Dominant mutations in the tyrosyl-tRNA synthetase gene recapitulate in Drosophila features of human Charcot-Marie-Tooth neuropathy

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 28, 2009, Pages 11782-11787

  Storkebaum, Erik ^a   Leitão Gonçalves, Ricardo ^a,b,c   Godenschwege, Tanja ^d   Nangle, Leslie ^e,f   Mejia, Monica ^d   Bosmans, Inge ^a   Ooms, Tinne ^b,c   Jacobs, An ^b,c   Van Dijck, Patrick ^a   Yang, Xiang Lei ^e   Schimmel, Paul ^e   Norga, Koen ^a   Timmerman, Vincent ^b,c   Callaerts, Patrick ^a   Jordanova, Albena ^b,c  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b UNIVERSITY OF ANTWERP   (Belgium)

^c UNIVERSITY OF ANTWERP   (Belgium)

^d FLORIDA ATLANTIC UNIVERSITY   (United States)

^e SCRIPPS RESEARCH INSTITUTE   (United States)

^f aTyr Pharma   (United States)

Author keywords

Aminoacylation; Cell autonomous; Disease model; Neurodegeneration; YARS

Indexed keywords

TYROSINE TRANSFER RNA LIGASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DROSOPHILA; ENZYME ACTIVITY; GENE MUTATION; HEREDITARY MOTOR SENSORY NEUROPATHY; MOTOR PERFORMANCE; NERVE FIBER DEGENERATION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; CHARCOT-MARIE-TOOTH DISEASE; DISEASE MODELS, ANIMAL; DROSOPHILA; ELECTROPHYSIOLOGY; GENES, DOMINANT; LUCIFERASES; MOTOR ACTIVITY; MUTATION; NEURONS; TYROSINE-TRNA LIGASE;

ANIMALIA;

EID: 67650882733     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0905339106     Document Type: Article

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