Di(2-ethylhexyl)phthalate exposure impairs insulin receptor and glucose transporter 4 gene expression in L6 myotubes

Human and Experimental Toxicology

Volumn 33, Issue 7, 2014, Pages 685-700

  Rajesh, P ^a   Balasubramanian, K ^a  

^a UNIVERSITY OF MADRAS   (India)

Author keywords

di(2 ethylhexyl)phthalate; glucose oxidation; glucose transporter4; insulin receptor; insulin signal transduction; L6 myotubes; reactive oxygen species

Indexed keywords

ANTIOXIDANT; GLUCOSE; GLUCOSE TRANSPORTER 4; GLUTAMINE FRUCTOSE 6 PHOSPHATE AMINOTRANSFERASE; HYDROGEN PEROXIDE; INDUCIBLE NITRIC OXIDE SYNTHASE; INSULIN RECEPTOR; LIPID; NITRIC OXIDE; PHTHALIC ACID BIS(2 ETHYLHEXYL) ESTER; REACTIVE OXYGEN METABOLITE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; ENDOCRINE DISRUPTOR; GLYCOGEN; SLC2A4 PROTEIN, RAT;

ANIMAL CELL; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY; ENVIRONMENTAL EXPOSURE; GENE EXPRESSION; GLUCOSE OXIDATION; GLUCOSE TRANSPORT; L6 MYOTUBE; LIPID PEROXIDATION; MYOTUBE; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; ANIMAL; CELL LINE; CELL SURVIVAL; DOSE RESPONSE; DRUG EFFECTS; GENETICS; INSULIN RESISTANCE; METABOLISM; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; SKELETAL MUSCLE; TIME;

ANIMALS; ANTIOXIDANTS; CELL LINE; CELL SURVIVAL; DIETHYLHEXYL PHTHALATE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOCRINE DISRUPTORS; GLUCOSE; GLUCOSE TRANSPORTER TYPE 4; GLYCOGEN; INSULIN RESISTANCE; LIPID PEROXIDATION; MUSCLE FIBERS, SKELETAL; OXIDATION-REDUCTION; OXIDATIVE STRESS; RATS; REACTIVE OXYGEN SPECIES; RECEPTOR, INSULIN; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 84903543274     PISSN: 09603271     EISSN: 14770903     Source Type: Journal    
DOI: 10.1177/0960327113506238     Document Type: Article

References (61)

