Site-specific regulation of gene expression by estrogen in the hypothalamus of adult female rats

Neuroscience Letters

Volumn 436, Issue 1, 2008, Pages 35-39

  Xu, Qing ^a   Hamada, Tomohiro ^a   Kiyama, Ryoiti ^b   Sakuma, Yasuo ^a   Wada Kiyama, Yuko ^a  

^a NIPPON MEDICAL SCHOOL   (Japan)

^b NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

Author keywords

Estrogen; Hypothalamus; Rat

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR DELTA; 4 AMINOBUTYRIC ACID CARRIER; 4 AMINOBUTYRIC ACID CARRIER 2; ESTROGEN; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR ALPHA4; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE C EPSILON; SEROTONIN RECEPTOR; SEROTONIN RECEPTOR 6; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HYPOTHALAMUS; NERVOUS SYSTEM; NEUROENDOCRINE SYSTEM; NONHUMAN; OVARIECTOMY; PREOPTIC AREA; PRIORITY JOURNAL; RAT; REAL TIME POLYMERASE CHAIN REACTION; THALAMUS VENTRAL NUCLEUS; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; ESTROGENS; FEMALE; GABA PLASMA MEMBRANE TRANSPORT PROTEINS; GENE EXPRESSION REGULATION; HYPOTHALAMUS; RATS; RATS, WISTAR; RECEPTORS, GABA-A; RECEPTORS, NICOTINIC; RECEPTORS, SEROTONIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 41749098806     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2008.02.054     Document Type: Article

References (21)

1. Akashi T., and Sakuma Y. Projections of oestrogen-sensitive neurons from the ventromedial hypothalamic nucleus of the female rat. Physiology 372 (1986) 207-220
2. Arancibia S., Estupina C., Pesco J., Belmar J., and Tapia-Arancibia L. Responsiveness to depolarization of hypothalamic neurons secreting somatostatin under stress and estrous cycle conditions: involvement of GABAergic and steroidal interactions. J. Neurosci. Res. 50 (1997) 575-584
3. Borden L.A., Smith K.E., Hartig P.R., Branchek T.A., and Weinshank R.L. Molecular heterogeniety of the γ-aminobutyric acid (GABA) transporter system. J. Biol. Chem. 267 (1992) 21098-21104
4. Centeno M.L., Luo J., Lindstrom J.M., Caba M., and Pau K.-Y.F. Expression of α4 and α7 nicotonic receptors in the brainstem of female rabbits after coitus. Brain Res. 1012 (2004) 1-12
5. Dorszewska J., Florczak J., Rozycka A., Jaroszewska-Kolecka J., Yrzeciak W.H., and Kozubski W. Polymorphisms of the CHRNA4 gene encoding the alpha4 subunit of nicotinic acetylcholine receptor as related to the oxidative DNA damage and the level of apoptotic proteins in lymphocytes of the patients with Alzheimer's disease. DNA Cell Biol. 24 (2005) 786-794
6. Gordon J.A. Anxiolytic drug targets: beyond the usual suspects. J. Clin. Invest. 110 (2002) 915-917
7. Inoue A., Tanji M., and Kiyama R. Focused microarray analysis: characteriztion of phenomes by gene expression profiling. Curr. Pharmacogenomics 4 (2006) 245-260
8. Israel J.M., and Poulain D.A. 17-Oestradiol modulates in vitro electrical properties and responses to kainite of oxytocin neurons in lactating rats. J. Physiol. 524 (2000) 457-470
9. Jarry H., Leonhardt S., Schwarze T., and Wuttke W. Preoptic rather than mediobasal hupothalamuc amino acid neurotransmitter regulates GnRH secretion during the estroegen-induced LH surge in the ovariectomized rat. Neuroendocrinology 62 (1995) 479-486
10. Kow L.M., Devidze N., Pataky S., Shibuya I., and Pfaff D.W. Acute estradiol application increases inward and decreases outward whole-cell currents of neurons in rat hypothalamic ventromedial nucleus. Brain Res. 1116 (2006) 1-11
11. Lovick T.A., Griffiths J.L., Dunn S.M., and Martin I.L. Changes in GABAA receptors subunit expression in the midbrain during the oestrous cycle in Wister rats. Neuroscience 131 (2005) 397-405
12. Mihalek R.M., Banerjee P.K., Korpik E.R., Quinlan J.J., Firestone L.L., Mi Z.-P., Lagenaur C., Tretter V., Sieghart W., Anagnostaras S.G., Sage J.R., Fanselow M.S., Guidotti A., Spigelman I., Li Z., DeLorey T.M., Olsen R.W., and Homanics G.E. Attenuated sensitivity to neuroactive steroids in γ-aminobutyrate type A receptor delta subunit knockout mice. Proc. Natl. Acad. Sci. U.S.A. 96 (1999) 12905-12910
13. Nilsen J., and Brinton R.D. Mechanism of estrogen-mediated neuroprotection: regulation of mitochondrial calcium and Bcl-2 expression. Proc. Natl. Acad. Sci. U.S.A. 100 (2003) 2842-2847
14. Olsen R.W., and Sapp D.W. Neuroactive steroid modulation of GABAA receptors. Adv. Biochem. Psychopharmacol. 48 (1995) 57-74
15. Papageorgiou A., and Denef C. Estradiol induces expression of 5-hydroxytryptamine (5-HT) 4,5-HT5 and 5-HT6 receptor messenger ribonucleic acid in rat anterior pituitary cell aggregates and allows prolactin release via the 5-HT4 receptor. Endocrinology 143 (2007) 1384-1395
16. Pfaff D.W., Sakuma Y., Kow L.-M., Lee A.W., and Easton A. Hormonal, neural, and genomic mechanisms for female reproductive behaviors, motivation, and arousal. In: Neil J.D. (Ed). Physiology of Reproduction (2006), Academic Press, San Diego 1825-1920
17. Rho J.-y., Wada-Kiyama Y., Onishi Y., Kiyama R., and Sakuma Y. Expressional regulation of neuronal and cancer-related genes by estrogen in adult female rats. Endocr. Res. 30 (2004) 257-267
18. Sakuma Y. Estrogen-induced changes in the neural impulse flow from the female rat preoptic region. Horm. Behav. 28 (1994) 438-444
19. Shibutani M., Masutomi N., Uneyama C., Abe N., Takagi H., Lee K.-Y., and Hirose M. Down-regulation of GAT-1 mRNA expression in the microdissected hypothlamis medial preoptic area of rat offspring exposed maternally to ethinylestradiol. Toxicology 208 (2005) 35-48
20. Suzuki M., Nishihara M., and Takahashi M. Hypothalamic gonadotoropin-releasing hormone gene expression during rat estrous cycle. Endocr. J. 42 (1995) 789-796
21. Wevers A., Burghaus L., Moser N., Witter B., Steinlein O.K., Schutz U., Achnitz B., Krempel U., Nowacki S., Pliz K., Stoodt J., Lindstrom J., De R.A.I., Steur E.N.H.J., and Schroder S. Expression of nicotinic acetylcholine receptors in Alzheimer's disease: postmortem investigations and experimental approaches. Behav. Brain Res. 113 (2000) 207-215