Activation of the PI3K-AKT-mTOR signaling pathway promotes DEHP-induced Hep3B cell proliferation

Food and Chemical Toxicology

Volumn 59, Issue , 2013, Pages 325-333

  Chen, Xi ^a,b   Qin, Qizhi ^a   Zhang, Wenjuan ^a,b   Zhang, Youjian ^a,b   Zheng, Hongyan ^a,b   Liu, Chuanyao ^a,b   Yang, Yuqing ^a,b   Xiong, Wei ^a,b   Yuan, Jing ^a,b  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

8 OHdG; AKT; DEHP; Di (2 ethylbexyl) phthalate; DMSO; GSH; GSSG; MTOR; Oxidative stress; P70S6K; PI3K; PI3K AKT mTOR pathway; PPAR; Proliferation; ROS; TBST

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 8 HYDROXY 20 DEOXYGUANOSINE; DEOXYGUANOSINE; DI(2 ETHYLBEXYL)PHTHALATE; GLUTATHIONE; MAMMALIAN TARGET OF RAPAMYCIN; MESSENGER RNA; MITOCHONDRIAL DNA; PHOSPHATIDYLINOSITOL 3 KINASE; PLASTICIZER; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

AKT GENE; ARTICLE; CANCER CELL; CELL CYCLE; CELL PROLIFERATION; CELL PROTECTION; CELL STRAIN; CELL STRAIN HEP3B; CELL VIABILITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNA DAMAGE; DNA REPLICATION; ENZYME ACTIVATION; GENE CONTROL; GENE EXPRESSION; HUMAN; HUMAN CELL; LIVER CANCER; LIVER MITOCHONDRION; MITOCHONDRIAL MEMBRANE POTENTIAL; MTOR GENE; OXIDATIVE STRESS; P70S6K GENE; PI3K GENE; SIGNAL TRANSDUCTION; UPREGULATION;

40S RIBOSOMAL PROTEIN S6 KINASE; 8-HYDROXY-2′-DEOXYGUANOSINE; 8-OHDG; AKT; BUFFERED SALINE WITH TWEEN 20; DEHP; DI-(2-ETHYLBEXYL) PHTHALATE; DI-(2-ETHYLHEXYL) PHTHALATE; DIMETHYL SULFOXIDE; DMSO; GLUTATHIONE; GSH; GSSG; MAMMALIAN TARGET OF RAPAMYCIN; MTOR; OXIDATIVE STRESS; OXIDIZED GLUTATHIONE; P70S6K; PEROXISOME PROLIFERATORS-ACTIVATED RECEPTOR; PHOSPHOINOSITIDE 3-KINASE; PI3K; PI3K-AKT-MTOR PATHWAY; PPAR; PROLIFERATION; PROTEIN KINASE B; REACTIVE OXYGEN SPECIES; ROS; TBST;

CARCINOGENS, ENVIRONMENTAL; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CHROMONES; DIETHYLHEXYL PHTHALATE; DNA DAMAGE; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, NEOPLASTIC; HEPATOCYTES; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MORPHOLINES; NEOPLASM PROTEINS; OSMOLAR CONCENTRATION; OXIDATIVE STRESS; PHOSPHATIDYLINOSITOL 3-KINASE; PLASTICIZERS; PROTO-ONCOGENE PROTEINS C-AKT; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84880369392     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2013.06.016     Document Type: Article

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