenous human CaMKII inhibitory protein suppresses tumor growth by inducing cell cycle arrest via p27 stabilization. J Biol Chem 2008, 283:11565-11574.
196. Wang J., Liao Y., Fan J., Ye T., Sun X., Dong S. Apigenin inhibits the expression of IL-6, IL-8, and ICAM-1 in DEHP-stimulated human umbilical vein endothelial cells and in vivo. Inflammation. 2012, 35(4):1466-1476.
197. Wang J., Sarkar T.R., Zhou M., Sharan S., Ritt D.A., Veenstra T.D., et al. CCAAT/enhancer binding protein delta (C/EBPdelta, CEBPD)-mediated nuclear import of FANCD2 by IPO4 augments cellular response to DNA damage. Proc Natl Acad Sci USA 2010, 107:16131-16136.
198. Wang H., Wu K., Sun Y., Li Y., Wu M., Qiao Q., et al. STC2 is upregulated in hepatocellular carcinoma and promotes cell proliferation and migration in vitro. BMB Rep 2012, 45:629-634.
199. Wang Y.P., Yu G.R., Lee M.J., Lee S.Y., Chu I.S., Leem S.H., et al. Lipocalin-2 negatively modulates the epithelial-to-mesenchymal transition in hepatocellular carcinoma through the epidermal growth factor (TGF-beta1)/Lcn2/Twist1 pathway. Hepatology 2013, 58:1349-1361.
200. Wegiel B., Bjartell A., Culig Z., Persson J.L. Interleukin-6 activates PI3K/Akt pathway and regulates cyclin A1 to promote prostate cancer cell survival. Int J Cancer 2008, 122:1521-1529.
201. Welcsh P.L., Lee M.K., Gonzalez-Hernandez R.M., Black D.J., Mahadevappa M., Swisher E.M., et al. BRCA1 transcriptionally regulates genes involved in breast tumorigenesis. Proc Natl Acad Sci USA 2002, 99:7560-7565.
202. Welshons W.V., Nagel S.C., vom Saal F.S. Large effects from small exposures. III. Endocrine mechanisms mediating effects of bisphenol A at levels of human exposure. Endocrinology 2006, 147:S56-S69.
203. Willoughby K.N., Sarkar A.J., Boyadjieva N.I., Sarkar D.K. Neonatally administered tert-octylphenol affects onset of puberty and reproductive development in female rats. Endocrine 2005, 26:161-168.
204. Wisdom R., Johnson R.S., Moore C. c-Jun regulates cell cycle progression and apoptosis by distinct mechanisms. EMBO J 1999, 18:188-197.
205. Wohleb E.S., Patterson J.M., Sharma V., Quan N., Godbout J.P., Sheridan J.F. Knockdown of interleukin-1 receptor type-1 on endothelial cells attenuated stress-induced neuroinflammation and prevented anxiety-like behavior. J Neurosci 2014, 34:2583-2591.
206. Wollenhaupt K., Jonas L., Tiemann U., Tomek W. Influence of the mycotoxins alpha- and beta-zearalenol (ZOL) on regulators of cap-dependent translation control in pig endometrial cells. Reprod Toxicol 2004, 19:189-199.
207. Wu S., Hong F., Gewirth D., Guo B., Liu B., Li Z. The molecular chaperone gp96/GRP94 interacts with Toll-like receptors and integrins via its C-terminal hydrophobic domain. J Biol Chem 2012, 287:6735-6742.
208. Wu T.S., Tan C.T., Chang C.C., Lin B.R., Lai W.T., Chen S.T., et al. B-cell lymphoma/leukemia 10 promotes oral cancer progression through STAT1/ATF4/S100P signaling pathway. Oncogene 2014, [in press].
209. Xiao L., Esliger A., Hurley M.M. Nuclear fibroblast growth factor 2 (FGF2) isoforms inhibit bone marrow stromal cell mineralization through FGF23/FGFR/MAPK in vitro. J Bone Miner Res 2013, 28:35-45.
210. Xing W., Yan W., Liu P., Ji L., Li Y., Sun L., et al. A novel mechanism for vascular insulin resistance in normotensive young SHRs: hypoadiponectinemia and resultant APPL1 downregulation. Hypertension 2013, 61:1028-1035.
