Exposure to tributyltin induces endoplasmic reticulum stress and the unfolded protein response in zebrafish

Aquatic Toxicology

Volumn 142-143, Issue , 2013, Pages 221-229

  Komoike, Yuta ^a   Matsuoka, Masato ^a  

^a TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

Author keywords

Endoplasmic reticulum (ER) stress; Tributyltin (TBT); Unfolded protein response (UPR); Zebrafish

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; CCAAT ENHANCER BINDING PROTEIN; CHAPERONE; GLUCOSE REGULATED PROTEIN 78; INITIATION FACTOR 2ALPHA; INOSITOL REQUIRING ENZYME 1; MESSENGER RNA; PERK PROTEIN; PROTEIN KINASE; TRIBUTYLTIN; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1;

EMBRYONIC DEVELOPMENT; ENDOCRINE DISRUPTOR; FISH; GENE EXPRESSION; HYBRIDIZATION; IMMUNOASSAY; MARINE POLLUTION; PHYSIOLOGICAL RESPONSE; POLLUTION EFFECT; POLLUTION EXPOSURE; PROTEIN; TOXICITY; TRIBUTYLTIN;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; ATF4B1 GENE; CHOP GENE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; EIF2S1 GENE; EIFAK3 GENE; EMBRYO; EMBRYO GROWTH; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; ERN1 GENE; FIBROBLAST; GENE; GENE EXPRESSION; GRP78 GENE; HSP90B1 GENE; HSPA5 GENE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; IN VITRO STUDY; IN VIVO STUDY; NEUROMAST; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENSE ORGAN; STEM CELL; UNFOLDED PROTEIN RESPONSE; VIBRATION; WATER FLOW; XBP1 GENE; ZEBRA FISH;

4,6-DIAMIDINO-2-PHENYLINDOLE; ACTIVATING TRANSCRIPTION FACTOR 4; ATF4; DAPI; DIG; DIGOXYGENIN; DIMETHYL SULFOXIDE; DMSO; EIF2Α; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM (ER) STRESS; ER; EUKARYOTIC TRANSLATION INITIATION FACTOR 2 ALPHA; FBS; FETAL BOVINE SERUM; HOURS POST FERTILIZATION; HPF; INOSITOL-REQUIRING ENZYME 1; IRE1; MAB; MALEIC ACID BUFFER; PBS; PCR; PERK; PHOSPHATE-BUFFERED SALINE; POLYMERASE CHAIN REACTION; PROTEIN KINASE RNA-ACTIVATED-LIKE ER KINASE; REVERSE TRANSCRIPTION; RT; SARCOPLASMIC-ENDOPLASMIC RETICULUM CA(2+)-ATPASE; SERCA; TBS; TBT; TG; THAPSIGARGIN; TM; TRIBUTYLTIN; TRIBUTYLTIN (TBT); TRIS BUFFERED SALINE; TUNICAMYCIN; UNFOLDED PROTEIN RESPONSE; UNFOLDED PROTEIN RESPONSE (UPR); UPR; X-BOX BINDING PROTEIN 1.; XBP1; ZEBRAFISH;

ANIMALS; CELL LINE; EMBRYO, NONMAMMALIAN; ENDOPLASMIC RETICULUM STRESS; FIBROBLASTS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; SIGNAL TRANSDUCTION; TRIALKYLTIN COMPOUNDS; UNFOLDED PROTEIN RESPONSE; WATER POLLUTANTS, CHEMICAL; ZEBRAFISH; ZEBRAFISH PROTEINS;

EID: 84884261688     PISSN: 0166445X     EISSN: 18791514     Source Type: Journal    
DOI: 10.1016/j.aquatox.2013.08.017     Document Type: Article

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