High throughput kinase inhibitor screens reveal TRB3 and MAPK-ERK/TGFβ pathways as fundamental Notch regulators in breast cancer

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 5, 2013, Pages 1714-1719

  Izrailit, Julia ^a,b   Berman, Hal K ^a,b   Datti, Alessandro ^c,d   Wrana, Jeffrey L ^c   Reedijk, Michael ^a,b  

^a PRINCESS MARGARET HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c MOUNT SINAI HOSPITAL   (Canada)

^d UNIVERSITY OF PERUGIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

JAGGED1; MITOGEN ACTIVATED PROTEIN KINASE; NOTCH RECEPTOR; PHOSPHOTRANSFERASE; PHOSPHOTRANSFERASE INHIBITOR; SMALL INTERFERING RNA; TRANSFORMING GROWTH FACTOR BETA; TRIBBLES HOMOLOG 3; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER INHIBITION; ENZYME ACTIVATION; FEMALE; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TUMOR GROWTH; TUMOR XENOGRAFT;

ANIMALS; BLOTTING, WESTERN; BREAST NEOPLASMS; CALCIUM-BINDING PROTEINS; CELL CYCLE PROTEINS; CELL LINE; CELL LINE, TUMOR; FEMALE; HEP G2 CELLS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; INTERLEUKIN RECEPTOR COMMON GAMMA SUBUNIT; MAP KINASE SIGNALING SYSTEM; MEMBRANE PROTEINS; MICE; MICE, INBRED NOD; MICE, KNOCKOUT; MICE, SCID; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; RECEPTOR, NOTCH1; REPRESSOR PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84873161936     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1214014110     Document Type: Article

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