211. Xu Q., Hamada T., Kiyama R., Sakuma Y., Wada-Kiyama Y. Site-specific regulation of gene expression by estrogen in the hypothalamus of adult female rats. Neurosci Lett 2008, 436:35-39.
212. Yamaga R., Ikeda K., Horie-Inoue K., Ouchi Y., Suzuki Y., Inoue S. RNA sequencing of MCF-7 breast cancer cells identifies novel estrogen-responsive genes with functional estrogen receptor-binding sites in the vicinity of their transcription start sites. Horm Cancer 2013, 4:222-232.
213. Yamashita U., Sugiura T., Kuroda E. Effect of endocrine disrupters on immune responses in vitro. J UOEH 2002, 24:1-10.
214. Zeng R., Chen Y.C., Zeng Z., Liu W.Q., Jiang X.F., Liu R., et al. Effect of mini-tyrosyl-tRNA synthetase/mini-tryptophanyl-tRNA synthetase on ischemic angiogenesis in rats: proliferation and migration of endothelial cells. Heart Vessels 2011, 26:69-80.
215. Zeng Q., Tran T.T., Tan H.X., Hong W. The cytoplasmic domain of Vamp4 and Vamp5 is responsible for their correct subcellular targeting: the N-terminal extenSion of VAMP4 contains a dominant autonomous targeting signal for the trans-Golgi network. J Biol Chem 2003, 278:23046-23054.
216. Zhang B., Abreu J.G., Zhou K., Chen Y., Hu Y., Zhou T., et al. Blocking the Wnt pathway, a unifying mechanism for an angiogenic inhibitor in the serine proteinase inhibitor family. Proc Natl Acad Sci USA 2010, 107:6900-6905.
217. Zhang L.F., Qin C., Wei Y.F., Wang Y., Chang J.K., Mi Y.Y., et al. Differential expression of the Wnt/β-catenin pathway in the genital tubercle (GT) of fetal male rat following maternal exposure to di-n-butyl phthalate (DBP). Syst Biol Reprod Med 2011, 57:244-250.
218. Zhang X., Xu W., Su J., Chu M., Jin H., Li G., et al. The prosurvival role of autophagy in resveratrol-induced cytotoxicity in GH3 cells. Int J Mol Med 2014, 33:987-993.
219. Zhang Y.F., Yuan Z.Q., Song D.G., Zhou X.H., Wang Y.Z. Effects of cannabinoid receptor 1 (brain) on lipid accumulation by transcriptional control of CPT1A and CPT1B. Anim Genet 2014, 45:38-47.
220. Zheng H., Gao L., Feng Y., Yuan L., Zhao H., Cornelius L.A. Down-regulation of Rap1GAP via promoter hypermethylation promotes melanoma cell proliferation, survival, and migration. Cancer Res 2009, 69:449-457.
221. Zheng H., Gupta V., Patterson-Fortin J., Bhattacharya S., Katlinski K., Wu J., et al. A BRISC-SHMT complex deubiquitinates IFNAR1 and regulates interferon responses. Cell Rep 2013, 5:180-193.
222. Zhu Z., Edwards R.J., Boobis A.R. Increased expression of histone proteins during estrogen-mediated cell proliferation. Environ Health Perspect 2009, 117:928-934.
223. Zinedine A., Soriano J.M., Moltó J.C., Mañes J. Review on the toxicity, occurrence, metabolism, detoxification, regulations and intake of zearalenone: an oestrogenic mycotoxin. Food Chem Toxicol 2007, 45:1-18.
224. Zou L., Feng Y., Li Y., Zhang M., Chen C., Cai J., et al. Complement factor B is the downstream effector of TLRs and plays an important role in a mouse model of severe sepsis. J Immunol 2013, 191:5625-5635.
225. Zu H., Wu J., Zhang J., Yu M., Hong Z. Testosterone up-regulates seladin-1 expression by iAR and PI3-K/Akt signaling pathway in C6 cells. Neurosci Lett 2012, 514:122-126.
226. Zukauskas A., Merley A., Li D., Ang L.H., Sciuto T.E., Salman S., et al. TM4SF1: a tetraspanin-like protein necessary for nanopodia formation and endothelial cell migration. Angiogenesis 2011, 14:345-354.