Genistein induces G2/M cell cycle arrest via stable activation of ERK1/2 pathway in MDA-MB-231 breast cancer cells

Cell Biology and Toxicology

Volumn 24, Issue 5, 2008, Pages 401-409

  Li, Zhong ^a   Li, Jing ^a   Mo, Baoqing ^a   Hu, Chunyan ^a   Liu, Huaqing ^a   Qi, Hong ^a   Wang, Xinru ^a   Xu, Jida ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Breast cancer; Cell cycle arrest; ERK1 2 pathway; Genistein

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CELL CYCLE PROTEIN; CELL CYCLE PROTEIN 25C; CYCLIN B1; CYCLIN DEPENDENT KINASE 1; GENISTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PROTEIN C FOS; PROTEIN C JUN; RAF PROTEIN; RAS PROTEIN; UNCLASSIFIED DRUG; FLAVONOID; PROTEIN KINASE INHIBITOR;

ARTICLE; BREAST CANCER; CANCER CELL; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL LINE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STEADY STATE; UPREGULATION; WESTERN BLOTTING; CELL CYCLE; CELL DIVISION; DOSE RESPONSE; ENZYME ACTIVATION; METABOLISM; METHODOLOGY; PHOSPHORYLATION; TUMOR CELL LINE;

GLYCINE MAX;

CELL CYCLE; CELL DIVISION; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; FLAVONOIDS; FLOW CYTOMETRY; G2 PHASE; GENISTEIN; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-RAF;

EID: 50249177143     PISSN: 07422091     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10565-008-9054-1     Document Type: Article

References (38)

