The helicase protein DHX29 promotes translation initiation, cell proliferation, and tumorigenesis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 52, 2009, Pages 22217-22222

  Parsyan, Armen ^a   Shahbazian, David ^a,c   Martineau, Yvan ^a   Petroulakis, Emmanuel ^a   Alain, Tommy ^a   Larsson, Ola ^a   Mathonnet, Geraldine ^a,d   Tettweiler, Gritta ^a   Hellen, Christopher U ^b   Pestova, Tatyana V ^b   Svitkin, Yuri V ^a   Sonenberg, Nahum ^a  

^a MCGILL UNIVERSITY   (Canada)

^b SUNY Downstate Medical Center   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF MONTREAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

HELICASE; HELICASE PROTEIN DHX29; MESSENGER RNA; MONOMER; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CANCER INHIBITION; CARCINOGENESIS; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; FEMALE; HUMAN; HUMAN CELL; POLYSOME; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN SYNTHESIS; PROTEIN TARGETING; TRANSLATION INITIATION; TUMOR XENOGRAFT;

5' UNTRANSLATED REGIONS; ANIMALS; CELL PROLIFERATION; DOWN-REGULATION; HELA CELLS; HUMANS; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; NEOPLASMS; PEPTIDE CHAIN INITIATION, TRANSLATIONAL; RIBOSOME SUBUNITS, SMALL, EUKARYOTIC; RNA HELICASES; RNA INTERFERENCE; RNA, MESSENGER; RNA, SMALL INTERFERING; TRANSPLANTATION, HETEROLOGOUS;

MAMMALIA;

EID: 76049108205     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0909773106     Document Type: Article

References (42)

