TROP2 is epigenetically inactivated and modulates IGF-1R signalling in lung adenocarcinoma

EMBO Molecular Medicine

Volumn 4, Issue 6, 2012, Pages 472-485

  Lin, Jau Chen ^a   Wu, Yi Ying ^b   Wu, Jing Yi ^c   Lin, Tzu Chieh ^c   Wu, Chen Tu ^d   Chang, Yih Leong ^d   Jou, Yuh Shan ^c   Hong, Tse Ming ^b   Yang, Pan Chyr ^c,e  

^a FU JEN CATHOLIC UNIVERSITY   (Taiwan)

^b NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^c INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

^d NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^e NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Epigenetic; IGF 1R; Lung cancer; Slug; TROP2

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; ANTINEOPLASTIC AGENT; BETA CATENIN; BISULFITE; CELL SURFACE PROTEIN; DNA; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; SHORT HAIRPIN RNA; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR; TROP 2 PROTEIN; UNCLASSIFIED DRUG;

ADULT; APOPTOSIS; ARTICLE; ATTENUATION; CANCER CELL; CANCER CELL CULTURE; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER TISSUE; CELL PROLIFERATION; COLONY FORMATION; CONTROLLED STUDY; CPG ISLAND; DIAGNOSTIC TEST ACCURACY STUDY; DNA METHYLATION; EPIGENETICS; FEMALE; GENE ACTIVATION; GENE EXPRESSION; GENE INACTIVATION; GENE SEQUENCE; GENE SILENCING; GENETIC TRANSFECTION; HETEROZYGOSITY LOSS; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LOW DRUG DOSE; LUNG ADENOCARCINOMA; LUNG CARCINOGENESIS; LUNG RESECTION; MAJOR CLINICAL STUDY; MALE; METHYLATION SPECIFIC POLYMERASE CHAIN REACTION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION; TUMOR CELL; TUMOR GROWTH; WESTERN BLOTTING;

ADENOCARCINOMA; AGED; ANIMALS; ANTIGENS, NEOPLASM; AZACITIDINE; BASE SEQUENCE; CELL ADHESION MOLECULES; CELL LINE, TUMOR; DISEASE MODELS, ANIMAL; EPIGENESIS, GENETIC; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE SILENCING; HISTOCYTOCHEMISTRY; HUMANS; IMMUNOHISTOCHEMISTRY; LUNG NEOPLASMS; MALE; MICE; MIDDLE AGED; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; RECEPTOR, IGF TYPE 1; SIGNAL TRANSDUCTION;

EID: 84861872034     PISSN: 17574676     EISSN: 17574684     Source Type: Journal    
DOI: 10.1002/emmm.201200222     Document Type: Article

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