1. Koo JW, Parham F, Kohn MC, et al. The association between biomarker-based exposure estimates for phthalates and demographic factors in a human reference population. Environ Health Perspect. 2002 ; 110: 405-410
2. Calafat AM, McKee RH. Integrating biomonitoring exposure data into the risk assessment process: phthalates (diethyl phthalate and di(2-ethylhexyl) phthalate) as a case study. Environ Health Perspect. 2006 ; 114: 1783-1789
3. Nassberger L, Arbin A, Ostelius J. Exposure of patients to phthalates from polyvinyl chloride tubes and bags during dialysis. Nephron. 1987 ; 45: 286-290
4. Petersen JH, Breindahl T. Plasticizers in total diet samples, baby food and infant formulae. Food Addit Contam. 2000 ; 17: 133-141
5. Schmid P, Schlatter C. Excretion and metabolism of di(2-ethylhexyl) phthalate in man. Xenobiotica. 1985 ; 15: 251-256
6. Hauser R, Calafat AM. Phthalates and human health. Occup Environ Med. 2005 ; 62: 806-818
7. Lind PM, Zethelius B, Lind L. Circulating levels of phthalate metabolites are associated with prevalent diabetes in the elderly. Diab Care. 2012 ; 35: 1519-1524
8. Stahlhut RW, van Wijngaarden E, Dye TD, et al. Concentrations of urinary phthalate metabolites are associated with increased waist circumference and insulin resistance in adult U.S. males. Environ Health Perspect. 2007 ; 115: 876-882
9. Hatch EE, Nelson JW, Qureshi MM, et al. Association of urinary phthalate metabolite concentrations with body mass index and waist circumference: a cross-sectional study of NHANES data, 1999-2002. Environ Health. 2008 ; 7: 27
10. Svensson K, Hernandez-Ramirez RU, Burguete-Garcia A, et al. Phthalate exposure associated with self-reported diabetes among Mexican women. Environ Res. 2011 ; 111: 792-796
11. Gayathri NS, Dhanya CR, Indu AR, Kurup PA. Changes in some hormones by low doses of di (2-ethyl hexyl) phthalate (DEHP), a commonly used plasticizer in PVC blood storage bags & medical tubing. Indian J Med Res. 2004 ; 119: 139-144
12. Rajesh P, Sathish S, Srinivasan C, et al. Phthalate is associated with insulin resistance in adipose tissue of male rat: role of antioxidant vitamins. J Cell Biochem. 2013 ; 114: 558-569
13. Srinivasan C, Khan AI, Balaji V, et al. Diethyl hexyl phthalate-induced changes in insulin signaling molecules and the protective role of antioxidant vitamins in gastrocnemius muscle of adult male rat. Toxicol Appl Pharmacol. 2011 ; 257: 155-164
14. Gupta RN, Pareek A, Suthar M, et al. Study of glucose uptake activity of Helicteres isora Linn. fruits in L-6 cell lines. Int J Diab Dev Ctries. 2009 ; 29: 170-173
15. Klip A, Li G, Logan WJ. Role of calcium ions in insulin action on hexose transport in L6 muscle cells. Am J Physiol. 1984 ; 247: E297 - E304
16. Hynes J, Hill R, Papkovsky DB. The use of a fluorescence-based oxygen uptake assay in the analysis of cytotoxicity. Toxicol vitro. 2006 ; 20: 785-792
17. Bagchi D, Bagchi M, Hassoun EA, Stohs SJ. In vitro and in vivo generation of reactive oxygen species, DNA damage and lactate dehydrogenase leakage by selected pesticides. Toxicology. 1995 ; 104: 129-140
18. Devasagayam TP, Tarachand U. Decreased lipid peroxidation in the rat kidney during gestation. Biochem Biophys Res Commun. 1987 ; 145: 134-138
19. Pick E, Keisari Y. Superoxide anion and hydrogen peroxide production by chemically elicited peritoneal macrophages - induction by multiple nonphagocytic stimuli. Cell Immunol. 1981 ; 59: 301-318
20. Puntarulo S, Cederbaum AI. Effect of oxygen concentration on microsomal oxidation of ethanol and generation of oxygen radicals. Biochem J. 1988 ; 251: 787-794
21. Marklund S, Marklund G. Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem. 1974 ; 47: 469-474
22. Sinha AK. Colorimetric assay of catalase. Anal Biochem. 1972 ; 47: 389-394
23. Rotruck JT, Pope AL, Ganther HE, et al. Selenium: biochemical role as a component of glutathione peroxidase. Science. 1973 ; 179: 588-590
24. Moron MS, Depierre JW, Mannervik B. Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver. Biochim Biophys Acta. 1979 ; 582: 67-78
25. Omaye ST, Turnbull JD, Sauberlich HE. Selected methods for the determination of ascorbic acid in animal cells, tissues, and fluids. Methods Enzymol. 1979 ; 62: 3-11
26. Quaife ML, Dju MY. Chemical estimation of vitamin E in tissue and the tocopherol content of some normal human tissues. J Biol Chem. 1949 ; 180: 263-272
27. Green LC, Wagner DA, Glogowski J, et al. Analysis of nitrate, nitrite, and [15 N]nitrate in biological fluids. Anal Biochem. 1982 ; 126: 131-138
28. Thorell JI, Johansson BG. Enzymatic iodination of polypeptides with 125I to high specific activity. Biochim Biophys Acta. 1971 ; 251: 363-369
29. Habberfield AD, Dix CJ, Cooke BA. Evidence for the rapid internalization and recycling of lutropin receptors in rat testis Leydig cells. Biochem J. 1986 ; 233: 369-376
30. Teruel T, Hernandez R, Lorenzo M. Ceramide mediates insulin resistance by tumor necrosis factor-alpha in brown adipocytes by maintaining Akt in an inactive dephosphorylated state. Diabetes. 2001 ; 50: 2563-2571
31. Blair AS, Hajduch E, Litherland GJ, et al. Regulation of glucose transport and glycogen synthesis in L6 muscle cells during oxidative stress. Evidence for cross-talk between the insulin and SAPK2/p38 mitogen-activated protein kinase signaling pathways. J Biol Chem. 1999 ; 274: 36293-36299