1. Shatkin AJ (1985) mRNA cap-binding proteins: Essential factors for initiating translation. Cell 40:223-224.
2. Richter JD, Sonenberg N (2005) Regulation of cap-dependent translation by eIF4E-inhibitory proteins. Nature 433:477-480.
3. Sonenberg N, HinnebuschAG(2009) Regulation of translation initiation in eukaryotes: Mechanisms and biological targets. Cell 136:731-745.
4. Pestova TV, Lorsch JR, Hellen CU (2007) in Translational Control in Biology and Medicine, eds Mathews MB, Sonenberg N, Hershey JW (Cold Spring Harbor Lab Press, Cold Spring Harbor, NY), pp 87-129.
5. Pestova TV, Kolupaeva VG (2002) The roles of individual eukaryotic translation initiation factors in ribosomal scanning and initiation codon selection. Genes Dev 16:2906-2922.
6. Lai MC, Lee YH, Tarn WY (2008) The DEAD-box RNA helicase DDX3 associates with export messenger ribonucleoproteins as well as tip-associated protein and participates in translational control. Mol Biol Cell 19:3847-3858.
7. Pisareva VP, Pisarev AV, Komar AA, Hellen CU, Pestova TV (2008) Translation initiation on mammalian mRNAs with structured 5′UTRs requires DExH-box protein DHX29. Cell 135:1237-1250.
8. Fraser CS, et al. (2004) The j-subunit of human translation initiation factor eIF3 is required for the stable binding of eIF3 and its subcomplexes to 40S ribosomal subunits in vitro. J Biol Chem 279:8946-8956.
9. Kolupaeva VG, Unbehaun A, Lomakin IB, Hellen CU, Pestova TV (2005) Binding of eukaryotic initiation factor 3 to ribosomal 40S subunits and its role in ribosomal dissociation and anti-association. RNA 11:470-486.
10. Diehn M, et al. (2003) SOURCE: A unified genomic resource of functional annotations, ontologies, and gene expression data. Nucleic Acids Res 31:219-223.
11. Rhodes DR, et al. (2004) ONCOMINE: A cancer microarray database and integrated data-mining platform. Neoplasia 6:1- 6.
12. Svitkin YV, et al. (2005) Eukaryotic translation initiation factor 4E availability controls the switch between cap-dependent and internal ribosomal entry site - mediated translation. Mol Cell Biol 25:10556-10565.
13. Ramirez-Valle F, Braunstein S, Zavadil J, Formenti SC, Schneider RJ (2008) eIF4GI links nutrient sensing by mTOR to cell proliferation and inhibition of autophagy. J Cell Biol 181:293-307.
14. Yoshida M, et al. (2006) Poly(A) binding protein (PABP) homeostasis is mediated by the stability of its inhibitor, Paip2. EMBO J 25:1934-1944.
15. Gallagher JW, Kubica N, Kimball SR, Jefferson LS (2008) Reduced eukaryotic initiation factor 2Bepsilon-subunit expression suppresses the transformed phenotype of cells overexpressing the protein. Cancer Res 68:8752-8760.
16. MathewsMB, Sonenberg N, Hershey JW (2007) in Translational Control in Biology and Medicine, eds Mathews MB, Sonenberg N, Hershey JW (Cold Spring Harbor Lab Press, Cold Spring Harbor, NY), pp 1-41.
17. Vournakis J, Rich A (1971) Size changes in eukaryotic ribosomes. Proc Natl Acad Sci USA 68:3021-3025.
18. Groppo R, Palmenberg AC (2007) Cardiovirus 2A protein associates with 40S but not 80S ribosome subunits during infection. J Virol 81:13067-13074.
19. Schneider RJ, SonenbergN(2007) in Translational Control in Biology and Medicine, eds Mathews MB, Sonenberg N, Hershey JW (Cold Spring Harbor Lab Press, Cold Spring Harbor, NY), pp 401-433.
20. Eberle J, Krasagakis K, Orfanos CE (1997) Translation initiation factor eIF-4A1 mRNA is consistently overexpressed in human melanoma cells in vitro. Int J Cancer 71:396-401.
21. Lazaris-Karatzas A, Montine KS, Sonenberg N (1990) Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5′ cap. Nature 345:544-547.
22. Silvera D, et al. (2009) Essential role for eIF4GI overexpression in the pathogenesis of inflammatory breast cancer. Nat Cell Biol 903-908.
23. Nakamura K, et al. (2000) Down-regulation of the insulin-like growth factor I receptor by antisense RNA can reverse the transformed phenotype of human cervical cancer cell lines. Cancer Res 60:760-765.
24. Wu Y, Pan S, Luo W, Lin SH, Kuang J (2002) Hp95 promotes anoikis and inhibits tumorigenicity of HeLa cells. Oncogene 21:6801-6808.
25. Sakaue-Sawano A, et al. (2008) Visualizing spatiotemporal dynamics of multicellular cell-cycle progression. Cell 132:487-498.
26. An J, et al. (2008) Inactivation of the CYLD deubiquitinase by HPV E6 mediates hypoxia-induced NF-kappaB activation. Cancer Cell 14:394-407.
27. Wang J, An H, Mayo MW, Baldwin AS, Yarbrough WG (2007) LZAP, a putative tumor suppressor, selectively inhibits NF-kappaB. Cancer Cell 12:239-251.
28. Huang JJ, et al. (2002) Ectopic expression of a COOH-terminal fragment of the human telomerase reverse transcriptase leads to telomere dysfunction and reduction of growth and tumorigenicity in HeLa cells. Cancer Res 62:3226-3232.
29. Tartour E, et al. (1999) Interleukin 17, a T cell - derived cytokine, promotes tumorigenicity of human cervical tumors in nude mice. Cancer Res 59:3698-3704.
30. Kato T, et al. (2009) Characterization of the HDAC1 complex that regulates the sensitivity of cancer cells to oxidative stress. Cancer Res 69:3597-3604.
31. Trachsel H, Erni B, Schreier MH, Staehelin T (1977) Initiation of mammalian protein synthesis, II: The assembly of the initiation complex with purified initiation factors. J Mol Biol 116:755-767.
32. Benne R, Hershey JW (1978) The mechanism of action of protein synthesis initiation factors from rabbit reticulocytes. J Biol Chem 253:3078-3087.
33. Pestova TV, Borukhov SI, Hellen CU (1998) Eukaryotic ribosomes require initiation factors 1 and 1A to locate initiation codons. Nature 394:854-859.
34. Larsson O, et al. (2006) Apoptosis resistance downstream of eIF4E: Posttranscriptional activation of an anti-apoptotic transcript carrying a consensus hairpin structure. Nucleic Acids Res 34:4375-4386.
35. Mamane Y, et al. (2007) Epigenetic activation of a subset of mRNAs by eIF4E explains its effects on cell proliferation. PLoS ONE 2:e242.
36. Shahbazian D, et al. (2006) The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity. EMBO J 25:2781-2791.
37. Methot N, Song MS, Sonenberg N (1996) A region rich in aspartic acid, arginine, tyrosine, and glycine (DRYG) mediates eukaryotic initiation factor 4B (eIF4B) self-association and interaction with eIF3. Mol Cell Biol 16:5328-5334.
38. Stewart SA, et al. (2003) Lentivirus-delivered stable gene silencing by RNAi in primary cells. RNA 9:493-501.
39. Zakikhani M, Dowling R, Fantus IG, Sonenberg N, Pollak M (2006) Metformin is an AMP kinase - dependent growth inhibitor for breast cancer cells. Cancer Res 66:10269-10273.
40. Martineau Y, et al. (2008) Poly(A)-binding protein - interacting protein 1 binds to eukaryotic translation initiation factor 3 to stimulate translation. Mol Cell Biol 28:6658-6667.
41. Rong L, et al. (2008) Control of eIF4E cellular localization by eIF4E-binding proteins, 4E-BPs. RNA 14:1318-1327.
42. Markham NR, Zuker M (2008) UNAFold: Software for nucleic acid folding and hybridization. Methods Mol Biol 453:3-31.