Regulation of uterine AHR battery gene expression by 17β-Estradiol is predominantly mediated by estrogen receptor a

Archives of Toxicology

Volumn 86, Issue 10, 2012, Pages 1603-1612

  Rataj, Felicitas ^a   Möller, Frank Josef ^a   Jähne, Maria ^a   Zierau, Oliver ^a   Diel, Patrick ^b   Vollmer, Günter ^a   Kretzschmar, Georg ^a  

^a DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^b GERMAN SPORT UNIVERSITY COLOGNE   (Germany)

Author keywords

17 Estradiol; ARNT; Aryl hydrocarbon receptor; ER selective agonists; Estrogen receptor; Uterus

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR PROTEIN 1; ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR PROTEIN 2; ARYL HYDROCARBON RECEPTOR REPRESSOR; CYTOCHROME P450 1A1; CYTOCHROME P450 1B1; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; GLUCURONOSYLTRANSFERASE; GLUTATHIONE TRANSFERASE A2; HYPOXIA INDUCIBLE FACTOR 1BETA; MESSENGER RNA; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DEHYDROGENASE; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

AHR GENE; AHRR GENE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARNT GENE; ARNT2 GENE; ARTICLE; CONTROLLED STUDY; CYP1A1 GENE; CYP1B1 GENE; FEMALE; GENE EXPRESSION; GSTA2 GENE; IMMUNOHISTOCHEMISTRY; NFE2L2 GENE; NONHUMAN; NQO1 GENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; UGT1 GENE;

ANIMALS; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FEMALE; GENE EXPRESSION REGULATION; OVARIECTOMY; RATS; RATS, WISTAR; RECEPTORS, ARYL HYDROCARBON; RNA, MESSENGER; SIGNAL TRANSDUCTION; UTERUS;

MUS; RATTUS NORVEGICUS;

EID: 84866527494     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-012-0870-y     Document Type: Article

References (40)

