Testosterone up-regulates seladin-1 expression by iAR and PI3-K/Akt signaling pathway in C6 cells

Neuroscience Letters

Volumn 514, Issue 1, 2012, Pages 122-126

  Zu, Hengbing ^a   Wu, Junfeng ^a   Zhang, Jianfeng ^a   Yu, Min ^b   Hong, Zhen ^c  

^a JINSHAN HOSPITAL OF FUDAN UNIVERSITY   (China)

^b FUDAN UNIVERSITY   (China)

^c FUDAN UNIVERSITY   (China)

Author keywords

Akt; Androgen receptor; Selective Alzheimer's disease indicator 1; Testosterone

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ANDROGEN RECEPTOR; BRAIN PROTEIN; FLUTAMIDE; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SELADIN 1; TESTOSTERONE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; GENE EXPRESSION; GENE INDUCTION; GLIA CELL; HORMONAL REGULATION; INTRACELLULAR SIGNALING; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; THYMOMA; UPREGULATION; VIRUS ONCOGENE;

ANIMALS; CELL LINE, TUMOR; NERVE TISSUE PROTEINS; NEURONS; OXIDOREDUCTASES ACTING ON CH-CH GROUP DONORS; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RECEPTORS, ANDROGEN; SIGNAL TRANSDUCTION; TESTOSTERONE; UP-REGULATION;

EID: 84862781982     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2012.02.072     Document Type: Article

References (22)

1. Alessandro P., Mario S. Neuroprotective effects of the Alzheimer's disease-related gene seladin-1. J. Mol. Endocrinol. 2008, 41:251-261.
2. Benvenuti S., Luciani P., Cellai I., Deledda C., Baglioni S., Saccardi R., Urbani S., Francini F., Squecco R., Giuliani C., Vannelli G.B., Serio M., Pinchera A., Peri A. Thyroid hormones promote cell differentiation and up-regulate the expression of the seladin-1 gene in vitro models of human neuronal precursors. J. Endocrinol. 2008, 197:437-446.
3. Benvenuti S., Saccardi R., Luciani P., Urbani S., Deledda C., Cellai I., Francini F., Squecco R., Rosati F., Danza G., Gelmini S., Greeve I., Rossi M., Maggi R., Serio M., Peri A. Neuronal differentiation of human mesenchymal stem cells: changes in the expression of the Alzheimer's disease-related gene seladin-1. Exp. Cell Res. 2006, 312:2592-2604.
4. Castoria G., Lombardi M., Barone M.V., Bilancio A., Di Domenico M., De Falco A., Varricchio L., Bottero D., Nanayakkara M., Migliaccio Auricchio F. Rapid signalling pathway activation by androgens in epithelial and stromal cells. Steroids 2004, 69:517-522.
5. Claessens F., Verrijdt G., Schoenmakers E., Haelens A., Peeters B., Verhoeven G., Rombauts W. Selective DNA binding by the androgen receptor as a mechanism for hormone-specific gene regulation. J. Steroid Biochem. Mol. Biol. 2001, 76:23-30.
6. Fuller S.J., Tan R.S., Martins R.N. Androgens in the etiology of Alzheimer's disease in aging men and possible therapeutic interventions. J. Alzheimers Dis. 2007, 12:129-142.
7. Gatson J.W., Kaur P., Singh M. Dihydrotestosterone differentially modulates the mitogen-activated protein kinase and the phosphoinositide 3-kinase/Akt pathways through the nuclear and novel membrane androgen receptor in C6 cells. Endocrinology 2006, 147:2028-2034.
8. Gatson J.W., Singh M. Activation of a membrane-associated androgen receptor promotes cell death in primary cortical astrocytes. Endocrinology 2007, 148:2458-2464.
9. Greeve I., Hermans-Borgmeyer I., Brellinger C., Kasper D., Gomez-Isla T., Behl C., Levkau B., Nitsch R.M. The human DIMINUTO/DWARF1 homolog seladin-1 confers resistance to Alzheimer's disease-associated neurodegeneration and oxidative stress. J. Neurosci. 2000, 20:7345-7352.
10. Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C (T)) method. Methods 2001, 25:402-408.
11. Kim Y.J., Lee C.J., Lee U., Yoo Y.M. Tamoxifen-induced cell death and expression of neurotrophic factors in cultured C6 glioma cells. J. Neurooncol. 2005, 71:121-125.
12. Kovacheva E.L., Hikim A.P., Shen R., Sinha I., Sinha-Hikim I. Testosterone supplementation reverses sarcopenia in aging through regulation of myostatin, c-Jun NH2-terminal kinase, Notch, and Akt signaling pathways. Endocrinology 2010, 151:628-638.
13. Lin J., Adam R.M., Santiestevan E., Freeman M.R. The phosphatidylinositol 3'-kinase pathway is a dominant growth factor-activated cell survival pathway in LNCaP human prostate carcinoma cells. Cancer Res. 1999, 59:2891-2897.
14. Livonen S., Hiltunen M., Alafuzoff I., Mannermaa A., Kerokskii P., Puolivali J., Salminen A., Helisalmi S., Soininen H. Seladin-1 transcription is linked to neuronal degeneration in Alzheimer's disease. Neuroscience 2002, 113:301-310.
15. McEwan I.J. Molecular mechanisms of androgen receptor-mediated gene regulation: structure-function analysis of the AF-1 domain. Endocrine-Related Cancer 2004, 11:281-293.
16. Peri A., Danza G., Benvenuti S., Luciani P., Deledda C., Rosati F., Cellai I., Serio M. New insights on the neuroprotective role of sterols and sex steroids: the seladin-1/DHCR24 paradigm. Front. Neuroendocrinol. 2009, 30:119-129.
17. Pike C.J., Nguyen T.V., Ramsden M., Yao M., Murphy M.P., Rosario E.R. Androgen cell signaling pathways involved in neuroprotective actions. Horm. Behav. 2007, 53:693-705.
18. Rosario E.R., Pike C.J. Androgen regulation of beta-amyloid protein and the risk of Alzheimer's disease. Brain Res. Rev. 2008, 57:444-453.
19. Sun M., Yang L., Feldman R.I., Sun X.M., Bhalla K.N., Jove R., Nicosia S.V., Cheng J.Q. Activation of phosphatidylinositol 3-kinase/Akt pathway by androgen through interaction of p85alpha, androgen receptor, and Src. J. Biol. Chem. 2003, 278:42992-43000.
20. Wang Y., Kreisberg J.I., Ghosh P.M. Cross-talk between the androgen receptor and the phosphatidylinositol 3-kinase/Akt pathway in prostate cancer. Curr. Cancer Drug Targets 2007, 7:591-604.
21. Wilson R.E., Coons K.D., Sengelaub D.R. Neuroprotective effects of testosterone on dendritic morphology following partial motoneuron depletion: efficacy in female rats. Neurosci. Lett. 2009, 465:123-127.
22. Zhang L., Charron M., Wright W.W., Chatterjee B., Song C.S., Roy A.K., Brown T.R. Nuclear factor-kappaB activates transcription of the androgen receptor gene in Sertoli cells isolated from testes of adult rats. Endocrinology 2004, 145:781-789.