1. DW Abbott JT Holt 1999 Mitogen-activated protein kinase kinase 2 activation is essential for progression through the G2/M checkpoint arrest in cells exposed to ionizing radiation J Biol Chem. 274 2732 2742
2. A Abrieu D Fisher MN Simon M Doree A Picard 1997 MAPK inactivation is required for the G2 to M-phase transition of the first mitotic cell cycle EMBO J. 16 6407 6413
3. SA Alhasan JF Ensley FH Sarkar 2000 Genistein induced molecular changes in a squamous cell carcinoma of the head and neck cell line Int J Oncol. 16 333 338
4. P Angel M Karin 1991 The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation Biochim Biophys Acta. 1072 129 157
5. C Borrás J Gambini MC Gómez-Cabrera 2006 Genistein, a soy isoflavone, up-regulates expression of antioxidant genes: involvement of estrogen receptors, ERK1/2, and NFkappaB FASEB J. 20 2136 2138
6. waf1/cip1 and Wee1 Biochem Pharmacol. 67 717 726
7. AC Chen SM Donovan 2004 Genistein at a concentration present in soy infant formula inhibits Caco-2BBe cell proliferation by causing G2/M cell cycle arrest J Nutr. 134 1303 1308
8. YH Choi L Zhang WH Lee KY Park 1998 Genistein-induced G2/M arrest is associated with the inhibition of cyclin B1 and the induction of p21 in human breast carcinoma cells Int J Oncol. 13 391 396
9. TG Cross D Scheel-Toellner NV Henriquez 2000 Serine/threonine protein kinases and apoptosis Exp Cell Res. 256 34 41
10. K Dampier EA Hudson LM Howells 2001 Differences between human breast cell lines in susceptibility towards growth inhibition by genistein Br J Cancer. 85 618 624
11. L Fioranvanti V Cappelletti P Miodini 1998 Genistein in the control of breast cancer cell growth: insights into the mechanism of action in vitro Cancer Lett. 130 143 152
12. T Fotsis M Pepper H Adlercreutz 1995 Genistein, a dietary ingested isoflavonoid, inhibits cell proliferation and in vitro angiogenesis J Nutr. 125 790S 797S
13. kip1, and Cdc25C expression Biochem Pharmacol 61 979 989
14. Y Gotoh E Nishida 1995 Activation mechanism and function of the MAP kinase cascade Mol Reprod Dev. 42 486 492
15. CY Hsieh RC Santell SZ Haslam WG Helferich 1998 Estrogenic effects of genistein on the growth of estrogen receptor-positive human breast cancer (MCF-7) cells in vitro and in vivo Cancer Res. 58 3833 3838
16. T Kobayashi T Nakata T Kuzumaki 2002 Effect of flavonoids on cell cycle progression in prostate cancer cells Cancer Lett 176 17 23
17. WAF1 upregulation, and apoptosis in a non-small-cell lung cancer cell line Nutr Cancer. 31 184 191
18. NJ Linford Y Yang DG Cook DM Dorsa 2001 Neuronal apoptosis resulting from high doses of the isoflavone genistein: role for calcium and p42/44 mitogen-activated protein kinase J Pharmacol Exp Ther. 299 67 75
19. Y Matsukawa N Marui T Sakai 1993 Genistein arrests cell cycle progression at G2-M Cancer Res 53 1328 1331
20. MJ Messina V Persky KD Setchell S Barnes 1994 Soy intake and cancer risk: a review of the in vitro and in vivo data Nutr Cancer 21 113 131
21. M Molinari 2000 Cell cycle checkpoints and their inactivation in human cancer Cell Prolif 33 261 274
22. E Monti BK Sinha 1994 Antiproliferative effect of genistein and adriamycin against estrogen-dependent and independent human breast carcinoma cell lines Anticancer Res 14 1221 1226
23. S Nomoto Y Arao H Horiguchi K Ikeda F Kayama 2002 Oestrogen causes G2/M arrest and apoptosis in breast cancer cells MDA-MB-231 Oncol Rep 9 773 776
24. G Peterson S Barnes 1991 Genistein inhibition of the growth of human breast cancer cells: independence from estrogen receptors and the multi-drug resistance gene Biochem Biophys Res Commun 179 661 667
25. KM Pumiglia SJ Decker 1997 Cell cycle arrest mediated by the MEK/mitogen-activated protein kinase pathway Proc Natl Acad Sci U S A 94 448 452
26. H Schaeffer M Weber 1999 Mitogen-activated protein kinases: specific messages from ubiquitous messengers Mol Cell Biol 19 2435 2444
27. ZM Shao J Wu ZZ Shen SH Barsky 1998 Genistein exerts multiple suppressive effects on human breast carcinoma cells Cancer Res 58 4851 4857
28. CJ Sherr 1996 Cancer cell cycle Science 274 1672 1677
29. SS Sridhar D Hedley LL Siu 2005 Raf kinase as a target for anticancer therapeutics Mol Cancer Ther 4 677 685
30. D Tang D Wu A Hirao 2002 ERK activation mediates cell cycle arrest and apoptosis after DNA damage independently of p53 J Biol Chem 277 12710 12717
31. F Traganos B Ardelt N Halko S Bruno Z Darzynkiewicz 1992 Effects of genistein on the growth and cell cycle progression of normal human lymphocytes and human leukemic MOLT-4 and HL-60 cells Cancer Res 52 6200 6208
32. WAF1 Clin Cancer Res 7 1782 1789
33. A Vivacqua D Bonofiglio L Albanito 2006 17beta-estradiol, genistein, and 4-hydroxytamoxifen induce the proliferation of thyroid cancer cells through the g protein-coupled receptor GPR30 Mol Pharmacol 70 1414 1423
34. AJ Whitmarsh RJ Davis 1996 Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways J Mol Med 74 589 607
35. Z Xia M Dickens J Raingeaud RJ Davis ME Greenberg 1995 Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis Science 270 1326 1331
36. Y Yan RS Spieker M Kim SM Stoeger KH Cowan 2005 BRCA1-mediated G2/M cell cycle arrest requires ERK1/2 kinase activation Oncogene 24 3285 3296
37. DT Zava G Duwe 1997 Estrogenic and antiproliferative properties of genistein and other flavonoids in human breast cancer cells in vitro Nutr Cancer 27 31 40
38. JR Zhou P Mukherjee ET Gugger 1998 Inhibition of murine bladder tumorigenesis by soy isoflavones via alterations in the cell cycle, apoptosis, and angiogenesis Cancer Res 58 5231 5238