1. Abbott BD, Schmid JE, Pitt JA et al (1999) Adverse reproductive outcomes in the transgenic Ah receptor-deficient mouse. Toxicol Appl Pharmacol 155:62-70. doi:10.1006/taap.1998.8601
2. Baba T, Mimura J, Nakamura N et al (2005) Intrinsic function of the aryl hydrocarbon (dioxin) receptor as a key factor in female reproduction. Mol Cell Biol 25:10040-10051. doi:10.1128/MCB. 25.22.10040-10051.2005
3. Bardin A, Boulle N, Lazennec G et al (2004) Loss of ERbeta expression as a common step in estrogen-dependent tumor progression. Endocr Relat Cancer 11:537-551
4. Beischlag TV, Perdew GH (2005) ER alpha-AHR-ARNT protein-protein interactions mediate estradiol-dependent transrepression of dioxin-inducible gene transcription. J Biol Chem 280:21607-21611. doi:10.1074/jbc.C500090200
5. Carlson DB, Perdew GH (2002) A dynamic role for the Ah receptor in cell signaling? Insights from a diverse group of Ah receptor interacting proteins. J Biochem Mol Toxicol 16:317-325. doi: 10.1002/jbt.10051
6. Chomczynski P, Sacchi N (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159. doi:10.1006/abio.1987.9999
7. Fernandez-Salguero PM, Ward JM, Sundberg JP, Gonzalez FJ (1997) Lesions of aryl-hydrocarbon receptor-deficient mice. Vet Pathol 34:605-614
8. Hankinson O (1995) The aryl hydrocarbon receptor complex. Annu Rev Pharmacol Toxicol 35:307-340. doi:10.1146/annurev.pa.35. 040195.001515
9. Harris HA (2007) Estrogen receptor-beta: Recent lessons from in vivo studies. Mol Endocrinol 21:1-13. doi:10.1210/me.2005-0459
10. Hernández-Ochoa I, Karman BN, Flaws JA (2009) The role of the aryl hydrocarbon receptor in the female reproductive system. Biochem Pharmacol 77:547-559. doi:10.1016/j.bcp.2008.09.037
11. Hillisch A, Peters O, Kosemund D et al (2004) Dissecting physiological roles of estrogen receptor alpha and beta with potent selective ligands from structure-based design. Mol Endocrinol 18:1599-1609. doi:10.1210/me.2004-0050
12. Kretzschmar G, Papke A, Zierau O et al (2010) Estradiol regulates aryl hydrocarbon receptor expression in the rat uterus. Mol Cell Endocrinol 321:253-257. doi:10.1016/j.mce.2010.02.018
13. Kuchenhoff A, Seliger G, Klonisch T et al (1999) Arylhydrocarbon receptor expression in the human endometrium. Fertil Steril 71:354-360
14. Kuiper GG, Enmark E, Pelto-Huikko M et al (1996) Cloning of a novel receptor expressed in rat prostate and ovary. Proc Natl Acad Sci USA 93:5925-5930
15. Kuiper GG, Carlsson B, Grandien K et al (1997) Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta. Endocrinology 138:863-870
16. Lahvis GP, Bradfield CA (1998) Ahr null alleles: Distinctive or different? Biochem Pharmacol 56:781-787
17. Lindberg MK, Movérare S, Skrtic S et al (2003) Estrogen receptor (ER)-beta reduces ERalpha-regulated gene transcription, supporting a "ying yang" relationship between ERalpha and ERbeta in mice. Mol Endocrinol 17:203-208
18. Matthews J, Gustafsson J-A (2003) Estrogen signaling: A subtle balance between ER alpha and ER beta. Mol Interv 3:281-292. doi:10.1124/mi.3.5.281
19. Matthews J, Wihlén B, Heldring N et al (2007) Co-planar 3,30,4,40, 5-pentachlorinated biphenyl and non-co-planar 2,20,4,6,60-pentachlorinated biphenyl differentially induce recruitment of oestrogen receptor alpha to aryl hydrocarbon receptor target genes. Biochem J 406:343-353. doi:10.1042/BJ20070585
20. Mimura J, Ema M, Sogawa K, Fujii-Kuriyama Y (1999) Identification of a novel mechanism of regulation of Ah (dioxin) receptor function. Genes Dev 13:20-25
21. Moller FJ, Zierau O, Hertrampf T et al (2009) Long-term effects of dietary isoflavones on uterine gene expression profiles. J Steroid Biochem Mol Biol 113:296-303. doi:10.1016/j.jsbmb.2009. 01.016
22. Moller FJ, Diel P, Zierau O et al (2010) Long-term dietary isoflavone exposure enhances estrogen sensitivity of rat uterine responsiveness mediated through estrogen receptor alpha. Toxicol Lett 196:142-153. doi:10.1016/j.toxlet. 2010.03.1117
23. Mosselman S, Polman J, Dijkema R (1996) ER beta: Identification and characterization of a novel human estrogen receptor. FEBS Lett 392:49-53
24. Nguyen LP, Bradfield CA (2008) The search for endogenous activators of the aryl hydrocarbon receptor. Chem Res Toxicol 21:102-116. doi:10.1021/ tx7001965
25. Nilsson S, Gustafsson JA (2000) Estrogen receptor transcription and transactivation: Basic aspects of estrogen action. Breast Cancer Res 2:360-366
26. Nioi P, Hayes JD (2004) Contribution of NAD(P)H:quinone oxidoreductase 1 to protection against carcinogenesis, and regulation of its gene by the Nrf2 basic-region leucine zipper and the arylhydrocarbon receptor basic helix-loop-helix transcription factors. Mutat Res 555:149-171. doi:10.1016/j.mrfmmm.2004.05.023
27. Owens W, Ashby J, Odum J, Onyon L (2003) The OECD program to validate the rat uterotrophic bioassay. Phase 2: Dietary phytoestrogen analyses. Environ Health Perspect 111:1559-1567
28. Pettersson K, Delaunay F, Gustafsson JA (2000) Estrogen receptor beta acts as a dominant regulator of estrogen signaling. Oncogene 19:4970-4978. doi:10.1038/sj.onc.1203828
29. Pfaffl MW (2001) A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 29:e45
30. Rasband WS (1997) ImageJ, U. S. National Institutes of Health, Bethesda, Maryland, USA, http://imagej.nih.gov/ij/
31. Safe S, Wormke M, Samudio I (2000) Mechanisms of inhibitory aryl hydrocarbon receptor-estrogen receptor crosstalk in human breast cancer cells. J Mammary Gland Biol Neoplasia 5:295-306
32. Shanle EK, Xu W (2011) Endocrine disrupting chemicals targeting estrogen receptor signaling: Identification and mechanisms of action. Chem Res Toxicol 24:6-19. doi:10.1021/tx100231n
33. Strasser SI, Smid SA, Mashford ML, Desmond PV (1997) Sex hormones differentially regulate isoforms of UDP-glucuronosyltransferase. Pharm Res 14:1115-1121
34. Swedenborg E, Pongratz I (2010) AhR and ARNT modulate ER signaling.Toxicology 268:132-138. doi:10.1016/j.tox.2009.09.007
35. Tian Q, Stepaniants SB, Mao M et al (2004) Integrated genomic and proteomic analyses of gene expression in mammalian cells. Mol Cell Proteomics 3:960-969. doi:10.1074/mcp.M400055-MCP200
36. Tsuchiya Y, Nakajima M, Kyo S et al (2004) Human CYP1B1 is regulated by estradiol via estrogen receptor. Cancer Res 64: 3119-3125
37. Tukey RH, Strassburg CP (2000) Human UDP-glucuronosyltransferases: Metabolism, expression, and disease. Annu Rev Pharmacol Toxicol 40:581-616. doi:10.1146/annurev.pharmtox. 40.1.581
38. Wakabayashi N, Slocum SL, Skoko JJ et al (2010) When NRF2 talks, who's listening? Antioxid Redox Signal 13:1649-1663. doi: 10.1089/ars.2010.3216
39. Welch BL (1947) The generalisation of student's problems when several different population variances are involved. Biometrika 34:28-35
40. Whitlock JP Jr (1999) Induction of cytochrome P4501A1. Annu Rev Pharmacol Toxicol 39:103-125. doi:10.1146/annurev.pharmtox. 39.1.103