Bisphenol A disrupts notch signaling by inhibiting gamma-secretase activity and causes eye dysplasia of Xenopus laevis

Toxicological Sciences

Volumn 108, Issue 2, 2009, Pages 344-355

  Baba, Kazunobu ^a   Okada, Kazushi ^a   Kinoshita, Tsutomu ^a,b   Imaoka, Susumu ^a  

^a KWANSEI GAKUIN UNIVERSITY   (Japan)

^b RIKKYO UNIVERSITY   (Japan)

Author keywords

Bisphenol A; Neurula; Notch signaling; Xenopus laevis embryo

Indexed keywords

4,4' ISOPROPYLIDENEDIPHENOL; GAMMA SECRETASE; GOOSECOID PROTEIN; HISTONE H4; MESSENGER RNA; NOTCH RECEPTOR; PRESENILIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FOXD3; TRANSCRIPTION FACTOR PAX6; TRANSCRIPTION FACTOR SOX17; TRANSCRIPTION FACTOR SOX17 ALPHA; TRANSCRIPTION FACTOR SOX2; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; DYSPLASIA; EMBRYO; EMBRYO DEVELOPMENT; EMBRYOTOXICITY; ENZYME ACTIVITY; ENZYME INHIBITION; EYE DYSPLASIA; EYE MALFORMATION; GENE DISRUPTION; NEURULATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PIGMENT DISORDER; PROTEIN DOMAIN; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCOLIOSIS; SIGNAL TRANSDUCTION; TADPOLE; XENOPUS LAEVIS;

AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; EMBRYO, NONMAMMALIAN; EMBRYONIC DEVELOPMENT; ENDOCRINE DISRUPTORS; EYE DISEASES; IN SITU HYBRIDIZATION; MEMBRANES; PHENOLS; PRESENILINS; RECEPTORS, NOTCH; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; STEM CELLS; SURFACE PLASMON RESONANCE; XENOPUS LAEVIS;

ESCHERICHIA COLI; XENOPUS LAEVIS;

EID: 64349101067     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfp025     Document Type: Article

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