32. Kraft LA, Johnson AD.. Epididymal carbohydrate metabolism. II. Substrates and pathway utilization of caput and cauda epididymal tissue from the rabbit, rat and mouse. Compar Biochem Physiol B, Compar Biochem. 1972 ; 42: 451-461
33. Roe JH, Dailey RE. Determination of glycogen with the anthrone reagent. Anal Biochem. 1966 ; 15: 245-250
34. Ye F, Maegawa H, Morino K, et al. A simple and sensitive method for glutamine: fructose-6-phosphate amidotransferase assay. J Biochem Biophys Method. 2004 ; 59: 201-208
35. Schmitz-Peiffer C. Signalling aspects of insulin resistance in skeletal muscle: mechanisms induced by lipid oversupply. Cell Signal. 2000 ; 12: 583-594
36. Neel BA, Sargis RM. The paradox of progress: environmental disruption of metabolism and the diabetes epidemic. Diabetes. 2011 ; 60: 1838-1848
37. Kim SH, Kim SS, Kwon O, et al. Effects of dibutyl phthalate and monobutyl phthalate on cytotoxicity and differentiation in cultured rat embryonic limb bud cells; protection by antioxidants. J Toxicol Environ Health A. 2002 ; 65: 461-472
38. Andriana BB, Tay TW, Maki I, et al. An ultrastructural study on cytotoxic effects of mono(2-ethylhexyl) phthalate (MEHP) on testes in Shiba goat in vitro. J Veterin Sci. 2004 ; 5: 235-240
39. Lim CK, Kim SK, Ko DS, et al. Differential cytotoxic effects of mono-(2-ethylhexyl) phthalate on blastomere-derived embryonic stem cells and differentiating neurons. Toxicology. 2009 ; 264: 145-154
40. Lee H, Kalmus GW. Cytotoxic effect of di(2-ethylhexyl) phthalate on cultured chick embryonic cells. Experientia. 1974 ; 30: 800-801
41. Rusyn I, Kadiiska MB, Dikalova A, et al. Phthalates rapidly increase production of reactive oxygen species in vivo: role of Kupffer cells. Mol Pharmacol. 2001 ; 59: 744-750
42. Palleschi S, Rossi B, Diana L, et al. Di(2-ethylhexyl)phthalate stimulates Ca(2+) entry, chemotaxis and ROS production in human granulocytes. Toxicol Lett. 2009 ; 187: 52-57
43. Wyllie AH. Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature. 1980 ; 284: 555-556
44. Abdul-Ghani MA, Muller FL, Liu Y, et al. Deleterious action of FA metabolites on ATP synthesis: possible link between lipotoxicity, mitochondrial dysfunction, and insulin resistance. Am J Physiol Endocrinol Metab. 2008 ; 295: E678 - E685
45. Bonnard C, Durand A, Peyrol S, et al. Mitochondrial dysfunction results from oxidative stress in the skeletal muscle of diet-induced insulin-resistant mice. J Clin Invest. 2008 ; 118: 789-800
46. Kumashiro N, Tamura Y, Uchida T, et al. Impact of oxidative stress and peroxisome proliferator-activated receptor gamma coactivator-1alpha in hepatic insulin resistance. Diabetes. 2008 ; 57: 2083-2091
47. Valko M, Leibfritz D, Moncol J, et al. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol. 2007 ; 39: 44-84
48. Yu BP. Cellular defenses against damage from reactive oxygen species. Physiol Rev. 1994 ; 74: 139-162
49. McCord JM. The evolution of free radicals and oxidative stress. Am J Med. 2000 ; 108: 652-659
50. Nourooz-Zadeh J, Tajaddini-Sarmadi J, McCarthy S, et al. Elevated levels of authentic plasma hydroperoxides in NIDDM. Diabetes. 1995 ; 44: 1054-1058
51. Nourooz-Zadeh J, Rahimi A, Tajaddini-Sarmadi J, et al. Relationships between plasma measures of oxidative stress and metabolic control in NIDDM. Diabetologia. 1997 ; 40: 647-653
52. Rudich A, Kozlovsky N, Potashnik R, et al. Oxidant stress reduces insulin responsiveness in 3T3-L1 adipocytes. Am J Physiol. 1997 ; 272: E935 - E940
53. Rengarajan S, Parthasarathy C, Anitha M, et al. Diethylhexyl phthalate impairs insulin binding and glucose oxidation in Chang liver cells. Toxicol Vitro. 2007 ; 21: 99-102
54. Furler SM, Jenkins AB, Storlien LH, et al. In vivo location of the rate-limiting step of hexose uptake in muscle and brain tissue of rats. Am J Physiol. 1991 ; 261: E337 - E347
55. Mueckler M.. Family of glucose-transporter genes. Implications for glucose homeostasis and diabetes. Diabetes. 1990 ; 39: 6-11
56. Armoni M, Kritz N, Harel C, et al. Peroxisome proliferator-activated receptor-gamma represses GLUT4 promoter activity in primary adipocytes, and rosiglitazone alleviates this effect. J Biol Chem. 2003 ; 278: 30614-30623
57. Xu Y, Cook TJ, Knipp GT. Effects of di-(2-ethylhexyl)-phthalate (DEHP) and its metabolites on fatty acid homeostasis regulating proteins in rat placental HRP-1 trophoblast cells. Toxicol Sci. 2005 ; 84: 287-300
58. Joost HG, Thorens B. The extended GLUT-family of sugar/polyol transport facilitators: nomenclature, sequence characteristics, and potential function of its novel members (review). Mol Membr Biol. 2001 ; 18: 247-256
59. Martinelli MI, Mocchiutti NO, Bernal CA. Dietary di(2-ethylhexyl) phthalate-impaired glucose metabolism in experimental animals. Hum Exp Toxicol. 2006 ; 25: 531-538
60. Marshall S, Bacote V, Traxinger RR. Discovery of a metabolic pathway mediating glucose-induced desensitization of the glucose transport system. Role of hexosamine biosynthesis in the induction of insulin resistance. J Biol Chem. 1991 ; 266: 4706-4712
61. Brownlee M. The pathobiology of diabetic complications: a unifying mechanism. Diabetes. 2005 ; 54: 1615-1625